2025
Anticonvulsant Use in Older Age Bipolar Disorder in a Global Sample from the Global Aging and Geriatric Experiments in Bipolar Disorder Project: Utilisation d'anticonvulsivants pour le traitement des troubles bipolaires du sujet âgé auprès d'un échantillon mondial provenant du projet GAGE-BD.
Bodenstein K, Lesage M, Lavin P, Schouws S, Orhan M, Beunders A, Almeida O, Altinbas K, Balanzá-Martínez V, Barbosa I, Blumberg H, Briggs F, Calkin C, Forlenza O, Forester B, Gildengers A, Haarman B, Hajek T, Lafer B, Nune P, Mulsant B, Olagunju A, Patrick R, Radua J, Sarna K, Simhandl C, Soares J, Sutherland A, Fiorelli N, Teixeira A, Tsai S, Vieta E, Yala J, Eyler L, Dols A, Sajatovic M, Rej S. Anticonvulsant Use in Older Age Bipolar Disorder in a Global Sample from the Global Aging and Geriatric Experiments in Bipolar Disorder Project: Utilisation d'anticonvulsivants pour le traitement des troubles bipolaires du sujet âgé auprès d'un échantillon mondial provenant du projet GAGE-BD. The Canadian Journal Of Psychiatry 2025, 7067437251372190. PMID: 40984046, PMCID: PMC12460282, DOI: 10.1177/07067437251372190.Peer-Reviewed Original ResearchOlder age bipolar disorderGlobal ageAnticonvulsant useGeriatric experiencesBipolar disorderGlobal sampleLinear mixed modelsPrescribing dataAntidepressant useGeneralized linear mixed modelsSecondary analysisAnticonvulsant usersGlobalPrescribing patternsClinical correlatesGeriatricMood episodesGAGE-BDMixed modelsCardiovascular comorbiditiesLeft Atrial Appendage Occlusion in Patients With Prior Intracranial Hemorrhage
Mansour M, Novack V, Freeman J, Zimmerman S, Tate W, Curtis J, Turi Z. Left Atrial Appendage Occlusion in Patients With Prior Intracranial Hemorrhage. JACC Clinical Electrophysiology 2025 PMID: 40965377, DOI: 10.1016/j.jacep.2025.07.017.Peer-Reviewed Original ResearchLeft atrial appendage occlusionIntracranial hemorrhageOral anticoagulantsGroup 2Group 1Stroke/transient ischemic attackAppendage occlusionNeurological complicationsAtrial fibrillationNo historyAssociated with similar patientIschemic attackHistory of intracranial hemorrhageHAS-BLED scoreEvent ratesStroke prevention methodsDevice-related thrombosisHAS-BLEDAssociated with greater useGastrointestinal bleedingActual event ratesCardiovascular comorbiditiesFollow-upIn-HospitalEnrollment criteriaPractice of oxygenation and respiratory support during fibreoptic bronchoscopy: the OxyFOB study protocol
Longhini F, Crimi C, Noto A, Pelaia C, Karakurt Z, Skoczyński S, Boléo-Tomé J, Winck J, Esquinas A, Melhorn J, Corneci D, Pobeha P, Bosco V, Garofalo E, Bruni A, Cammarota G, Todorova V, Puci M, Sotgiu G, Kostikas K, Maggiore S, De Robertis E, Ergan B, Landoni G, Simonte R, Nava S, Navalesi P, Scala R, Karakurt Z, Gundogus B, Donmez G, Ernam D, Campainha S, Oliveira A, Teixeira M, Gouveia F, Monteiro C, Veske N, Altın S, Günlüoğlu G, Chousein E, Arıkan H, Karakurt S, Lacedonia D, Torraco R, Tondo P, Bialka S, Palaczynski P, Danel J, Jankowiak P, Kędra M, Bednarska M, Carpagnano E, Boniello E, Portacci A, Scarlata S, Finamore P, Fontata D, Kania A, Celejewska-Wojcik N, Rygiel K, Tobiczyk E, Springer D, Cofta S, Maugeri J, Bellissima A, Tamburrini M, Papi A, Morandi L, Franco C, Chiesa S, Verti N, Zieliński M, Mondoni M, Intravaia C, Carlucci P, Karnak D, Çiledağ A, Kaya