2025
Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis
Mukhtar H, Zhou D, Farina E, Saxena A, Cahill J, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshwan M, Mathalon D, Perkins D, Stone W, Cho Y, Powers A, Walker E, Woods S. Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis. Psychological Medicine 2025, 55: e241. DOI: 10.1017/s0033291725101372.BooksClinical high riskCHR-PLifetime historyAugmentation of antidepressant treatmentComorbid major depressionAP useAntidepressant treatmentPositive symptomsMajor depressionAP medicationNAPLS-2Independent predictorsCHR-P.High riskBaseline clinical variablesPsychosisBaseline predictorsClinical variablesParticipantsBaseline characteristicsUnivariate analysisLogistic regression modelsObservational cohortMultivariate analysisAP initiationAssociation between Hospital Safety-Net Status and Delivery of Rehabilitation to Older Adults with Acute Respiratory Failure
Jimenez J, Zhang L, Lin Z, Ferrante L, Falvey J, Walkey A, Krumholz H, Jain S. Association between Hospital Safety-Net Status and Delivery of Rehabilitation to Older Adults with Acute Respiratory Failure. CHEST Journal 2025 PMID: 40818773, DOI: 10.1016/j.chest.2025.07.4079.Peer-Reviewed Original ResearchSafety-net hospitalMedian odds ratioSafety-net hospital statusDelivery of rehabilitationOlder adultsRehabilitation deliveryNon-SNHsIntensive care unitSocioeconomic disadvantageRetrospective cohort studyCohort study of older adultsHospital safety-net statusDisproportionate share hospital indexRetrospective cohort study of older adultsHierarchical multivariable logistic regression modelsStudy of older adultsSafety-net statusMedicare Provider AnalysisMultivariate logistic regression modelCritical illnessLogistic regression modelsRehabilitation servicesSocioeconomic disparitiesHospital characteristicsUS hospitalsDemographic, Socioeconomic, and Clinical Variables Associated With Nonmedical Pharmaceutical Opioid Use and Heroin Use Among US Adults in 2021 to 2022.
Moss M, Buonora M, Becker W. Demographic, Socioeconomic, and Clinical Variables Associated With Nonmedical Pharmaceutical Opioid Use and Heroin Use Among US Adults in 2021 to 2022. Substance Abuse 2025, 29767342251348150. PMID: 40667774, DOI: 10.1177/29767342251348150.Peer-Reviewed Original ResearchUS adultsOpioid useLower self-rated healthSelf-rated healthSevere mental illnessNational Survey on Drug Use and HealthDrug Use and HealthPublic health effortsHeroin useClinical variablesMultivariate logistic regression modelCross-sectional studyAssociated with opioid useLogistic regression modelsSedative/tranquilizer useOpioid overdose epidemicOpioid use patternsMental illnessHealth effortsMiddle age groupNonmedical opioid usePharmaceutical opioid useNonmedical stimulant useSocioeconomic variablesMultisubstance use1170-P: Gender Identity, Racial/Ethnic Identity, and Health Behaviors—Which High Schoolers Are at Highest Risk for Type 2 Diabetes?
SHARER A, BRIMACOMBE M, OYOLA-CARTAGENA K, DOYLE R, FINCK C, OLEZESKI C, SANTOS M. 1170-P: Gender Identity, Racial/Ethnic Identity, and Health Behaviors—Which High Schoolers Are at Highest Risk for Type 2 Diabetes? Diabetes 2025, 74 DOI: 10.2337/db25-1170-p.Peer-Reviewed Original ResearchHealth behaviorsYouth Risk Behavior SurveyType 2 diabetesRisk of obesityRegression modelsBinary logistic regression modelTransgender youthLogistic regression modelsPhysical activityRacial/ethnic groupsDevelopment of type 2 diabetesRisk Behavior SurveyUnique stressorsHealthBehavior SurveyObesityMinority stress theoryHigh riskMinority stressNon-significant relationshipT2DYouthTreatment outcomesRiskGender identityUnderstanding Racial and Ethnic Disparities in Myasthenia Gravis Outcomes
McLaren N, Roy B, Nowak R. Understanding Racial and Ethnic Disparities in Myasthenia Gravis Outcomes. Neurology Clinical Practice 2025, 15: e200503. PMID: 40584640, PMCID: PMC12204767, DOI: 10.1212/cpj.0000000000200503.Peer-Reviewed Original ResearchLong-term outcomes of patientsOutcomes of patientsLong-term outcomesAA patientsNon-Hispanic patientsMyasthenia gravisWhite patientsHistory of thymomaLong-term outcome analysisRetrospective cohort studyYears of follow-up dataDiagnosis of MGRepetitive nerve stimulationFollow-up dataSingle-fiber electromyographyMG crisisClinical featuresClinical profileLogistic regression modelsEthnic differencesAntibody seropositivityCohort studyNerve stimulationOutcome analysisPatientsTreatment outcomes of successful M1 versus M2 thrombectomy for low-ASPECTS stroke patients.
