2025
Differences in pain episodes among children with complex chronic conditions at end of life
Bogetz J, Phan M, Ayala E, Alayli Y, Johnston E, Ananth P, McGalliard J, Strub B, Bradford M, Rosenberg A. Differences in pain episodes among children with complex chronic conditions at end of life. Journal Of Pain And Symptom Management 2025 PMID: 40998221, DOI: 10.1016/j.jpainsymman.2025.09.015.Peer-Reviewed Original ResearchComplex chronic conditionsEnd-of-lifePain episodesChronic conditionsIntensive care unitYoung adults aged 0End of lifeElectronic health recordsDays of lifeHighest proportion of childrenAdults aged 0Proportion of childrenPearson chi-square testHealth disparitiesRetrospective studyHealth recordsChi-square testHighest proportionRetrospective study of childrenDescriptive statisticsStudy of childrenSevere pain episodesAged 0Demographic factorsU.S. academic institutionsLarge language models accurately identify immunosuppression in intensive care unit patients
Guggilla V, Kang M, Bak M, Tran S, Pawlowski A, Nannapaneni P, Rasmussen L, Schneider D, Donnelly H, Agrawal A, Liebovitz D, Misharin A, Budinger G, Wunderink R, Walunas T, Gao C, Hauser A, Peltekian A, Misharin A, Wolfe A, Szabo A, Choudhary A, Ludwig A, Moghadam A, Yeldandi A, Agrawal A, Bharat A, Pawlowski A, Joudi A, Tambe A, Smith-Nunez A, Singer B, Ulrich B, Tran B, Gottardi C, Gao C, Qi C, Pickens C, Schroedl C, Meza D, Schneider D, Garcia D, Ozer E, Gusman E, Shanes E, Leibenguth E, Olson E, Hartmann E, Korth E, Diaz E, Guzman E, Martinez F, Matias G, Budinger G, Donnelly H, Abdala-Valencia H, Sumner J, Sznajder J, Kruser J, Glowala J, Walter J, Rowell J, Arnold J, Coleman J, Lomasney J, Bailey J, Hultquist J, Fiala J, Starren J, Ridge K, Senkow K, Helmin K, Gates K, Simmons L, Pinzon L, Gradone L, Wolfe L, Luo L, Morales-Nebreda L, Rasmussen L, Jain M, Sala M, Schleck M, Ross M, Querrey M, Kang M, Cuttica M, Prickett M, Nadig N, Rhodes N, Chandel N, Markov N, Sporn P, Nannapaneni P, Liu Q, Kadar R, Medernach R, Lorenzo-Redondo R, Kalhan R, Clepp R, Wunderink R, Morimoto R, Grant R, Mylvaganam R, Fenske S, Laurenzo S, Smith S, Han S, Nozick S, Panchamukhi S, Eisenbarth S, Swaminathan S, Russell S, Poor T, Cybulski T, Lombardo T, Walunas T, Bolig T, Stoeger T, Doan T, Rowe T, Guggilla V, Liao W, Luo Y, Sokolenko Y, Yu Z, Lu Z. Large language models accurately identify immunosuppression in intensive care unit patients. Journal Of The American Medical Informatics Association 2025, ocaf141. PMID: 40977378, DOI: 10.1093/jamia/ocaf141.Peer-Reviewed Original ResearchNatural language processing approachNatural language processingF1 scoreData algorithmLanguage modelHeterogeneous typesIntensive care unitIntensive care unit patientsLanguage processingImmunosuppressive conditionsMedication ordersPrimary cohortClinical notesPoor generalizabilityCohort identificationAlgorithmDiagnosis codesValidation cohortHospital admission notesType of immunosuppressionCodeBeth Israel Deaconess Medical CenterImmunosuppressive medication useRobust external validationNorthwestern Memorial HospitalImmune landscape in liver of neonatal mice with phlebotomy-induced anemia
Ramatchandirin B, Wang W, Balamurugan M, Alnahhas Y, Desiraju S, Subrramanya A, George Raj J, Lawal Z, Ferris M, Tseng G, Konnikova L, MohanKumar K. Immune landscape in liver of neonatal mice with phlebotomy-induced anemia. Pediatric Research 2025, 1-11. PMID: 40962864, DOI: 10.1038/s41390-025-04361-x.Peer-Reviewed Original ResearchPhlebotomy-induced anemiaPreclinical mouse modelsPreterm infantsImmune landscapeRed blood cellsStress erythropoiesisLiver of neonatal miceNeonatal intensive care unitDownregulation of inflammatory markersAssociated with myelopoiesisNeonatal mouse pupsLow red blood cellPostnatal day 2Immune cell responsesIntensive care unitAnalysis of monocytesDeficiency of lymphocytesBackgroundSevere anaemiaNeonatal miceErythropoietin levelsSevere anemiaEmergency myelopoiesisInflammatory markersImmune cellsMouse pupsOperationalizing a complex acute clinical trial: Lessons from the BEACH study
