2025
Comparative effectiveness of OW GLP-1 RAs and other glucose-lowering therapies among Medicare beneficiaries with T2D and ASCVD
Tan X, Harton J, Gutierrez C, Liang Y, Xie L, Muhammad C, Swift C, de Havenon A. Comparative effectiveness of OW GLP-1 RAs and other glucose-lowering therapies among Medicare beneficiaries with T2D and ASCVD. Diabetes Research And Clinical Practice 2025, 229: 112473. PMID: 40934962, DOI: 10.1016/j.diabres.2025.112473.Peer-Reviewed Original ResearchHealthcare resource utilizationAssociated with reduced riskMedicare beneficiariesAssociated with reduced risk of CV eventsGLP-1 RAsMedicare fee-for-service claims dataTotal medical visitsOW GLP-1 RAsTotal medical costsObservational cohort studyMedical visitsRisk of CV eventsClaims dataGuideline recommendationsIncidence rateCohort studyReal-world settingsMedicareMedical costsOnce-weeklyGLP-1Glucose-lowering therapyStudy findingsASCVDLow riskPractice of oxygenation and respiratory support during fibreoptic bronchoscopy: the OxyFOB study protocol
Longhini F, Crimi C, Noto A, Pelaia C, Karakurt Z, Skoczyński S, Boléo-Tomé J, Winck J, Esquinas A, Melhorn J, Corneci D, Pobeha P, Bosco V, Garofalo E, Bruni A, Cammarota G, Todorova V, Puci M, Sotgiu G, Kostikas K, Maggiore S, De Robertis E, Ergan B, Landoni G, Simonte R, Nava S, Navalesi P, Scala R, Karakurt Z, Gundogus B, Donmez G, Ernam D, Campainha S, Oliveira A, Teixeira M, Gouveia F, Monteiro C, Veske N, Altın S, Günlüoğlu G, Chousein E, Arıkan H, Karakurt S, Lacedonia D, Torraco R, Tondo P, Bialka S, Palaczynski P, Danel J, Jankowiak P, Kędra M, Bednarska M, Carpagnano E, Boniello E, Portacci A, Scarlata S, Finamore P, Fontata D, Kania A, Celejewska-Wojcik N, Rygiel K, Tobiczyk E, Springer D, Cofta S, Maugeri J, Bellissima A, Tamburrini M, Papi A, Morandi L, Franco C, Chiesa S, Verti N, Zieliński M, Mondoni M, Intravaia C, Carlucci P, Karnak D, Çiledağ A, Kaya A, Ghinassi G, Guidelli L, Santus P, Radovanovic D, Saad M, Roquete C, Fortes R, Porpodis K, Tsiouprou I, Lagoudi K, Pelaia G, Marrazzo G, Montenegro N, Biondini D, Damin M, Spagnolo P, Rodrigues J, Pinto M, Maia D, Sampsonas F, Tzouvelekis A, Tsirikos G, Loukides S, Raptakis T, Papavasileiou V, Vaschetto R, Tonino A, Patrucco F, Gomes R, Soares J, Santana M, Neri G, Corea A, Caroleo A, Grande A, Veltri D, Costumato G, Di Lorenzo F, Bonadio G, Caroleo Z, Guerriero G, Mazza G, Mellace F, Perrelli G, Riillo S, Ruocco G, Camastra A, Gaetano G, Mesiti A, Guzzi G, Mastrangelo H, Pisani L, VegaPittao M, Stratakos G, Koukaki E, Anagnostopoulos N, Dongilli R, Stirpe E, Köhl J, Skyba P, Sokolová E, Santos M, Aguiar M, Zias N, Papadakis I, Terragni P, Pistidda L, Castagna R, Popescu M, Rogliani P, Puxeddu E, Frugoni C, Notaro S, Piscitelli E, González E, Cañigral Á, Turi S, Mucchetti M, Belletti A, Volonterio G, Sommaruga S, Navarria R, Nardo A, Morana G, Palmiotto G, Iuliano A, Bastos H, Scolletta S, Biuzzi C, Sorino C, Hida D, Arrighi E, Gambardella P, Perri G, Cortegiani A, Ippolito M, Alessandri F, Sanda V, Zullino V, Rocco M, Fiorelli S, Nunes L, Gregoretti C, Misseri G, Piattoli M, Curto I, Tescione M, Vadalà E, Piccolo A, Mammone S, Gnass M, Gniady P, Steiropoulos P, Drakopanagiotakis F, Gianozzi L, Chronis C, Novelli L, Katsoulis K, Fois A, Oraczewska A. Practice of oxygenation and respiratory support during fibreoptic bronchoscopy: the OxyFOB study protocol. BMJ Open 2025, 15: e104747. PMID: 40897500, PMCID: PMC12410610, DOI: 10.1136/bmjopen-2025-104747.Peer-Reviewed Original ResearchConceptsVentilatory support strategiesFlexible bronchoscopyOxygen therapyContinuous positive airway pressurePositive airway pressureHigh-flow oxygen therapyConventional oxygen therapyInvasive mechanical ventilationNon-invasive ventilationObservational cohort studyMultivariate logistic regressionCase report formsElectronic case report formsVentilatory approachAirway pressurePrimary endpointRespiratory supportPostprocedural complicationsHaemodynamic complicationsClinical outcomesFibreoptic bronchoscopyCardiovascular comorbiditiesClinical impactMechanical ventilationFB proceduresHospital Implementation of Endovascular Thrombectomy and Health Equity in Acute Stroke Outcomes.
