2025
Resiliency in Child–Caregiver Dyads and the Impact on Health Outcomes in Sickle Cell Disease
Zavadil J, Azul M, Carpenter B, Calhoun C. Resiliency in Child–Caregiver Dyads and the Impact on Health Outcomes in Sickle Cell Disease. Children 2025, 12: 394. PMID: 40310076, PMCID: PMC12025687, DOI: 10.3390/children12040394.Peer-Reviewed Original ResearchMedian resilience scoreConnor-Davidson Resilience ScaleCaregiver resilienceChild-caregiver dyadsHistory of strokeResilience scoresHealth outcomesChildren's resiliencePerceived stressStress scoresChild's SCDCaregivers' perceived stressSickle cell diseasePerceived stress scoresCross-sectional cohort studyPerceived Stress ScaleAssociated with fewer hospitalizationsDavidson Resilience ScaleChronic health diseasesEmergency room visitsAssociated with childrenCOVID-19 pandemicFrequency of stressorsPSS-10Child caregiversP-2008. Chronic Conditions as Risk Factors for COVID-19–Associated Hospitalization Among Adults, 2022-2023
Hamid S, Derado G, Pham H, Woodruff R, Sachdev D, Kawasaki B, Meek J, Witt L, Ryan P, Kim S, Bye E, Akpo J, Rowlands J, Licherdell E, Shiltz E, Sutton M, Talbot K, Price A, Havers F, Taylor C. P-2008. Chronic Conditions as Risk Factors for COVID-19–Associated Hospitalization Among Adults, 2022-2023. Open Forum Infectious Diseases 2025, 12: ofae631.2165. PMCID: PMC11777768, DOI: 10.1093/ofid/ofae631.2165.Peer-Reviewed Original ResearchChronic conditionsHospitalization ratesRisk factorsBehavioral Risk Factor Surveillance SystemRate ratiosRisk Factor Surveillance SystemPopulation-based active surveillance systemCOVID-19-associated hospitalizationSurveillance systemCounty-level population dataOlder ageAge groupsAssociated with increased riskHistory of strokeCouncil of StateCOVID-19-Associated Hospitalization Surveillance NetworkPoisson regressionRate denominatorCatchment areaActive surveillance systemAnalytic populationConfidence intervalsAdult populationHospitalization countsHospitalized adults
2024
Polygenic Risk of Epilepsy and Poststroke Epilepsy
Clocchiatti-Tuozzo S, Rivier C, Misra S, Zelano J, Mazumder R, Sansing L, de Havenon A, Hirsch L, Liebeskind D, Gilmore E, Sheth K, Kim J, Worrall B, Falcone G, Mishra N. Polygenic Risk of Epilepsy and Poststroke Epilepsy. Stroke 2024, 55: 2835-2843. PMID: 39502073, PMCID: PMC11653790, DOI: 10.1161/strokeaha.124.047459.Peer-Reviewed Original ResearchParticipants of European ancestryRisk of poststroke epilepsyPolygenic riskPoststroke epilepsyEuropean ancestryGenome-wide association study meta-analysisPRS decileCase-control genetic association studyGenetic risk lociLowest decilePolygenic risk scoresGenetic association studiesMultivariate logistic regression modelStudy meta-analysisMultivariate logistic regression resultsHistory of strokeLogistic regression modelsRisk lociAssociation studiesStroke survivorsUK BiobankGenetic informationGenetic ancestryLogistic regression resultsGenetic variantsImplementation of American Society of Hematology (ASH) Neuro-Related Guidelines at a Sickle Cell Center: How Are We Doing?