A, Ghinassi G, Guidelli L, Santus P, Radovanovic D, Saad M, Roquete C, Fortes R, Porpodis K, Tsiouprou I, Lagoudi K, Pelaia G, Marrazzo G, Montenegro N, Biondini D, Damin M, Spagnolo P, Rodrigues J, Pinto M, Maia D, Sampsonas F, Tzouvelekis A, Tsirikos G, Loukides S, Raptakis T, Papavasileiou V, Vaschetto R, Tonino A, Patrucco F, Gomes R, Soares J, Santana M, Neri G, Corea A, Caroleo A, Grande A, Veltri D, Costumato G, Di Lorenzo F, Bonadio G, Caroleo Z, Guerriero G, Mazza G, Mellace F, Perrelli G, Riillo S, Ruocco G, Camastra A, Gaetano G, Mesiti A, Guzzi G, Mastrangelo H, Pisani L, VegaPittao M, Stratakos G, Koukaki E, Anagnostopoulos N, Dongilli R, Stirpe E, Köhl J, Skyba P, Sokolová E, Santos M, Aguiar M, Zias N, Papadakis I, Terragni P, Pistidda L, Castagna R, Popescu M, Rogliani P, Puxeddu E, Frugoni C, Notaro S, Piscitelli E, González E, Cañigral Á, Turi S, Mucchetti M, Belletti A, Volonterio G, Sommaruga S, Navarria R, Nardo A, Morana G, Palmiotto G, Iuliano A, Bastos H, Scolletta S, Biuzzi C, Sorino C, Hida D, Arrighi E, Gambardella P, Perri G, Cortegiani A, Ippolito M, Alessandri F, Sanda V, Zullino V, Rocco M, Fiorelli S, Nunes L, Gregoretti C, Misseri G, Piattoli M, Curto I, Tescione M, Vadalà E, Piccolo A, Mammone S, Gnass M, Gniady P, Steiropoulos P, Drakopanagiotakis F, Gianozzi L, Chronis C, Novelli L, Katsoulis K, Fois A, Oraczewska A. Practice of oxygenation and respiratory support during fibreoptic bronchoscopy: the OxyFOB study protocol. BMJ Open 2025, 15: e104747. PMID: 40897500, PMCID: PMC12410610, DOI: 10.1136/bmjopen-2025-104747.Peer-Reviewed Original ResearchConceptsVentilatory support strategiesFlexible bronchoscopyOxygen therapyContinuous positive airway pressurePositive airway pressureHigh-flow oxygen therapyConventional oxygen therapyInvasive mechanical ventilationNon-invasive ventilationObservational cohort studyMultivariate logistic regressionCase report formsElectronic case report formsVentilatory approachAirway pressurePrimary endpointRespiratory supportPostprocedural complicationsHaemodynamic complicationsClinical outcomesFibreoptic bronchoscopyCardiovascular comorbiditiesClinical impactMechanical ventilationFB proceduresBlunted Hemodynamic Response to Pharmacological Stress is Predictive of Mortality in Liver Transplant Candidates
Csecs I, Sharma A, Khungar V, Sinusas A, Possick S, Miller E, Feher A. Blunted Hemodynamic Response to Pharmacological Stress is Predictive of Mortality in Liver Transplant Candidates. Journal Of Nuclear Cardiology 2025, 102454. PMID: 40769316, DOI: 10.1016/j.nuclcard.2025.102454.Peer-Reviewed Original ResearchLiver transplant candidatesMELD scoreAssociated with mortalityRetrospective studyCardiovascular comorbiditiesLiver diseaseMedian follow-up periodTransplant candidatesResponse to pharmacological stressSingle-photon Emission Computed TomographyRegadenoson stress testingEnd-stage liver diseaseIncremental prognostic valueNuclear stress testingRetrospective cohort analysisFollow-up periodChronic liver diseaseBody mass indexCoronary artery diseaseHemodynamic responseStress testEmission Computed TomographyDiastolic blood pressurePredictive of mortalityPositron emission tomographyPerioperative Stroke: Mechanisms, Risk Stratification, and Management
