2025
Aggregated postpartum cerebral autoregulatory curves in normotensive individuals, preeclampsia with severe features, and superimposed preeclampsia with severe features
Woolcock H, Katsidoniotaki M, Meng L, Haghighi N, van Wingerden A, Alian A, Booker W, Bello N, Marshall R, Kougioumtzoglou I, Petersen N, Miller E. Aggregated postpartum cerebral autoregulatory curves in normotensive individuals, preeclampsia with severe features, and superimposed preeclampsia with severe features. Physiological Measurement 2025, 46: 09nt01. PMID: 40845907, PMCID: PMC12441783, DOI: 10.1088/1361-6579/adfeb4.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureCerebrovascular CirculationFemaleHomeostasisHumansPostpartum PeriodPre-EclampsiaPregnancyProspective StudiesConceptsMean arterial pressureSuperimposed preeclampsiaPreeclampsia groupProspective observational studyNormotensive groupCerebral blood velocityRetrospective analysisPostpartum participantsAutoregulatory rangeRetrospective analysis of dataAutoregulatory curveContinuous mean arterial pressureImpaired cerebral autoregulationSevere featuresChronic hypertensionPreeclampsiaArterial pressureCerebral autoregulatory curveNormotensive individualsFinger plethysmographyPostpartum periodPair-wise comparisonsTranscranial DopplerAutoregulation curveCerebral autoregulationNormative serum cortisol levels in second and third trimesters and their associated factors: A prospective cohort study from Sri Lanka
Menike I, Rajapakse S, Amarasinghe G, Warnasekara J, Wickramasinghe N, Agampodi T, Agampodi S. Normative serum cortisol levels in second and third trimesters and their associated factors: A prospective cohort study from Sri Lanka. PLOS ONE 2025, 20: e0322685. PMID: 40920792, PMCID: PMC12416640, DOI: 10.1371/journal.pone.0322685.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHumansHydrocortisonePregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdProspective StudiesSri LankaYoung AdultConceptsSerum cortisol levelsHistory of miscarriagePregnant womenWeeks POGPrimi gravidSerum cortisolAssociated with serum cortisol levelsCortisol levelsCohort of pregnant womenMaternity care programMorning serum cortisol levelsRajarata Pregnancy CohortPre-pregnancy BMIAssociated with serum cortisolFollow-up visitProspective cohort studyRural Sri LankaEPDS scoresBMI categoriesCare programTwin pregnanciesPre-pregnancyNo significant differencePregnancy cohortStudy participantsEstimating the associations between women’s maltreatment in childhood and inflammatory biomarker levels prior to and during pregnancy
Wu B, Vyas C, Medina A, Slopen N, Mahalingaiah S, Chavarro J, Mukherjee R, Weisskopf M, Roberts A. Estimating the associations between women’s maltreatment in childhood and inflammatory biomarker levels prior to and during pregnancy. PLOS ONE 2025, 20: e0331905. PMID: 40920854, PMCID: PMC12416833, DOI: 10.1371/journal.pone.0331905.Peer-Reviewed Original ResearchConceptsTumor necrosis factor alpha receptor 2Associated with higher riskC-reactive proteinAdverse neurodevelopmentInflammatory biomarkersNurses' Health Study 3Risk of adverse neurodevelopmentInterleukin-6Gestational risk factorsMaternal childhood abuseMaternal childhood maltreatmentGeneralized Estimating EquationsSample of well-educatedChronic systemic inflammationInflammatory biomarker levelsChildhood maltreatmentNon-HispanicExposure to maltreatmentPregnant participantsVulnerable populationsOffspring neurodevelopmentSystemic inflammationIFN-gProspective cohortInterferon-gammaSerum Proteomic Profile Based on the TGF‐β Pathway Stratifies Risk of Hepatocellular Carcinoma
