2025
Sex-specific gonadal status determines prefrontal cortex proteome response to tibolone
McGovern A, Arevalo M, Ciordia S, Garcia-Segura L, Barreto G. Sex-specific gonadal status determines prefrontal cortex proteome response to tibolone. Biomedicine & Pharmacotherapy 2025, 190: 118419. PMID: 40779885, DOI: 10.1016/j.biopha.2025.118419.Peer-Reviewed Original ResearchPrefrontal cortexHormone therapyCellular stress response pathwaysStress response pathwaysFemale miceFunctional enrichment analysisSex-SpecificEmotion regulationClinical trialsCytoskeletal functionBrain functionMitochondrial metabolismSex differencesMenopausal hormone therapyResponse pathwaysGonadal hormonesProteomic analysisSynaptic plasticityEnrichment analysisNeurotransmitter signalingMolecular mechanismsFunctional convergenceGonadectomized animalsHormone therapy efficacyNeurodegenerative diseasesSex-Related Measurement Bias in Autism Spectrum Disorder Symptoms in the Baby Siblings Research Consortium
Burrows C, Sung S, Zheng S, Young G, Charman T, Klaiman C, Klin A, Marrus N, Ozonoff S, Piven J, Robins D, Schmidt R, Schwichtenberg A, Webb S, Zwaigenbaum L, Carver L, Chawarska K, Curtin S, Jeste S, Iverson J, Landa R, Messinger D, Roberts J, Stone W, Tager-Flusberg H, Esler A, Miller M, Bishop S, Elison J. Sex-Related Measurement Bias in Autism Spectrum Disorder Symptoms in the Baby Siblings Research Consortium. JAMA Network Open 2025, 8: e2525887. PMID: 40779266, PMCID: PMC12334962, DOI: 10.1001/jamanetworkopen.2025.25887.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAutism Diagnostic Observation ScheduleSex differencesQuality of social overturesMeasures of ASD symptomsResponsiveness to joint attentionAutism spectrum disorder symptomsHFL groupSocial communication difficultiesPrevalence of autism spectrum disorderConfirmatory factor analysisModerate levelsSocial overturesDisorder symptomsASD symptomsAutistic traitsClinician trainingJoint attentionMeasurement invarianceAge of diagnosisSpectrum disorderDevelopmental differencesMain OutcomesObservation ScheduleDiagnostic groups1761-P: Sex Differences in Emotion Regulation, Leptin, and Eating Behavior in Response to Stress and Food Cues
HORVATH-DIANO C, DAUGINIKAS E, HEILNER E, SAKMAR E, SINHA R, HARVANEK Z. 1761-P: Sex Differences in Emotion Regulation, Leptin, and Eating Behavior in Response to Stress and Food Cues. Diabetes 2025, 74 DOI: 10.2337/db25-1761-p.Peer-Reviewed Original ResearchEmotion regulationResponse to stressEating behaviorsSex differencesLaboratory sessionsFunding National Institutes of HealthSex-specific effectsStress-related eating behaviorFood cuesBehavioral therapyCue conditionEffect of genderEmotionsPersonal stressHormone samplingSnack testAssociated with lower leptinMultiple pre-CuesSignificant interactionAd libAssociated with lower totalSessionsHigher leptinAcute Physiology649-P: Sex Differences in Predictors of Food Craving, Eating Behavior, and Weight Changes Assessed Longitudinally over a 24-Month Period
DAUGINIKAS E, HORVATH-DIANO C, HEILNER E, SAKMAR E, SINHA R, HARVANEK Z. 649-P: Sex Differences in Predictors of Food Craving, Eating Behavior, and Weight Changes Assessed Longitudinally over a 24-Month Period. Diabetes 2025, 74 DOI: 10.2337/db25-649-p.Peer-Reviewed Original ResearchEmotion regulationEating behaviorsSex differencesOvereating behaviorFood cravingsResilience factorsDutch Eating Behavior QuestionnaireEmotion Regulation ScaleFood Craving InventoryProblems Experienced questionnaireEating Behavior QuestionnairePerceived Stress ScaleImpact eating behaviorRegulation ScaleCoping OrientationCravingWeight gainBehavior QuestionnaireObesity riskStress ScaleTarget stressEmotionsEatingLinear mixed-effects modelsReduce obesity riskSex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias
He J, Cabrera‐Mendoza B, Friligkou E, Mecca A, van Dyck C, Pathak G, Polimanti R. Sex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias. Alzheimer's & Dementia 2025, 21: e70215. PMID: 40421744, PMCID: PMC12107445, DOI: 10.1002/alz.70215.Peer-Reviewed Original ResearchConceptsSocioeconomic factorsFamily historySocioeconomic statusFamily history of Alzheimer's diseaseAssociation of socioeconomic factorsHistory of Alzheimer's diseaseUs Research ProgramCognitive performanceHigher socioeconomic statusSex-specific associationsAlzheimer's Disease AssessmentSex differencesUK BiobankADRDAlzheimer's diseaseGenetically informed analysesDementiaSample sizeSexGenetic analysisAlzheimerLimited informationStatusConfoundingBiobankGreater neuroimmune system deficit in women than men with alcohol use disorder
Zakiniaeiz Y, Hillmer A, Shi H, Pittman B, Nabulsi N, Huang Y, Bonomi R, Matuskey D, Angarita G, McKee S, Cosgrove K. Greater neuroimmune system deficit in women than men with alcohol use disorder. Biological Psychiatry 2025 PMID: 40412787, DOI: 10.1016/j.biopsych.2025.05.012.Peer-Reviewed Original ResearchTranslocator protein availabilityAlcohol-induced neurodegenerationExecutive function tasksConsequences of alcohol useAlcohol use disorderBrain imaging scansTranslocator protein levelsSex-matched controlsExecutive functionLower hippocampalTSPO availabilityFrontal cortexTranslocator proteinUse disorderNeurocognitive functionBrain regionsSex differencesAlcohol useBrain-resident immune cellsNeuroimmune mechanismsFunctional tasksSystem deficitsAUDImaging scansNeuroimmune cellsSex differences in event-related potentials and their clinical predictive value in first-episode antipsychotic-naïve schizophrenia
Qin Q, Lu C, Li S, Liu N, Li Y, Li T, Dong Y, Wang X, Li S, Li J, Zhang X. Sex differences in event-related potentials and their clinical predictive value in first-episode antipsychotic-naïve schizophrenia. European Archives Of Psychiatry And Clinical Neuroscience 2025, 1-10. PMID: 40397181, DOI: 10.1007/s00406-025-02020-0.Peer-Reviewed Original ResearchPositive and Negative Syndrome ScaleHamilton Depression ScaleHamilton Anxiety ScaleReduced P3 amplitudeHamilton Anxiety Scale scoresEvent-related potentialsSex differencesP3 amplitudeP3a latencyHealthy controlsN1 amplitudeAntipsychotic-naive schizophreniaGeneral psychopathology scoreNegative Syndrome ScaleHamilton Depression Scale scoresAuditory oddball paradigmSyndrome ScaleCompare sex differencesProlonged latencyPsychopathology scoresP3 componentN100 amplitudeAnxiety ScaleOddball paradigmCognitive impairmentIncreased face perception in individuals at clinical high-risk for psychosis: mechanisms, sex differences, and clinical correlates
Tran T, Keane B, Thompson J, Robinson B, Kenney J, Williams T, Waltz J, Levin J, Kafadar E, Gold J, Schiffman J, Ellman L, Walker E, Strauss G, Mittal V, Zinbarg R, Corlett P, Powers A, Woods S, Silverstein S. Increased face perception in individuals at clinical high-risk for psychosis: mechanisms, sex differences, and clinical correlates. Schizophrenia 2025, 11: 74. PMID: 40355455, PMCID: PMC12069608, DOI: 10.1038/s41537-025-00624-y.Peer-Reviewed Original ResearchClinical high riskCHR participantsCHR groupPhase of psychotic illnessAssessment of psychosis riskSevere positive symptomsGender of facesAssess response biasClinical correlatesPositive symptomsPsychiatric controlsPsychosis riskPsychotic illnessAccuracy of perceptionFace perceptionScrambled conditionPerceptual sensitivityPoorer roleResponse biasFace testPerceptual organizationComputerized assessmentSex differencesAltered visual perceptionPsychosisSex Differences in Histamine Regulation of Striatal Dopamine
