2025
Molecular Breast Imaging and Digital Breast Tomosynthesis for Dense Breast Screening: The Density MATTERS Trial.
Hruska C, Hunt K, Larson N, Miller P, Ellis R, Shermis R, Rauch G, Conners A, Gasal Spilde J, Semaan D, Siegal E, Zingula S, Mandava S, Martin T, Ahmed R, Whaley D, Adrada B, Gray L, Mehta R, Roll R, Redfern R, O'Connor M, Rhodes D. Molecular Breast Imaging and Digital Breast Tomosynthesis for Dense Breast Screening: The Density MATTERS Trial. Radiology 2025, 316: e243953. PMID: 40985829, DOI: 10.1148/radiol.243953.Peer-Reviewed Original ResearchConceptsMolecular breast imagingAnnual screening roundsDigital breast tomosynthesisDense breastsIncremental cancer detection rateNode-negative cancersTyrer-Cuzick riskCancer detection rateInterval cancer rateBreast tomosynthesisInvasive cancer detectionBreast imagingYear 1Year 2Invasive cancerMulticenter trialBreast screeningBreast densityCancer ratesAdvanced cancerCancerCancer detectionFunctional uptakePrevalenceBreastVariability in Long COVID Definitions and Validation of Published Prevalence Rates
Wisk L, L’Hommedieu M, Diaz Roldan K, Ebna Mannan I, Spatz E, Weinstein R, Venkatesh A, Gottlieb M, Huebinger R, Rising K, Montoy J, Stephens K, Rodriguez R, Hill M, O’Laughlin K, Gentile N, Idris A, Li S, Santangelo M, Kean E, McDonald S, Gatling K, Elmore J, Koo K, Derden A, Ahmed Z, Guzman D, Hassaballa M, Kaadan A, Kinsman J, Malicki C, Lin Z, Yu H, Yang Z, Liu M, Ulrich A, Dorney J, Pierce S, Puente X, Salah W, Nichol G, Anderson J, Schiffgens M, Morse D, Adams K, Stober T, Maat Z, Geyer R, Willis M, Zhang Z, Chang G, Lyon V, Klabbers R, Ruiz L, Malone K, Park J, Chang A, Renzi N, Watts P, Kelly M, Schaeffer K, Grau D, Cheng D, Shutty C, Charlton A, Shughart L, Shughart H, Amadio G, Miao J, Hannikainen P, Chandler C, Eguchi M, Moreno R, Wang R, Kemball R, Chan V, Lara Chavez C, Wong A, Arreguin M, Kane A, Nikonowicz P, Sapp S, Gallegos D, Martin K, Saydah S, Plumb I, Hall A, Briggs-Hagen M. Variability in Long COVID Definitions and Validation of Published Prevalence Rates. JAMA Network Open 2025, 8: e2526506. PMID: 40794409, PMCID: PMC12344537, DOI: 10.1001/jamanetworkopen.2025.26506.Peer-Reviewed Original ResearchConceptsSelf-reported long COVIDSARS-CoV-2 testingCohort studyPublished definitionsLong COVIDFollow-up surveyPrevalence of long COVIDPublished prevalence ratesOlder with symptomsInspiring participationNegative SARS-CoV-2 testCOVID prevalenceMonths postinfectionMain OutcomesClinical carePublished literatureSecondary outcomesPrevalence ratesCOVID-19 illnessCriterion standardMulticenter cohort studySARS-CoV-2ParticipantsPrevalenceLow-to-moderate sensitivityHypertension Prevalence, Awareness, and Control in US Adults Before and After the COVID‐19 Pandemic
Essa M, Malik D, Lu Y, Yang H, Spatz E, Krumholz H, Faridi K. Hypertension Prevalence, Awareness, and Control in US Adults Before and After the COVID‐19 Pandemic. Journal Of Clinical Hypertension 2025, 27: e70093. PMID: 40685707, PMCID: PMC12277530, DOI: 10.1111/jch.70093.Peer-Reviewed Original ResearchConceptsHypertension prevalencePrevalence ratiosUS adultsAge-standardized prevalence estimatesAggressive public health effortsPublic health effortsPre-pandemicControl of hypertensionCOVID-19 pandemicHypertension awarenessHealth effortsPoisson regressionImpact of hypertensionPost-pandemicPrevalence estimatesNHANES dataNationwide prevalenceCause of deathUnited StatesBlood pressure controlNational trendsPrevalenceCOVID-19AdultsHypertensionCumulative Exposure to Adverse Childhood Experiences and its Impact on Impulsivity among Mexican Adults
