2025
Molecular Breast Imaging and Digital Breast Tomosynthesis for Dense Breast Screening: The Density MATTERS Trial.
Hruska C, Hunt K, Larson N, Miller P, Ellis R, Shermis R, Rauch G, Conners A, Gasal Spilde J, Semaan D, Siegal E, Zingula S, Mandava S, Martin T, Ahmed R, Whaley D, Adrada B, Gray L, Mehta R, Roll R, Redfern R, O'Connor M, Rhodes D. Molecular Breast Imaging and Digital Breast Tomosynthesis for Dense Breast Screening: The Density MATTERS Trial. Radiology 2025, 316: e243953. PMID: 40985829, DOI: 10.1148/radiol.243953.Peer-Reviewed Original ResearchConceptsMolecular breast imagingAnnual screening roundsDigital breast tomosynthesisDense breastsIncremental cancer detection rateNode-negative cancersTyrer-Cuzick riskCancer detection rateInterval cancer rateBreast tomosynthesisInvasive cancer detectionBreast imagingYear 1Year 2Invasive cancerMulticenter trialBreast screeningBreast densityCancer ratesAdvanced cancerCancerCancer detectionFunctional uptakePrevalenceBreastCollagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis.
Ahmad A, Ghim M, Kukreja G, Neishabouri A, Zhang Z, Li J, Salarian M, Toczek J, Gona K, Hedayatyanfard K, Morrison T, Zhang J, Huang Y, Liu C, Yu S, Sadeghi M. Collagen Hybridizing Peptide-Based Radiotracers for Molecular Imaging of Collagen Turnover in Pulmonary Fibrosis. Journal Of Nuclear Medicine 2025, 66: 425-433. PMID: 39915119, PMCID: PMC11876730, DOI: 10.2967/jnumed.124.268832.Peer-Reviewed Original ResearchConceptsPulmonary fibrosisTracer uptakeLung uptakeMurine model of pulmonary fibrosisModel of pulmonary fibrosisMice 3 wkEffect of antifibrotic therapyCollagen turnoverInterstitial lung diseaseClinical diagnostic methodsSPECT/CT imagingHybrid tracersLung histologyAntifibrotic therapyControl miceDisease activityMurine modelLung diseaseMice 8Tissue fibrosisPatient managementLiver uptakeSPECT/CTFibrosisSPECT images
2022
Artificial Intelligence in Nuclear Medicine: Opportunities, Challenges, and Responsibilities Toward a Trustworthy Ecosystem
Saboury B, Bradshaw T, Boellaard R, Buvat I, Dutta J, Hatt M, Jha A, Li Q, Liu C, McMeekin H, Morris M, Scott P, Siegel E, Sunderland J, Pandit-Taskar N, Wahl R, Zuehlsdorff S, Rahmim A. Artificial Intelligence in Nuclear Medicine: Opportunities, Challenges, and Responsibilities Toward a Trustworthy Ecosystem. Journal Of Nuclear Medicine 2022, 64: jnumed.121.263703. PMID: 36522184, PMCID: PMC9902852, DOI: 10.2967/jnumed.121.263703.Peer-Reviewed Original ResearchThrombus Imaging Following Myocardial Infarction Does Molecular Imaging Offer an Advantage? ∗
Sinusas A. Thrombus Imaging Following Myocardial Infarction Does Molecular Imaging Offer an Advantage? ∗. JACC Cardiovascular Imaging 2022, 16: 833-836. PMID: 36648044, DOI: 10.1016/j.jcmg.2022.10.015.Peer-Reviewed Original ResearchRadiochemical Synthesis and Evaluation of 3‑[11C]Methyl-4-aminopyridine in Rodents and Nonhuman Primates for Imaging Potassium Channels in the CNS
