2025
Nutritional Impairment and Quality of Life Trajectories Among Older Adults With Advanced Cancer
Singhal S, Wang Y, Dunne R, Kehoe L, Sohn M, Jensen‐Battaglia M, Canin B, Tylock R, Mohamed M, Khatri J, Bearden J, Philip T, Mohile S, Loh K. Nutritional Impairment and Quality of Life Trajectories Among Older Adults With Advanced Cancer. Journal Of The American Geriatrics Society 2025 PMID: 40616260, PMCID: PMC12236448, DOI: 10.1111/jgs.19617.Peer-Reviewed Original ResearchQuality of lifeGDS-15FACT-GAdvanced cancerHealth trajectoriesOlder adultsAssociated with membershipFunctional Assessment of Cancer Therapy-GeneralPsychological healthGeriatric Depression Scale-15Quality of life trajectoriesTrajectories of quality of lifeAssess quality of lifeMini Nutritional Assessment-Short Form scoreNutritional impairmentAssess psychological healthHigher quality of lifePalliative cancer treatmentDepression groupMild depression groupMultinomial logistic regressionGroup-based trajectoryTrajectory group membershipQOL trajectoriesAssociated with group membershipFatigue, physical function, and the context of social vulnerability for older adults with cancer
Jensen-Battaglia M, Delmerico A, Mohamed M, Tylock R, Flannery M, Burnette B, Desai N, Anthony N, Mustian K, Loh K, Mohile S, Seplaki C, Gilmore N. Fatigue, physical function, and the context of social vulnerability for older adults with cancer. Journal Of Geriatric Oncology 2025, 16: 102284. PMID: 40450795, PMCID: PMC12226210, DOI: 10.1016/j.jgo.2025.102284.Peer-Reviewed Original ResearchConceptsSocial determinants of healthPhysical functionOlder adultsShort Physical Performance BatteryEstimate adjusted relative risksCluster randomized clinical trialRelative riskAdvanced cancerCancer-related fatigueDeterminants of healthPhysical Performance BatteryAdjusted relative risksAssociated with increased riskGreater fatigueSocial determinantsPerformance BatteryBaseline fatigueManaging fatigueFollow-up timepointsAssociated with declinesSocial vulnerabilitySocial Vulnerability IndexSPPBPatient-Reported Outcomes Common Terminology Criteria for Adverse EventsCommunity levelTemporal Trends in Opioid Use and Associated Outcomes for Patients Living with Advanced Cancer
Jairam V, Lindsay M, Soulos P, Gross C, Prsic E, Baum L, Park H. Temporal Trends in Opioid Use and Associated Outcomes for Patients Living with Advanced Cancer. Journal Of Pain And Symptom Management 2025 PMID: 40403779, DOI: 10.1016/j.jpainsymman.2025.05.007.Peer-Reviewed Original ResearchPain-related ED visitsOpioid useGabapentinoid useOpioid-related encountersAdvanced cancerOpioid prescribingED visitsAdvanced solid tumor cancersEnd Results (SEER)-Medicare databaseHigh-risk opioid useNonopioid pain medicationsMultivariate logistic regression modelNon-cancer patientsSolid tumor cancersPain controlPain medicationInvestigate time trendsIndex dateLogistic regression modelsCancer cohortOpioidNoncancer patientsOpioid epidemicPatientsNoncancer cohortEHR-facilitated Symptom Control Intervention Impacts Palliative Care Consultation for Advanced Cancer Patients
Pachman D, Grzegorczyk V, Ruddy K, Griffin J, Strand J, Ridgeway J, Chlan L, Tofthagen C, Leventakos K, Austin J, Smith A, Mitchell S, Herrin J, Cheville A, Pachman D. EHR-facilitated Symptom Control Intervention Impacts Palliative Care Consultation for Advanced Cancer Patients. Journal Of Pain And Symptom Management 2025, 69: e426-e427. DOI: 10.1016/j.jpainsymman.2025.02.033.Peer-Reviewed Original ResearchOutpatient palliative careCollaborative care modelPalliative careImprove symptom managementSymptom managementAdvanced cancer patientsIntervention periodQuality of lifeAdvanced cancerPC consultationPC servicesSymptom surveillancePC utilizationPopulation of patientsCCM-based interventionsPalliative care consultationUsual care periodPalliative care utilizationSelf-management informationClinician decision supportMulti-state health systemCancer symptom controlMedical oncology clinicCancer patientsOutpatient PCCombined Treatment With Cognitive Behavioral Therapy for Insomnia and Acceptance and Commitment Therapy Enhances Objective and Subjective Reports of Sleep in Patients With Advanced Cancer