Afranie-Sakyi J, Karimi M, Bozzo J, Cole J, Van Doren L, Calhoun C. Implementation of American Society of Hematology (ASH) Neuro-Related Guidelines at a Sickle Cell Center: How Are We Doing? Blood 2024, 144: 5009-5009. DOI: 10.1182/blood-2024-201816.Peer-Reviewed Original ResearchYale New Haven Health SystemHistory of strokeCognitive screeningGuideline publicationHealth systemSilent cerebral infarctionCognitive disordersImplementation ratePredictors of screeningSickle cell diseaseRates of screeningMood disordersAmerican Society of HematologyPrevalence of cognitive disordersDetect silent cerebral infarctsDevelopment of interventionsCognitive impairmentManual chart reviewICD-10 diagnosisEmergency room visitsDiagnosis of sickle cell diseaseSickle Cell CenterAmerican Society of Hematology guidelinesOutpatient encountersMRI screeningScreening for Cognitive Impairment and Depression in Sickle Cell Disease: How Are We Doing?
Afranie-Sakyi J, Karimi M, Bozzo J, Cole J, Van Doren L, Calhoun C. Screening for Cognitive Impairment and Depression in Sickle Cell Disease: How Are We Doing? Blood 2024, 144: 2249-2249. DOI: 10.1182/blood-2024-211906.Peer-Reviewed Original ResearchPatient Health QuestionnaireCognitive screeningAmerican Society of HematologyPsychiatric disordersSickle cell diseaseMood screeningMood disordersCognitive disordersDisorder screeningYale New Haven Health SystemPredictors of screeningDisease-modifying therapiesICD-10 diagnosisManual chart reviewImplementation of recommendationsEmergency room visitsDiagnosis of sickle cell diseaseHistory of strokeCell diseaseScreening ratesAnxious symptomsHealthcare teamPromote screeningNeuropsychological testsCognitive domains2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association
Bushnell C, Kernan W, Sharrief A, Chaturvedi S, Cole J, Cornwell W, Cosby-Gaither C, Doyle S, Goldstein L, Lennon O, Levine D, Love M, Miller E, Nguyen-Huynh M, Rasmussen-Winkler J, Rexrode K, Rosendale N, Sarma S, Shimbo D, Simpkins A, Spatz E, Sun L, Tangpricha V, Turnage D, Velazquez G, Whelton P. 2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association. Stroke 2024, 55: e344-e424. PMID: 39429201, DOI: 10.1161/str.0000000000000475.Peer-Reviewed Original ResearchPrimary prevention of strokePrimary preventionPrevention of strokeAmerican Heart Association/American Stroke AssociationRisk factor preventionNo history of strokeLife's Essential 8American Heart AssociationHistory of strokeIncident strokeStroke guidelinesStroke AssociationPrevention strategiesBrain healthRelevant databasesCochrane LibraryComprehensive searchEssential 8Hemorrhagic strokeHeart AssociationStrokeNo historyGuidelinesPreventionAmericanAssociations Between Ultra-Processed Food Consumption and Adverse Brain Health Outcomes.
Bhave V, Oladele C, Ament Z, Kijpaisalratana N, Jones A, Couch C, Patki A, Garcia Guarniz A, Bennett A, Crowe M, Irvin M, Kimberly W. Associations Between Ultra-Processed Food Consumption and Adverse Brain Health Outcomes. Neurology 2024, 102: e209432. PMID: 38776524, PMCID: PMC11175629, DOI: 10.1212/wnl.0000000000209432.Peer-Reviewed Original ResearchConceptsUltra-processed foodsIntake of ultra-processed foodsRisk of cognitive impairmentIncident cognitive impairmentRecommended dietary patternsMinimally processed foodsCognitive impairmentEffects of ultra-processed foodsDietary patternsUltra-processed food consumptionAssociated with higher risk of cognitive impairmentSelf-reported dietary dataBaseline food frequency questionnaireAssociated with risk of strokeHigher risk of cognitive impairmentMediterranean-DASH InterventionBrain health outcomesFood frequency questionnaireAssociated with riskAssociated with higher riskIndependent of adherenceHistory of strokeReview of medical recordsCox proportional hazards modelsUltra-processedSecondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts
Rivier C, Acosta J, Leasure A, Forman R, Sharma R, de Havenon A, Spatz E, Inzucchi S, Kernan W, Falcone G, Sheth K. Secondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts. Journal Of The American Heart Association 2024, 13: e033322. PMID: 38639369, PMCID: PMC11179946, DOI: 10.1161/jaha.123.033322.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsBlood PressureCross-Sectional StudiesFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPractice Guidelines as TopicRisk AssessmentRisk FactorsSecondary PreventionStrokeUnited KingdomUnited StatesConceptsMyocardial infarctionPrevention scoreSecondary preventionImplementation of preventive therapyNational cohortUK BiobankAntiplatelet therapy useGuideline-directed therapyPrevention profilesBlood pressure controlAdherence to guideline-directed therapyLow-density lipoprotein controlNeighborhood deprivation levelHistory of strokeVascular risk profileStatin useAntiplatelet useTherapy usePreventive therapyComparison to participantsPrevention criteriaCross-sectional analysisBlood pressurePatientsPressure control
2023
Accordance to a MIND–Style Diet is Associated with Decreased Risk of Dementia Mortality in the REasons for Geographic and Racial Disparities in Stroke (REGARDS) Cohort
Judd S, Howard G, Tangney C, Pearson K, Shikany J, Cushman M, Wilson N, Howard V, Sawyer R, Oladele C, Manly J. Accordance to a MIND–Style Diet is Associated with Decreased Risk of Dementia Mortality in the REasons for Geographic and Racial Disparities in Stroke (REGARDS) Cohort. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.072481.Peer-Reviewed Original ResearchMIND diet scoreDiet scoreMIND dietDementia mortalityHigher MIND diet scoresDementia-related mortalityHistory of strokeNational Death IndexProportional hazards regressionBi-racial cohortMediterranean-DASH InterventionRate of dementiaBaseline cognitive impairmentNeurodegenerative Delay (MIND) dietDeath HRDementia deathCohort studyPrimary outcomeREGARDS cohortStroke cohortDietary interventionDeath IndexDecreased riskHazards regressionMedical conditionsOutcomes in Patients With Poststroke Seizures
Misra S, Kasner S, Dawson J, Tanaka T, Zhao Y, Zaveri H, Eldem E, Vazquez J, Silva L, Mohidat S, Hickman L, Khan E, Funaro M, Nicolo J, Mazumder R, Yasuda C, Sunnerhagen K, Ihara M, Ross J, Liebeskind D, Kwan P, Quinn T, Engel J, Mishra N. Outcomes in Patients With Poststroke Seizures. JAMA Neurology 2023, 80: 1155-1165. PMID: 37721736, PMCID: PMC10507596, DOI: 10.1001/jamaneurol.2023.3240.Peer-Reviewed Original ResearchConceptsPoststroke seizuresPoor functional outcomeLate seizuresEarly seizuresStroke subtypesFunctional outcomeOdds ratioSystematic reviewJoanna Briggs Institute toolsHemorrhagic stroke subtypesOutcomes of patientsHistory of strokeTrials of interventionsRisk of biasMeta-Analyses (PRISMA) checklistPreferred Reporting ItemsMeta-regression analysisWeb of ScienceRecurrent strokeGreater disabilityPoor outcomeDementia riskSubgroup analysisBias assessmentEgger's testAge at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women
Tschiderer L, Peters S, van der Schouw Y, van Westing A, Tong T, Willeit P, Seekircher L, Moreno‐Iribas C, Huerta J, Crous‐Bou M, Söderholm M, Schulze M, Johansson C, Själander S, Heath A, Macciotta A, Dahm C, Ibsen D, Pala V, Mellemkjær L, Burgess S, Wood A, Kaaks R, Katzke V, Amiano P, Rodriguez‐Barranco M, Engström G, Weiderpass E, Tjønneland A, Halkjær J, Panico S, Danesh J, Butterworth A, Onland‐Moret N. Age at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women. Journal Of The American Heart Association 2023, 12: e030280. PMID: 37681566, PMCID: PMC10547274, DOI: 10.1161/jaha.123.030280.Peer-Reviewed Original ResearchConceptsMendelian randomization analysisRisk of strokeStatistically significant associationRandomization analysisSignificant associationHistory of strokeEPIC-CVDPooled mean ageHigh risk of strokeUK BiobankYears younger ageBaseline ageHazard ratioStroke subtypesObservational studyPooled hazard ratioHemorrhagic strokeEarly menopauseYounger ageMean ageHigh riskMedian Follow-UpStrokeRegression analysisWomenOutcomes of recurrent stroke in patients with atrial fibrillation according to presumed etiology