Hernández-Vicencio J, González-Castro T, Tovilla-Zárate C, Hernández-Díaz Y, Juárez-Rojop I, López-Narváez M, Ovando-Ricárdez J, Mártinez-Magaña J. Cumulative Exposure to Adverse Childhood Experiences and its Impact on Impulsivity among Mexican Adults. Journal Of Psychosomatic Research 2025, 196: 112308. PMID: 40633521, DOI: 10.1016/j.jpsychores.2025.112308.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesScore of adverse childhood experiencesExposure to adverse childhood experiencesChildhood experiencesAccumulation of adverse childhood experiencesEffects of childhood adversityCumulative scoreMexican adultsACE questionnaireMean scoreChildhood adversityScreening toolSPSS v.Mexican populationParticipantsAdultsPlutchik Impulsivity ScaleAdversityImpulsiveness ScaleAdulthoodPopulationOddsQuestionnaireCumulative numberPrevalencePrevalence and Phenotype of Food Allergy in Children with Cystic Fibrosis
Nguyen H, Shabanova V, McCollum S, Polk B, Lee T, Whittington K, Cunha P, Bruscia E, Egan M, Emmenegger M, Leeds S. Prevalence and Phenotype of Food Allergy in Children with Cystic Fibrosis. Annals Of Allergy Asthma & Immunology 2025 PMID: 40550267, DOI: 10.1016/j.anai.2025.06.024.Peer-Reviewed Original ResearchCystic fibrosisCF patientsFood allergyUS pediatric populationElectronic medical recordsPediatric populationPhenotypes of food allergyRetrospective pediatric cohort studyPrevalence of FAFA prevalenceCystic Fibrosis Foundation RegistryMale CF patientsUnited StatesPediatric CF patientsPancreatic enzyme replacementPediatric cohort studyIgE-mediated FACohort studyEstimated prevalenceInclusion criteriaMedical informationDevelopment of FAMedical recordsFA diagnosisPrevalenceThe prevalence of moral distress and moral injury among U.S. veterans
Litz B, Walker H, Pietrzak R, Rusowicz-Orazem L. The prevalence of moral distress and moral injury among U.S. veterans. Journal Of Psychiatric Research 2025, 189: 435-444. PMID: 40602027, DOI: 10.1016/j.jpsychires.2025.06.031.Peer-Reviewed Original ResearchPrevalence of moral distressMoral distressU.S. veteransMoral injuryMental health challengesMental health concernsNationally Representative SampleCross-sectional studyPMIE exposureWeighted prevalenceAssociated with significant functional impairmentSignificant functional impairmentInjury eventsHealth challengesRepresentative sampleVeteransDistressHealth concernFunctional impairmentAdverse outcomesPrevalencePMIEsInjuryKnowledgePanelU.S.Risk Factors Associated With Tuberculosis Infection Among Household Contacts of Patients With Microbiologically Confirmed Pulmonary Tuberculosis in 3 High Tuberculosis Burden Countries
Ntshiqa T, Nagudi J, Hamada Y, Copas A, Stender S, Sabi I, Ntinginya E, Lalashowi J, Matete M, Ntshamane K, Morojele I, Ngobeni M, Mudzengi D, Minja L, Chirwa T, Lönnroth K, Dreyer V, Niemann S, Rangaka M, Charalambous S, Velen K. Risk Factors Associated With Tuberculosis Infection Among Household Contacts of Patients With Microbiologically Confirmed Pulmonary Tuberculosis in 3 High Tuberculosis Burden Countries. The Journal Of Infectious Diseases 2025, 232: e448-e458. PMID: 40576297, PMCID: PMC12455307, DOI: 10.1093/infdis/jiaf320.Peer-Reviewed Original ResearchConceptsTuberculosis preventive therapyTuberculosis infectionPulmonary tuberculosisHousehold contactsPreventive therapyMicrobiologically confirmed PTBHousehold contacts of patientsWorld Health Organization criteriaQuantiFERON-TB Gold PlusTuberculosis infection prevalenceContacts of patientsTuberculosis burden countriesTuberculosis historyCross-sectional studyXpert UltraOrganization criteriaTherapy guidelinesBurden countriesRisk factorsHighest tuberculosis burden countriesTuberculosis prevalenceTuberculosisTherapyInfectionPrevalencePrevalence of Suspected Medical Child Abuse in the School Setting: A Study of School Nurses.