Sorensen G, Remillard W, Schlechter M, Kampp M, Brady C, Kildahl K, Mould A, Ziai W, Lane K, Van Eldik L, Distasio A, Lu J, Sansing L, Hanley D, Magid-Bernstein J. Operationalizing a complex acute clinical trial: Lessons from the BEACH study. Journal Of Clinical And Translational Science 2025, 9: e215. DOI: 10.1017/cts.2025.10152.Peer-Reviewed Original ResearchNeuroscience intensive care unitPatient careYale-New Haven HospitalCare delivery teamPatient care environmentInterdisciplinary collaborationPatient safetyCare environmentDelivery teamSchool of MedicineClinical trial protocolsUniversity School of MedicineIntracerebral hemorrhageIntensive care unitPatient outcomesCareMultidisciplinary collaborationTrial protocolResearch teamNew Haven HospitalCare unitPatient enrollmentSignals of efficacyYale University School of MedicineInnovative treatment strategiesNeonatal Pain Experience and Pain Sensitivity Trajectories in Preterm Infants: A Longitudinal Study of Flexion Withdrawal Reflex Thresholds Over the First Two Years of Age
Wu W, Wang W, Li A, Chen J, Lainwala S, Matson A, Chen M, Li J, Cong X. Neonatal Pain Experience and Pain Sensitivity Trajectories in Preterm Infants: A Longitudinal Study of Flexion Withdrawal Reflex Thresholds Over the First Two Years of Age. Journal Of Pain 2025, 105558. PMID: 40945636, DOI: 10.1016/j.jpain.2025.105558.Peer-Reviewed Original ResearchNeonatal intensive care unitFlexion withdrawal reflexPreterm infantsPain sensitivityDevelopment of pain sensitizationNeonatal pain experienceHigh-risk infantsWithdrawal reflex thresholdIntensive care unitYears of ageMonths of ageGestational ageNociceptive systemAnalgesic useLongitudinal studyPretermPain managementReflex thresholdNeonatal experienceNon-Black femalesCare unitNeuroprotective strategiesInfantsPain experienceMale subgroupManagement of Adolescent Asthma
Chen L, Sheares B, Bruzzese J. Management of Adolescent Asthma. 2025, 182-193. DOI: 10.1201/9781003287209-22.Peer-Reviewed Original ResearchEmergency departmentStraight-A studentLocal emergency departmentAsthma medicationsBasketball practicePediatric intensive care unitDaily inhaled corticosteroidsYears of ageSevere asthma exacerbationsIntensive care unitShortness of breathAsthma exacerbationsBasketball teamCare unitStatus asthmaticusBalancing schoolBasketballBasketball coachesSymptomsEffect of peri‐operative pharmacological interventions on postoperative delirium in patients having cardiac surgery: a systematic review and Bayesian network meta‐analysis
Queiroz I, Barbosa L, Ruelas M, Araújo B, Defante M, Tavares A, de Mesquita C, Pimentel T, Mendes B, Felix I, Rivera A, Ferreira R, de Oliveira H, Righetto B, Smischney N, Tong G, Ma D. Effect of peri‐operative pharmacological interventions on postoperative delirium in patients having cardiac surgery: a systematic review and Bayesian network meta‐analysis. Anaesthesia 2025 PMID: 40888048, DOI: 10.1111/anae.16757.Peer-Reviewed Original ResearchIncidence of postoperative deliriumRandomised controlled trialsCardiac surgeryPostoperative deliriumPharmacological interventionsControlled TrialsRisk ratioMeta-analysis of randomised controlled trialsNetwork meta-analysis of randomised controlled trialsBayesian Network Meta-AnalysisEffective pharmacological strategiesGrading of RecommendationsIntensive care unitEffects of pharmacological interventionsCertainty of evidenceCumulative ranking curveEffective prevention strategiesNetwork Meta-AnalysisEffective interventionsPharmacological strategiesCare unitPrevention strategiesSystematic reviewLow certaintyPatientsInterstitial Thermal Therapy in Mesial Temporal Lobe Epilepsy