Chen H, Colasurdo M, Matsukawa H, Cunningham C, Maier I, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Shaban A, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Crosa R, Grandhi R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Chowdhry S, Altschul D, Spiotta A, Kan P. Treatment outcomes of successful M1 versus M2 thrombectomy for low-ASPECTS stroke patients. Interventional Neuroradiology 2025, 15910199251343283. PMID: 40530425, PMCID: PMC12176791, DOI: 10.1177/15910199251343283.Peer-Reviewed Original ResearchLow Alberta Stroke Program Early CT ScoreAlberta Stroke Program Early CT ScoreEffect of endovascular thrombectomyM2 occlusionsIntracranial hemorrhageM2 patientsAssociated with intracranial hemorrhageOdds of all-cause mortalityMulticenter retrospective studyOdds of poor outcomeMultivariate logistic regression modelAll-Cause MortalityMiddle cerebral arteryStroke patientsM1 patientsM1 occlusionCT scoreRetrospective studyLogistic regression modelsPoor outcomeMultivariable adjustmentPrimary outcomeCerebral arteryTreatment outcomesEndovascular thrombectomyLinking prolonged childhood and adolescent loneliness to schizophrenia spectrum disorders: results from EU-GEI study.
Andreu-Bernabeu Á, González-Peñas J, Mora A, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Santos J, Jiménez-López E, Arrojo M, Carracedo A, Parellada M, Maric N, Atbaşoğlu C, Üçok A, Alptekin K, Saka M, Pries L, O'Donovan M, van Os J, Rutten B, Delespaul P, Guloksuz S, Arango C, Díaz-Caneja C. Linking prolonged childhood and adolescent loneliness to schizophrenia spectrum disorders: results from EU-GEI study. The British Journal Of Psychiatry 2025, 1-9. PMID: 40519115, DOI: 10.1192/bjp.2025.100.Peer-Reviewed Original ResearchGene-environment interactionsGenetic riskSchizophrenia spectrum disordersAdverse mental health outcomesGenetic liabilityAssociated with higher oddsPolygenic risk scoresIdentification of high-risk individualsMental health outcomesRelative excess riskHigh-risk individualsEU-GEILogistic regression modelsHealth outcomesExcess riskHigher oddsPrevention strategiesVulnerable populationsRisk scoreRegression modelsLonelinessEarly identificationLong-term effectsWorsening symptomsAssociated with psychosisCompounded Challenges: The Impact of Race and Disability on Leave of Absence and Time to Graduation During Undergraduate Medical Education.