Xiang X, Shetty K, Yu H, Mishra B, Wong L, Zhou X, Satapathy S, Crawford J, Latham P, Han S, Mathew B, Dagher N, Lau L, Cacaj F, Vegesna A, Dasarathy S, He A, Huang H, Amdur R, Mishra L. Serum Proteomic Profile Based on the TGF‐β Pathway Stratifies Risk of Hepatocellular Carcinoma. Liver International 2025, 45: e70325. PMID: 40919824, PMCID: PMC12416123, DOI: 10.1111/liv.70325.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkers, TumorCarcinoma, HepatocellularCross-Sectional StudiesFemaleHumansLiver CirrhosisLiver NeoplasmsLogistic ModelsLongitudinal StudiesMaleMiddle AgedProspective StudiesProteomicsReceptor, Transforming Growth Factor-beta Type IIRisk AssessmentRisk FactorsTransforming Growth Factor betaConceptsRisk of hepatocellular carcinomaHepatocellular carcinomaCohort ALogistic regression analysisCohort CLongitudinal follow-up analysisTGF-bHepatocellular carcinoma riskCancer-related deathsProtein signaturesSix-protein panelSerum proteomic profilesLate-stage diagnosisAFP levelsCirrhotic patientsCohort BMulticenter studyLogistic regression analyses of cross-sectional dataClinical factorsMultivariable prediction modelEarly diagnosisMatched subgroupsPatientsCirrhosisFunction biomarkersAn adaptive simulation intervention decreases emergency physician physiologic stress while caring for patients during COVID-19: A randomized clinical trial
Evans L, Bonz J, Buck S, Gerwin J, Bonner S, Ikejiani S, Moylan T, Joseph M, de Oliveira Almeida G, Ray J, Dziura J, Venkatesh A, Wong A. An adaptive simulation intervention decreases emergency physician physiologic stress while caring for patients during COVID-19: A randomized clinical trial. PLOS ONE 2025, 20: e0331488. PMID: 40901855, PMCID: PMC12407420, DOI: 10.1371/journal.pone.0331488.Peer-Reviewed Original ResearchConceptsSelf-report State-Trait Anxiety InventoryClinician well-beingSimulation interventionIntervention groupEducational interventionEmergency medicineClinical shiftsSimulation-based educational interventionRoot-mean-square standard deviationHeart rate variabilityPatient care qualitySimulated educational interventionState-Trait Anxiety InventoryWell-beingStressful work environmentOptimal patient careEM physiciansPost-interventionPatient safetyEM workforcePatient careControl groupEmergency physiciansAnxiety InventoryRandomized clinical trialsFrequency and Diagnostic Implications of Paramagnetic Rim Lesions in People Presenting for Diagnosis to a Multiple Sclerosis Clinic
Renner B, Verter E, Absinta M, Daboul L, Raza P, Martin M, Cao Q, O'Donnell C, Rodrigues P, Ramos M, Prchkovska V, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Pelletier D, Samudralwar R, Schindler M, Sotirchos E, Sicotte N, Solomon A, Shinohara R, Reich D, Ontaneda D, Sati P. Frequency and Diagnostic Implications of Paramagnetic Rim Lesions in People Presenting for Diagnosis to a Multiple Sclerosis Clinic. Neurology 2025, 105: e213912. PMID: 40893055, DOI: 10.1212/wnl.0000000000213912.Peer-Reviewed Original ResearchConceptsParamagnetic rim lesionsDiagnosis of MSClinically established diagnosisRadiological suspicionMultiple sclerosisClinical presentationMcDonald criteriaDiagnostic performanceRim lesionsSymptom onsetDiagnostic valueImaging biomarkersDiagnostic implicationsActive multiple sclerosisMultiple Sclerosis ClinicChronic active multiple sclerosisAlternative diagnosesClinical symptomsAssociated with higher probabilityBrain MRIObservational studyDiagnostic thresholdMS centersGold standardDiagnosisPractice of oxygenation and respiratory support during fibreoptic bronchoscopy: the OxyFOB study protocol