Sun Y, Guehl N, Zhou Y, Takahashi K, Belov V, Dhaynaut M, Moon S, Fakhri G, Normandin M, Brugarolas P. Radiochemical Synthesis and Evaluation of 3‑[11C]Methyl-4-aminopyridine in Rodents and Nonhuman Primates for Imaging Potassium Channels in the CNS. ACS Chemical Neuroscience 2022, 13: 3342-3351. PMID: 36417797, PMCID: PMC9732819, DOI: 10.1021/acschemneuro.2c00364.Peer-Reviewed Original ResearchConceptsRegional brain time-activity curvesBrain time-activity curvesOne-tissue compartment modelBlood-brain barrierConsistent with <i>inNonhuman primatesTime-activity curvesPositron emission tomographySpinal cord injuryDemyelinated neuronsNeurological symptomsPotassium channelsNeuronal conductionBrain uptakeEmission tomographyStille cross-couplingMultiple sclerosisCord injurySlow kineticsBrain permeabilityTraumatic brainMyelin sheathStronger binding affinityNeuronsBrainDual-polarity voltage imaging of the concurrent dynamics of multiple neuron types
Kannan M, Vasan G, Haziza S, Huang C, Chrapkiewicz R, Luo J, Cardin J, Schnitzer M, Pieribone V. Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types. Science 2022, 378: eabm8797. PMID: 36378956, PMCID: PMC9703638, DOI: 10.1126/science.abm8797.Peer-Reviewed Original ResearchHot spot imaging in cardiovascular diseases: an information statement from SNMMI, ASNC, and EANM
Sperry BW, Bateman TM, Akin EA, Bravo PE, Chen W, Dilsizian V, Hyafil F, Khor YM, Miller RJH, Slart RHJA, Slomka P, Verberne H, Miller EJ, Liu C. Hot spot imaging in cardiovascular diseases: an information statement from SNMMI, ASNC, and EANM. Journal Of Nuclear Cardiology 2022, 30: 626-652. PMID: 35864433, DOI: 10.1007/s12350-022-02985-8.Peer-Reviewed Original ResearchMolecular Imaging in Acute Aortic Syndrome Lighting a Path to Better Risk Assessment ∗
Tawakol A, Mezue K. Molecular Imaging in Acute Aortic Syndrome Lighting a Path to Better Risk Assessment ∗. JACC Cardiovascular Imaging 2022, 15: 1305-1307. PMID: 35798406, DOI: 10.1016/j.jcmg.2022.04.022.Peer-Reviewed Original ResearchDemystifying Medico-legal Challenges of Artificial Intelligence Applications in Molecular Imaging and Therapy
Mezrich JL. Demystifying Medico-legal Challenges of Artificial Intelligence Applications in Molecular Imaging and Therapy. PET Clinics 2022, 17: 41-49. PMID: 34809868, DOI: 10.1016/j.cpet.2021.08.002.Peer-Reviewed Original ResearchMeSH KeywordsArtificial IntelligenceDelivery of Health CareHumansLiability, LegalMolecular ImagingNuclear MedicineConceptsCause of actionMedico-legal challengesLegal causesLegal developmentsProduct liabilityMedical malpracticeArtificial intelligenceArtificial intelligence applicationsVariety of benefitsLawsuitsLegislationLiabilityMalpracticeAppropriate guidelinesHealth careAgenciesIntelligence applicationsActionNotionHurdlesMolecular imaging
2021
Near-Infrared Fluorescence Imaging of Carotid Plaques in an Atherosclerotic Murine Model
Wu X, Ulumben A, Long S, Katagiri W, Wilks M, Yuan H, Cortese B, Yang C, Kashiwagi S, Choi H, Normandin M, Fakhri G, Zaman R. Near-Infrared Fluorescence Imaging of Carotid Plaques in an Atherosclerotic Murine Model. Biomolecules 2021, 11: 1753. PMID: 34944397, PMCID: PMC8698491, DOI: 10.3390/biom11121753.Peer-Reviewed Original ResearchNuclear Medicine and Artificial Intelligence: Best Practices for Algorithm Development