Lusk J, Liu B, O'Brien E, Hasan D, Fonarow G, Sheth K, Schwamm L, Xian Y, Albers G, Saver J, Li F, Mac Grory B. Hospital Implementation of Endovascular Thrombectomy and Health Equity in Acute Stroke Outcomes. Stroke 2025 PMID: 40891327, PMCID: PMC12433677, DOI: 10.1161/strokeaha.125.051312.Peer-Reviewed Original ResearchIn-Hospital MortalityHealth equityHospital implementationHospital levelInsurance statusGuidelines-Stroke programIschemic stroke mortalityEducational attainmentCounty-level povertyIn-hospital mortality/dischargeMedian income >American Heart AssociationAcute stroke outcomeGuidelines-StrokeStroke mortalityCounty poverty ratesObservational cohort studyAssociated with improvementsHealth outcomesHospital characteristicsPrimary exposureEndovascular thrombectomyCohort studyAmbulatory statusSocioeconomic equityImpact of Nimodipine-Induced Blood Pressure Reductions on Cerebral Autoregulation and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage
Stoehr K, Bartolome D, Jayasundara S, Thinzar P, Vargas D, Kim J, Magid-Bernstein J, O’Keefe L, de Havenon A, Hebert R, Matouk C, Sheth K, Gilmore E, Ortega-Gutierrez S, Petersen N. Impact of Nimodipine-Induced Blood Pressure Reductions on Cerebral Autoregulation and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care 2025, 1-11. PMID: 40847251, DOI: 10.1007/s12028-025-02338-6.Peer-Reviewed Original ResearchAneurysmal subarachnoid hemorrhageMean arterial pressureAssociated with worse functional outcomeBP reductionFunctional outcomesNimodipine administrationSubarachnoid hemorrhageHunt & Hess scoreBlood pressureAssociated with BP reductionSevere aneurysmal subarachnoid hemorrhageModified Fisher gradeResponse to nimodipineSensitive to nimodipineCerebral autoregulationDelayed Cerebral IschemiaBlood pressure reductionRegional oxygen saturationObservational cohort studyModified Rankin ScaleLimits of autoregulationFisher gradeHess scoreAneurysm securementNeurological outcomeMepolizumab in patients with severe asthma & BEC ≥150–<300 cells/µL: Benefits at 2 years
Canonica G, Bagnasco D, Lee J, Chupp G, Schleich F, Oppenheimer J, Zhang L, Alfonso-Cristancho R, Howarth P. Mepolizumab in patients with severe asthma & BEC ≥150–<300 cells/µL: Benefits at 2 years. ERJ Open Research 2025, 01390-2024. DOI: 10.1183/23120541.01390-2024.Peer-Reviewed Original ResearchClinically significant exacerbationsBlood eosinophil countMaintenance oral corticosteroidsSevere asthmaRate of clinically significant exacerbationsMedian average daily doseFEV 1Effect of mepolizumabInitiation of mepolizumabProportion of patientsObservational cohort studyReal-world effectivenessClinical trial evidenceForced expiratory volumePoor disease controlMepolizumab treatmentAverage daily doseOral corticosteroidsSingle-armACQ-5Daily doseSignificant exacerbationsEosinophil countMepolizumabCohort studyClinical Predictors of Pain Relief with 60-Day Peripheral Nerve Stimulation: A Multicenter Observational Study
Odonkor C, Oghenesume O, Hirani S, Bohacek S, Gutierrez D, Sekhar R, McCormick Z, Poree L, Abd-Elsayed A. Clinical Predictors of Pain Relief with 60-Day Peripheral Nerve Stimulation: A Multicenter Observational Study. Journal Of Pain Research 2025, 18: 3963-3976. PMID: 40799305, PMCID: PMC12341798, DOI: 10.2147/jpr.s524870.Peer-Reviewed Original ResearchBaseline physical activityPhysical activityPsychological distressHigher pain self-efficacyPeripheral nerve stimulationPain self-efficacyChronic pain durationClinical predictorsMorbid obesityOpioid dependencePatient selectionNon-respondersObservational cohort studyLow catastrophizersPredictors of pain reliefFactors associated with treatment outcomeBaseline assessmentPain durationPredictors of early responseSelf-EfficacyCohort studyPsychological resilienceMulticenter observational studyTreatment expectationsLogistic regressionEvaluation of a Region-Wide Hospital-Based Violence Intervention Program : A Pilot Cohort Study.
