Ilan Harpaz-Rotem, PhD, ABPP
Professor of Psychiatry and of PsychologyDownloadHi-Res Photo
Cards
Appointments
Psychiatry
Primary
Department of Psychology
Secondary
Additional Titles
Director, PTSD Advanced Fellowship in Mental Illness Research and Treatment
Deputy Director, Evaluation Division at the National Center for PTSD, VA Connecticut Healthcare System
Contact Info
Appointments
Psychiatry
Primary
Department of Psychology
Secondary
Additional Titles
Director, PTSD Advanced Fellowship in Mental Illness Research and Treatment
Deputy Director, Evaluation Division at the National Center for PTSD, VA Connecticut Healthcare System
Contact Info
Appointments
Psychiatry
Primary
Department of Psychology
Secondary
Additional Titles
Director, PTSD Advanced Fellowship in Mental Illness Research and Treatment
Deputy Director, Evaluation Division at the National Center for PTSD, VA Connecticut Healthcare System
Contact Info
About
Titles
Professor of Psychiatry and of Psychology
Director, PTSD Advanced Fellowship in Mental Illness Research and Treatment
Positions outside Yale
Deputy Director, Evaluation Division at the National Center for PTSD, VA Connecticut Healthcare System
Biography
Dr. Harpaz-Rotem is a Professor of Psychiatry and of Psychology at Yale University. He is a clinical psychologist who, for many years, has conducted research and provided treatment to individuals exposed to trauma. Dr. Harpaz-Rotem serves as an investigator at the National Center for PTSD, and he also directs the evaluation of VA PTSD treatment programs at the Department of Veterans Affairs, Northeast Program Evaluation Center, Office of Mental Health and Suicide Prevention, VA Central Office. Research into how to modify traumatic memories and their associated emotions is one of the core questions that guide his work.
Appointments
Psychiatry
ProfessorPrimaryDepartment of Psychology
ProfessorSecondary
Other Departments & Organizations
- Center for Brain & Mind Health
- Department of Psychology
- Division of Mental Health Services
- Harpaz-Rotem Lab
- MR Center
- Psychiatry
- Psychology Section
- VA National Center for PTSD
- VA-Yale Clinical Neurosciences PTSD Research Program
- Wu Tsai Institute
- Yale Ventures
Education & Training
- Postdoc
- NIH NRSA Postdoctoral Fellowship Yale University Department of Psychiatry (2004)
- PhD
- New School for Social Research (2002)
- Clinical training
- University of California at Davis School of Medicine (2002)
- Clinical training
- Albert Einstein School of Medicine Bronx Lebanon Hospital (2001)
- Clinical training
- New York University Medical Center & Bellevue Hospital (2000)
- Clinical training
- Beth Israel Medical Center (1998)
Research
Overview
Medical Research Interests
Afghanistan; Anxiety Disorders; Biomarkers, Pharmacological; Depression; Iraq; Magnetic Resonance Imaging; Mental Health Services; Positron Emission Tomography Computed Tomography; Psychiatry; Psychotherapy; Stress Disorders, Post-Traumatic; Veterans
ORCID
0000-0002-6066-9406- View Lab Website
Harpaz-Rotem PTSD Treatment & Research Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Ilan Harpaz-Rotem's published research.
Publications Timeline
A big-picture view of Ilan Harpaz-Rotem's research output by year.
Research Interests
Research topics Ilan Harpaz-Rotem is interested in exploring.