Bradshaw TJ, Boellaard R, Dutta J, Jha AK, Jacobs P, Li Q, Liu C, Sitek A, Saboury B, Scott PJH, Slomka PJ, Sunderland JJ, Wahl RL, Yousefirizi F, Zuehlsdorff S, Rahmim A, Buvat I. Nuclear Medicine and Artificial Intelligence: Best Practices for Algorithm Development. Journal Of Nuclear Medicine 2021, 63: 500-510. PMID: 34740952, PMCID: PMC10949110, DOI: 10.2967/jnumed.121.262567.Peer-Reviewed Original ResearchHigh-Resolution Label-Free Molecular Imaging of Brain Tumor
Guo R, Ma C, Li Y, Zhao Y, Wang T, Li Y, Fakhri G, Liang Z. High-Resolution Label-Free Molecular Imaging of Brain Tumor. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2021, 00: 3049-3052. PMID: 34891886, DOI: 10.1109/embc46164.2021.9630623.Peer-Reviewed Original ResearchConceptsMagnetic resonance spectroscopic imagingBrain tumorsIntra-tumoural metabolic heterogeneityAssessment of treatment efficacySmall-sized tumorsClinical applicationN-acetyl aspartateBrain tumor characterizationPotential clinical applicationsApplication of magnetic resonance spectroscopic imagingTumor characterizationMolecular imaging techniquesBrain metabolitesImaging of brain tumorsTumorTreatment efficacyClinical relevanceMetabolic imagingDiagnosed brain tumorsHigh-resolution metabolic imagingMetabolic heterogeneityTumor detectionMolecular imaging of brain tumorsLabel-free molecular imagingLabel-free molecular imaging techniqueChromatin tracing and multiplexed imaging of nucleome architectures (MINA) and RNAs in single mammalian cells and tissue
Liu M, Yang B, Hu M, Radda JSD, Chen Y, Jin S, Cheng Y, Wang S. Chromatin tracing and multiplexed imaging of nucleome architectures (MINA) and RNAs in single mammalian cells and tissue. Nature Protocols 2021, 16: 2667-2697. PMID: 33903756, PMCID: PMC9007104, DOI: 10.1038/s41596-021-00518-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineChromatinGene Expression ProfilingHumansMolecular ImagingRNASingle-Cell AnalysisConceptsSame single cellNucleome architecturesGene expressionMammalian tissuesChromatin foldingNuclear laminaSingle cellsNumerous RNA speciesDifferent biological processesSingle mammalian cellsDifferent cell typesMultiplexed imagingGenomic organizationGenomic architectureChromatin loopsGenomic regionsRNA speciesIndividual chromosomesMammalian cellsGenomic techniquesBiological processesDetailed protocolCopy numberCell typesNormal developmentGraph of graphs analysis for multiplexed data with application to imaging mass cytometry
Lin YE, Shnitzer T, Talmon R, Villarroel-Espindola F, Desai S, Schalper K, Kluger Y. Graph of graphs analysis for multiplexed data with application to imaging mass cytometry. PLOS Computational Biology 2021, 17: e1008741. PMID: 33780435, PMCID: PMC8032202, DOI: 10.1371/journal.pcbi.1008741.Peer-Reviewed Original ResearchElastin-specific MRI of extracellular matrix-remodelling following hepatic radiofrequency-ablation in a VX2 liver tumor model
Collettini F, Reimann C, Brangsch J, Chapiro J, Savic LJ, Onthank DC, Robinson SP, Karst U, Buchholz R, Keller S, Hamm B, Goldberg SN, Makowski MR. Elastin-specific MRI of extracellular matrix-remodelling following hepatic radiofrequency-ablation in a VX2 liver tumor model. Scientific Reports 2021, 11: 6814. PMID: 33767303, PMCID: PMC7994448, DOI: 10.1038/s41598-021-86417-6.Peer-Reviewed Original ResearchBackground Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study.