Longhini F, Crimi C, Noto A, Pelaia C, Karakurt Z, Skoczyński S, Boléo-Tomé J, Winck J, Esquinas A, Melhorn J, Corneci D, Pobeha P, Bosco V, Garofalo E, Bruni A, Cammarota G, Todorova V, Puci M, Sotgiu G, Kostikas K, Maggiore S, De Robertis E, Ergan B, Landoni G, Simonte R, Nava S, Navalesi P, Scala R, Karakurt Z, Gundogus B, Donmez G, Ernam D, Campainha S, Oliveira A, Teixeira M, Gouveia F, Monteiro C, Veske N, Altın S, Günlüoğlu G, Chousein E, Arıkan H, Karakurt S, Lacedonia D, Torraco R, Tondo P, Bialka S, Palaczynski P, Danel J, Jankowiak P, Kędra M, Bednarska M, Carpagnano E, Boniello E, Portacci A, Scarlata S, Finamore P, Fontata D, Kania A, Celejewska-Wojcik N, Rygiel K, Tobiczyk E, Springer D, Cofta S, Maugeri J, Bellissima A, Tamburrini M, Papi A, Morandi L, Franco C, Chiesa S, Verti N, Zieliński M, Mondoni M, Intravaia C, Carlucci P, Karnak D, Çiledağ A, Kaya A, Ghinassi G, Guidelli L, Santus P, Radovanovic D, Saad M, Roquete C, Fortes R, Porpodis K, Tsiouprou I, Lagoudi K, Pelaia G, Marrazzo G, Montenegro N, Biondini D, Damin M, Spagnolo P, Rodrigues J, Pinto M, Maia D, Sampsonas F, Tzouvelekis A, Tsirikos G, Loukides S, Raptakis T, Papavasileiou V, Vaschetto R, Tonino A, Patrucco F, Gomes R, Soares J, Santana M, Neri G, Corea A, Caroleo A, Grande A, Veltri D, Costumato G, Di Lorenzo F, Bonadio G, Caroleo Z, Guerriero G, Mazza G, Mellace F, Perrelli G, Riillo S, Ruocco G, Camastra A, Gaetano G, Mesiti A, Guzzi G, Mastrangelo H, Pisani L, VegaPittao M, Stratakos G, Koukaki E, Anagnostopoulos N, Dongilli R, Stirpe E, Köhl J, Skyba P, Sokolová E, Santos M, Aguiar M, Zias N, Papadakis I, Terragni P, Pistidda L, Castagna R, Popescu M, Rogliani P, Puxeddu E, Frugoni C, Notaro S, Piscitelli E, González E, Cañigral Á, Turi S, Mucchetti M, Belletti A, Volonterio G, Sommaruga S, Navarria R, Nardo A, Morana G, Palmiotto G, Iuliano A, Bastos H, Scolletta S, Biuzzi C, Sorino C, Hida D, Arrighi E, Gambardella P, Perri G, Cortegiani A, Ippolito M, Alessandri F, Sanda V, Zullino V, Rocco M, Fiorelli S, Nunes L, Gregoretti C, Misseri G, Piattoli M, Curto I, Tescione M, Vadalà E, Piccolo A, Mammone S, Gnass M, Gniady P, Steiropoulos P, Drakopanagiotakis F, Gianozzi L, Chronis C, Novelli L, Katsoulis K, Fois A, Oraczewska A. Practice of oxygenation and respiratory support during fibreoptic bronchoscopy: the OxyFOB study protocol. BMJ Open 2025, 15: e104747. PMID: 40897500, PMCID: PMC12410610, DOI: 10.1136/bmjopen-2025-104747.Peer-Reviewed Original ResearchConceptsVentilatory support strategiesFlexible bronchoscopyOxygen therapyContinuous positive airway pressurePositive airway pressureHigh-flow oxygen therapyConventional oxygen therapyInvasive mechanical ventilationNon-invasive ventilationObservational cohort studyMultivariate logistic regressionCase report formsElectronic case report formsVentilatory approachAirway pressurePrimary endpointRespiratory supportPostprocedural complicationsHaemodynamic complicationsClinical outcomesFibreoptic bronchoscopyCardiovascular comorbiditiesClinical impactMechanical ventilationFB proceduresMolecular Breast Imaging and Digital Breast Tomosynthesis for Dense Breast Screening: The Density MATTERS Trial.