Shu L, Aziz Y, de Havenon A, Messe S, Nguyen T, Sur N, Xiong L, Yaghi S. Perioperative Stroke: Mechanisms, Risk Stratification, and Management. Stroke 2025, 56: 2798-2809. PMID: 40444359, PMCID: PMC12354081, DOI: 10.1161/strokeaha.125.051673.Peer-Reviewed Original ResearchCerebrovascular eventsPerioperative strokeProcedure-related risk factorsHigh-risk surgical interventionsPreoperative risk stratificationPatient-specific riskPrevalence of perioperative strokePerioperative ischemic strokeChronic vascular conditionsAging surgical populationComplexity of surgeryIncreased healthcare utilizationPostoperative settingSubstantial morbiditySurgical interventionIntraoperative hypotensionRisk stratificationSurgical populationAtrial fibrillationCardiovascular comorbiditiesIntraoperative techniquesCerebral embolismVascular manipulationAdvanced ageCarotid stenosis
2024
Largest Real-World Evaluation of Treatment Regimens and Clinical Outcomes Among Patients with Acute Promyelocytic Leukemia in the US: Data from the Command Consortium
Canadeo A, Giever E, Szabo A, Jin Y, Winer E, Badar T, Campos J, Lin C, Anderson C, Shallis R, Muradashvili T, Coltoff A, Guo Q, Patel A, Goldberg L, Abaza Y, Fariduddin M, Ayoub R, Foucar C, Nai N, Kota V, Dalgetty M, Gold M, Guduru M, Atallah E. Largest Real-World Evaluation of Treatment Regimens and Clinical Outcomes Among Patients with Acute Promyelocytic Leukemia in the US: Data from the Command Consortium. Blood 2024, 144: 5174-5174. DOI: 10.1182/blood-2024-198914.Peer-Reviewed Original ResearchWhite blood cell countAcute promyelocytic leukemiaIncidence of relapseHigh-risk diseaseAll-Trans Retinoic AcidOverall survivalDifferentiation syndromeHigh riskArsenic trioxideInduction regimenTreatment regimensSupportive care strategiesCardiovascular comorbiditiesMedian white blood cell countData collection formDoses of gemtuzumab ozogamicinIncidence of CNS relapseIncidence of differentiation syndromeLow incidence of relapseOutcome of APL patientsSuspected acute promyelocytic leukemiaCumulative incidence of relapseDiagnosis of acute promyelocytic leukemiaLow-risk acute promyelocytic leukemiaMortality rate
2023
Impact of sex on Transcatheter aortic valve replacement outcomes: Results of a single-center study
See C, Wang Y, Yang Y, Tirziu D, Papoutsidakis N, Francese D, Kaple R, Cleman M, Lansky A, Forrest J. Impact of sex on Transcatheter aortic valve replacement outcomes: Results of a single-center study. International Journal Of Cardiology 2023, 398: 131643. PMID: 38065329, DOI: 10.1016/j.ijcard.2023.131643.Peer-Reviewed Original ResearchNew-generation valvesTranscatheter Aortic Valve Replacement OutcomesImpact of sexTAVR outcomesArtery diseaseYale-New Haven HospitalSTS mortality scorePeripheral artery diseaseSingle-center studyCoronary artery diseaseKaplan-Meier curvesLog-rank testNew Haven HospitalSex-based disparitiesSignificant differencesCardiovascular comorbiditiesSAPIEN 3Transfemoral accessSAPIEN XTConsecutive patientsCox modelingMortality scoreEvolut RFemale sexEvolut PROIbrutinib discontinuation and associated factors in a real-world national sample of elderly Medicare beneficiaries with chronic lymphocytic leukemia