Pedreira B, Zachrison K, Singhal A, Yan Z, Oliveira-Filho J, Schwamm L. Outcomes of recurrent stroke in patients with atrial fibrillation according to presumed etiology. Arquivos De Neuro-Psiquiatria 2023, 81: 616-623. PMID: 37336506, PMCID: PMC10371407, DOI: 10.1055/s-0043-1769124.Peer-Reviewed Original ResearchConceptsUndetermined stroke etiologyAtrial fibrillationRecurrent strokeStroke etiologyAF patientsFavorable outcomeAcademic comprehensive stroke centerHealth Stroke Scale scoreMedian National InstitutesSingle-center sampleComprehensive stroke centerRecurrent ischemic strokeStroke Scale scoreHistory of strokePotent risk factorDifferent treatment strategiesHospital mortalitySecondary prophylaxisReperfusion therapyCardioembolic strokeIschemic strokeStroke centersDischarge outcomesRisk factorsTreatment strategies
2022
Decreased Resiliency Associated with Increased Hospitalizations for Children with Sickle Cell Disease (S535)
Zavadil J, Carpenter B, Calhoun C. Decreased Resiliency Associated with Increased Hospitalizations for Children with Sickle Cell Disease (S535). Journal Of Pain And Symptom Management 2022, 63: 924-925. DOI: 10.1016/j.jpainsymman.2022.02.158.Peer-Reviewed Original ResearchSickle cell disease managementCD-RISCParental resilienceFrequency of hospitalizationSources of stressPSS-10Resilience of childrenConnor-Davidson Resilience ScaleSickle cell diseasePSS-10 scoreChildren's resiliencePerceived Stress ScaleCD-RISC scoreEmergency room visitsHistory of strokeDepression ScalePsychosocial factorsChild healthChronic illnessPerceived stressStress ScaleResilience scoresCOVID pandemicResilience ScaleImprove resilienceCardiovascular Risk Factor Profiles, Emergency Department Visits, and Hospitalizations for Women and Men with a History of Stroke or Transient Ischemic Attack: A Cross-Sectional Study
Chang TE, Goldstein LB, Leifheit EC, Howard VJ, Lichtman JH. Cardiovascular Risk Factor Profiles, Emergency Department Visits, and Hospitalizations for Women and Men with a History of Stroke or Transient Ischemic Attack: A Cross-Sectional Study. Journal Of Women's Health 2022, 31: 834-841. PMID: 35148481, DOI: 10.1089/jwh.2021.0471.Peer-Reviewed Original ResearchConceptsStroke/transient ischemic attackTransient ischemic attackPrior stroke/transient ischemic attackCause ED visitsEmergency department visitsHealth care utilizationCross-sectional studyCause hospitalizationED visitsIschemic attackDepartment visitsCare utilizationCVD-RFsCardiovascular risk factor profileCardiovascular disease risk factorsCovariate-adjusted logistic regression modelsCause emergency department visitsHigher health care utilizationMedical Expenditure Panel Survey dataRisk factor profileDisease risk factorsHistory of strokeOdds of hospitalizationRepresentative Medical Expenditure Panel Survey dataSex-specific predictors
2021
Awareness of Diabetic Retinopathy: Insight From the National Health and Nutrition Examination Survey
Nwanyanwu KMJH, Nunez-Smith M, Gardner TW, Desai MM. Awareness of Diabetic Retinopathy: Insight From the National Health and Nutrition Examination Survey. American Journal Of Preventive Medicine 2021, 61: 900-909. PMID: 34426057, PMCID: PMC8608699, DOI: 10.1016/j.amepre.2021.05.018.Peer-Reviewed Original ResearchConceptsSelf-reported diabetesNutrition Examination SurveyDiabetic retinopathyExamination SurveyNational HealthDiabetic retinopathy diagnosisHispanic race/ethnicityUndiagnosed diabetic retinopathyElevated blood pressureHistory of strokeSelf-reported hypertensionRetinopathy diagnosisRace/ethnicityCurrent smokingBlood pressureMale sexBlack raceFundus photographyDecreased oddsRetinopathyPreventable blindnessDiabetesOlder ageLogistic regressionDiagnosisIs a picture-perfect thrombectomy necessary in acute ischemic stroke?
Chen C, Chalhoub R, Ding D, Kumar J, Ironside N, Kellogg R, Worrall B, Southerland A, Jabbour P, Wolfe S, Arthur A, Goyal N, Fragata I, Maier I, Matouk C, Grossberg J, Kan P, Schirmer C, Crowley R, Ares W, Ogilvy C, T A, Levitt M, Mokin M, Guerrero W, Mascitelli J, Yoo A, Williamson R, Grande A, Crosa R, Webb S, Psychogios M, Starke R, Spiotta A, Park M. Is a picture-perfect thrombectomy necessary in acute ischemic stroke? Journal Of NeuroInterventional Surgery 2021, 14: 111-116. PMID: 33593800, PMCID: PMC10947782, DOI: 10.1136/neurintsurg-2020-017193.Peer-Reviewed Original ResearchConceptsModified Rankin ScaleNear-complete reperfusionMTICI 2cPrimary outcomeSecondary outcomesBaseline modified Rankin scaleModified Rankin Scale scoreProcedure-related complicationsCompare clinical outcomesNational Institutes of Health Stroke Scale scoreSymptomatic intracerebral hemorrhageHistory of strokeStroke Scale scoreAcute ischemic strokeMTICI 3 reperfusionReperfusion gradeReperfusion statusMTICI 3Retrospective studyClinical outcomesIntracerebral hemorrhageMatched CohortMTICIIncreased oddsRankin Scale
2020
Improvements in Health-Related Quality of Life for Patients Treated with LentiGlobin for Sickle Cell Disease (bb1111) Gene Therapy
Kanter J, Tisdale J, Mapara M, Kwiatkowski J, Krishnamurti L, Chen R, Gallagher M, Ding Y, Goyal S, Paramore C, Thompson A, Walters M. Improvements in Health-Related Quality of Life for Patients Treated with LentiGlobin for Sickle Cell Disease (bb1111) Gene Therapy. Blood 2020, 136: 10. DOI: 10.1182/blood-2020-136193.Peer-Reviewed Original ResearchSickle cell diseaseAcute chest syndromeNumeric rating scalePatient-reported outcomesMonth 12Pain intensitySleep disturbance domainsBaseline scoresPhysical functionBluebird BioPopulation normsMeaningful improvementsMonth 6Pain intensity numeric rating scalePROMIS-57T-scorePatient-reported HRQoL outcomesUS general population normsAdvisory CommitteePain interference scoresGene therapyGroup C patientsCohort of patientsHealth-related qualityHistory of strokeRisk of Ischemic Stroke in Patients With Atrial Fibrillation After Extracranial Hemorrhage
Zhou E, Lord A, Boehme A, Henninger N, de Havenon A, Vahidy F, Ishida K, Torres J, Mistry EA, Mac Grory B, Sheth KN, Gurol ME, Furie K, Elkind MSV, Yaghi S. Risk of Ischemic Stroke in Patients With Atrial Fibrillation After Extracranial Hemorrhage. Stroke 2020, 51: 3592-3599. PMID: 33028172, PMCID: PMC7751804, DOI: 10.1161/strokeaha.120.029959.Peer-Reviewed Original ResearchConceptsExtracranial hemorrhageIschemic strokeAtrial fibrillationAnticoagulation therapyGenitourinary cancersSubgroup analysisCalifornia State Inpatient DatabaseFuture ischemic strokePrimary admission diagnosisAcute ischemic strokeAtrial appendage closureHistory of strokeCox regression modelState Inpatient DatabasesSeverity/typeVASc scoreAdmission diagnosisHemorrhagic complicationsSubsequent hospitalizationAppendage closureHazard ratioHospital admissionInpatient DatabasePertinent demographicPrevious diagnosisRisk Factors for Coronavirus Disease 2019 (COVID-19)–Associated Hospitalization: COVID-19–Associated Hospitalization Surveillance Network and Behavioral Risk Factor Surveillance System