Hruska CB, Geske JR, Conners AL, Whaley DH, Rhodes DJ, O'Connor MK, Carter RE, Scott CG, Vachon CM. Background Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study. American Journal Of Roentgenology 2021, 216: 1193-1204. PMID: 32755210, PMCID: PMC8640999, DOI: 10.2214/ajr.20.23854.Peer-Reviewed Original ResearchConceptsBackground parenchymal uptakeMolecular breast imagingPostmenopausal womenBreast cancer riskAbsolute riskBreast cancerCohort studyDiscriminatory accuracyDense breastsRisk factorsParenchymal uptakeCancer riskRisk scoreFuture breast cancer diagnosisGreater breast cancer riskBreast cancer risk factorsCox proportional hazards modelGail risk scoreBreast cancer eventsIndependent risk factorSubset of womenCancer risk factorsCase-control studyProportional hazards modelBreast cancer diagnosisAdvancing the mission of cardiovascular molecular imaging
Dorbala S, Zhou W, Sadeghi M. Advancing the mission of cardiovascular molecular imaging. Journal Of Nuclear Cardiology 2021, 30: 2266-2267. PMID: 33655449, PMCID: PMC7924910, DOI: 10.1007/s12350-021-02534-9.Peer-Reviewed Original Research
2020
Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging
Gona K, Toczek J, Ye Y, Sanzida N, Golbazi A, Boodagh P, Salarian M, Jung JJ, Rajendran S, Kukreja G, Wu TL, Devel L, Sadeghi MM. Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging. Journal Of Medicinal Chemistry 2020, 63: 15037-15049. PMID: 33206510, PMCID: PMC8010999, DOI: 10.1021/acs.jmedchem.0c01514.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmMMP-12 inhibitorsSelective MMP-12 inhibitorMurine abdominal aortic aneurysmsRadiochemical stabilityFast blood clearanceMolecular imagingAortic aneurysmAAA progressionMMP-12Blood clearanceUpregulated MMPsAortic regionElastase inhibitorLead tracerNovel familyRupture riskMacrophage elastaseInhibitorsSelectivitySpecific bindingSynthesisVivo competitionImagingMonitoring Atsttrin-Mediated Inhibition of TNFα/NF-κβ Activation Through In Vivo Bioluminescence Imaging
Hettinghouse A, Fu W, Liu C. Monitoring Atsttrin-Mediated Inhibition of TNFα/NF-κβ Activation Through In Vivo Bioluminescence Imaging. Methods In Molecular Biology 2020, 2248: 201-210. PMID: 33185877, PMCID: PMC8140391, DOI: 10.1007/978-1-0716-1130-2_14.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansLuminescent MeasurementsMiceMolecular ImagingNF-kappa BProgranulinsTumor Necrosis Factor-alphaConceptsTumor necrosis factorDouble mutant miceNF-κBOverexpression of TNFMutant miceBioluminescence imagingTransgenic reporter mouse modelNF-κB luciferaseNF-κβ activationVivo bioluminescence imagingReporter mouse modelAutoimmune conditionsTNF-TgNF-κβNecrosis factorImmune responseMouse modelMolecular mediatorsTransgenic modelTherapeutic objectivesVivo efficacyProgranulinPotential therapeuticsAtsttrinLuciferase activity3D in situ imaging of female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice
Ded L, Hwang JY, Miki K, Shi HF, Chung JJ. 3D in situ imaging of female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice. ELife 2020, 9: e62043. PMID: 33078708, PMCID: PMC7707823, DOI: 10.7554/elife.62043.Peer-Reviewed Original ResearchConceptsFemale reproductive tractFemale tractCalcium channel complexSitu molecular imagingReproductive tractMolecular insightsSuccessful fertilizationCatSper channelsMolecular signaturesSperm cellsSperm selectionChannel complexMouse spermatozoaFertilization siteSpermSperm migrationSpermatozoaMammalsPhosphorylationCatSper1ProteinSitu imagingAcrosomeUtero-tubal junctionSelection
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