Landazuri P, Cheng J, Leuthardt E, Kim A, Southwell D, Fecci P, Neimat J, Sun D, Lega B, Panov F, Chiang V, Abel T, Ben-Haim S, Piccioni D, Shih J, Palys V, Rodriguez A, Bandt S, Petronio J, Lacroix M, Baumgartner J. Interstitial Thermal Therapy in Mesial Temporal Lobe Epilepsy. JAMA Neurology 2025, 82: 915-924. PMID: 40622685, PMCID: PMC12235534, DOI: 10.1001/jamaneurol.2025.1897.Peer-Reviewed Original ResearchConceptsLaser interstitial thermal therapyDrug-resistant mesial temporal lobe epilepsyMesial temporal lobe epilepsySeizure outcomeInterstitial thermal therapyTemporal lobe epilepsyFollow-upProcedural outcomesSafety dataQuality of lifeLobe epilepsyIntensive care unit timeMonths of follow-upAssociated with seizure outcomeYears of follow-upProspective multicenter registryPostsurgical seizure outcomeMesial temporal sclerosisIntensive care unitThermal therapyQuality of life improvementQuality of life scoresInternational League Against EpilepsyLength of stayMagnetic resonance imagingNoninvasive Hemodynamic Characterization of Cardiohepatic Syndrome in the Cardiac Intensive Care Unit.
Butt A, Padkins M, Miller P, Katz J, Hillerson D, Rosenbaum D, Samsky M, Jokhadar M, Jentzer J. Noninvasive Hemodynamic Characterization of Cardiohepatic Syndrome in the Cardiac Intensive Care Unit. Journal Of The American Heart Association 2025, 14: e043895. PMID: 40879063, DOI: 10.1161/jaha.125.043895.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitVentricular systolic dysfunctionIntensive care unitHepatocellular injuryRisk of mortalityHigh riskSyndrome phenotypeCICU patientsCombination groupBiventricular functionSystolic dysfunctionTransthoracic echocardiogramCardiohepatic syndromeAdmission liver function testsRight ventricular systolic dysfunctionCare unitLeft ventricular systolic dysfunctionAdmission diagnosisAdmission diagnosis of heart failureHigher risk of adverse outcomesDiagnosis of heart failureRisk of adverse outcomesPatients to 1Poor cardiac functionLiver function testsAn Educational Curriculum for Residents, Advanced Practice Providers, and Fellows in Cardiac Intensive Care Units
Carnicelli A, Senman B, Miller P, Dahiya G, Jentzer J, Ambalavanan M, Garfinkel A, Zaas A, Poindexter E, Judge D, Sinha S, Berg D, Elliott A, Morrow D, Katz J. An Educational Curriculum for Residents, Advanced Practice Providers, and Fellows in Cardiac Intensive Care Units. JACC Advances 2025, 4: 102110. PMID: 40882606, PMCID: PMC12417554, DOI: 10.1016/j.jacadv.2025.102110.Peer-Reviewed Original ResearchContemporary cardiac intensive care unitsCardiac intensive care unitIntensive care unitEducational experienceCare unitAdvanced practice providersDynamic educational environmentSubspecialty training programsPractice providersPostgraduate physiciansEducational environmentEducation curriculumLearner progressEducational objectivesLearning objectivesTraining programAdvanced stageCardiovascular pathologyTraining pathwaysCurriculumLearnersRenal and Bladder Ultrasonography for the Intensivist
Suwondo D, Baloescu C. Renal and Bladder Ultrasonography for the Intensivist. Respiratory Medicine 2025, 481-490. DOI: 10.1007/978-3-031-80038-2_43.Peer-Reviewed Original ResearchAcute kidney injuryIntensive care unitPost-renal acute kidney injuryIncidence of acute kidney injuryUrinary catheter useEvaluation of patientsBedside diagnostic modalityBladder ultrasoundUrinary retentionBladder ultrasonographyCatheter useDiagnostic modalitiesBladder volumeKidney injuryUreteral patencyUrinary catheterRenal stonesProcedural interventionCare unitBladderImmediate managementPoint-of-carePatientsPOCUSIntensivistsStandard complete blood count to predict long‐term outcomes in febrile infection–related epilepsy syndrome (FIRES): A multicenter study
