Matthew Ellis
Research
Publications
2024
Fully biologic endothelialized-tissue-engineered vascular conduits provide antithrombotic function and graft patency
Park J, Riaz M, Qin L, Zhang W, Batty L, Fooladi S, Kural M, Li X, Luo H, Xu Z, Wang J, Banno K, Gu S, Yuan Y, Anderson C, Ellis M, Zhou J, Luo J, Shi X, Shin J, Liu Y, Lee S, Yoder M, Elder R, Mak M, Thorn S, Sinusas A, Gruber P, Hwa J, Tellides G, Niklason L, Qyang Y. Fully biologic endothelialized-tissue-engineered vascular conduits provide antithrombotic function and graft patency. Cell Stem Cell 2024 PMID: 39644899, DOI: 10.1016/j.stem.2024.11.006.Peer-Reviewed Original ResearchTissue-engineered vascular conduitsSingle-ventricle congenital heart defectsEndothelial cellsBiodegradable polymeric scaffoldsGraft patencyAutologous bone marrow cellsAntithrombotic functionCongenital heart defectsInferior vena cava graftHiPSC-derived endothelial cellsBone marrow cellsHuman umbilical arteryDecellularized human umbilical arteriesPolymeric scaffoldsHost endothelial cellsHuman induced pluripotent stem cell (hiPSC)-derived endothelial cellsUmbilical arteryHeart defectsVascular conduitsMarrow cellsFlow bioreactorVena cava graftNude ratsGraft stenosisClinical trialsDe Novo Elastin Assembly Alleviates Development of Supravalvular Aortic Stenosis—Brief Report
Ellis M, Riaz M, Huang Y, Anderson C, Hoareau M, Li X, Luo H, Lee S, Park J, Luo J, Batty L, Huang Q, Lopez C, Reinhardt D, Tellides G, Qyang Y. De Novo Elastin Assembly Alleviates Development of Supravalvular Aortic Stenosis—Brief Report. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 1674-1682. PMID: 38752350, PMCID: PMC11209776, DOI: 10.1161/atvbaha.124.320790.Peer-Reviewed Original ResearchSupravalvular aortic stenosisVascular smooth muscle cellsSmooth muscle cellsMuscle cellsAortic stenosisMedial vascular smooth muscle cellsVascular proliferative diseasesEpigallocatechin gallate treatmentProliferative abnormalitiesPreclinical findingsHeart failureLuminal occlusionMouse modelCell hyperproliferationDefective elastinProliferative diseasesCardiovascular disordersFormation of elastinTherapeutic interventionsElastin assemblyElastin depositionStenosisMiceAortic mechanicsImproper formationThe Impact of Mechano-Electric Feedback on Drug- and Stretch- Induced Arrhythmia Using a Computational Model of Cardiac Electromechanics
Asencio A, Buonocunto M, Ellis M, Munthe K, Stark K, Sundnes J, Finsberg H, Arevalo H. The Impact of Mechano-Electric Feedback on Drug- and Stretch- Induced Arrhythmia Using a Computational Model of Cardiac Electromechanics. Simula SpringerBriefs On Computing 2024, 17: 87-97. DOI: 10.1007/978-3-031-53145-3_6.Peer-Reviewed Original ResearchStretch-activated ion channelsMechano-electrical feedbackCardiac cellsO’Hara-RudyIncreased arrhythmic riskAction potential durationAnti-arrhythmic drugsPro-arrhythmic drugsStretch-induced arrhythmiasPro-arrhythmic effectsCoupled electro-mechanical modelElectro-mechanical modelComputational models of cardiac electromechanicsArrhythmic riskPotential durationHeart failureModels of cardiac electromechanicsElectrophysiological parametersInfarction patientsPathological stretchRisk classificationRisk profileCardiac electrophysiologyIon channelsAnti-arrhythmic compounds
2023
Calcium “stress” adds a third hit in driving heart failure with preserved ejection fraction
Fujita K, Ellis M, Sheikh F. Calcium “stress” adds a third hit in driving heart failure with preserved ejection fraction. AJP Heart And Circulatory Physiology 2023, 324: h414-h416. PMID: 36763507, PMCID: PMC9988519, DOI: 10.1152/ajpheart.00075.2023.Peer-Reviewed Original Research