Mueller K, Kaser T, Cooper B, Lew D, Moran V, Ancona R, Chapman-Kramer K, Coffey M, Page K, Batha A, Harris S, Rice-Barnes L, Williams M, Kranker L, Spruce M, Behr C, Mancini M, Schuerer D, Clukies L, Santucci N, Trolard A, Anwuri V, Ranney M, Foraker R, Vogel M. Evaluation of a Region-Wide Hospital-Based Violence Intervention Program : A Pilot Cohort Study. Annals Of Internal Medicine 2025, 178: 1116-1126. PMID: 40658952, PMCID: PMC12379808, DOI: 10.7326/annals-24-01576.Peer-Reviewed Original ResearchConceptsHospital-based violence intervention programsViolence intervention programsIntervention programsControl participantsCohort studyLevel 1 trauma hospitalViolent reinjuryEncounter-level dataIndividual-level impactInjury visitsObservational cohort studySociodemographic characteristicsIndex injuryInjury survivorsIntervention efficacyReinjuryPartner hospitalsOverwhelming riskPilot phaseEligible patientsParticipantsPilot studyKaplan-Meier estimatesPropensity score matchingHospitalGenome sequencing is critical for forecasting outcomes following congenital cardiac surgery
Watkins W, Hernandez E, Miller T, Blue N, Zimmerman R, Griffiths E, Frise E, Bernstein D, Boskovski M, Brueckner M, Chung W, Gaynor J, Gelb B, Goldmuntz E, Gruber P, Newburger J, Roberts A, Morton S, Mayer J, Seidman C, Seidman J, Shen Y, Wagner M, Yost H, Yandell M, Tristani-Firouzi M. Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery. Nature Communications 2025, 16: 6365. PMID: 40640177, PMCID: PMC12246213, DOI: 10.1038/s41467-025-61625-0.Peer-Reviewed Original ResearchConceptsCongenital heart defectsCongenital cardiac surgeryCilia-related genesGenome sequenceChromatin modifiersCardiac surgeryExome sequencingHeart defectsClinical outcomesRisk of adverse post-operative outcomesPediatric Cardiac Genomics ConsortiumCongenital heart defect phenotypesCongenital heart defect patientsAdverse post-operative outcomesWhole-genome sequencingPredictive valueExtra-cardiac anomaliesProspective observational cohort studyComplex heart defectsPost-operative outcomesWhole-exome sequencingElevated riskAdverse postoperative outcomesObservational cohort studyPostoperative outcomesRelation Between the Incidence of In-Hospital Cardiac Arrest and Survival in Older Patients
Nathani R, Li Q, Chan P, Nguyen C, Koshy T, Hall H, Mentias A, Girotra S, Investigators A, Chan P, Girotra S, Grossestreuer A, Moskowitz A, Ornato J, Churpek M, Starks M, Perman S. Relation Between the Incidence of In-Hospital Cardiac Arrest and Survival in Older Patients. Journal Of The American College Of Cardiology 2025, 86: 49-59. PMID: 40602944, DOI: 10.1016/j.jacc.2025.04.067.Peer-Reviewed Original ResearchConceptsIn-hospital cardiac arrestIn-hospital cardiac arrest survivalIn-hospital cardiac arrest incidenceRisk-standardized ratesHospital variablesIncidence rateRisk-standardized rates of survivalIncidence of in-hospital cardiac arrestAmerican Hospital Association dataHospitalization ratesNurse-patient ratioCase-mix adjustmentHierarchical multivariate regression modelsCardiac arrestCase mix indexNurse-staffingIn-hospital cardiac arrest survival ratesGuidelines-ResuscitationObservational cohort studyMultivariate regression modelMedicare admissionsHospital characteristicsU.S. hospitalsCohort studyModifiable variablesCharacteristics of Veterans Receiving Medication for Opioid Use Disorder: An Observational Cohort Study
Jones K, Mandavia A, Gurewich D, Wyse J, Sung M, Becker W, Livingston N. Characteristics of Veterans Receiving Medication for Opioid Use Disorder: An Observational Cohort Study. Journal Of General Internal Medicine 2025, 1-4. PMID: 40588710, DOI: 10.1007/s11606-025-09657-6.Peer-Reviewed Original ResearchSerum chloride and the response to combining loop and thiazide diuretics for acute heart failure: the ALCALOTIC study
