Inderjit Singh, MBChB, BMedSci, FRCP, FCCP
Associate Professor TermCards
About
Research
Publications
2024
The metabolic and physiologic impairments underlying long COVID associated exercise intolerance
Leitner B, Joseph P, Quast A, Ramirez M, Heerdt P, Villalobos J, Singh I. The metabolic and physiologic impairments underlying long COVID associated exercise intolerance. Pulmonary Circulation 2024, 14: e70009. PMID: 39544193, PMCID: PMC11560803, DOI: 10.1002/pul2.70009.Peer-Reviewed Original ResearchPeak VO<sub>2</sub>Long COVID patientsCOVID patientsReduced peak VOSeverity of SARS-CoV-2 infectionSystemic oxygen extractionSARS-CoV-2 infectionLong COVIDArterial blood samplesQuantitative metabolomicsPeak VOVenous lactateCardiac outputImpaired mitochondrial ATP productionMild infectionExercise capacityPatientsMitochondrial ATP productionExercise intoleranceArteriovenous gradientBlood samplesOxygen extractionDependent mannerMetabolomicsPhysiological impairmentDyspnea in a Patient With Metastatic Breast Cancer
Tarras E, Sen S, Wang H, Singh I. Dyspnea in a Patient With Metastatic Breast Cancer. CHEST Pulmonary 2024, 2: 100074. DOI: 10.1016/j.chpulm.2024.100074.Peer-Reviewed Original ResearchThe casting of invasive cardiopulmonary exercise testing: towards a common goal.
Singh I, Waxman A. The casting of invasive cardiopulmonary exercise testing: towards a common goal. European Respiratory Journal 2024, 64: 2400783. PMID: 38991723, DOI: 10.1183/13993003.00783-2024.Peer-Reviewed Original ResearchRight Ventricular Pressure Waveform Analysis—Clinical Relevance and Future Directions
Heerdt P, Kheyfets V, Oakland H, Joseph P, Singh I. Right Ventricular Pressure Waveform Analysis—Clinical Relevance and Future Directions. Journal Of Cardiothoracic And Vascular Anesthesia 2024, 38: 2433-2445. PMID: 39025682, DOI: 10.1053/j.jvca.2024.06.022.Peer-Reviewed Original ResearchRight ventricular pressureRight ventricular functionVentricular pressureVentricular functionMeasuring right ventricular pressureMeasurements of right ventricular pressurePeak right ventricular pressurePulmonary artery pressureEvaluate cardiac functionPulmonary arteryStroke volume measurementsRight atriumCardiac functionDiastolic fillingSurgical patientsArterial pressureClinical valueDemonstrating utilityVolume measurementsMeasurements of pressurePressure waveformAccurate surrogateContinuous measurement of pressurePhysiological factorsEchocardiographyStiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodelingThree-dimensional (3D) Right Ventricular Surface Strain Computed From 3D Echocardiography Correlates With RVEF and Reveals Differences in Deformation Based on Severity of Pulmonary Arterial Hypertension Symptoms
Oakland H, Bellumkonda L, Sugeng L, Joseph P, Izzi D, Zalik F, McCabe S, Raza A, Amendola R, Heerdt P, Singh I, Hunter K. Three-dimensional (3D) Right Ventricular Surface Strain Computed From 3D Echocardiography Correlates With RVEF and Reveals Differences in Deformation Based on Severity of Pulmonary Arterial Hypertension Symptoms. 2024, a7381-a7381. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7381.Peer-Reviewed Original ResearchTumoral Pulmonary Hypertension in a Patient With Metastatic Breast Cancer: Diagnostic Opportunity of the Right Heart Catheterization
Tarras E, Sen S, Wang H, Singh I. Tumoral Pulmonary Hypertension in a Patient With Metastatic Breast Cancer: Diagnostic Opportunity of the Right Heart Catheterization. 2024, a2208-a2208. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2208.Peer-Reviewed Original Research
2023
Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance
Kahn P, Joseph P, Heerdt P, Singh I. Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance. ERJ Open Research 2023, 10: 00714-2023. PMID: 38348243, PMCID: PMC10860209, DOI: 10.1183/23120541.00714-2023.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testingRight heart catheterizationPASC patientsExertional intoleranceCardiac outputPulmonary artery wedge pressurePeak VO 2Supranormal cardiac outputPeak exercise capacityCardiopulmonary exercise testingMaximal voluntary ventilationPost-acute sequelaeBody mass indexSystemic oxygen extractionMild acute illnessSARS-CoV-2Exercise hemodynamicsHFpEF patientsHFpEF phenotypeHeart catheterizationWedge pressureAcute illnessExercise capacityExercise testingHemodynamic abnormalitiesRight Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment.