Van Zandt M, Pittenger C. Sex Differences in Histamine Regulation of Striatal Dopamine. Journal Of Neuroscience 2025, 45: e2182242025. PMID: 40355265, PMCID: PMC12160404, DOI: 10.1523/jneurosci.2182-24.2025.Peer-Reviewed Original ResearchConceptsSubstantia nigra pars compactaAttention deficit hyperactivity disorderStriatal dopamineTourette syndromeSex differencesNeuropsychiatric conditionsModulation of striatal dopamineDysregulation of dopamineRegulation of dopamineReplicating previous workDeficit hyperactivity disorderInfusion of agonistsStriatal circuitryDopamine modulationHyperactivity disorderDopamineHistamine regulationBasal gangliaH3R agonistTargeted infusionGABAergic neuronsIntracerebroventricularMale miceEffect of histamineHistamine receptors270. Sex-Differences in Molecular and Synaptic Mechanisms Contributing to Stress-Related pathology: Insight from a Synaptic Density Pet and Proteomic Study in Rats
Asch R, Garcia-Milian R, Hernandez-Martin N, Cai Z, Esterlis I. 270. Sex-Differences in Molecular and Synaptic Mechanisms Contributing to Stress-Related pathology: Insight from a Synaptic Density Pet and Proteomic Study in Rats. Biological Psychiatry 2025, 97: s207. DOI: 10.1016/j.biopsych.2025.02.508.Peer-Reviewed Original ResearchF-33 | Sex Differences in Cardiovascular Outcomes of Intravascular Imaging-Guided Percutaneous Coronary Intervention: A Meta-analysis of Randomized Controlled Trials
Ezenna C, Ramesh P, Gbegbaje O, Ibrahim S, Hama J, Krishna M, Joseph M, Rossi R, Nanna M, Goldsweig A. F-33 | Sex Differences in Cardiovascular Outcomes of Intravascular Imaging-Guided Percutaneous Coronary Intervention: A Meta-analysis of Randomized Controlled Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2025, 4: 103418. DOI: 10.1016/j.jscai.2025.103418.Peer-Reviewed Original ResearchSex differencesRandomized Controlled Trials32. Cognitive Impairment in Patients With Early Onset Psychosis and Their Siblings: Age and Sex Differences
Mollon J, Lanzagorta N, Mathias S, Rodrigue A, Knowles E, Deaso E, Saavedra J, Cadavid L, Polat N, Nieto M, Brownstein C, D’Angelo E, Deo A, Gonzalez-Heydrich J, Sarmiento E, Walsh C, Almasy L, Nicolini H, Glahn D. 32. Cognitive Impairment in Patients With Early Onset Psychosis and Their Siblings: Age and Sex Differences. Biological Psychiatry 2025, 97: s87-s88. DOI: 10.1016/j.biopsych.2025.02.222.Peer-Reviewed Original ResearchA-119 | Sex Differences in Acute Myocardial Infarction Complicated by Cardiogenic Shock Supported with pLVAD
Shah T, Thompson J, Truesdell A, Hanson I, Ako J, Bharadwaj A, Burkhoff D, Redfors B, Kapur N, O'Neill W, Basir B, Lansky A. A-119 | Sex Differences in Acute Myocardial Infarction Complicated by Cardiogenic Shock Supported with pLVAD. Journal Of The Society For Cardiovascular Angiography & Interventions 2025, 4: 102869. DOI: 10.1016/j.jscai.2025.102869.Peer-Reviewed Original ResearchSex differences20. Imaging Sex Differences in Amphetamine-Induced Dopamine Release in the Prefrontal Cortex in Individuals With Alcohol Use Disorder
Zakiniaeiz Y, Riordan W, Gallezot J, Nabulsi N, Huang Y, Bonomi R, Matuskey D, Cosgrove K. 20. Imaging Sex Differences in Amphetamine-Induced Dopamine Release in the Prefrontal Cortex in Individuals With Alcohol Use Disorder. Biological Psychiatry 2025, 97: s82-s83. DOI: 10.1016/j.biopsych.2025.02.210.Peer-Reviewed Original ResearchSex differences in cerebrospinal fluid proteomics of patients with restless legs syndrome
Mogavero M, Peng G, Marchese G, Lanza G, Ferini-Strambi L, Ferri R, Koo B. Sex differences in cerebrospinal fluid proteomics of patients with restless legs syndrome. Sleep 2025, zsaf112. PMID: 40289925, DOI: 10.1093/sleep/zsaf112.Peer-Reviewed Original ResearchRestless legs syndromeProteomic signatureCerebrospinal fluid proteomeUntreated RLS patientsObservational cross-sectional studyBody mass indexProteome of patientsCerebrospinal fluid samplesSex-specific mechanismsCross-sectional studyRLS patientsSex-specific analysesMass indexSex differencesTherapeutic strategiesImmune responseInflammatory pathwaysEffective treatmentCerebrospinal fluid proteome of patientsDisease pathophysiologyPatientsSyndromeProtein levelsFluid samplesProteomic alterationsSex differences in problematic pornography use among adolescents: a network analysis