Gregorio S, Flowers S, Peng J, Marks D, Probst D, Zaleta A, Benson D, Cohn D, Lustberg M, Carson W, Magalang U, Baltimore S, Ancoli‐Israel S. Combined Treatment With Cognitive Behavioral Therapy for Insomnia and Acceptance and Commitment Therapy Enhances Objective and Subjective Reports of Sleep in Patients With Advanced Cancer. Psycho-Oncology 2025, 34: e70141. PMID: 40204663, PMCID: PMC11981972, DOI: 10.1002/pon.70141.Peer-Reviewed Original ResearchMeSH KeywordsAcceptance and Commitment TherapyActigraphyAdultAgedCognitive Behavioral TherapyCombined Modality TherapyDepressionFatigueFemaleHumansMaleMiddle AgedNeoplasmsPilot ProjectsQuality of LifeSelf ReportSeverity of Illness IndexSleepSleep Initiation and Maintenance DisordersTreatment OutcomeConceptsAdvanced cancerSelf-reported insomnia severitySeverity ratingsWait-list control armCognitive behavioral therapyCognitive-behavioral interventionsAssociated with poorer moodActigraphy sleep efficiencyInsomnia Severity IndexTwenty-eight peopleCircadian rhythm disruptionBehavioral therapyInsomnia severityCancer survivorsRandomized pilot studyBrief interventionPost-interventionInsomnia improvementSleep difficultiesPoor moodFocused interventionsIntervention sampleSelf-ReportActigraphic measuresInsomniaAdvancing the Evaluation and Management of CDH1-Associated Gastric Cancer.
Lerner B, Gupta S, Burke C, Kupfer S, Katona B, Grady W, Samadder J, Yurgelun M, Kelly K, Moreno Prats M, Joseph N, Idos G, Swanson B, Kieber-Emmons A, Weiss J, Llor X. Advancing the Evaluation and Management of CDH1-Associated Gastric Cancer. Journal Of The National Comprehensive Cancer Network 2025, 23 PMID: 40203872, DOI: 10.6004/jnccn.2025.7006.Peer-Reviewed Original ResearchConceptsSignet ring cell carcinomaPathogenic variant carriersGastric cancerEndoscopic surveillanceTotal gastrectomyVariant carriersGermline pathogenic variant carriersBenefits of gastrectomyCDH1 pathogenic variantsRisk of gastric cancerAdvanced gastric cancerProphylactic total gastrectomyPathogenic germline variantsFollow-up periodCumulative lifetime riskEvidence-based recommendationsUpper endoscopyCell carcinomaGlobal health concernDetected signet ring cell carcinomasGermline variantsPathogenic variantsGastrectomyGastrectomy specimensAdvanced cancerRelationships between patient‐reported and clinician‐rated toxicities and daily functioning in older adults with advanced cancer undergoing systemic therapy
Culakova E, Mohamed M, Flannery M, Jensen‐Battaglia M, Zhang Z, Ramsdale E, Tylock R, Stauffer F, Wells M, Magnuson A, Loh K, Gada U, Janelsins M, Mohile S. Relationships between patient‐reported and clinician‐rated toxicities and daily functioning in older adults with advanced cancer undergoing systemic therapy. Cancer 2025, 131: e35766. PMID: 39945245, PMCID: PMC11822747, DOI: 10.1002/cncr.35766.Peer-Reviewed Original ResearchConceptsActivities of daily livingInstrumental ADLOlder adultsPatient-reported toxicityAdvanced cancerPhysical performanceActivities of daily living impairmentPRO-CTCAEInstrumental activities of daily livingShort Physical Performance BatteryImpaired activities of daily livingFunctional declineMitigate functional declinePhysical Performance BatteryImpaired instrumental ADLSystemic therapyGeneralized Estimating EquationsClinician-ratedIADL impairmentPerformance BatteryRisk of treatment-related toxicityDaily livingMonths of treatment initiationPatient reportsTreatment-related toxicitySelf-affirmation intervention for patients newly diagnosed with advanced cancer: a preliminary efficacy trial