Huntington S, de Nigris E, Puckett J, Kamal-Bahl S, Farooqui M, Ryland K, Sarpong E, Leng S, Yang X, Doshi J. Ibrutinib discontinuation and associated factors in a real-world national sample of elderly Medicare beneficiaries with chronic lymphocytic leukemia. Leukemia & Lymphoma 2023, 64: 2286-2295. PMID: 37870435, DOI: 10.1080/10428194.2023.2256911.Peer-Reviewed Original ResearchConceptsChronic lymphocytic leukemiaIbrutinib discontinuationLymphocytic leukemiaHalf of patientsMonths of initiationElderly Medicare beneficiariesLarge unmet needPart D low-income subsidyLow-income subsidyCardiovascular comorbiditiesElderly patientsReal-world practiceIbrutinib treatmentLymphocytic lymphomaAdvanced ageClinical trialsMedical CenterMedicare claimsDiscontinuationHigh riskMedicare beneficiariesUnmet needPatientsLeukemiaTwo-thirdsT4. FINGER ON THE PULSE: INTEGRATING GENETIC AND WEARABLE DATA TO EXPLORE THE LINK BETWEEN HEART RATE VARIABILITY, ANXIETY, AND ANTIDEPRESSANTS
Friligkou E, Koller D, Pathak G, Miller E, Lampert R, Stein M, Polimanti R. T4. FINGER ON THE PULSE: INTEGRATING GENETIC AND WEARABLE DATA TO EXPLORE THE LINK BETWEEN HEART RATE VARIABILITY, ANXIETY, AND ANTIDEPRESSANTS. European Neuropsychopharmacology 2023, 75: s164. DOI: 10.1016/j.euroneuro.2023.08.294.Peer-Reviewed Original ResearchHeart rate variabilityAverage RR intervalElectronic health recordsPolygenic risk scoresReuptake inhibitorsAntidepressant classesAntidepressant useSelective serotonin reuptake inhibitorsAntidepressant substancesMendelian randomizationRate variabilityRR intervalsCo-existing health conditionsNorepinephrine reuptake inhibitorsSerotonin reuptake inhibitorsAvailable electronic health recordsBackground Anxiety disordersCardiovascular comorbiditiesAntidepressant prescriptionsOne-sample Mendelian randomizationSerotonin antagonistsTricyclic antidepressantsMajor depressionMillion Veteran ProgramObservational natureRacial and Ethnic Differences in the Risk of Ischemic Stroke After Nontraumatic Intracerebral Hemorrhage
Simonetto M, Sheth K, Ziai W, Iadecola C, Zhang C, Murthy S. Racial and Ethnic Differences in the Risk of Ischemic Stroke After Nontraumatic Intracerebral Hemorrhage. Stroke 2023, 54: 2401-2408. PMID: 37462054, PMCID: PMC10529487, DOI: 10.1161/strokeaha.123.043160.Peer-Reviewed Original ResearchConceptsNon-Hispanic white patientsNon-Hispanic blacksIschemic strokeIntracerebral hemorrhageHispanic patientsWhite patientsAtrial fibrillationICH patientsHigh riskNon-Hispanic black patientsCox proportional hazards modelIncident ischemic strokeRetrospective cohort studyNontraumatic intracerebral hemorrhageValvular heart diseaseTime of dischargeLarge heterogeneous cohortProportional hazards modelNon-Hispanic whitesICH hospitalizationsCardiovascular comorbiditiesMedian followCohort studyVascular comorbiditiesConcomitant diagnosisAssociation Between Hospital-Documented Atrial Fibrillation and Central Retinal Artery Occlusion
Lusk J, Song A, Unnithan S, Al-Khalidi H, Delic A, de Havenon A, Biousse V, Schrag M, Poli S, Piccini J, Xian Y, O’Brien E, Mac Grory B. Association Between Hospital-Documented Atrial Fibrillation and Central Retinal Artery Occlusion. Stroke 2023, 54: 983-991. PMID: 36729390, PMCID: PMC11173326, DOI: 10.1161/strokeaha.122.042292.Peer-Reviewed Original ResearchConceptsCentral retinal artery occlusionRetinal artery occlusionCardiovascular comorbiditiesArtery occlusionAtrial fibrillationInverse associationNon-Hispanic white race/ethnicityState Emergency Department DatabasesWhite race/ethnicityPrespecified sensitivity analysisPrimary end pointRisk of strokeCause-specific hazards modelEmergency Department DatabasesEmergency department settingPrimary risk factorState Inpatient DatabasesPositive control outcomesRace/ethnicityMedian followCohort studyCumulative incidenceIschemic strokeAF statusInpatient Database