Eidtson W, Nguyen M, Hodgens T, Pereira-Lima K, Fancher T, Sheets Z, Smeltz L, Rastogi S, Curry R, Jain S, Green C, Grabowski C, Patwari R, LaRochelle J, Francis J, Moreland C, Tarlanov S, Stauffer C, Hardin B, Tolby L, Abrams G, Low C, Betchkal R, Arnold J, Coates C, Park Y, Meeks L, Kim M. Compounded Challenges: The Impact of Race and Disability on Leave of Absence and Time to Graduation During Undergraduate Medical Education. Academic Medicine 2025 PMID: 40499042, DOI: 10.1097/acm.0000000000006125.Peer-Reviewed Original ResearchLeaves of absenceLogistic regression modelsMixed-effects logistic regression modelsAdjusted analysesSupportive of studentsChronic health disabilitiesUndergraduate medical educationAdmission Test scoresImpact of raceCollege Admission Test scoresAuthors analyzed dataEthnic populationsNondisabled peersEducational pathWhite studentsTest scoresHealth disabilitiesHeightened riskURiM studentsWhite peersNondisabled controlsDisproportionate ratesAcademic disruptionGraduating cohortsStudentsEvaluating the association between routine pneumococcal vaccination and COVID-19 severity among older adults in the United States: A case control study
Prunas O, Tiu A, Shioda K, Bansal S, Weinberger D. Evaluating the association between routine pneumococcal vaccination and COVID-19 severity among older adults in the United States: A case control study. Vaccine X 2025, 24: 100622. DOI: 10.1016/j.jvacx.2025.100622.Peer-Reviewed Original ResearchCOVID-19 patientsCase-control studyIntensive care unitSevere respiratory symptomsPneumococcal vaccineSevere outcomesRespiratory symptomsOdds of progressionReceipt of pneumococcal vaccinationCOVID-19 severitySevere COVID-19 outcomesLogistic regression modelsSevere acute respiratory syndrome coronavirus 2Streptococcus pneumoniaeAcute respiratory syndrome coronavirus 2Non-severeRespiratory syndrome coronavirus 2Care unitControlled studiesPatientsSyndrome coronavirus 2COVID-19 outcomesSARS-CoV-2VaccineCoronavirus 2An integrative analysis of circulating and tumor microenvironment (TME) determinants of patient response in the Checkmate 9ER (CM 9ER) trial of nivolumab and cabozantinib (NIVO+CABO) in advanced renal cell carcinoma (aRCC).
Braun D, Vemula S, Cook D, Verma A, Carrigan P, Kelly K, Choueiri T, Gupta S. An integrative analysis of circulating and tumor microenvironment (TME) determinants of patient response in the Checkmate 9ER (CM 9ER) trial of nivolumab and cabozantinib (NIVO+CABO) in advanced renal cell carcinoma (aRCC). Journal Of Clinical Oncology 2025, 43: 4511-4511. DOI: 10.1200/jco.2025.43.16_suppl.4511.Peer-Reviewed Original ResearchAdvanced renal cell carcinomaPD-L1 stainingObjective response rateTumor microenvironmentLogistic regression modelsPD-L1Patient responseIncreased objective response rateTumoral PD-L1 stainingCirculating factorsDeterminants of therapeutic responseTumor response to therapyCirculating immune cell populationsTrials of nivolumabResponse to therapyImmune cell populationsRenal cell carcinomaCancer cell numberPlasma cell numbersCell numberActivation of stromal cellsAssociated with responseExtracellular matrixProgression-FreeRegression modelsPrediction of Lymph Node Metastasis in Non–Small Cell Lung Carcinoma Using Primary Tumor Somatic Mutation Data
Lee V, Moore N, Doyle J, Hicks D, Oh P, Bodofsky S, Hossain S, Patel A, Aneja S, Homer R, Park H. Prediction of Lymph Node Metastasis in Non–Small Cell Lung Carcinoma Using Primary Tumor Somatic Mutation Data. JCO Clinical Cancer Informatics 2025, 9: e2400303. PMID: 40446175, DOI: 10.1200/cci-24-00303.Peer-Reviewed Original ResearchThis study investigates machine learning models using tumor genetic data to predict lymph node metastasis in lung cancer, showing improved accuracy over traditional methods and more potential for personalized treatment.The impact of race on the association between structural racism and the quality of non-small cell lung cancer (NSCLC).