Guillemaud M, Hanin A, Riviello J, Chavez M, Batra A, Berry M, Bisulli F, Castillo‐Pinto C, Cobos‐Hernandez C, Demeret S, Eschbach K, Farias‐Moeller R, Fields M, Gaspard N, Gerard E, Gofton T, Gopaul M, Gruen M, Jimenez A, Kazazian K, Kim M, Mansour M, Marcuse L, Marois C, Morales M, Muccioli L, Pasini E, Pham M, Rosas S, Struck A, Torcida N, Wainwright M, Yoo J, Muscal E, Navarro V, Hirsch L, Lai Y. Standard complete blood count to predict long‐term outcomes in febrile infection–related epilepsy syndrome (FIRES): A multicenter study. Epilepsia 2025 PMID: 40844418, DOI: 10.1111/epi.18605.Peer-Reviewed Original ResearchFebrile infection-related epilepsy syndromeMonocyte-to-lymphocyte ratioNeutrophil-to-lymphocyte ratioComplete blood countNew-onset refractory status epilepticusSecond-line immunotherapyUnfavorable outcomeBlood countComplete blood count levelsHigh red cell distribution widthEpilepsy syndromesTreatment phaseFirst-line immunotherapyInitiation of immunotherapyRed cell distribution widthRefractory status epilepticusComplete blood count dataCell distribution widthLong-term outcomesIntensive care unitSubtypes of leukocytesLeave-one-patient-outMulticenter studyStatus epilepticusImmunotherapyApplying Lessons from the COVID-19 Pandemic to Everyday Crises: The Role of Policy, Innovation, and Stewardship in Healthcare Emergencies
Welch R, Greeno R, Tolchin B, Kashyap N, Showstark M, Herbst J, Kim N, Jubanyik K. Applying Lessons from the COVID-19 Pandemic to Everyday Crises: The Role of Policy, Innovation, and Stewardship in Healthcare Emergencies. Journal Of Emergency Medicine 2025, 78: 192-201. PMID: 40976122, DOI: 10.1016/j.jemermed.2025.08.011.Peer-Reviewed Original ResearchMoral distressEmergency departmentDNR policyEmergency medicinePublic health emergencyLevels of moral distressCritical careEnd-of-life decisionsCOVID-19 testingNon-beneficial careIntensive care unitQuality improvement studyEnd-of-lifeFront-line cliniciansCOVID-19 pandemicCOVID-19 public health emergencyClinician decision-makingHealth emergencyDNR statusPatient's clinical conditionCode statusResuscitation policyCare deliveryEveryday crisesED staffAssociation between Hospital Safety-Net Status and Delivery of Rehabilitation to Older Adults with Acute Respiratory Failure
Jimenez J, Zhang L, Lin Z, Ferrante L, Falvey J, Walkey A, Krumholz H, Jain S. Association between Hospital Safety-Net Status and Delivery of Rehabilitation to Older Adults with Acute Respiratory Failure. CHEST Journal 2025 PMID: 40818773, DOI: 10.1016/j.chest.2025.07.4079.Peer-Reviewed Original ResearchSafety-net hospitalMedian odds ratioSafety-net hospital statusDelivery of rehabilitationOlder adultsRehabilitation deliveryNon-SNHsIntensive care unitSocioeconomic disadvantageRetrospective cohort studyCohort study of older adultsHospital safety-net statusDisproportionate share hospital indexRetrospective cohort study of older adultsHierarchical multivariable logistic regression modelsStudy of older adultsSafety-net statusMedicare Provider AnalysisMultivariate logistic regression modelCritical illnessLogistic regression modelsRehabilitation servicesSocioeconomic disparitiesHospital characteristicsUS hospitalsArnold Schwarzenegger or Danny DeVito? The Fate of Twins with Necrotizing Enterocolitis in the NICU
Hellmann Z, Thaxton C, Sapir N, Rehman S, Cowles R, Christison-Lagay E, Solomon D. Arnold Schwarzenegger or Danny DeVito? The Fate of Twins with Necrotizing Enterocolitis in the NICU. Journal Of Pediatric Surgery 2025, 162526. PMID: 40812408, DOI: 10.1016/j.jpedsurg.2025.162526.Peer-Reviewed Original ResearchMultiple gestation pregnanciesGestation pregnanciesSingleton birthsUncontrolled cohortIncidence of necrotizing enterocolitisNeonatal intensive care unitDevelopment of NECIncidence of NECPediatric Health Information SystemIntensive care unitSingleton gestationsGestational ageMultiple gestationsNICU populationSingleton infantsNecrotizing enterocolitisNICU infantsLow birthweightAverage birthweightInternal validityPrimary outcomeGestationCare unitShort gestationInfantsUse and Outcomes of Peripherally Inserted Central Catheters in Hospitalized Infants.