Bai M, Cella D, Jeon S, Govindarajan R, Birrer M. Self-affirmation intervention for patients newly diagnosed with advanced cancer: a preliminary efficacy trial. Journal Of Psychosocial Oncology 2025, 43: 593-615. PMID: 39812781, DOI: 10.1080/07347332.2025.2450013.Peer-Reviewed Original ResearchFunctional Assessment of Cancer Therapy - GeneralAdvanced cancerCancer patients' quality of lifeFACIT-Sp-12Functional assessmentInterrupted time series designPost-intervention changesCancer patients' qualityTime series designQuality of lifePatients' quality of lifePost-interventionPsychosocial interventionsAdvanced stage cancerLinear mixed modelsGeneralized linear mixed modelsSeries designPreliminary efficacyCancer diagnosisIntent-to-treat analysisSelf-affirmation interventionChanges pre-Existential concernsIntervention approachesItem scale
2024
Cardiovascular Considerations During Cancer Therapy Gaps in Evidence and JACC: CardioOncology Expert Panel Recommendations
Leong D, Waliany S, Abdel-Qadir H, Atkins K, Neilan T, Lang N, Liu J, Blaes A, Mian H, Moore H, Hajjar L, Morgans A, Ellis P, Dent S. Cardiovascular Considerations During Cancer Therapy Gaps in Evidence and JACC: CardioOncology Expert Panel Recommendations. JACC CardioOncology 2024, 6: 815-834. PMID: 39801647, PMCID: PMC11711816, DOI: 10.1016/j.jaccao.2024.06.005.Peer-Reviewed Original ResearchCardiovascular toxicityCancer therapyContinuation of cancer therapySpectrum of toxicityDiverse health care professionalsExpert panelSevere cardiovascular diseaseHealth care professionalsExpert panel recommendationsCardiovascular ConsiderationsCardio-OncologyInvasive managementTherapy gapAdvanced cancerPrimary preventionTherapyCancerCardiovascular diseaseCardiovascular treatmentCare professionalsCardiovascular carePanel recommendationsPatientsToxicityTreatmentExploring geriatric assessment‐driven rehabilitation referral patterns and its influence on functional outcomes and survival in older adults with advanced cancer
Brick R, Jensen‐Battaglia M, Streck B, Page L, Tylock R, Cacciatore J, Mustian K, Khatri J, Giguere J, Dib E, Mohile S, Culakova E. Exploring geriatric assessment‐driven rehabilitation referral patterns and its influence on functional outcomes and survival in older adults with advanced cancer. Journal Of The American Geriatrics Society 2024, 73: 136-149. PMID: 39487813, PMCID: PMC12102744, DOI: 10.1111/jgs.19250.Peer-Reviewed Original ResearchConceptsRehabilitation servicesHealth-related qualityInstrumental ADLOlder adultsAdvanced cancerFunctional disabilityPatient utilizationOncologist's decisionHealth-related quality of lifeAssociated with lower oddsAssociated with higher oddsFunctional status impairmentQuality of lifeCox proportional hazards modelsMultivariate logistic regressionProportional hazards modelPhysical performancePost-referralLower oddsHigher oddsHRQoLDisability statusReferral patternsSecondary analysisRehabilitationMapping extrachromosomal DNA amplifications during cancer progression
Kim H, Kim S, Wade T, Yeo E, Lipsa A, Golebiewska A, Johnson K, An S, Ko J, Nam Y, Lee H, Kang S, Chung H, Niclou S, Moon H, Paek S, Bafna V, Luebeck J, Verhaak R. Mapping extrachromosomal DNA amplifications during cancer progression. Nature Genetics 2024, 56: 2447-2454. PMID: 39402156, PMCID: PMC11549044, DOI: 10.1038/s41588-024-01949-7.Peer-Reviewed Original ResearchConceptsPretreatment tumorsCancer progressionChemotherapy-pretreated patientsNewly diagnosed tumorsVariant allele fractionUntreated metastasesPrimary cancerUntreated cancerTreatment responseFocal amplificationTumor samplesChromosomal amplificationsDiagnosed cancerTumorExtrachromosomal DNA amplificationsAdvanced cancerCancerEcDNATime pointsMetastasisNewlyDNA amplificationProgressionExtrachromosomal DNAPatientsSIOG2024-4-P-088 Patient-level predictors of geriatric assessment-driven referral to occupational or physical therapy for older adults with advanced cancer
