Felicitas Bijari, PhD
Associate Research Scientist in Radiology and Biomedical ImagingCards
About
Research
Publications
2025
3748 A large-animal pilot study of cardio-respiratory-gated radiation ablation for ventricular tachycardia targets using proton therapy
Jee K, Bijari F, Chemli Y, Chen Y, Deng H, Depauw N, Dhaynaut M, Garonna A, Kang J, Kim H, Macdonald-Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian K, Levine R, Lehmann H, Fakhri G. 3748 A large-animal pilot study of cardio-respiratory-gated radiation ablation for ventricular tachycardia targets using proton therapy. Radiotherapy And Oncology 2025, 206: s3543-s3544. DOI: 10.1016/s0167-8140(25)01927-9.Peer-Reviewed Original ResearchPO-04-096 NEW CARDIO-RESPIRATORY-GATED (5D) DELIVERY OF PROTON BEAMS FOR ABLATION OF VENTRICULAR ARRHYTHMIAS IN A PORCINE MODEL: LESION OUTCOMES AND COMPARISON TO RESPIRATORY GATED DELIVERY
Kang J, Bijari F, Jee K, Chemli Y, Chen Y, Deng H, Depauw N, Dhaynaut M, Garonna A, Kim H, Macdonald-Soccorso M, Moon S, Normandin M, Woodcock R, Yaghoubian K, Fakhri G, Levine R, Lehmann H. PO-04-096 NEW CARDIO-RESPIRATORY-GATED (5D) DELIVERY OF PROTON BEAMS FOR ABLATION OF VENTRICULAR ARRHYTHMIAS IN A PORCINE MODEL: LESION OUTCOMES AND COMPARISON TO RESPIRATORY GATED DELIVERY. Heart Rhythm 2025, 22: s484. DOI: 10.1016/j.hrthm.2025.03.1230.Peer-Reviewed Original Research
2024
Free‐breathing 3D cardiac extracellular volume (ECV) mapping using a linear tangent space alignment (LTSA) model
Lee W, Han P, Marin T, Mounime I, Eslahi S, Djebra Y, Chi D, Bijari F, Normandin M, Fakhri G, Ma C. Free‐breathing 3D cardiac extracellular volume (ECV) mapping using a linear tangent space alignment (LTSA) model. Magnetic Resonance In Medicine 2024, 93: 536-549. PMID: 39402014, PMCID: PMC11606777, DOI: 10.1002/mrm.30284.Peer-Reviewed Original ResearchExtracellular volume mappingContrast agent injectionExtracellular volumeGradient echo readoutECV mapsAgent injectionWhole heartEcho readoutExtracellular volume valuesVoxel-by-voxelInversion recovery sequenceSpatial resolutionScan timeImaging timeIn vivo studiesHealthy volunteersModel-based methodsRecovery sequenceInjectionReadout
2023
Injectable ice slurry for reducing pericardial adipose tissue
Shuhaiber J, Tuchayi S, Bijari F, Guehl N, Wang Y, Farinelli W, Arkun K, Fakhri G, Anderson R, Garibyan L. Injectable ice slurry for reducing pericardial adipose tissue. Lasers In Surgery And Medicine 2023, 55: 674-679. PMID: 37464943, DOI: 10.1002/lsm.23709.Peer-Reviewed Original ResearchConceptsPericardial adipose tissuePericardial adipose tissue volumeChest computed tomographyPAT volumeBaseline chest computed tomographyAnimal modelsSubcutaneous adipose tissue volumesCardiovascular diseaseHigh risk of cardiovascular diseaseAdipose tissueLow patient complianceRisk of cardiovascular diseaseWeight lossPreclinical large animal modelAdipose tissue volumeLarge animal modelBariatric surgeryComputed tomographyPatient complianceHigh riskNovel treatmentTreated groupCT imagesTissue volumeCryolipolysis
2022
PET imaging of mitochondrial function in acute doxorubicin-induced cardiotoxicity: a proof-of-principle study
Detmer F, Alpert N, Moon S, Dhaynaut M, Guerrero J, Guehl N, Xing F, Brugarolas P, Shoup T, Normandin M, Pelletier-Galarneau M, El Fakhri G, Petibon Y. PET imaging of mitochondrial function in acute doxorubicin-induced cardiotoxicity: a proof-of-principle study. Scientific Reports 2022, 12: 6122. PMID: 35414642, PMCID: PMC9005533, DOI: 10.1038/s41598-022-10004-6.Peer-Reviewed Original ResearchConceptsLeft anterior descending coronary arteryDoxorubicin-induced cardiotoxicityCardiac membrane potentialDoxorubicin infusionMembrane potentialAnimal modelsAcute doxorubicin-induced cardiotoxicityLeft anterior descending coronary artery territoryAcute cardiotoxic effectsAnterior descending coronary arteryControl saline infusionDescending coronary arteryDoxorubicin doseSaline infusionTest infusionCardiotoxic effectsMitochondrial membrane potentialInfusion catheterCoronary arteryInfusionMitochondrial functionDoxorubicinMyocardial areaPET imagingIntracoronary catheter
2021
Quantification of Myocardial Mitochondrial Membrane Potential Using PET
Pelletier-Galarneau M, Detmer F, Petibon Y, Normandin M, Ma C, Alpert N, El Fakhri G. Quantification of Myocardial Mitochondrial Membrane Potential Using PET. Current Cardiology Reports 2021, 23: 70. PMID: 33970353, PMCID: PMC8443083, DOI: 10.1007/s11886-021-01500-8.Peer-Reviewed Original Research
2020
In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study
Pelletier-Galarneau M, Petibon Y, Ma C, Han P, Kim S, Detmer F, Yokell D, Guehl N, Normandin M, El Fakhri G, Alpert N. In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 48: 414-420. PMID: 32719915, PMCID: PMC7839097, DOI: 10.1007/s00259-020-04878-9.Peer-Reviewed Original ResearchConceptsMembrane potentialBolus injectionHealthy subjectsHematocrit levelsSerial venous blood samplesT1 mapping imagesVenous blood samplesExtracellular space fractionMethodsThirteen healthy subjectsDynamic PET acquisitionCellular membrane potentialGadolinium injectionPrognostic informationVentricular arrhythmiasHeart failureMyocardial hypertrophyMitochondrial membrane potentialCardiac diseaseIn vitro assessmentTherapy monitoringBlood concentrationsPET acquisitionImaging protocolBlood samplesPlasma tracer concentrationBlebs in intracranial aneurysms: prevalence and general characteristics
Ashkezari S, Detmer F, Mut F, Chung B, Yu A, Stapleton C, See A, Amin-Hanjani S, Charbel F, Jahromi B, Niemelä M, Frösen J, Zhou J, Maiti S, Robertson A, Cebral J. Blebs in intracranial aneurysms: prevalence and general characteristics. Journal Of NeuroInterventional Surgery 2020, 13: 226-230. PMID: 32680877, PMCID: PMC8294207, DOI: 10.1136/neurintsurg-2020-016274.Peer-Reviewed Original ResearchConceptsAssociated with dental infectionDental infectionsIntracranial aneurysmsPercentage of aneurysmsHormone therapyPresence of blebsAssociated with hormone replacement therapyHormone replacement therapyHistory of hypertensionInternal carotid arteryReplacement therapyClinical factorsAneurysmVascular reconstructionCarotid arteryAneurysm neckRisk factorsMultiple blebsTherapyAngiographic imagesNeckInfectionRupture risk factorsBlebsHypertensionA note on coding and standardization of categorical variables in (sparse) group lasso regression
Detmer F, Cebral J, Slawski M. A note on coding and standardization of categorical variables in (sparse) group lasso regression. Journal Of Statistical Planning And Inference 2020, 206: 1-11. DOI: 10.1016/j.jspi.2019.08.003.Peer-Reviewed Original ResearchWithin-group sparsityCategorical covariatesRegressor variablesCoding schemeDesign matrixVariable selectionGroup lassoBoost performanceCategorical predictorsRe-scalingGroups of variablesOrthonormalityIndicator variablesTibshiraniSparsityCase studyConvenient approachComputerCase of interactionLASSOCovariatesSchemeIdentifiersExtensionVariablesIncorporating variability of patient inflow conditions into statistical models for aneurysm rupture assessment
Detmer F, Mut F, Slawski M, Hirsch S, Bijlenga P, Cebral J. Incorporating variability of patient inflow conditions into statistical models for aneurysm rupture assessment. Acta Neurochirurgica 2020, 162: 553-566. PMID: 32008209, PMCID: PMC7172014, DOI: 10.1007/s00701-020-04234-8.Peer-Reviewed Original ResearchConceptsFlow conditionsCFD simulationsComputational hemodynamicsComputed flow fieldSteady CFD simulationsInflow boundary conditionsFlow variationsInflow conditionsRupture assessmentFlow fieldCFD dataAneurysm rupture predictionRupture predictionInflow rateBoundary conditionsCFDInfluence of inter-FlowHemodynamic parametersSimulation