Hansen G, Hamilton J. Prevalence of Suspected Medical Child Abuse in the School Setting: A Study of School Nurses. Child Maltreatment 2025, 10775595251345065. PMID: 40405586, DOI: 10.1177/10775595251345065.Peer-Reviewed Original ResearchBleeding Definitions in Pediatric Extracorporeal Membrane Oxygenation (ECMO) Studies: A Systematic Review and Meta-Analysis.
Atchison C, Chegondi M, Aldairi N, Carmona C, Mahmood H, Levasseur J, Funaro M, Faustino E, Nellis M, Willems A, Labarinas S, Karam O. Bleeding Definitions in Pediatric Extracorporeal Membrane Oxygenation (ECMO) Studies: A Systematic Review and Meta-Analysis. ASAIO Journal 2025 PMID: 40397688, DOI: 10.1097/mat.0000000000002468.Peer-Reviewed Original ResearchExtracorporeal membrane oxygenationPrevalence of bleedingExtracorporeal Life Support OrganizationBleeding definitionsMembrane oxygenationChildren treated with extracorporeal membrane oxygenationPooled prevalencePediatric extracorporeal membrane oxygenationSevere cardiorespiratory failureMeta-analysisLife Support OrganizationSystematic reviewBleeding prevalenceBleeding riskCardiorespiratory failureIntracranial bleedingIntracranial hemorrhageControl bleedingBleedingDatabase inceptionClinical practicePrevalenceScreening studiesNeonatesTransfusionDetection of Hypertrophic Cardiomyopathy on Electrocardiogram Using Artificial Intelligence
Hillis J, Bizzo B, Mercaldo S, Ghatak A, MacDonald A, Halle M, Schultz A, L’Italien E, Tam V, Bart N, Moura F, Awad A, Bargiela D, Dagen S, Toland D, Blood A, Gross D, Jering K, Lopes M, Marston N, Nauffal V, Dreyer K, Scirica B, Ho C. Detection of Hypertrophic Cardiomyopathy on Electrocardiogram Using Artificial Intelligence. Circulation Heart Failure 2025, 18: e012667. PMID: 40365710, DOI: 10.1161/circheartfailure.124.012667.Peer-Reviewed Original ResearchHypertrophic cardiomyopathyDetection of hypertrophic cardiomyopathyAssociated with significant morbidityPredictive valueNegative predictive valueArea under the curvePositive predictive valueSudden cardiac deathSignificant morbidityChart reviewCardiac deathScreening electrocardiogramDiagnostic codesCardiac imagingClinical expertisePopulation prevalenceBinary outcomesCardiomyopathyElectrocardiogramDiagnosisImprove detectionPrevalenceElectrocardiogram featuresTrends in Cancer Incidence and Mortality Rates in Early-Onset and Older-Onset Age Groups in the United States, 2010-2019.