Page L, Jensen-Battaglia M, Streck B, Tylock R, Cacciatore J, Berenberg J, Panikkar R, Burnette B, Mohile S, Culakova E, Brick R. SIOG2024-4-P-088 Patient-level predictors of geriatric assessment-driven referral to occupational or physical therapy for older adults with advanced cancer. Journal Of Geriatric Oncology 2024, 15: 101969. DOI: 10.1016/j.jgo.2024.101969.Peer-Reviewed Original ResearchSIOG2024-4-P-089* Function, quality of life, and survival among older adults with advanced cancer: differences by geriatric assessment-driven referral to occupational or physical therapy
Jensen-Battaglia M, Page L, Streck B, Tylock R, Cacciatore J, Khatri J, Braiteh F, Dib E, Mohile S, Culakova E, Brick R. SIOG2024-4-P-089* Function, quality of life, and survival among older adults with advanced cancer: differences by geriatric assessment-driven referral to occupational or physical therapy. Journal Of Geriatric Oncology 2024, 15: 101970. DOI: 10.1016/j.jgo.2024.101970.Peer-Reviewed Original ResearchEffect of polypharmacy and potentially inappropriate medications on physical functional decline among older adults with advanced cancer receiving systemic treatment
Mohamed M, Juba K, Awad H, Flannery M, Culakova E, Wells M, Cacciatore J, Jensen-Battaglia M, Mohile S, Ramsdale E. Effect of polypharmacy and potentially inappropriate medications on physical functional decline among older adults with advanced cancer receiving systemic treatment. Supportive Care In Cancer 2024, 32: 674. PMID: 39294452, PMCID: PMC12093274, DOI: 10.1007/s00520-024-08877-6.Peer-Reviewed Original ResearchConceptsShort Physical Performance BatteryPhysical function outcomesPhysical function declineInstrumental ADLOlder adultsAssociated with increased riskAdvanced cancerRisk of IADL declineFunctional declinePhysical Performance BatteryInstrumental ADL scoresVulnerable older adultsSystemic treatmentMethodsThis secondary analysisFunctional outcomesEffects of polypharmacyADL declineIADL declinePerformance BatteryADL scoreBeers criteriaMedication useMonths of treatment initiationRelevant covariatesScreening toolBreast Cancers Detected during a Decade of Screening with Digital Breast Tomosynthesis: Comparison with Digital Mammography.
Philpotts L, Grewal J, Horvath L, Giwerc M, Staib L, Etesami M. Breast Cancers Detected during a Decade of Screening with Digital Breast Tomosynthesis: Comparison with Digital Mammography. Radiology 2024, 312: e232841. PMID: 39287520, DOI: 10.1148/radiol.232841.Peer-Reviewed Original ResearchConceptsDigital breast tomosynthesisBreast cancerDigital mammographyAdvanced cancerHuman epidermal growth factor 2-positiveOverdiagnosis of breast cancerProportion of advanced cancersBreast cancer detection rateEffectiveness of digital breast tomosynthesisRate of advanced cancerDuctal carcinoma in situInterval cancer rateTwo-dimensional digital mammographyInvasive cancer sizeTriple-negative tumorsCancer detection rateCarcinoma in situBreast tomosynthesisFalse-negative findingsIncreased cancer detectionIncident screensIncident roundsAxillary nodesDM screeningInvasive cancerTrends in use of intensive care during hospitalizations at the end‐of‐life among older adults with advanced cancer
Jain S, Long J, Rao V, Law A, Walkey A, Prsic E, Lindenauer P, Krumholz H, Gross C. Trends in use of intensive care during hospitalizations at the end‐of‐life among older adults with advanced cancer. Journal Of The American Geriatrics Society 2024, 72: 3840-3848. PMID: 39090970, PMCID: PMC11637920, DOI: 10.1111/jgs.19119.Peer-Reviewed Original ResearchEnd-of-life hospitalizationsLife-sustaining treatmentEnd-of-lifeIntensity of careIn-Hospital DeathOlder adultsIntensive care unitAdvanced cancerRisk-adjusted hospitalEvaluate trendsIncreased intensity of careIntensive care unit useSEER-Medicare dataIntensive care unit careMultinomial regression modelsYear of diagnosisIntensive careHospital categoryMedicare beneficiariesSEER-MedicareHospitalization ratesCareCancer characteristicsNoninvasive ventilationHospitalNavigating the Complexities of Brain Metastases Management.