Gaddy J, Lee D, Herrin J, Yu J, Pollack C, Dean L, Hamid S, Feder S, Canavan M, Soulos P, Gross C. The impact of race on the association between structural racism and the quality of non-small cell lung cancer (NSCLC). Journal Of Clinical Oncology 2025, 43: 1598-1598. DOI: 10.1200/jco.2025.43.16_suppl.1598.Peer-Reviewed Original ResearchPatient raceStructural racismNon-small cell lung cancerBlack patientsWhite patientsTwo-year survivalAppropriate evaluationSurveillance, EpidemiologyMixed effects logistic regression modelsMultivariable mixed effects logistic regression modelsEffects logistic regression modelsRegression modelsLogistic regression modelsLowest quintileHealth careRacial disparitiesRacial inequalityImpact of raceLocal stagingQuintileCell lung cancerMinoritized communitiesInteraction termsAssociationDisparitiesAssociation Between Sleep-Related Leg Movements and Diabetes Prevalence: A Cohort Study From the United States
Ding Q, Xie Y, Koo B, Hass Z, Wojeck B, Sico J, Murray-Kolb L, Bravata D, Zinchuk A. Association Between Sleep-Related Leg Movements and Diabetes Prevalence: A Cohort Study From the United States. Cureus 2025, 17: e84701. PMID: 40557002, PMCID: PMC12185253, DOI: 10.7759/cureus.84701.Peer-Reviewed Original ResearchNational Health and Nutrition Examination SurveyShort sleep durationSleep durationDiabetes prevalenceHealth and Nutrition Examination SurveyNational population-based cohort studyNon-Hispanic white individualsCohort studyPopulation-based cohort studyWeighted logistic regression modelsOdds of diabetesNutrition Examination SurveyUS adult populationPrevalence of diabetesRisk of diabetesLeg movementsDiabetes mellitusLogistic regression modelsDM prevalenceExamination SurveyCardiometabolic healthUnited StatesWhite individualsAdult populationPotential mediatorsTemporal Trends in Opioid Use and Associated Outcomes for Patients Living with Advanced Cancer
Jairam V, Lindsay M, Soulos P, Gross C, Prsic E, Baum L, Park H. Temporal Trends in Opioid Use and Associated Outcomes for Patients Living with Advanced Cancer. Journal Of Pain And Symptom Management 2025 PMID: 40403779, DOI: 10.1016/j.jpainsymman.2025.05.007.Peer-Reviewed Original ResearchPain-related ED visitsOpioid useGabapentinoid useOpioid-related encountersAdvanced cancerOpioid prescribingED visitsAdvanced solid tumor cancersEnd Results (SEER)-Medicare databaseHigh-risk opioid useNonopioid pain medicationsMultivariate logistic regression modelNon-cancer patientsSolid tumor cancersPain controlPain medicationInvestigate time trendsIndex dateLogistic regression modelsCancer cohortOpioidNoncancer patientsOpioid epidemicPatientsNoncancer cohortShort-term exposure to ambient temperature variability and myocardial infarction hospital admissions: A nationwide case-crossover study in Sweden
Ni W, Stafoggia M, Zhang S, Ljungman P, Breitner S, de Bont J, Jernberg T, Atar D, Schneider A, Agewall S. Short-term exposure to ambient temperature variability and myocardial infarction hospital admissions: A nationwide case-crossover study in Sweden. PLOS Medicine 2025, 22: e1004607. PMID: 40392899, PMCID: PMC12091774, DOI: 10.1371/journal.pmed.1004607.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionNon-ST-segment elevation myocardial infarctionAssociated with increased riskHospital admissionAssociated with increased risk of hospital admissionElevation myocardial infarctionHospitalization riskRisk of hospital admissionConditional logistic regression modelsPopulation-based nationwide studyMyocardial infarctionShift exposureCase-crossover designPotential effect modifiersCase-crossover studyAssociated with decreased riskPatient's residential areaTemperature variabilityLogistic regression modelsNo significant associationHistory of diseaseTime-stratifiedMI hospitalizationSWEDEHEART registryClimate changeIs university attendance associated with differences in health service use for a mental health problem in emerging adulthood? Evidence from the ALSPAC population-based cohort
Osborn T, Saunders R, Fonagy P. Is university attendance associated with differences in health service use for a mental health problem in emerging adulthood? Evidence from the ALSPAC population-based cohort. Social Psychiatry And Psychiatric Epidemiology 2025, 1-14. PMID: 40389705, DOI: 10.1007/s00127-025-02922-3.Peer-Reviewed Original ResearchHealth service useMental health problemsAssociated with health service useService useHealth problemsAvon Longitudinal Study of ParentsMultiple imputationLongitudinal Study of ParentsAvon Longitudinal StudyMaternal education levelPopulation-based cohortStudy of parentsRobustness of associationsLogistic regression modelsHealth servicesSTROBE guidelinesConfounder adjustmentAnalytic sampleEducation levelALSPACMental disordersAttend universityEmerging adulthoodStudy protocolHealthSpinal Cord Protection for Open Descending Thoracic and Thoracoabdominal Aorta Surgery: An STS Adult Cardiac Surgery Database Analysis