Tarras E, Khosla A, Heerdt P, Singh I. Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment. Journal Of Intensive Care Medicine 2023, 8850666231216889. PMID: 38031338, DOI: 10.1177/08850666231216889.Peer-Reviewed Original ResearchRight heart failureFailure patientsHeart failureTreatment optionsIntensive care unit settingMechanical circulatory support devicesIntensive care unitCirculatory support devicesCardio-pulmonary physiologyCare unitDifferent pharmacotherapiesUnit settingClinical guidancePathophysiological manifestationsCirculatory physiologyIntensivistsPatientsSupport devicesSupport optionsCirculatory systemHigh rateTreatmentDiagnosisFailureOptionsPost-Acute Sequelae of SARS-CoV-2 More Than Deconditioning
Joseph P, Singh I. Post-Acute Sequelae of SARS-CoV-2 More Than Deconditioning. CHEST Journal 2023, 164: 583-584. PMID: 37689472, DOI: 10.1016/j.chest.2023.03.014.Peer-Reviewed Original Research
Clinical Trials
Current Trials
A Phase 2a Study of LAM-001 for the Treatment of Pulmonary Hypertension
HIC ID2000035353RoleSub InvestigatorPrimary Completion Date02/28/2024Recruiting ParticipantsGenderBothAge18+ yearsA Study of Sotatercept for the Treatment of Cpc-PH Due to HFpEF (MK-7962-007/​A011-16) (CADENCE)
HIC ID2000032349RoleSub InvestigatorPrimary Completion Date08/31/2023Recruiting ParticipantsGenderBothAge18 years - 85 years
Academic Achievements & Community Involvement
Clinical Care
Overview
Inderjit Singh, MBChB, (a medical degree awarded in the United Kingdom) is director of the Pulmonary Vascular Disease Program and specializes in treating pulmonary hypertension (high blood pressure in the heart-to-lung system).
Dr. Singh was steered toward medicine at an early age while growing up in Malaysia, where his father was a pediatrician. He often accompanied his father to work and says he enjoyed watching him help others feel better.
During medical school, he was drawn to pulmonary medicine, within which he discovered pulmonary vascular medicine—and pulmonary hypertension in particular.
“I have a strong interest in understanding the right heart and how it interacts with the pulmonary circulation,” Dr. Singh says. “And I like how pulmonary hypertension overlaps with so many specialties from cardiology to rheumatology to hepatology. You need to know all the different organs and disease processes to understand pulmonary hypertension.”
Pulmonary hypertension is also an exciting field because of many advancements in treatment, he says. “For a long time, we didn’t have much to offer in terms of therapy. But now there is more understanding of the disease, so much so that now you have dedicated training programs for pulmonary hypertension,” he says.
For research, Dr. Singh explores how the right ventricle of the heart and the pulmonary circulation interact, particularly during exercise.
“Our research is mainly focused on how the right heart interacts with the lungs’ blood vessels at rest and during exercise,” he explains. “We are one of the few centers in the world that performs invasive cardiopulmonary exercise test (iCPET). We primarily perform iCPET for patients who have unexplained shortness of breath or fatigue. So, these are patients who've had all the routine investigative testing, all of which do not explain their symptoms.”
Clinical Specialties
Fact Sheets
Pulmonary Hypertension
Learn More on Yale MedicinePulmonary Embolism
Learn More on Yale MedicineAcute Respiratory Distress Syndrome (ARDS)
Learn More on Yale MedicineCOVID-19
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Board Certifications
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2015
- Original Certification Date
- 2013
Yale Medicine News
News
News
- November 05, 2024
Yale Researchers at American Heart Association Scientific Session 2024
- July 24, 2024
Yale Department of Internal Medicine Faculty Promotions and Appointments (July 2024)
- April 27, 2023
Study Uncovers Reduced Exercise Tolerance and Other Changes in Long COVID
- February 21, 2022Source: Hartford Courant
Yale researchers offer insight into diminished exercise ability for those with long-haul COVID-19