Jack Tsai
Or Duek, PhD
John Krystal, MD
Robert Pietrzak, PhD, MPH
Georgina Gross, PhD
Ifat Levy, PhD
178Publications
4,568Citations
Stress Disorders, Post-Traumatic
Veterans
Magnetic Resonance Imaging
Mental Health Services
Psychotherapy
Depression
Publications
2024
Generalizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness
Chopra S, Dhamala E, Lawhead C, Ricard J, Orchard E, An L, Chen P, Wulan N, Kumar P, Rubenstein A, Moses J, Chen L, Levi P, Holmes A, Aquino K, Fornito A, Harpaz-Rotem I, Germine L, Baker J, Yeo B, Holmes A. Generalizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness. Science Advances 2024, 10: eadn1862. PMID: 39504381, PMCID: PMC11540040, DOI: 10.1126/sciadv.adn1862.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPrediction of cognitionCognitive functionPrediction of cognitive functionFunctional neuroimaging dataTransdiagnostic sampleComputational psychiatryPsychiatric illnessNeuroimaging dataCognitive impairmentCognitionPopulation-level datasetsPsychiatryAssociated with poor outcomesUK BiobankImpairmentBrainIllnessSymptomsPrediction studiesParticipantsPoor outcomeClinical studiesSamplesUnveiling the Structure in Mental Disorder Presentations
Spiller T, Duek O, Helmer M, Murray J, Fielstein E, Pietrzak R, von Känel R, Harpaz-Rotem I. Unveiling the Structure in Mental Disorder Presentations. JAMA Psychiatry 2024, 81: 1101-1107. PMID: 39110437, PMCID: PMC11307158, DOI: 10.1001/jamapsychiatry.2024.2047.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSymptom combinationsNational Institute of Mental Health Data ArchivePosttraumatic stress disorderDiagnostic criteriaHeterogeneity of symptomsSecondary data analysisCross-sectional studyRevision of diagnostic criteriaSymptom-based definitionsDSM criteriaStress disorderSymptom heterogeneityDisorder presentationsClinical populationsMain OutcomesAssess symptomsGroup of individualsParticipantsSymptomsNational InstituteDisordersIndividualsSchizophreniaAnxietyIndividual frequenciesPrevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans.
Fischer I, Na P, Harpaz-Rotem I, Marx B, Pietrzak R. Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39480145, DOI: 10.4088/jcp.24m15465.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsSubthreshold posttraumatic stress disorderPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersLifetime psychiatric disordersUS veteransUS military veteransSymptom-related distressStress disorderPsychiatric disordersSymptom clustersTreating veteransCriterion AMilitary veteransTraumatic eventsCognitive functionWorking case definitionMental healthCriterion FFunctional impairmentVeteransNationally representative sampleFunctional correlatesDisordersElevated oddsGreater oddsAmygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsCerebellar Contributions to Traumatic Autobiographical Memory in People with Post-Traumatic Stress Disorder
Blithikioti C, Duek O, Gordon C, Krystal J, Levy I, Harpaz-Rotem I, Schiller D, Perl O. Cerebellar Contributions to Traumatic Autobiographical Memory in People with Post-Traumatic Stress Disorder. The Cerebellum 2024, 1-9. PMID: 39180693, DOI: 10.1007/s12311-024-01731-9.Peer-Reviewed Original ResearchAltmetricConceptsPost-traumatic stress disorderFunctional magnetic resonance imagingRight cerebellar lobule VICerebellar lobule VIAutobiographical memoryTraumatic eventsAutobiographical recallStress disorderLobule VIRe-experiencing of traumatic eventsChronic post-traumatic stress disorderDebilitating mental health conditionPTSD pathophysiologyProcessing negative emotionsNegative affective statesCerebellar Crus IIMental health conditionsCerebellar engagementRe-experiencingTrauma exposureCerebellar contributionReactivity paradigmNegative emotionsAffective statesCrus IIPost-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT
Korem N, Duek O, Ben-Zion Z, Spiller T, Gordon C, Amen S, Levy I, Harpaz-Rotem I. Post-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT. Psychiatry Research Neuroimaging 2024, 343: 111864. PMID: 39111111, DOI: 10.1016/j.pscychresns.2024.111864.Peer-Reviewed Original ResearchAltmetricConceptsReduced resting-state functional connectivityPost-traumatic stress disorderPost-traumatic stress disorder symptomsFunctional connectivityPost-treatment changesReducing PTSD symptom severityFollow-up changesResting-state functional connectivityIntensive exposure therapyExposure-based psychotherapyVentromedial prefrontal cortexPTSD symptom severityReduced structural connectivityFunctional connectivity patternsPost-treatmentWhite matter integrityPrefrontal cortexExposure therapyPTSD symptomsStress disorderSymptom severityUncinate fasciculusLimbic systemSecondary analysisAssociated with sustained changesUnraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment
Gross G, Spiller T, Ben-Zion Z, Rubenstein A, Pietrzak R, Duek O, Hoff R, Harpaz-Rotem I. Unraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment. Psychological Trauma Theory Research Practice And Policy 2024 PMID: 38990694, DOI: 10.1037/tra0001734.Peer-Reviewed Original ResearchAltmetricConceptsPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder clustersSymptom clustersIntrusive symptomsResidential treatmentTreatment of posttraumatic stress disorderPosttraumatic stress disorder symptomsResidential PTSD treatmentPTSD symptom clustersNovel treatment interventionsDifferential treatment responseReduce symptom severityDifferential patterns of changeAvoidance symptomsPTSD treatmentTreatment gainsStress disorderVeterans AffairsSymptom severityCluster CTreatment interventionsCluster BIndividual symptomsCohort of veteransBarriers to Mental Health Care in US Military Veterans
Lewis C, Fischer I, Tsai J, Harpaz-Rotem I, Pietrzak R. Barriers to Mental Health Care in US Military Veterans. Psychiatric Quarterly 2024, 95: 367-383. PMID: 38940875, DOI: 10.1007/s11126-024-10078-7.Peer-Reviewed Original ResearchConceptsMental health careMental health treatmentHealth careHealth treatmentReduce barriersUS veteransNegative beliefsInstrumental barriersNational Health and ResiliencePromote engagementMental health servicesPopulation-based effortsUS military veteransNationally representative dataMultivariate logistic regressionPerceived stigmaHealth servicesSocial supportPsychiatric needsVeterans StudyPractical barriersLow purposeConclusionsNearly halfMilitary veteransCare351. High-Threshold-Low-Tolerance: A Model for the Emotionality Paradox in PTSD
Korem N, Duek O, Spiller T, Ben-Zion Z, Levy I, Harpaz-Rotem I. 351. High-Threshold-Low-Tolerance: A Model for the Emotionality Paradox in PTSD. Biological Psychiatry 2024, 95: s243. DOI: 10.1016/j.biopsych.2024.02.850.Peer-Reviewed Original ResearchEmotional State Transitions in Trauma-Exposed Individuals With and Without Posttraumatic Stress Disorder
Korem N, Duek O, Spiller T, Ben-Zion Z, Levy I, Harpaz-Rotem I. Emotional State Transitions in Trauma-Exposed Individuals With and Without Posttraumatic Stress Disorder. JAMA Network Open 2024, 7: e246813. PMID: 38625701, PMCID: PMC11022112, DOI: 10.1001/jamanetworkopen.2024.6813.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPosttraumatic stress disorderTrauma-exposed individualsEmotional numbing symptomsTrauma-exposed controlsNegative emotional statesNumbing symptomsEmotional numbingDSM-5Valence ratingsStress disorderEmotional statesTrauma-exposed control groupPTSD experiencesPosttraumatic stress disorder symptomsPosttraumatic Stress Disorder ChecklistDSM-5 criteriaAge-related associationsStimulus valencePCL-5Emotional responsesEmotional state transitionEmotional transitionSymptomsParticipantsDisorders
Clinical Trials
Current Trials
Eligibility for Participation in Neuroimaging Studies
HIC ID2000027842RoleSub InvestigatorPrimary Completion Date12/31/2023Recruiting ParticipantsUsing Neuroimaging to track symptom change in PTSD treatment
HIC ID2000025892RolePrincipal InvestigatorPrimary Completion Date07/31/2029Recruiting ParticipantsNeurofeedback of Amygdala Activity for Post-traumatic Stress Disorder (PTSD)
HIC ID2000022668RolePrincipal InvestigatorPrimary Completion Date06/30/2023Recruiting ParticipantsGenderBothAge18+ yearsImaging mGluR5 and synaptic density in psychiatric disorders
HIC ID2000020186RoleSub InvestigatorPrimary Completion Date01/31/2018Recruiting ParticipantsGenderBothAge18 years - 80 yearsIntensive 7-day Treatment for PTSD Combining Ketamine With Exposure Therapy (PTSD)
HIC ID1509016530RolePrincipal InvestigatorPrimary Completion Date08/01/2030Recruiting ParticipantsGenderBothAge21 years - 70 years
Academic Achievements & Community Involvement
honor Distinguished Mentorship Award
National AwardInternational Society for Traumatic Stress Studies (ISTSS)Details11/11/2022United States
News & Links
News
- September 09, 2024Source: Yale News
Endocannabinoids Are Associated With Emotional Numbing in PTSD
- August 07, 2024Source: Yale News
Mental Disorder Symptoms Present in Predictable Ways
- May 03, 2024Source: Yale News
Rapid Emotion Transitions May Explain Numbness and Hyperreactivity in PTSD
- April 23, 2024Source: APA PsycNet
To Expose or Not to Expose: A Comprehensive Perspective on Treatment for Posttraumatic Stress Disorder
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Mailing Address
Psychiatry
300 George Street
New Haven, CT 06511
United States
Locations
300 George Street
Academic Office
Rm 836
New Haven, CT 06511