Chegondi M, Ness-Cochinwala M, Schreiber H, Pinto M, Polikoff L, Kothari H, Bloxham J, Kaipa S, Bergman-Sieger A, Mancuso B, Harder T, Korn S, Gillette C, Taillie E, Cholette J, Kerris E, Johnson R, Faustino E. Use and Outcomes of Peripherally Inserted Central Catheters in Hospitalized Infants. Hospital Pediatrics 2025, 15: 748-757. PMID: 40763931, DOI: 10.1542/hpeds.2024-008246.Peer-Reviewed Original ResearchConceptsPeripherally inserted central cathetersCatheter-related thrombosisRandomized clinical trialsMulticenter retrospective cohort studyHospitalized infantsAntiplatelet therapyCentral cathetersElevated mean platelet volumeMean platelet volumeIntensive care unitMichigan Appropriateness GuideMedian agePlatelet volumePediatric guidelinesClinical trialsIntravenous cathetersCare unitInfantsMedical recordsElectronic medical recordsTherapyCatheterAvailability of patientsAntiplateletDaysAssociation between fine particulate matter (PM2.5) and severity of acute respiratory infections among young US children in the major cities in the United States: a claims-based cohort study
Foo D, Regan A, Heo S, Schneider E, Canner J, Song Y, Bell M. Association between fine particulate matter (PM2.5) and severity of acute respiratory infections among young US children in the major cities in the United States: a claims-based cohort study. Open Forum Infectious Diseases 2025, ofaf442. DOI: 10.1093/ofid/ofaf442.Peer-Reviewed Original ResearchShort-term PM2.5 exposurePM2.5 exposureShort-term exposure to fine particulate matterIntensive care unitPrescription claimsClaims-based cohort studyExposure to fine particulate matterInterquartile range increaseAcute respiratory infectionsYoung US childrenChildren aged <5 yearsHealth insurance plansRisk of ICU admissionHospital-admittedLength of stayUS childrenInfluenza vaccination statusRange increasePrivate health insurance plansArea levelSeverity of acute respiratory infectionsHospital admissionCohort studyGeneralized linear modelInsurance plansThe SEDS score: A daily severity score for monitoring patients with refractory SE in the ICU
Damien C, Habryka S, Torcida N, Wang L, Legros B, Yuan F, Gaspard N. The SEDS score: A daily severity score for monitoring patients with refractory SE in the ICU. Seizure 2025, 131: 344-350. PMID: 40811895, DOI: 10.1016/j.seizure.2025.07.011.Peer-Reviewed Original ResearchConceptsRefractory status epilepticusWeek of intensive care unitArea under the receiver operating characteristic curveIntensive care unitSequential Organ Failure AssessmentIntensive care unit admissionDaily severity scoreValidation cohortDerivation cohortRSE episodesSeverity scoreSequential Organ Failure Assessment scoreOrgan Failure AssessmentTertiary-care centerRetrospective observational studyReceiver operating characteristic curveC-reactive proteinMann-Whitney testOperating characteristics curveRefractory SEPrognostic scoreSOFA scoreCRP levelsStatus epilepticusPoor outcomePrevalence of Critical Congenital Heart Defects Among Neonates Born With Abdominal Wall Defects
Hellmann Z, Buu L, Rehman S, Thaxton C, Solomon D, Cowles R. Prevalence of Critical Congenital Heart Defects Among Neonates Born With Abdominal Wall Defects. Prenatal Diagnosis 2025, 45: 1115-1121. PMID: 40670328, DOI: 10.1002/pd.6861.Peer-Reviewed Original ResearchConceptsCritical congenital heart defectsNeonatal intensive care unitPediatric Health Information SystemNeonatal intensive care unit admissionCongenital heart defectsOpen cardiac surgeryCardiac surgeryHeart defectsConcomitant diagnosisNeonatal intensive care unit populationPediatric Health Information System hospitalsDiagnosis of gastroschisisGeneral populationIntensive care unitRate of gastroschisisAbdominal wall defectsIndex hospital admissionHigher RatesLive birthsGastroschisisCare unitNeonatesWall defectsHospital admissionAdmissionTransfusion Medicine in the Pediatric Intensive Care Unit
Labarinas S, Karam O. Transfusion Medicine in the Pediatric Intensive Care Unit. 2025, 643-656. DOI: 10.1007/978-3-031-64762-8_40.Peer-Reviewed Original Research
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