Hruska C, Hunt K, Larson N, Miller P, Ellis R, Shermis R, Rauch G, Conners A, Gasal Spilde J, Semaan D, Siegal E, Zingula S, Mandava S, Martin T, Ahmed R, Whaley D, Adrada B, Gray L, Mehta R, Roll R, Redfern R, O'Connor M, Rhodes D. Molecular Breast Imaging and Digital Breast Tomosynthesis for Dense Breast Screening: The Density MATTERS Trial. Radiology 2025, 316: e243953. PMID: 40985829, DOI: 10.1148/radiol.243953.Peer-Reviewed Original ResearchConceptsMolecular breast imagingAnnual screening roundsDigital breast tomosynthesisDense breastsIncremental cancer detection rateNode-negative cancersTyrer-Cuzick riskCancer detection rateInterval cancer rateBreast tomosynthesisInvasive cancer detectionBreast imagingYear 1Year 2Invasive cancerMulticenter trialBreast screeningBreast densityCancer ratesAdvanced cancerCancerCancer detectionFunctional uptakePrevalenceBreastInterstitial Thermal Therapy in Mesial Temporal Lobe Epilepsy
Landazuri P, Cheng J, Leuthardt E, Kim A, Southwell D, Fecci P, Neimat J, Sun D, Lega B, Panov F, Chiang V, Abel T, Ben-Haim S, Piccioni D, Shih J, Palys V, Rodriguez A, Bandt S, Petronio J, Lacroix M, Baumgartner J. Interstitial Thermal Therapy in Mesial Temporal Lobe Epilepsy. JAMA Neurology 2025, 82: 915-924. PMID: 40622685, PMCID: PMC12235534, DOI: 10.1001/jamaneurol.2025.1897.Peer-Reviewed Original ResearchConceptsLaser interstitial thermal therapyDrug-resistant mesial temporal lobe epilepsyMesial temporal lobe epilepsySeizure outcomeInterstitial thermal therapyTemporal lobe epilepsyFollow-upProcedural outcomesSafety dataQuality of lifeLobe epilepsyIntensive care unit timeMonths of follow-upAssociated with seizure outcomeYears of follow-upProspective multicenter registryPostsurgical seizure outcomeMesial temporal sclerosisIntensive care unitThermal therapyQuality of life improvementQuality of life scoresInternational League Against EpilepsyLength of stayMagnetic resonance imagingComparison of dengue, chikungunya, and Zika among children in Nicaragua across 18 years: a single-centre, prospective cohort study
Carrillo F, Ojeda S, Sanchez N, Plazaola M, Collado D, Miranda T, Saborio S, Mercado B, Monterrey J, Arguello S, Campredon L, Chu Z, Carlson C, Gordon A, Balmaseda A, Kuan G, Harris E. Comparison of dengue, chikungunya, and Zika among children in Nicaragua across 18 years: a single-centre, prospective cohort study. The Lancet Child & Adolescent Health 2025, 9: 622-633. PMID: 40774783, PMCID: PMC12325154, DOI: 10.1016/s2352-4642(25)00168-3.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChikungunya FeverChildChild, PreschoolDengueFemaleHumansMaleNicaraguaProspective StudiesZika Virus InfectionConceptsPediatric Dengue Cohort StudyAbsence of feverPresence of arthralgiaClinical featuresProspective cohort studyDays of illnessPresence of basophiliaCohort studyDifferential diagnosisUS National InstitutesDengue disease severityFeatures of dengueDengue virus infectionUS National Institutes of HealthConjunctival injectionGeneralised rashAbdominal painZika casesMedian agePaediatric cohortSingle-centrePaediatric populationPapular rashNational Institutes of HealthVirus infectionZika in Infants and Pregnancy (ZIP) study: results from a prospective international cohort study of prenatal Zika virus infection and adverse fetal and infant outcomes