2022
Screening Tool to Identify Patients with Advanced Aortic Valve Stenosis
Yousef S, Amabile A, Ram C, Huang H, Korutla V, Singh S, Agarwal R, Assi R, Milewski RK, Zhang Y, Patel PA, Krane M, Geirsson A, Vallabhajosyula P. Screening Tool to Identify Patients with Advanced Aortic Valve Stenosis. Journal Of Clinical Medicine 2022, 11: 4386. PMID: 35956007, PMCID: PMC9369431, DOI: 10.3390/jcm11154386.Peer-Reviewed Original ResearchAortic stenosisRisk prediction modelTertiary academic care centerAcademic care centerSevere aortic stenosisAortic valve stenosisBody mass indexCross-sectional analysisLogistic regression modelsLarge population cohortCardiovascular comorbiditiesEchocardiographic studyValve stenosisMass indexClinical burdenClinical variablesUnique patientsC-statisticCare centerMale genderPatient riskComorbidity variablesC-indexMultivariable modelInclusion criteriaDemographic and clinical characteristics of lithium‐treated older adults with bipolar disorder
Forlenza OV, Hajek T, Almeida OP, Beunders AJM, Blumberg HP, Briggs FBS, De‐Paula V, Dols A, Eyler LT, Forester BP, Gildengers A, Jimenez E, Korten NCM, Lafer B, McWhinney SR, Mulsant B, Rej S, Sarna K, Schouws S, Sutherland A, Tsai S, Vieta E, Yala J, Sajatovic M, initiative G. Demographic and clinical characteristics of lithium‐treated older adults with bipolar disorder. Acta Psychiatrica Scandinavica 2022, 146: 442-455. PMID: 35837985, PMCID: PMC9588573, DOI: 10.1111/acps.13474.Peer-Reviewed Original ResearchConceptsLithium usersBipolar disorderClinical characteristicsOlder adultsDepression Rating ScaleCross-sectional analysisGlobal cognitive stateCardiovascular comorbiditiesCross-sectional approachClinical profileMood stabilizersLithium therapySevere depressionPsychiatric diagnosisRating ScaleCurrent prescriptionGlobal AGEingDisordersRapid cyclingAdultsRelevant differencesSafety concernsLower scoresCurrent useMethodological limitationsThe Association Between Proton Pump Inhibitor Exposure and Key Liver-Related Outcomes in Patients With Cirrhosis: A Veterans Affairs Cohort Study
Mahmud N, Serper M, Taddei TH, Kaplan DE. The Association Between Proton Pump Inhibitor Exposure and Key Liver-Related Outcomes in Patients With Cirrhosis: A Veterans Affairs Cohort Study. Gastroenterology 2022, 163: 257-269.e6. PMID: 35398042, PMCID: PMC10020994, DOI: 10.1053/j.gastro.2022.03.052.Peer-Reviewed Original ResearchConceptsLiver-related mortalityPPI exposureGastrointestinal bleedingCause mortalityProton pump inhibitor exposurePrior gastrointestinal bleedingTime-updated variablesCause-specific mortality analysesLarge national cohortVeterans Health AdministrationRisk of infectionCardiovascular comorbiditiesPPI useCohort studyStatin exposureCox regressionRetrospective studyAdverse outcomesAppropriate indicationsNational cohortInhibitor exposureSevere infectionsCirrhosis diagnosisAdditional adjustmentAdjusted modelAssociation of Recent Use of Non–Vitamin K Antagonist Oral Anticoagulants With Intracranial Hemorrhage Among Patients With Acute Ischemic Stroke Treated With Alteplase