Núñez J, Miñana G, Villalonga M, Asenjo M, Carrera M, Epelde F, Gil M, Chivite D, Contra A, Pla X, Casado J, Miró Ò, de la Espriella R, Testani J, Trullàs J. Serum chloride and the response to combining loop and thiazide diuretics for acute heart failure: the ALCALOTIC study. Internal And Emergency Medicine 2025, 20: 1399-1409. PMID: 40379935, DOI: 10.1007/s11739-025-03961-z.Peer-Reviewed Original ResearchAcute heart failureHeart failureDiuretic responseSerum chlorideThiazide diureticsWeight lossAssociated with smaller weight lossPatients admitted with acute heart failurePathophysiology of heart failureIn-hospital weight lossAssociated with higher weight lossObservational cohort studyDiuretic resistanceHF prognosisThiazideCohort studyDiureticsPatientsHyperchloraemiaOverall populationHypochloraemiaClinical sitesSerumSmall weight lossFailureAntithrombotic Trends Before and After Publication of Randomized Clinical Trials in Cervical Artery Dissection: A Secondary Analysis of the STOP‐CAD Study
Penckofer M, Shu L, Strelecky L, Yaghi S, Henninger N, Muppa J, Bakradze E, Heldner M, Antonenko K, Salehi Omran S, Seiffge D, Arnold M, Zedde M, Zubair A, Marto J, Ghannam M, Engelter S, Traenka C, Mac Grory B, Kam W, Elnazeir M, Romoli M, Saleh Velez F, Siegler J. Antithrombotic Trends Before and After Publication of Randomized Clinical Trials in Cervical Artery Dissection: A Secondary Analysis of the STOP‐CAD Study. Stroke Vascular And Interventional Neurology 2025, 5 DOI: 10.1161/svin.125.001728.Peer-Reviewed Original ResearchAcute cervical artery dissectionCervical artery dissectionBaseline National Institutes of Health Stroke Scale scoreNational Institutes of Health Stroke Scale scoreAnticoagulant useVertebral artery involvementArtery dissectionRandomized clinical trialsStroke Scale scoreOral anticoagulantsArtery involvementClinical trialsDuration of oral anticoagulationMultinational observational cohort studyRate of anticoagulationTreated with anticoagulationOral anticoagulant useScale scorePublications of randomized clinical trialsObservational cohort studyMultivariate logistic regressionClinical practice dataPresence of infarctionSecondary analysisPartially occlusive thrombiEvaluating the Effect of Routine Lethal Means Counseling in the Emergency Department on Suicide Mortality Among Mental Health Patients
Marcus S, Cullen S, Xie M, Bridge J, Caterino J, Schmutte T, Olfson M. Evaluating the Effect of Routine Lethal Means Counseling in the Emergency Department on Suicide Mortality Among Mental Health Patients. AJPM Focus 2025, 4: 100336. PMID: 40688469, PMCID: PMC12274817, DOI: 10.1016/j.focus.2025.100336.Peer-Reviewed Original ResearchLethal means counselingMental health disordersEmergency departmentHealth disordersNational Medicaid claims dataSuicide deathsMental health patientsPeriod post-dischargeStorage of firearmsOdds ratio of deathMedicaid claims dataRisk of suicideHealth patientsObservational cohort studyRatio of deathED episodesED visitsSuicide mortalityPost-dischargeLethal meansOdds ratioED patientsStored firearmsCohort studyED management2024 Update of the RECOVER-Adult Long COVID Research Index
Geng L, Erlandson K, Hornig M, Letts R, Selvaggi C, Ashktorab H, Atieh O, Bartram L, Brim H, Brosnahan S, Brown J, Castro M, Charney A, Chen P, Deeks S, Erdmann N, Flaherman V, Ghamloush M, Goepfert P, Goldman J, Han J, Hess R, Hirshberg E, Hoover S, Katz S, Kelly J, Klein J, Krishnan J, Lee-Iannotti J, Levitan E, Marconi V, Metz T, Modes M, Nikolich J, Novak R, Ofotokun I, Okumura M, Parthasarathy S, Patterson T, Peluso M, Poppas A, Quintero Cardona O, Scott J, Shellito J, Sherif Z, Singer N, Taylor B, Thaweethai T, Verduzco-Gutierrez M, Wisnivesky J, McComsey G, Horwitz L, Foulkes A, Cribbs S, Francis A, Hang T, Ingram K, Lainez J, Wiley Z, Lewis K, Ager A, Atha M, Fineman R, Gray N, Grimes A, Hewitt L, Huerta C, Johnson B, Khalil L, Kleinhenz D, Koumanelis A, Lee M, Litvack M, Panganiban B, Rahman K, Smith V, Stringer A, Tolbert M, Traenkner J, Unterberger K, Wimberly E, Han J, Marconi V, Ofotokun I, Patzer R, Walker T, Abraham R, Aguilar F, Ahmadi-Izad G, Ahmed D, Alvarez