Amouzegar A, Haig S, Kahn A, Tawbi H, Jones J, Goldberg S. Navigating the Complexities of Brain Metastases Management. American Society Of Clinical Oncology Educational Book 2024, 44: e433694. PMID: 38781565, DOI: 10.1200/edbk_433694.Peer-Reviewed Original ResearchConceptsBrain metastasesSystemic therapySolid tumorsIncidence of brain metastasesManagement of brain metastasesEfficacy of systemic therapyBrain metastasis managementMetastatic solid tumorsComplication of advanced cancerExclusion of patientsEnhanced imaging technologiesMetastasis managementSystemic treatmentTargeted therapyBreast cancerExtended survivalClinical dataClinical trialsMetastasisAdvanced cancerTherapyEarly detectionTumorPatientsCancerTransforming Written and Spoken Words into Quantitative Data for Palliative Care Research Using Natural Language Processing (ME301)
Lindvall C, Walling A, Ananth P. Transforming Written and Spoken Words into Quantitative Data for Palliative Care Research Using Natural Language Processing (ME301). Journal Of Pain And Symptom Management 2024, 67: e847-e848. DOI: 10.1016/j.jpainsymman.2024.02.491.Peer-Reviewed Original ResearchGoals of care conversationsPay-for-performance programsPay-for-performanceChart abstractionCare conversationsElectronic health record dataQuality improvementPalliative care deliveryAssess care qualityCare process measuresAdvanced cancerHealth record dataElectronic health recordsManual chart abstractionEnd-of-lifeManual chart reviewUS healthcare systemIllness careCare qualityNatural language processingCare deliveryAudio-recorded conversationsHealth recordsSocial supportIllness researchCohort study of patients with advanced cancer: outcomes associated with duration of antibiotic therapy for non-ventilator hospital-acquired pneumonia
Lee S, Benson J, Cohen A, Quagliarello V, Juthani-Mehta M, Datta R. Cohort study of patients with advanced cancer: outcomes associated with duration of antibiotic therapy for non-ventilator hospital-acquired pneumonia. Antimicrobial Stewardship & Healthcare Epidemiology 2024, 4: e48. PMID: 38655023, PMCID: PMC11036428, DOI: 10.1017/ash.2024.54.Peer-Reviewed Original ResearchNon-ventilator hospital-acquired pneumoniaAdvanced cancerPalliative care settingHospital-acquired pneumoniaCohort study of patientsCare settingsOlder adultsAdjusted oddsDuration of antibiotic therapyAssociated with reduced adjusted oddsSingle-center observational studyCohort studyProlonged antibiotic durationObservational studyStudy of patientsAntimicrobial stewardship effortsAntibiotic durationAntibiotic therapyStewardship effortsPneumoniaCancerOddsReadmissionAdultsCohortImmunotherapy utilization patterns in patients with advanced cancer and autoimmune disease
Li H, Huntington S, Gross C, Wang S. Immunotherapy utilization patterns in patients with advanced cancer and autoimmune disease. PLOS ONE 2024, 19: e0300789. PMID: 38625861, PMCID: PMC11020359, DOI: 10.1371/journal.pone.0300789.Peer-Reviewed Original ResearchConceptsAutoimmune diseasesImmunotherapy cycleFirst-lineNon-small cell lung cancerAdvanced cancerFirst-line immunotherapyOverall treatment toleranceCell lung cancerRenal cell carcinomaRetrospective cohort studyAssociated with lower oddsAdvanced melanomaCell carcinomaTreatment toleranceAbsolute contraindicationImmunotherapyConsensus guidelinesImprove cancer survivalLung cancerCohort studyClinical variablesCancer patientsAcademic centersPatientsIncidence rate
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