Lebov J, Nason M, Stolka K, Ximenes R, Mussi-Pinhata M, Moye J, Zorrilla C, Velez Vega C, Cordero J, Scalabrin D, Ko A, Moreira M, Galvão L, Britt W, Marques E, Balmaseda A, Harris E, Arias J, Schultz-Cherry S, Garces A, Krebs N, Ochoa T, Ugarte-Gil C, Fogleman E, Gabriel E, Welton M, Irizarry C, de Moura Negrini S, Coutinho C, de Barros Miranda-Filho D, Montarroyos U, Cordeiro M, Gajewski A, Osorio J, Figueroa L. Zika in Infants and Pregnancy (ZIP) study: results from a prospective international cohort study of prenatal Zika virus infection and adverse fetal and infant outcomes. BMC Pregnancy And Childbirth 2025, 25: 903. PMID: 40885911, PMCID: PMC12399002, DOI: 10.1186/s12884-025-07774-y.Peer-Reviewed Original ResearchConceptsZika virus infectionZIKV exposureCongenital malformationsRelative riskInfant outcomesZika virusComposite endpointPrenatal Zika virus infectionPrimary analysisZika virus exposureSecondary analysisCo-primary analysisWeeks gestationPrimary endpointRNA testingProspective studyProspective cohortPregnant participantsWeeks postpartumPregnancyVirus infectionInfantsAdequate sample sizeInfant deathsPregnant peopleThe Effect of Ambient Artificial Intelligence Scribes on Trainee Documentation Burden
Wright D, Kanaparthy N, Melnick E, Levy D, Huot S, Hsiao A, Schwamm L, Ong S. The Effect of Ambient Artificial Intelligence Scribes on Trainee Documentation Burden. Applied Clinical Informatics 2025, 16: 872-878. PMID: 40602775, PMCID: PMC12367366, DOI: 10.1055/a-2647-1142.Peer-Reviewed Original ResearchConceptsDocumentation burdenResident physician traineesPhysician traineesSystem Usability ScaleNet Promoter ScoreAssociated with improvementsMeasures of acceptabilityPilot periodNASA Task Load IndexMeasures of usabilityProspective observational studyTask Load IndexTrainee experienceNASA-TLX scoresUsability ScaleTrainee learningObservational studyGenerative artificial intelligenceTraineesPromoter ScoreArtificial intelligenceUtilization metricsTrainee useBurdenNASA-TLXBaseline values for Quantra® QPlus® in healthy pregnant women at term and comparison to standard laboratory coagulation values: a prospective observational study
Anakmeteeprugsa S, Gonzalez-Fiol A, Garay A, Lin H, He Z, Alian A. Baseline values for Quantra® QPlus® in healthy pregnant women at term and comparison to standard laboratory coagulation values: a prospective observational study. BMC Pregnancy And Childbirth 2025, 25: 826. PMID: 40781663, PMCID: PMC12333236, DOI: 10.1186/s12884-025-07927-z.Peer-Reviewed Original ResearchConceptsManagement of postpartum hemorrhageStandard laboratory coagulation testsPostpartum hemorrhageLaboratory coagulation testsCesarean deliveryPoint-of-care viscoelastic testingPregnant womenHealthy pregnant womenProspective observational studyCoagulation testsObservational studyMethodsHealthy pregnant womenSevere postpartum hemorrhageEarly recognitionElective cesarean deliveryPartial Pearson correlationsLabor groupFibrinogen levelsHealthy term pregnant womenTerm pregnant womenBaseline valuesAssociated with progressionAssessment of hemostasisPearson correlationInterquartile rangeDevice-Detected Atrial Fibrillation in Patients With and Without Cryptogenic Ischemia: The ANTARCTICA Pooled Analysis