Kam W, Holmes D, Hernandez A, Saver J, Fonarow G, Smith E, Bhatt D, Schwamm L, Reeves M, Matsouaka R, Khan Y, Unverdorben M, Birmingham M, Lyden P, Asimos A, Altschul D, Schoonover T, Jumaa M, Nomura J, Suri M, Moore S, Lafranchise E, Olson D, Peterson E, Xian Y. Association of Recent Use of Non–Vitamin K Antagonist Oral Anticoagulants With Intracranial Hemorrhage Among Patients With Acute Ischemic Stroke Treated With Alteplase. JAMA 2022, 327: 760-771. PMID: 35143601, PMCID: PMC8832308, DOI: 10.1001/jama.2022.0948.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeSymptomatic intracranial hemorrhageSecondary functional outcomesSecondary safety outcomesProportion of patientsIntravenous alteplaseIntracranial hemorrhageIschemic strokeFunctional outcomeOral anticoagulantsInpatient mortalitySafety outcomesNon-Vitamin K Antagonist Oral AnticoagulantsK Antagonist Oral AnticoagulantsBaseline clinical factorsGuidelines-Stroke programIntravenous alteplase administrationLong-term anticoagulantsUse of NOACsRetrospective cohort studyUse of anticoagulantsSignificant differencesAlteplase administrationCardiovascular comorbiditiesNOAC group
2021
Androgen Effects on Baroreflex Sensitivity in Women with AE‐PCOS
Stone T, Chiles M, Leone C, Pal L, Stachenfeld N. Androgen Effects on Baroreflex Sensitivity in Women with AE‐PCOS. The FASEB Journal 2021, 35 DOI: 10.1096/fasebj.2021.35.s1.04149.Peer-Reviewed Original ResearchMuscle sympathetic nerve activityLower body negative pressureSympathetic baroreflex sensitivityPolycystic ovary syndromeBaroreflex sensitivityBR controlDiastolic BPHormone suppressionImpaired blood pressure regulationGonadotropin-releasing hormone antagonistOral glucose tolerance testDays of GnRHSympathetic nerve activityInsulin-resistant womenMean arterial pressureVascular resistance changesReproductive-age womenGlucose tolerance testBody negative pressureBlood pressure regulationSuppression of E2Bursts/100 heartbeatsCardiovascular comorbiditiesPCOS phenotypeResistant women
2020
The Reintervention Index: A New Outcome Measure for Comparative Effectiveness of Lower Extremity Revascularization
Ochoa Chaar CI, Gholitabar N, DeTrani M, Jorshery S, Zhuo H, Zhang Y, Dardik A. The Reintervention Index: A New Outcome Measure for Comparative Effectiveness of Lower Extremity Revascularization. Annals Of Vascular Surgery 2020, 69: 52-61. PMID: 32474144, DOI: 10.1016/j.avsg.2020.05.040.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAmputation, SurgicalComparative Effectiveness ResearchEndarterectomyEndovascular ProceduresFemaleHumansLimb SalvageLower ExtremityMaleMiddle AgedPeripheral Arterial DiseasePostoperative ComplicationsRetreatmentRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeVascular GraftingConceptsOpen lower extremity revascularizationLower extremity revascularizationPeripheral artery diseaseEndovascular groupExtremity revascularizationOutcome measuresEndovascular lower extremity revascularizationFrequency of reinterventionsTertiary care centerCurrent outcome measuresNew outcome measureType of procedureCardiovascular comorbiditiesMajor amputationEndovascular revascularizationReintervention ratePatient characteristicsArtery diseaseConsecutive patientsMultivariable analysisRetrospective reviewOpen groupCare centerEndovascular proceduresReinterventionThe Evolving Burden of Drug Use Associated Infective Endocarditis in the United States