A, Anderson B, Asencios W, Beaty C, Bedi B, Berry J, Boone D, Bower M, Bremner J, Brent C, Brown-Smith K, Bull R, Capo G, Carl-Igwe K, Chitadze C, Chukwumerije N, Clyburn E, Collins S, Costello J, Couture G, Craft A, Cui X, del Rio C, Detelich J, Dixon C, Dow J, Doyle D, Elchommali J, Elsey I, Franks N, Gallini J, Gutter E, Harding J, Hernandez L, Holloway C, Ifejika C, Jasarevic R, Javia V, Jeter M, Joseph Y, Juarez M, Kirkpatrick C, Koumanelis A, Kozoman R, Krishnan S, Leon J, Lew V, Maier C, Makkaoui N, Maroney M, Martin C, Mbogo L, McCaslin A, McIntyre J, Moanna A, Montoya M, Morales E, Moran C, Murray C, Nelson R, Nguyen T, Ojoawo B, Osinski E, Oviedo S, Paredes-Gaitan Y, Prude M, Ramakrishnan G, Rebolledo P, Roberts M, Robinson K, Rogers C, Rouphael N, Searles C, Segall M, Shah A, Silva R, Simpson C, Simpson-Derrell K, Sirajud-Deen T, Stroud J, Suthar M, Sylber C, Sylvera A, Teunis L, Thomas K, Titanji K, Toy C, Truong A, Vaccarino V, Varney K, Vyas K, Vyas K, Walkow M, Wesley T, Winston J, Winter T, Wongtrakool C, Gander J, Neuman R, Bush P, Hudgins A, Kolailat I, Martinez M, Thompson S, Pemu P, Dandy A, Ibeawuchi C, Lawrence B, Morgan-Billingslea J, Ojemakinde E, Mullington J, Collier A, Fong T, Haack M, Hauser K, Maley J, Quintana Y, Shaughnessy L, Stephenson K, Thomas R, Torres R, Marathe J, Duffy E, Hamburg N, Kobayashi M, O'Connor G, Shepherd F, Williams C, Zhang H, Levy B, Aikawa M, Baden L, Baslet G, Bennett L, Bhattacharyya S, Buring J, Cagnina R, Chen L, Clark C, Cohen P, Czeisler C, Estill P, Gay E, Hong J, Lamas D, Levy-Carrick N, Manson J, Monafrared T, Redline S, Remis E, Schilkrut D, Sesso H, Solomon S, Sparks J, Spencer L, Systrom D, Thu P, Walt D, Washko G, Whittelsey M, Wiener R, John J, Ticotsky A, Bassett I, Alba G, Aung T, Ginns L, Haas J, Hu Y, Juelg B, Kanjilal D, Kim A, Klerman E, Lewis G, Ojikutu B, Perlis R, Rosand J, Wallace Z, Xerras D, Zionts D, Ward H, Blazey-Martin D, Ghamloush M, Jordan M, Kogelman L, Carton T, Miele L, Brown T, Sutherland E, Fuloria J, Datri P, Hagensee M, Leggio C, Perkins A, Trauth A, Trotter S, Van Deerlin A, Weiser S, Young M, Erdmann N, Levitan E, Tita A, Armstrong D, Binkley S, Blackwell K, Causey A, Cook F, Domingo J, Donahue C, Eady M, Edberg J, Garcia-McClaney N, Garner M, Gray B, Hall W, Hart C, Hebson C, Hidalgo B, Holtzapfel K, Jinright A, Judd S, Kennedy T, Kirkwood L, Maier M, McCormack P, Mitchell K, Montgomery A, Peralta-Carcelen M, Pilco J, Powell L, Shevin R, Skipworth S, Spurgeon L, Ware G, Wilson R, Woodruff D, Young B, Gillespie M, Daniel C, Hansel J, Wu J, Ashktorab H, Brim H, Laiyemo A, Sherif Z, Durrani S, Nezamloo A, Ngwa J, Njoku N, Gentil M, Mehari A, Solemani A, Chang L, Thuluvath P, Alemu M, Anderson J, Chauhan M, Cho S, Goodman K, Lanke G, Lebron R, Maheshwari A, Ok J, To C, Shellito J, Greenway F, Kirwan J, Rosen C, Arruda A, Emery I, Roelke T, Berger P, Hoover S, Black L, Tjarks B, Fonseca V, Gupta S, Longo M, Yang M, Shikuma C, Chow D, MarGangcuangco L, Castro M, Bengtson C, Howard T, Koontz B, Spikes L, Simmons C, Whiteheart S, Garvy B, Wood J, Marshall G, Garla V, Kuebler J, Nandi U, Vasey A, Warren D, Dickinson J, VanWagoner T, Bogie A, James J, Scott J, Sukhera F, Luciano Roman C, Perez Frontera S, Santana Bagur J, Hodder S, Bardes J, Dominique-Villanueva D, Juskowich J, Reece R, Sarwari A, Certa M, Chessier E, Everett E, Kindred E, Harris P, Sudhindra P, Olds L, Aponte-Soto L, Del Rios M, Diaz M, Ibanez A, Rolon C, Cranford S, Brown D, Dixon J, Gale L, Hammerl S, Hartwig K, Madineni A, Swearingen P, Hendrickson M, Noland S, Terlinde T, Hobbs B, Klein J, Krishnan J, Lin J, Muramatsu N, Prabhakar B, Prendergast H, Vanden Hoek T, Adams D, Baker A, Barbera S, Basu S, Bleasdale S, Boyd A, Breiter T, Buhimschi I, Carrithers M, Chalamalla R, Chestek D, Cook J, Darbar D, Dasgupta R, Davis Blakley F, DeLisa J, Diviak K, Donlon M, Dworkin M, Ellison A, Flanigan C, Freedman M, Gerald L, Giles W, Gordon H, Hammad B, Hasek S, Hasse