Shiels M, Haque A, Berrington de González A, Camargo M, Clarke M, Davis Lynn B, Engels E, Freedman N, Gierach G, Hofmann J, Jones R, Loftfield E, Sinha R, Morton L, Chanock S. Trends in Cancer Incidence and Mortality Rates in Early-Onset and Older-Onset Age Groups in the United States, 2010-2019. Cancer Discovery 2025, of1-of14. PMID: 40338148, DOI: 10.1158/2159-8290.cd-24-1678.Peer-Reviewed Original ResearchSex and Gender in Relation to use of E-cigarette Product Characteristics in United States Datasets: A Systematic Review
DeVito E, Stern E, Szpilzinger M, Petersen N, Pang R, Weinberger A. Sex and Gender in Relation to use of E-cigarette Product Characteristics in United States Datasets: A Systematic Review. Nicotine & Tobacco Research 2025, ntaf092. PMID: 40357915, DOI: 10.1093/ntr/ntaf092.Peer-Reviewed Original ResearchE-cigarette useE-cigarettesCannabis vapingAddictive potentialPrevalence of e-cigarette useE-cigarette product characteristicsCessation of tobacco productsPrevalence of nicotineSystematic reviewHarm reduction potentialGender differencesE-cigarette characteristicsE-cigarette productsCombustible cigarettesUnited StatesUnited States youthNicotineSex-specific findingsCannabisPeer-reviewed journalsGender minoritiesPrevalenceSexVapingFlavor useTemporal Trends in Inadequate Vegetable and Fruit Consumption Among Adolescents Aged 12–15 Years From 31 Countries in Asia, Africa, and the Americas
Smith L, Sánchez G, Tully M, Barnett Y, Butler L, Keyes H, Jacob L, Kostev K, Oh H, Rahmati M, Shin J, Koyanagi A. Temporal Trends in Inadequate Vegetable and Fruit Consumption Among Adolescents Aged 12–15 Years From 31 Countries in Asia, Africa, and the Americas. Health Science Reports 2025, 8: e70711. PMID: 40260027, PMCID: PMC12010760, DOI: 10.1002/hsr2.70711.Peer-Reviewed Original ResearchInadequate fruitVegetable consumptionVegetable intakeLow intake of fruitsIntake of fruitsNegative health outcomesNationally Representative SampleStudy analyzed dataInadequate vegetableHealth outcomesFruit consumptionLinear regression modelsStable trendScarcity of literatureLow intakeRepresentative sampleRegression modelsAdolescent populationAdolescent ageTemporal trendsAnalyzed dataAttend schoolPrevalenceAdolescentsLinear trendCraniosynostosis among children with X-linked hypophosphatemia: A systematic review and meta-analysis
Fisch S, Tudor A, Benchekroun E, Landsberg W, Feldstein N, Lamb M, Carpenter T, Rundle A, Jacobson J, Neugut A, Freedberg D. Craniosynostosis among children with X-linked hypophosphatemia: A systematic review and meta-analysis. Bone 2025, 196: 117488. PMID: 40220947, DOI: 10.1016/j.bone.2025.117488.Peer-Reviewed Original ResearchX-linked hypophosphatemiaPrevalence of craniosynostosisPooled prevalenceSystematic reviewMeta-analysisRandom-effects modelWeb of SciencePediatric populationSkull abnormalitiesCohort studyImpaired phosphate reabsorptionElevated FGF23 levelsPrevalenceFemale predominanceCase seriesFGF23 levelsPhosphate reabsorptionGene variantsChildrenIncreased vigilanceCraniosynostosisAbnormal bone growthGenetic disordersHypophosphatemiaAbnormalitiesThe case-only design is a powerful approach to detect interactions but should be used with caution
Dong R, Wang G, DeWan A, Leal S. The case-only design is a powerful approach to detect interactions but should be used with caution. BMC Genomics 2025, 26: 222. PMID: 40050722, PMCID: PMC11884093, DOI: 10.1186/s12864-025-11318-1.Peer-Reviewed Original ResearchConceptsCase-only designRare disease assumptionType I error rateIncreased type I error ratesDisease prevalenceInvestigated type I errorComplex traitsInteraction termsInteraction effect sizesDetect interactionsCase-control designControlled type I error ratesSample sizeHigher disease prevalenceEffect sizeLow disease prevalenceType I errorPrevalenceExposure frequencyGenesType I andDesign studyEnvironmental factorsTraitsEnvironment interactionCardiovascular Event Prevalence in Type 1 Versus Type 2 Diabetes: Veradigm Metabolic Registry Insights