Geirsson A, Schranz A, Jawitz O, Mori M, Feng L, Zwischenberger BA, Iribarne A, Dearani J, Rushing G, Badhwar V, Crestanello JA. The Evolving Burden of Drug Use Associated Infective Endocarditis in the United States. The Annals Of Thoracic Surgery 2020, 110: 1185-1192. PMID: 32387035, PMCID: PMC7502470, DOI: 10.1016/j.athoracsur.2020.03.089.Peer-Reviewed Original ResearchConceptsInfective endocarditisValve surgeryClinical profileOpioid epidemicDrug Use-Associated Infective EndocarditisThoracic Surgeons Adult Cardiac Surgery DatabaseValve operationsAdult Cardiac Surgery DatabaseUnique clinical profileCardiac Surgery DatabaseRisk-adjusted outcomesEndocarditis surgeryCardiovascular comorbiditiesHospital mortalityMajor morbidityEarly outcomesSurgery DatabaseWorse outcomesMultivariable regressionEast South CentralDrug useSurgeryPatientsStudy periodOutcomesSafety and Outcomes of Intravenous tPA in Acute Ischemic Stroke Patients With Prior Stroke Within 3 Months
Shah S, Liang L, Kosinski A, Hernandez A, Schwamm L, Smith E, Fonarow G, Bhatt D, Feng W, Peterson E, Xian Y. Safety and Outcomes of Intravenous tPA in Acute Ischemic Stroke Patients With Prior Stroke Within 3 Months. Circulation Cardiovascular Quality And Outcomes 2020, 13: e006031. PMID: 31903770, DOI: 10.1161/circoutcomes.119.006031.Peer-Reviewed Original ResearchMeSH KeywordsAdministrative Claims, HealthcareAgedAged, 80 and overBrain IschemiaDatabases, FactualFemaleFibrinolytic AgentsHospital MortalityHumansInfusions, IntravenousIntracranial HemorrhagesMaleMedicareRecurrenceRegistriesRetrospective StudiesRisk AssessmentRisk FactorsStrokeThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorTreatment OutcomeUnited StatesConceptsAcute ischemic stroke patientsPrior ischemic strokeSymptomatic intracranial hemorrhageIschemic stroke patientsPrior strokeHospital mortalityIntravenous tPAIschemic strokeIntracranial hemorrhageStroke patientsGuidelines-Stroke hospitalsHigher stroke severityGood functional outcomeHistory of strokeRetrospective observational studyYears of ageCardiovascular comorbiditiesStroke providersStroke severityUnadjusted riskFunctional outcomeHigh prevalenceObservational studyMedicare claimsElevated risk
2019
Safety and efficacy of venous ablation in octogenarians
Aurshina A, Zhang Y, Zhuo H, Cardella J, Orion K, Sumpio B, Sarac T, Chaar C. Safety and efficacy of venous ablation in octogenarians. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2019, 7: 685-692. PMID: 31421837, DOI: 10.1016/j.jvsv.2019.05.006.Peer-Reviewed Original ResearchConceptsVenous ablationYounger patientsTechnical successClinical successAge groupsRetrospective single-center reviewSingle-center reviewResolution of symptomsNumeric rating scaleAdvanced clinical stageSuperficial venous insufficiencyLarger vein diametersIntensity of symptomsYounger age groupsCardiovascular comorbiditiesPain improvementConsecutive patientsOutpatient officePathophysiology (CEAP) classificationVenous insufficiencyVenous diseaseClinical stageDuplex ultrasoundPatient populationUltrasound findings
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