W, Hryniewicka M, Illendula S, Ismail N, Jain A, Jennette K, Kadubek G, Kent D, Kent D, Kim K, Kotini-Shah P, Large L, Lash J, Lu J, Mahamed A, Malchenko S, Martinez M, Mauntel-Medici C, McCauley M, Menchaca M, Mermelstein R, Moreno D, Morrissy L, Musick H, Norwick L, Novak R, Ortiz M, Patel K, Perez N, Pliskin N, Pope S, Prasad B, Predki B, Quigley J, Ramchandran R, Ramirez A, Rappe S, Rehman J, Rowley M, Rudraraju G, Rutherfoord M, Sculley J, Smith-Mack J, Sun J, Tartt N, Villanueva L, Warfield Kelly S, Yazici C, Stewart de Ramirez S, Bolliger D, Boyineni J, Chebrolu P, Curry H, Donohue S, Edmonds S, Kelly S, Maholovich P, Sader S, Thompson T, Welter H, Woolley B, Hafner J, Hanson K, Hutton R, Charney A, Kovatch P, Merad M, Nadkarni G, Wisnivesky J, Aberg J, Ascolillo S, Bagiella E, Bartram L, Becker J, Beckmann N, Bendl A, Chen B, Civil A, Crawford G, Dhar K, Evo-Ortega L, Fierer D, Gallagher E, Garcia-Sastre A, Gnjatic S, Gray I, Guliyeva S, Harvey-Ingram L, Herrera-Moreno J, Hill M, Horowitz C, Jackson R, Kastrat D, Lala-Trindade A, Lin J, Macaluso N, Marcon K, Meyer D, Morinigo J, Natelson B, Nussenzweig M, Padua T, Putrino D, Richardson L, Russo S, Seifert A, Serri A, Walker J, Yee M, Bateman L, Vernon S, Deakyne Davies S, Gardner E, Bryan T, Buck K, Hawkins K, Oakes J, Horne B, Knowlton K, Woller S, Aguirre B, Anderson J, Bair T, Bosh L, Evans L, Garrett C, Harris D, Herrera K, Iverson L, Jensen M, Juan J, Knight S, Leither L, Maestas H, May H, Najarian G, Webb T, Zubal S, Erlandson K, Sokol R, Brightman M, Davis D, Feuerriegel E, Fudge H, Garg L, Graham P, Higgins J, Johnson B, Jolley S, Lockie T, McCandless S, Molden J, Owen M, Pitch C, Reid K, Reusch J, Thurman B, Tran H, West S, Wodushek T, Friedman N, Ludwig K, Decker L, Raissy H, Adolphi N, Archuleta D, Bradfute S, Brito R, Elifritz J, Garcia-Soberanez N, Gentry F, Harkins M, Martinez N, Montoya L, Parada A, Quinn D, Ramos A, Sheehan E, Treacher I, Hess R, Truong D, Alekhina N, Barlocker J, Brown J, Cortez M, Donohue D, Facelli J, Ford I, Gouripeddi R, Hermansen J, Johnny J, Lindsay A, Ling L, Lloyd J, Lu Y, Medina J, Morimoto S, Pace L, Powell J, Scholand M, Shah K, Sharareh N, Spivak A, Stringham C, Trinity J, Velinder M, Weaver L, Kaelber D, McComsey G, Adams C, Atieh O, Baissary J, Baloi A, Barnboym E, Boldt N, Conrad A, Consolo M, Curtis L, D’anza B, DiFrancesco K, Eteshola E, Gallagher M, Harris P, Hernandez C, Hershey M, Iqbal S, Jacob J, Kennedy O, Labbato D, Levert A, Levin J, Lim J, Malakooti S, Mouchati C, Pearman A, Pettinato K, Rivera A, Rodgers M, Rodgers T, Roy A, Scott S, Sheth N, Smith B, Tejani V, Tribout M, Yendewa G, Zhang D, Zisis S, Singer N, Ayache M, Chesnick H, Edminston M, Greenwood C, Haghiac M, Kaufman E, Lengu K, Lowenthal R, Oleson C, Smith C, Weinberger E, Chen P, Caudill A, Chopra T, Contreras F, Dahlke L, Gudipudi L, Jackman S, Modes M, Muttera N, Parimon T, Salinas N, Tadeo J, Torbati S, Heath J, Brennan C, Edmark R, Gutierrez V, Hadlock J, Li S, Magis A, McDonald C, Murray K, Rowen L, Yuan D, Tuttle K, Alicic R, Baxter J, Emerson S, Hood S, Kuykendall K, White S, Wilcox L, Goldman J, Algren H, Del Alcazar J, Duven A, Kaneko J, Kim C, Manner P, Mason C, Poussier R, Satira R, Wallick J, Chu H, Harteloo A, Kemp M, Logue J, McCaffrey K, McDonald D, Nackviseth C, Nguyen H, Watanabe K, Hasbani K, Nambiar A, Patterson T, Potter J, Salehi M, Sharma K, Verduzco-Gutierrez M, Anderson R, Arellanes A, Barajas R, Chauhan S, Clarke G, Farner C, Fischer M, Goldberg M, Hastings G, Heard P, Hernandez J, Herrera I, Infante E, Johnson H, Jones J, Kellogg D, Kraig E, Longoria L, Okafor E, Patterson J, Pinones A, Reeves W, Scholler I, Seshadri S, Shah P, Shah D, Soileau B, Solis P, Stoebner C, Sullivan M, Taylor B, Tragus R, Tsevat J, Saade G, Sharma K, Paredes C, Alvarado S, Blish C, Go M, Jagannathan P, Maldonado Y, Singh U, Utz P, Ahuja N, Blomkalns A, Bonilla H, Brotherton R, Clinton K, Dingankar V, Geng L, Haddad F, Jamero C, Jee K, Jia