Goldsweig A, Knee A, Tak H, Desai N, Bradley S, Lotfi A, Spertus J, Goldsweig B. Cardiovascular Event Prevalence in Type 1 Versus Type 2 Diabetes: Veradigm Metabolic Registry Insights. Journal Of The Society For Cardiovascular Angiography & Interventions 2025, 4: 102502. PMID: 40231053, PMCID: PMC11993881, DOI: 10.1016/j.jscai.2024.102502.Peer-Reviewed Original ResearchIncident cardiovascular eventsPrevalence ratiosDiabetes mellitus type 1Risk of incident cardiovascular eventsCardiovascular diseaseCardiovascular eventsPrimary carePercutaneous coronary interventionMyocardial infarctionType 2 diabetesOutpatient facilitiesEvent prevalenceLimb ischemiaCoronary interventionAge categoriesStudy populationDM2 patientsRisk factorsHemoglobin A1cCarePrevalencePeripheral revascularizationInterventionComorbiditiesDM2Prevalence of Moral Injury in Nationally Representative Samples of Combat Veterans, Healthcare Workers, and First Responders
Maguen S, Griffin B, Pietrzak R, McLean C, Hamblen J, Norman S. Prevalence of Moral Injury in Nationally Representative Samples of Combat Veterans, Healthcare Workers, and First Responders. Journal Of General Internal Medicine 2025, 1-7. PMID: 39881119, DOI: 10.1007/s11606-024-09337-x.Peer-Reviewed Original ResearchNationally Representative SampleHealthcare workersRepresentative sampleMoral injuryDesignCross-sectional surveyPrevalence of moral injuryFirst respondersExposure to PMIEsMoral injury symptomsCombat veteransHigh-risk populationHigh-risk groupInjury eventsInjury exposureHealthcareVeteransWell-beingOccupational differencesRespondentsPMIEsPrevalenceWorkersComplex decisionsClinicInjuryTuberculosis and people who use drugs: why focus on this overlooked population is important and why adapted interventions are necessary
D'Ottavi M, Godfrey-Faussett P, Merle C, Sofonea M, Laureillard D, Vickerman P, Molès J, Altice F, Van de Perre P, Stone J, Nagot N. Tuberculosis and people who use drugs: why focus on this overlooked population is important and why adapted interventions are necessary. The Lancet Global Health 2025, 13: e593-e598. PMID: 39862874, DOI: 10.1016/s2214-109x(24)00481-9.Peer-Reviewed Original ResearchConceptsReduce health inequalitiesCommunity-based approachActive case findingNational Tuberculosis ProgrammeHealth inequalitiesTargeted interventionsTuberculosis interventionsCase findingTreatment adherenceGeneral populationTuberculosis ProgrammeMarginalised populationsHIV fieldInterventionPrevalence of tuberculosisTuberculosis burdenPopulation levelTuberculosis transmissionHigher incidencePeoplePopulationAdherenceHIVPrevalenceLinkageIncidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study
Vernon S, Zheng T, Do H, Marconi V, Jason L, Singer N, Natelson B, Sherif Z, Bonilla H, Taylor E, Mullington J, Ashktorab H, Laiyemo A, Brim H, Patterson T, Akintonwa T, Sekar A, Peluso M, Maniar N, Bateman L, Horwitz L, Hess R. Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study. Journal Of General Internal Medicine 2025, 40: 1085-1094. PMID: 39804551, PMCID: PMC11968624, DOI: 10.1007/s11606-024-09290-9.Peer-Reviewed Original ResearchSARS-CoV-2 infectionLongitudinal observational cohort studyClinical diagnostic criteriaSelf-reported symptomsResultsThe incidence rateBackgroundMyalgic encephalomyelitis/chronic fatigue syndromeTiming of SARS-CoV-2 infectionPost-exertional malaiseObservational cohort studyUninfected participantsPost-AcuteSARS-CoV-2Diagnostic criteriaCohort studyHazard ratioStudy visitsFatigue syndromeParticipantsEnhanced recoveryME/CFS symptomsLong COVIDMyalgic encephalomyelitisDays of infectionPrevalenceInfected participantsmosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae
Dolan B, Correa Gaviria T, Dong Y, Cresswell P, Dimopoulos G, Chuang Y, Fikrig E. mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae. Nature Communications 2025, 16: 592. PMID: 39799117, PMCID: PMC11724845, DOI: 10.1038/s41467-025-55902-1.Peer-Reviewed Original ResearchConceptsCausative agent of malariaTransmission-blocking vaccinesMurine infection modelPlasmodium life cycleAgent of malariaGamma-interferon-inducible lysosomal thiol reductaseP. falciparumInfection modelAnopheles gambiaeMosquito midgutPlasmodiumLysosomal thiol reductaseCausative agentAntibodiesOocyst stageInfection prevalenceThiol reductaseMalariaGambiaInfectionMosquitoesPrevalenceVaccine
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