Estimating the associations between women’s maltreatment in childhood and inflammatory biomarker levels prior to and during pregnancy
Wu B, Vyas C, Medina A, Slopen N, Mahalingaiah S, Chavarro J, Mukherjee R, Weisskopf M, Roberts A. Estimating the associations between women’s maltreatment in childhood and inflammatory biomarker levels prior to and during pregnancy. PLOS ONE 2025, 20: e0331905. PMID: 40920854, PMCID: PMC12416833, DOI: 10.1371/journal.pone.0331905.Peer-Reviewed Original ResearchConceptsTumor necrosis factor alpha receptor 2Associated with higher riskC-reactive proteinAdverse neurodevelopmentInflammatory biomarkersNurses' Health Study 3Risk of adverse neurodevelopmentInterleukin-6Gestational risk factorsMaternal childhood abuseMaternal childhood maltreatmentGeneralized Estimating EquationsSample of well-educatedChronic systemic inflammationInflammatory biomarker levelsChildhood maltreatmentNon-HispanicExposure to maltreatmentPregnant participantsVulnerable populationsOffspring neurodevelopmentSystemic inflammationIFN-gProspective cohortInterferon-gamma
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