X, Khurana N, Kumar A, 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Cheng D, Chibnik L, Ciriello M, Costenbader K, Dimitrov D, Estiri H, Fayad M, Feldman C, Gainer V, Ghosh B, Gollub R, Guan Z, Harris A, Helmer K, Hendrix A, Holzbach A, Huang W, Kaufman D, Keogh D, Kerr J, Klann J, Krishnamoorthy A, Lasky-Su J, Liao K, MacFadden D, Maram A, Martel M, Mendis M, Metta R, Monteiro J, Morales E, Morse R, Nazaire M, Neils G, Nguyen A, Norman J, Paik H, Pant D, Park H, Rabideau D, Reeder H, Rossi-Roh K, Santacroce L, Schlepphorst K, Schulte C, Selvaggi C, Shinnick D, Simons W, Simpson L, St. Jean Flanders M, Strasser Z, Thakrar M, Thaweethai T, Thorn M, Trewett P, Van Fleet D, Wagholikar K, Wang T, Wattanasin N, Weber G, Williams M, Zhang R, Cicek M, Flotte T, Boysen E, Chang N, Ellingworth E, Frisch E, Welch G, Yusuf A, Zahnle N, Cerda M, Clash V, Taylor B, Zissis M, Akintonwa T, Blancero F, Brown H, Carmilani M, Copeland D, Hall Y, kondo K, Lerma L, Lindsay J, Marti H, Maughan C, Minor T, Vincent H, Aragon L, Bander B, Bishof K, Carignan E, Castro Baucom L, Clash V, Coombs K, Corchado C, Davis H, Diggs M, Dunn M, Edwards B, Fisher L, Fitzgerald M, Gage Witvliet M, Gustafson T, Holmes V, Hornig M, Hornig M, Jain N, Kochis N, Lam J, Letts R, Lewis J, Martinez T, McCorkell L, McGrath R, Nguyen K, Nichols L, O'Brien L, Peddie A, Perlowski A, Phillips-Lorenzo E, Prentiss L, Raytselis N, Regino L, Rockwell M, Rutter J, Seibert E, Sekar A, Taylor E, Wallace A, Wilensky R, Williams M, Williams N, Williams-Dawson K, Wylam A. 2024 Update of the RECOVER-Adult Long COVID Research Index. JAMA 2025, 333: 694-700. PMID: 39693079, PMCID: PMC11862971, DOI: 10.1001/jama.2024.24184.Peer-Reviewed Original ResearchConceptsLong COVIDQuality-of-life measuresStudy visitsPost-COVID-19 conditionObservational cohort studyMain OutcomesPatient communityParticipant dataParticipant-reported symptomsCohort studyPostexertional malaiseSymptom listSARS-CoV-2 infectionShortness of breathParticipantsEnhanced recoveryBrain fogAdultsResearch indexVisitsChest painSymptomsPost-COVID-19Symptom subtypesChronic coughQuantitative Pupillometry Predicts Neurologic Deterioration in Patients with Large Middle Cerebral Artery Stroke
Du Y, Pohlmann J, Chatzidakis S, Brush B, Malinger L, Stafford R, Cervantes‐Arslanian A, Benjamin E, Gilmore E, Dupuis J, Greer D, Smirnakis S, Mohammed S, Ong C. Quantitative Pupillometry Predicts Neurologic Deterioration in Patients with Large Middle Cerebral Artery Stroke. Annals Of Neurology 2025, 97: 930-941. PMID: 39825740, PMCID: PMC12011534, DOI: 10.1002/ana.27178.Peer-Reviewed Original ResearchNeurological Pupil indexMiddle cerebral arteryQuantitative pupillometryNeurological deteriorationMiddle cerebral artery strokeDilation velocitySingle-center observational cohort studyAlberta Stroke Program Early CT ScoreCox proportional hazards modelsObservational cohort studyIntensive care unitProportional hazards modelCT scoreCohort studyYouden indexCerebral arteryCare unitHazards modelTukey testLinear mixed-effects modelsPatientsArtery strokeDilatationOptimal thresholdMixed-effects modelsIncidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study
Vernon S, Zheng T, Do H, Marconi V, Jason L, Singer N, Natelson B, Sherif Z, Bonilla H, Taylor E, Mullington J, Ashktorab H, Laiyemo A, Brim H, Patterson T, Akintonwa T, Sekar A, Peluso M, Maniar N, Bateman L, Horwitz L, Hess R. Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study. Journal Of General Internal Medicine 2025, 40: 1085-1094. PMID: 39804551, PMCID: PMC11968624, DOI: 10.1007/s11606-024-09290-9.Peer-Reviewed Original ResearchSARS-CoV-2 infectionLongitudinal observational cohort studyClinical diagnostic criteriaSelf-reported symptomsResultsThe incidence rateBackgroundMyalgic encephalomyelitis/chronic fatigue syndromeTiming of SARS-CoV-2 infectionPost-exertional malaiseObservational cohort studyUninfected participantsPost-AcuteSARS-CoV-2Diagnostic criteriaCohort studyHazard ratioStudy visitsFatigue syndromeParticipantsEnhanced recoveryME/CFS symptomsLong COVIDMyalgic encephalomyelitisDays of infectionPrevalenceInfected participantsTranscatheter Aortic Valve Replacement in Hypertrophic Cardiomyopathy: A Systematic Review and Meta‐Analysis