Ko JY, Danielson ML, Town M, Derado G, Greenlund KJ, Kirley PD, Alden NB, Yousey-Hindes K, Anderson EJ, Ryan PA, Kim S, Lynfield R, Torres SM, Barney GR, Bennett NM, Sutton M, Talbot HK, Hill M, Hall AJ, Fry AM, Garg S, Kim L, Whitaker M, O’Halloran A, Holstein R, Garvin W, Chai S, Kawasaki B, Meek J, Openo K, Monroe M, Henderson J, Como-Sabetti K, Davis S, Spina N, Felsen C, West N, Schaffner W, George A. Risk Factors for Coronavirus Disease 2019 (COVID-19)–Associated Hospitalization: COVID-19–Associated Hospitalization Surveillance Network and Behavioral Risk Factor Surveillance System. Clinical Infectious Diseases 2020, 72: e695-e703. PMID: 32945846, PMCID: PMC7543371, DOI: 10.1093/cid/ciaa1419.Peer-Reviewed Original ResearchConceptsCOVID-19-Associated Hospitalization Surveillance NetworkCOVID-19-associated hospitalizationChronic kidney diseaseHospitalization ratesRace/ethnicitySevere obesityKidney diseaseRisk factorsMedical conditionsLaboratory-confirmed COVID-19Chronic obstructive pulmonary diseaseBehavioral Risk Factor Surveillance SystemRisk Factor Surveillance SystemHigher hospitalization riskRace/ethnicity strataHistory of strokeObstructive pulmonary diseaseUnderlying medical conditionsCoronary artery diseaseHigher hospitalization ratesCommunity-dwelling adultsCoronavirus disease 2019Surveillance networkPoisson regression modelsSurveillance systemSafety and Outcomes of Intravenous tPA in Acute Ischemic Stroke Patients With Prior Stroke Within 3 Months
Shah S, Liang L, Kosinski A, Hernandez A, Schwamm L, Smith E, Fonarow G, Bhatt D, Feng W, Peterson E, Xian Y. Safety and Outcomes of Intravenous tPA in Acute Ischemic Stroke Patients With Prior Stroke Within 3 Months. Circulation Cardiovascular Quality And Outcomes 2020, 13: e006031. PMID: 31903770, DOI: 10.1161/circoutcomes.119.006031.Peer-Reviewed Original ResearchMeSH KeywordsAdministrative Claims, HealthcareAgedAged, 80 and overBrain IschemiaDatabases, FactualFemaleFibrinolytic AgentsHospital MortalityHumansInfusions, IntravenousIntracranial HemorrhagesMaleMedicareRecurrenceRegistriesRetrospective StudiesRisk AssessmentRisk FactorsStrokeThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorTreatment OutcomeUnited StatesConceptsAcute ischemic stroke patientsPrior ischemic strokeSymptomatic intracranial hemorrhageIschemic stroke patientsPrior strokeHospital mortalityIntravenous tPAIschemic strokeIntracranial hemorrhageStroke patientsGuidelines-Stroke hospitalsHigher stroke severityGood functional outcomeHistory of strokeRetrospective observational studyYears of ageCardiovascular comorbiditiesStroke providersStroke severityUnadjusted riskFunctional outcomeHigh prevalenceObservational studyMedicare claimsElevated risk
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