Yaghi S, Sposato L, Shu L, García-Rodríguez D, Urda V, Kreimer F, Gotzmann M, Greisenegger S, Nahab F, Alshaer Q, Koge J, Ikenouchi H, Kitsiou A, Tsivgoulis G, Triantafyllou S, Skrebelyte-Strøm L, Rønning O, Lambert A, Aamodt A, Bufano G, Renda G, Godia E, Pikija S, Buck B, Ondraskova E, Healey J, McIntyre W, Hill M, Saver J, Kasner S, Kamel H, Elkind M, Schwamm L, Kent D, Katsanos A, Fridman S, Investigators O. Device-Detected Atrial Fibrillation in Patients With and Without Cryptogenic Ischemia: The ANTARCTICA Pooled Analysis. Stroke 2025, 56: 2895-2903. PMID: 40765508, DOI: 10.1161/strokeaha.125.051749.Peer-Reviewed Original ResearchConceptsIndividual-participant data meta-analysisRandomized Controlled TrialsMeta-analysis of prospective studiesMultilevel logistic regression analysisMultilevel multivariable logistic regression modelNonstroke patientsInsertable cardiac monitorAF detection rateIschemic strokeMultivariate logistic regression modelHistory of strokeLogistic regression modelsLogistic regression analysisProspective studyAtrial fibrillationOdds ratioMultiple imputationPrimary outcomeStudy populationPatient characteristicsRubin's rulesRegression modelsPooled analysisTransient ischemic attackCryptogenic strokeWork Impairment and Financial Outcomes Among Adults With vs Without Long COVID
Gottlieb M, Chen J, Yu H, Santangelo M, Spatz E, Gentile N, Geyer R, Malicki C, Gatling K, O’Laughlin K, Stephens K, Elmore J, Wisk L, L’Hommedieu M, Rodriguez R, Montoy J, Wang R, Rising K, Kean E, Dyal J, Hill M, Venkatesh A, Weinstein R, Koo K, Derden A, Ahmed Z, Gomez C, Guzman D, Hassaballa M, Kaadan A, Kinsman J, Lin Z, Li S, Mannan I, Yang Z, Liu M, Ulrich A, Dorney J, Pierce S, Puente X, Salah W, Nichol G, Anderson J, Schiffgens M, Morse D, Adams K, Stober T, Maat Z, Willis M, Zhang Z, Chang G, Lyon V, Klabbers R, Ruiz L, Malone K, Park J, Chang A, Renzi N, Watts P, Kelly M, Schaeffer K, Grau D, Cheng D, Shutty C, Charlton A, Shughart L, Shughart H, Amadio G, Miao J, Hannikainen P, Chandler C, Eguchi M, Diaz Roldan K, Moreno R, Kemball R, Chan V, Lara Chavez C, Wong A, Arreguin M, Huebinger R, Kane A, Nikonowicz P, Sapp S, Idris A, McDonald S, Gallegos D, Martin K, Saydah S, Plumb I, Hall A, Briggs-Hagen M. Work Impairment and Financial Outcomes Among Adults With vs Without Long COVID. JAMA Network Open 2025, 8: e2526310. PMID: 40794410, PMCID: PMC12344534, DOI: 10.1001/jamanetworkopen.2025.26310.Peer-Reviewed Original ResearchConceptsProspective cohort studyWork impairmentFinancial toxicityFollow-up electronic surveyProspective cohort study of adultsCohort study of adultsChronic Illness TherapyLongitudinal cohort studyActivity Impairment QuestionnaireStudy of adultsQuality of lifeLong COVIDFinancial outcomesIllness TherapyHealth statusImpairment QuestionnaireMain OutcomesElectronic surveySelf-ReportCohort studyAdult participantsOddsHealthWork productivityAssistance programsSex-Related Measurement Bias in Autism Spectrum Disorder Symptoms in the Baby Siblings Research Consortium