Amabile A, Bonnell L, Del Vecchio A, Basciano A, Antonios J, Kaneko T, Habib R, Di Luozzo G. Spinal Cord Protection for Open Descending Thoracic and Thoracoabdominal Aorta Surgery: An STS Adult Cardiac Surgery Database Analysis. The Annals Of Thoracic Surgery 2025 PMID: 40389192, DOI: 10.1016/j.athoracsur.2025.05.002.Peer-Reviewed Original ResearchThoracoabdominal aortic aneurysmsThoracoabdominal aortic aneurysm repairSpinal cord injuryDrain placementDTAA/TAAA repairDrain useThe Society of Thoracic Surgeons Adult Cardiac Surgery DatabaseSociety of Thoracic Surgeons Adult Cardiac Surgery DatabaseAdult Cardiac Surgery DatabaseOpen descending thoracicCardiac Surgery DatabaseSpinal cord protectionMultivariate logistic regression modelRate of spinal cord injuryArch involvementDescending ThoracicPreoperative paralysisSurgery DatabaseSpinal drainAdult patientsAortic rootAortic aneurysmLogistic regression modelsSpinal injuryStudy populationIdentifying subgroups of adverse childhood experiences (ACEs) in adult general hospital attendees: associations with mental and physical health measures
Saunders R, Nolte T, Osborn T, Delamain H, Riedl D, Fonagy P, Lampe A. Identifying subgroups of adverse childhood experiences (ACEs) in adult general hospital attendees: associations with mental and physical health measures. Journal Of Psychiatric Research 2025, 187: 291-298. PMID: 40408977, DOI: 10.1016/j.jpsychires.2025.05.024.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesACE clustersHealth outcomesHealth conditionsAssessment of adverse childhood experiencesCombinations of adverse childhood experiencesIncreased ACE exposurePhysical health measuresChildhood experiencesPhysical health conditionsMental health conditionsPhysical health outcomesAdult health outcomesHigh adverse childhood experiencesAustrian university hospitalLogistic regression modelsACE exposureMental healthHealth measuresSubgroups of individualsOdds ratioLatent class analysisPrevention strategiesOutpatient departmentHospital attendees[Association between dietary behavior and sarcopenia in older adults aged 65 years and above in longevity areas of China: a latent class analysis].
Zhao Y, Zhang Z, Wang J, Zhou J, Chen H, Qi L, Li Y, Chen Y, Meng X, Zhang Z, Chen C, Shi X, Lyu Y, Shi W. [Association between dietary behavior and sarcopenia in older adults aged 65 years and above in longevity areas of China: a latent class analysis]. Chinese Journal Of Epidemiology 2025, 46: 746-752. PMID: 40494780, DOI: 10.3760/cma.j.cn112338-20241117-00729.Peer-Reviewed Original ResearchConceptsDietary behaviorsOlder adultsCategory scoresLatent class analysisDietary intakeFood intake frequencyRisk of sarcopeniaIncreased riskBalanced dietary patternFood frequency questionnaireIntake of cerealsMultivariate logistic regression modelChronic disease historyNon-sarcopenia groupLogistic regression modelsClass analysisIntake categoriesSARC-CalF.Frequency questionnaireBiomarkers Cohort StudyIntake frequencyDietary patternsSarcopenia groupCohort studyLongevity areas[Association between physical activity and cognitive impairment in older adults aged 65 years and above in longevity areas of China].
Xu H, Wu Y, Chen C, Meng X, Chen J, Zhang Z, Zhong Z, Yang J, Fu X, Chen S, Chen Y, Li Z, Ye L, Shi X, Lyu Y. [Association between physical activity and cognitive impairment in older adults aged 65 years and above in longevity areas of China]. Chinese Journal Of Epidemiology 2025, 46: 753-760. PMID: 40494781, DOI: 10.3760/cma.j.cn112338-20250124-00060.Peer-Reviewed Original ResearchConceptsLevels of physical activityPhysical activityOlder adultsCognitive impairmentIntensity levels of physical activityIntensity of physical activityPhysical Activity ScaleChronic disease historyWork-related activitiesMultifactorial logistic regression modelsLogistic regression modelsMini-MentalBiomarkers Cohort StudyChinese versionActivity ScaleActive leisureCohort studyLongevity areasDemographic characteristicsHealthy agingDisease historyHousehold activitiesRegression modelsCognitive functionNegative association
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply