Assaf Alon, PhD
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Pharmacology
Primary
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About
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Assistant Professor of Pharmacology
Appointments
Pharmacology
Assistant ProfessorPrimary
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Education & Training
- Postdoctoral Fellow
- Harvard Medical School (2022)
- Postdoctoral Fellow
- Weizmann Institute of Science (2015)
- PhD
- Weizmann Institute of Science, Structural Biology (2012)
- BSc
- Tel Aviv University, Biotechnology (2005)
Research
Research at a Glance
Publications Timeline
A big-picture view of Assaf Alon's research output by year.
18Publications
277Citations
Publications
Featured Publications
The dynamic disulphide relay of quiescin sulphydryl oxidase
Alon A, Grossman I, Gat Y, Kodali V, DiMaio F, Mehlman T, Haran G, Baker D, Thorpe C, Fass D. The dynamic disulphide relay of quiescin sulphydryl oxidase. Nature 2012, 488: 414-418. PMID: 22801504, PMCID: PMC3521037, DOI: 10.1038/nature11267.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsIdentification of the gene that codes for the σ(2) receptor.
Alon A, Schmidt HR, Wood MD, Sahn JJ, Martin SF, Kruse AC. Identification of the gene that codes for the σ(2) receptor. Proc Natl Acad Sci U S A 2017, 114: 7160-7165. PMID: 28559337, DOI: 10.1073/pnas.1705154114.Peer-Reviewed Original ResearchStructures of the σ(2) receptor enable docking for bioactive ligand discovery.
Alon A, Lyu J, Braz JM, Tummino TA, Craik V, O'Meara MJ, Webb CM, Radchenko DS, Moroz YS, Huang XP, Liu Y, Roth BL, Irwin JJ, Basbaum AI, Shoichet BK, Kruse AC. Structures of the σ(2) receptor enable docking for bioactive ligand discovery. Nature 2021, 600: 759-764. PMID: 34880501, DOI: 10.1038/s41586-021-04175-x.Peer-Reviewed Original Research
2022
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination.
Gao Y, Barajas-Ornelas RDC, Amon JD, Ramírez-Guadiana FH, Alon A, Brock KP, Marks DS, Kruse AC, Rudner DZ. The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination. Genes Dev 2022, 36: 634-646. PMID: 35654455, DOI: 10.1101/gad.349488.122.Peer-Reviewed Original Research
2021
The Spliced Leader RNA Silencing (SLS) Pathway in Trypanosoma brucei Is Induced by Perturbations of Endoplasmic Reticulum, Golgi Complex, or Mitochondrial Protein Factors: Functional Analysis of SLS-Inducing Kinase PK3.
Okalang U, Mualem Bar-Ner B, Rajan KS, Friedman N, Aryal S, Egarmina K, Hope R, Khazanov N, Senderowitz H, Alon A, Fass D, Michaeli S. The Spliced Leader RNA Silencing (SLS) Pathway in Trypanosoma brucei Is Induced by Perturbations of Endoplasmic Reticulum, Golgi Complex, or Mitochondrial Protein Factors: Functional Analysis of SLS-Inducing Kinase PK3. MBio 2021, 12: e0260221. PMID: 34844425, DOI: 10.1128/mBio.02602-21.Peer-Reviewed Original ResearchDormant spores sense amino acids through the B subunits of their germination receptors.
Artzi L, Alon A, Brock KP, Green AG, Tam A, Ramírez-Guadiana FH, Marks D, Kruse A, Rudner DZ. Dormant spores sense amino acids through the B subunits of their germination receptors. Nat Commun 2021, 12: 6842. PMID: 34824238, DOI: 10.1038/s41467-021-27235-2.Peer-Reviewed Original ResearchDrug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2.
Tummino TA, Rezelj VV, Fischer B, Fischer A, O'Meara MJ, Monel B, Vallet T, White KM, Zhang Z, Alon A, Schadt H, O'Donnell HR, Lyu J, Rosales R, McGovern BL, Rathnasinghe R, Jangra S, Schotsaert M, Galarneau JR, Krogan NJ, Urban L, Shokat KM, Kruse AC, García-Sastre A, Schwartz O, Moretti F, Vignuzzi M, Pognan F, Shoichet BK. Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2. Science 2021, 373: 541-547. PMID: 34326236, DOI: 10.1126/science.abi4708.Peer-Reviewed Original ResearchCOVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms.
Malone RW, Tisdall P, Fremont-Smith P, Liu Y, Huang XP, White KM, Miorin L, Moreno E, Alon A, Delaforge E, Hennecker CD, Wang G, Pottel J, Blair RV, Roy CJ, Smith N, Hall JM, Tomera KM, Shapiro G, Mittermaier A, Kruse AC, García-Sastre A, Roth BL, Glasspool-Malone J, Ricke DO. COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms. Front Pharmacol 2021, 12: 633680. PMID: 33833683, DOI: 10.3389/fphar.2021.633680.Peer-Reviewed Original Research
2019
cis-Proline mutants of quiescin sulfhydryl oxidase 1 with altered redox properties undermine extracellular matrix integrity and cell adhesion in fibroblast cultures.
Javitt G, Grossman-Haham I, Alon A, Resnick E, Mutsafi Y, Ilani T, Fass D. cis-Proline mutants of quiescin sulfhydryl oxidase 1 with altered redox properties undermine extracellular matrix integrity and cell adhesion in fibroblast cultures. Protein Sci 2019, 28: 228-238. PMID: 30367560, DOI: 10.1002/pro.3537.Peer-Reviewed Original Research
2017
Structural Perspectives on Sigma-1 Receptor Function.
Alon A, Schmidt H, Zheng S, Kruse AC. Structural Perspectives on Sigma-1 Receptor Function. Adv Exp Med Biol 2017, 964: 5-13. PMID: 28315261, DOI: 10.1007/978-3-319-50174-1_2.Peer-Reviewed Original Research
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