Burrows C, Sung S, Zheng S, Young G, Charman T, Klaiman C, Klin A, Marrus N, Ozonoff S, Piven J, Robins D, Schmidt R, Schwichtenberg A, Webb S, Zwaigenbaum L, Carver L, Chawarska K, Curtin S, Jeste S, Iverson J, Landa R, Messinger D, Roberts J, Stone W, Tager-Flusberg H, Esler A, Miller M, Bishop S, Elison J. Sex-Related Measurement Bias in Autism Spectrum Disorder Symptoms in the Baby Siblings Research Consortium. JAMA Network Open 2025, 8: e2525887. PMID: 40779266, PMCID: PMC12334962, DOI: 10.1001/jamanetworkopen.2025.25887.Peer-Reviewed Original ResearchMeSH KeywordsAutism Spectrum DisorderChild, PreschoolFemaleHumansInfantLongitudinal StudiesMaleProspective StudiesSex FactorsSiblingsConceptsAutism spectrum disorderAutism Diagnostic Observation ScheduleSex differencesQuality of social overturesMeasures of ASD symptomsResponsiveness to joint attentionAutism spectrum disorder symptomsHFL groupSocial communication difficultiesPrevalence of autism spectrum disorderConfirmatory factor analysisModerate levelsSocial overturesDisorder symptomsASD symptomsAutistic traitsClinician trainingJoint attentionMeasurement invarianceAge of diagnosisSpectrum disorderDevelopmental differencesMain OutcomesObservation ScheduleDiagnostic groupsVariability in Long COVID Definitions and Validation of Published Prevalence Rates
Wisk L, L’Hommedieu M, Diaz Roldan K, Ebna Mannan I, Spatz E, Weinstein R, Venkatesh A, Gottlieb M, Huebinger R, Rising K, Montoy J, Stephens K, Rodriguez R, Hill M, O’Laughlin K, Gentile N, Idris A, Li S, Santangelo M, Kean E, McDonald S, Gatling K, Elmore J, Koo K, Derden A, Ahmed Z, Guzman D, Hassaballa M, Kaadan A, Kinsman J, Malicki C, Lin Z, Yu H, Yang Z, Liu M, Ulrich A, Dorney J, Pierce S, Puente X, Salah W, Nichol G, Anderson J, Schiffgens M, Morse D, Adams K, Stober T, Maat Z, Geyer R, Willis M, Zhang Z, Chang G, Lyon V, Klabbers R, Ruiz L, Malone K, Park J, Chang A, Renzi N, Watts P, Kelly M, Schaeffer K, Grau D, Cheng D, Shutty C, Charlton A, Shughart L, Shughart H, Amadio G, Miao J, Hannikainen P, Chandler C, Eguchi M, Moreno R, Wang R, Kemball R, Chan V, Lara Chavez C, Wong A, Arreguin M, Kane A, Nikonowicz P, Sapp S, Gallegos D, Martin K, Saydah S, Plumb I, Hall A, Briggs-Hagen M. Variability in Long COVID Definitions and Validation of Published Prevalence Rates. JAMA Network Open 2025, 8: e2526506. PMID: 40794409, PMCID: PMC12344537, DOI: 10.1001/jamanetworkopen.2025.26506.Peer-Reviewed Original ResearchConceptsSelf-reported long COVIDSARS-CoV-2 testingCohort studyPublished definitionsLong COVIDFollow-up surveyPrevalence of long COVIDPublished prevalence ratesOlder with symptomsInspiring participationNegative SARS-CoV-2 testCOVID prevalenceMonths postinfectionMain OutcomesClinical carePublished literatureSecondary outcomesPrevalence ratesCOVID-19 illnessCriterion standardMulticenter cohort studySARS-CoV-2ParticipantsPrevalenceLow-to-moderate sensitivityEffects of long COVID on healthcare utilization