Ahmed A, Kaddoura R, Aggarwal A, Zinyandu T, Webber F, Davila C, Zarich S. Transcatheter Aortic Valve Replacement in Hypertrophic Cardiomyopathy: A Systematic Review and Meta‐Analysis. Catheterization And Cardiovascular Interventions 2025, 105: 754-760. PMID: 39748537, DOI: 10.1002/ccd.31367.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementOutcomes of transcatheter aortic valve replacementAortic valve replacementHypertrophic cardiomyopathyAortic stenosisRenal impairmentValve replacementAortic dissectionVascular complicationsCardiogenic shockOdds ratioTranscatheter Aortic Valve Replacement OutcomesSevere aortic stenosisPermanent pacemaker implantationComplete heart blockAssociated with higher ratesObservational cohort studyGold standard managementConfidence intervalsRandom-effects modelSignificantly higher occurrenceSurgical riskPacemaker implantationHeart blockSurgical intervention
2024
Real-world infection risk in multiple sclerosis patients on long-term immunomodulatory treatments
Lambert C, Hussain T, Peters J, Longbrake E. Real-world infection risk in multiple sclerosis patients on long-term immunomodulatory treatments. Multiple Sclerosis And Related Disorders 2024, 94: 106236. PMID: 39755026, PMCID: PMC11869388, DOI: 10.1016/j.msard.2024.106236.Peer-Reviewed Original ResearchConceptsCharlson Comorbidity IndexAnti-CD20 medicationsDisease-modifying treatmentsDMT useS1P modulatorsImmunomodulatory treatmentImmune cellsSevere infectionsMultiple sclerosisLong-term immunomodulatory treatmentReal-life practice patternsTreatment durationInfection rateSelection of patientsClinical selection of patientsDeplete immune cellsObservational cohort studyBody mass indexSevere infection rateAnalyzed medical recordsIncreased infection riskInfection riskDisease modifying therapiesMultiple sclerosis patientsImmune subsetsDoor-In-Door-Out Times at Referring Hospitals and Outcomes of Hemorrhagic Stroke
Royan R, Ayodele I, Stamm B, Alhanti B, Sheth K, Pruitt P, Mac Grory B, Meurer W, Prabhakaran S. Door-In-Door-Out Times at Referring Hospitals and Outcomes of Hemorrhagic Stroke. Annals Of Emergency Medicine 2024, 85: 132-143. PMID: 39453306, DOI: 10.1016/j.annemergmed.2024.09.002.Peer-Reviewed Original ResearchDoor-in-door-out timeDoor-in-door-outAssociated with greater oddsEmergency departmentHemorrhagic strokeGreater oddsUnadjusted analysisGuidelines-Stroke participating hospitalsInhospital mortalityCare of patientsObservational cohort studyIntracerebral hemorrhageDIDO timeReceiving HospitalInterhospital transferIndependent ambulationRegistry dataSubarachnoid hemorrhageTime of transferCohort studySecondary outcomesEffect sizePrimary outcomeUS registry dataOddsFunctional Connectivity Relationships to Longitudinal Motor Outcomes Differ in Very Preterm Children With and Without Brain Injury
Cyr P, Lean R, Kenley J, Kaplan S, Meyer D, Neil J, Alexopoulos D, Brady R, Shimony J, Rodebaugh T, Rogers C, Smyser C. Functional Connectivity Relationships to Longitudinal Motor Outcomes Differ in Very Preterm Children With and Without Brain Injury. Neurology Clinical Practice 2024, 15: e200397. PMID: 39439574, PMCID: PMC11492901, DOI: 10.1212/cpj.0000000000200397.Peer-Reviewed Original ResearchTerm-equivalent ageVery preterm childrenVery pretermChildren born very pretermBayley Scales of Infant DevelopmentMotor deficitsObservational cohort studyBrain injuryLongitudinal observational cohort studyAge 2 yearsAge 5 yearsStructural MRI findingsFine motor scoresNeonatal periodMRI findingsFunctional connectivityBayley ScalesFollow-upCohort studySD decreaseIncreased oddsInjured groupOutcome differencesMotor scoresUninjured group
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