Villena-Moya A, Potenza M, Granero R, Paiva Ú, Arrondo G, Chiclana-Actis C, Fernández-Aranda F, Jiménez-Murcia S, Normand E, Ballester L, Mestre-Bach G. Sex differences in problematic pornography use among adolescents: a network analysis. BMC Psychology 2025, 13: 347. PMID: 40200245, PMCID: PMC11978135, DOI: 10.1186/s40359-025-02624-0.Peer-Reviewed Original ResearchConceptsPornography useVulnerability of malesPotential of network analysisGender-sensitive preventionOnline victimizationSexual pleasureCentral variableUnique needsNetwork analysisDigital harmMood modificationSpanish sampleSex differencesVulnerabilityPornographyAdolescentsIntervention strategiesVictimsConflictSexualityConclusionsThese findingsSexLonelinessHarmMalePreclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review
Barrios N, Riordan W, Garcia-Rivas V, Peltier M, Roberts W, Verplaetse T, Kohler R, Zhou H, Banini B, McKee S, Cosgrove K, Zakiniaeiz Y. Preclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review. Biology Of Sex Differences 2025, 16: 24. PMID: 40200334, DOI: 10.1186/s13293-025-00706-7.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol-induced dopamine releaseEffects of alcoholSex differencesAlcohol exposureDopamine measurementsMu-opioid receptorsDopamine releaseEffects of sexProgression of alcohol use disorderDopamine D1 receptor availabilityAlcohol use disorder developmentEffects of prenatal alcohol exposureD1 receptor availabilityStriatal dopamine concentrationsAir-exposed controlsAlcohol-exposed animalsMu-opioid receptor activationPrenatal alcohol exposureDuration of alcohol exposureVentral striatumBrain dopamineReward processingNeurobiological mechanismsReceptor availabilitySex differences in proteomics of cardiovascular disease – Results from the Yale-CMD registry
Liu Y, Wang Z, Collins S, Testani J, Safdar B. Sex differences in proteomics of cardiovascular disease – Results from the Yale-CMD registry. IJC Heart & Vasculature 2025, 58: 101667. PMID: 40224648, PMCID: PMC11987697, DOI: 10.1016/j.ijcha.2025.101667.Peer-Reviewed Original ResearchCMD patientsUpregulation of immune pathwaysCardiovascular diseaseProximity extension assayBody mass indexRegulation of blood flowSex differencesProteomic profilingIschemic symptomsCAD patientsMass indexIncreased angiogenesisGlucose metabolic pathwaysDifferential protein expressionPatientsSex-specific pathwaysProtein expressionImmune pathwaysBlood flowBlood samplesPrecision medicineINSL3Metabolic pathwaysPathway analysisExtension assayRe-examining NCTN clinical trials for sex differences in outcomes and toxicities in patients with neuroendocrine neoplasms
Ying T, Cramer L, T G, Vijayvergia N, Lustberg M, H K, C Y, B B, Kunz P. Re-examining NCTN clinical trials for sex differences in outcomes and toxicities in patients with neuroendocrine neoplasms. Endocrine Abstracts 2025 DOI: 10.1530/endoabs.108.p11.Peer-Reviewed Original ResearchSex differences in the microglial response to stress and chronic alcohol exposure in mice
Soares A, Garcia-Rivas V, Fai C, Thomas M, Zheng X, Picciotto M, Mineur Y. Sex differences in the microglial response to stress and chronic alcohol exposure in mice. Biology Of Sex Differences 2025, 16: 19. PMID: 40038827, PMCID: PMC11881309, DOI: 10.1186/s13293-025-00701-y.Peer-Reviewed Original ResearchConceptsResponse to stressSex differencesAlcohol exposureStress-induced alcohol drinkingHeightened reactivity to stressInescapable footshock stressDevelopment of AUDReactivity to stressChronic alcohol exposureProminent sex differencesIncreased alcohol intakeCharacterize sex differencesFemale C57BL/6J miceDark paradigmComorbid moodFootshock stressStress disorderLimbic circuitsNeurobiological processesModify drinkingNeuroimmune signalingAdministered alcoholFemale rodentsMicroglial densityAlcohol drinking
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