Gottlieb M, Spatz E, Yu H, Mannan I, Santangelo M, Malicki C, Gentile N, Geyer R, Charlton A, Dyal J, Elmore J, Gatling K, Hill M, Montoy J, O’Laughlin K, Rising K, Saydah S, Stephens K, Wang R, Wisk L, Venkatesh A, Weinstein R, Group F. Effects of long COVID on healthcare utilization. PLOS ONE 2025, 20: e0327218. PMID: 40700379, PMCID: PMC12286388, DOI: 10.1371/journal.pone.0327218.Peer-Reviewed Original ResearchConceptsHealthcare utilizationElectronic health record dataLong COVIDHealth record dataHealthcare resource planningQuality of lifeEffects of long COVIDHealthcare usageVisit lengthED visitsVisit categoryTelehealth visitsVisit typeOffice visitsSecondary analysisRecord dataAdult participantsInclusion criteriaSecondary outcomesPrimary outcomeConfirmed with testsHealthcareNon-LC groupVisitsVisit numberInterplay between the gut microbiome and typhoid fever: insights from endemic countries and a controlled human infection model
Ashton P, Mageiros L, Meiring J, Chunga-Chirambo A, Khanam F, Dongol S, Banda H, Karkey A, Preciado-Llanes L, Thomaides-Brears H, Gibani M, Rajib N, Rahman N, Biswas P, Bhuiyan M, Kay S, Auger K, Seret O, Thomson N, Pollard A, Baker S, Basnyat B, Clemens J, Dolecek C, Dunstan S, Dougan G, Heyderman R, Pitzer V, Qadri F, Gordon M, Holt K, Darton T. Interplay between the gut microbiome and typhoid fever: insights from endemic countries and a controlled human infection model. Microbiome 2025, 13: 168. PMID: 40696437, PMCID: PMC12281769, DOI: 10.1186/s40168-025-02125-7.Peer-Reviewed Original ResearchConceptsMetabolic gene clustersShort-chain fatty acidsTyphoid fever patientsS. typhiGut microbiomeTyphoid feverShort-chain fatty acid metabolismInfection modelAsymptomatic household contactsHuman infection modelPotential functional roleGene clusterShotgun metagenomicsInvasive SalmonellaFever patientsBacterial diversityMicrobiota characteristicsAssociated with typhoid feverBackgroundTyphoid feverStool microbiomeBacterial speciesClade ADevelopment of clinical infectionSCFA metabolismIngestion of contaminated foodTrajectories of antenatal depression and adverse pregnancy outcomes: A prospective cohort study
Chen J, Li S, Yang S, Chen Y, Ndenkeh J, Batubara I, Zhu L, Liu J, Pan X, Zou Z, Fan C, Chen X, Ni Z. Trajectories of antenatal depression and adverse pregnancy outcomes: A prospective cohort study. European Psychiatry 2025, 68: e109. PMID: 40685554, PMCID: PMC12438993, DOI: 10.1192/j.eurpsy.2025.10058.Peer-Reviewed Original ResearchMeSH KeywordsAdultChinaDepressionDiabetes, GestationalFemaleHumansPregnancyPregnancy ComplicationsPregnancy OutcomeProspective StudiesRisk FactorsYoung AdultConceptsAntenatal depressive symptomsEdinburgh Postnatal Depression ScaleDepressive symptom trajectoriesAdverse pregnancy outcomesDepressive symptomsProspective cohort studySymptom trajectoriesHigh depression groupPersistently high groupGestational diabetes mellitusCohort studyDepression groupPostnatal Depression ScalePregnant womenLatent class growth modelingMental health assessmentRisk factorsModerate depression groupMental illness historyLow social capitalAntenatal depressionHigher depression severityDepression ScaleHigh groupModerate group
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