2025
Endovascular management of tandem occlusions: current evidence and future directions
Krothapalli N, Heit J, de Havenon A, Singhal A, Sussman E, Hasan D, Mac Grory B. Endovascular management of tandem occlusions: current evidence and future directions. Journal Of NeuroInterventional Surgery 2025, jnis-2025-023793. PMID: 40780815, PMCID: PMC12338063, DOI: 10.1136/jnis-2025-023793.Peer-Reviewed Original ResearchRandomized Controlled TrialsEndovascular thrombectomyEndovascular managementAssociated with high mortalityArtery steno-occlusionOptimal antithrombotic therapyStandard treatment approachExtracranial carotid lesionsIntracranial revascularizationAntithrombotic therapyClot burdenTandem occlusionSteno-occlusionClinical predicamentCarotid lesionsIntravenous thrombolysisOptimal managementOcclusion strokeObservational studyPractice patternsControlled TrialsTreatment approachesHigher mortalityAnterograde flowNarrative reviewProject HERO: a randomized trial of Tai Chi qigong versus intensity-matched exercise and usual care for fatigue in older male cancer survivors
Kinney A, An J, Lin Y, Tundealao S, Saraiya B, Lu S, Guest D, Harding E, Amorim F, Heidt E, Arana-Chicas E, Chen C, Boyce T, Kim I, Arap W, Blair C, Irwin M. Project HERO: a randomized trial of Tai Chi qigong versus intensity-matched exercise and usual care for fatigue in older male cancer survivors. BMC Complementary Medicine And Therapies 2025, 25: 239. PMID: 40616105, PMCID: PMC12228344, DOI: 10.1186/s12906-025-04988-7.Peer-Reviewed Original ResearchConceptsTai chi qigongMale cancer survivorsCancer survivorsUsual careMind-body exercise interventionSupervised group exercise programHealth-related quality of lifeAssociated with psychological distressGroup exercise programHealth-related qualityCancer-related symptomsPatient-reported fatigueQuality of lifeRandomized Controlled TrialsExercise interventionExercise programCohort of menPost-interventionPsychological distressEmotional healthUnmet needsIntensity-matchedQigongThree-armSleep qualityConsensus Guideline for the Management of Gastric Cancer with Synchronous Peritoneal Metastases
Butensky S, Bansal V, Su D, Waheed M, Nikiforchin A, Gomez-Mayorga J, Olecki E, Radomski S, Sun B, Turaga K, Gunderson C, Lacy J, Badgwell B, In H, Kennedy T, Yoon H, Greer J, Sundar R, Woo Y. Consensus Guideline for the Management of Gastric Cancer with Synchronous Peritoneal Metastases. Annals Of Surgical Oncology 2025, 1-18. PMID: 40560499, DOI: 10.1245/s10434-025-17361-2.Peer-Reviewed Original ResearchSynchronous peritoneal metastasesCytoreductive surgeryPeritoneal metastasisConsensus guidelinesLow peritoneal carcinomatosis indexPeritoneal carcinomatosis indexManagement of gastric cancerMultidisciplinary preoperative assessmentLimited treatment optionsNon-surgical managementLevel of evidenceClinical management pathwaysDiagnostic laparoscopyRandomized Controlled TrialsSystemic therapySurvival benefitPreoperative assessmentDisease subsetsTreatment optionsClinical trialsGastric cancerPathway blockBurden of diseasePatientsBackgroundGastric cancerConsensus guideline for the management of gastric cancer with synchronous peritoneal metastases
Butensky S, Bansal V, Su D, Waheed M, Nikiforchin A, Gomez‐Mayorga J, Olecki E, Radomski S, Sun B, Turaga K, Gunderson C, Lacy J, Badgwell B, In H, Kennedy T, Yoon H, Greer J, Sundar R, Woo Y, Group P. Consensus guideline for the management of gastric cancer with synchronous peritoneal metastases. Cancer 2025, 131: e35870. PMID: 40558029, DOI: 10.1002/cncr.35870.Peer-Reviewed Original ResearchConceptsSynchronous peritoneal metastasesManagement of gastric cancerPeritoneal metastasisGastric cancerCytoreductive surgeryConsensus guidelinesLow peritoneal carcinomatosis indexPeritoneal carcinomatosis indexMultidisciplinary preoperative assessmentLimited treatment optionsPatient's goals of careLevel of evidenceGoals of careClinical management pathwaysCytology-negativeCytology-positiveRandomized Controlled TrialsDiagnostic laparoscopySystemic therapySurvival benefitBurden of diseasePreoperative assessmentNonsurgical managementDisease subsetsTreatment options1186-P: A Short-Term Low Carbohydrate Diet Improves Glycemia in Adolescents and Young Adults with Type 1 Diabetes—Results from a Randomized Crossover Study
NALLY L, LUKASIK J, HERZOG R, MITTENDORFER B, GOSS A, SAVOYE M, ROSE P, MCCOLLUM S, SHABANOVA V, SHERR J. 1186-P: A Short-Term Low Carbohydrate Diet Improves Glycemia in Adolescents and Young Adults with Type 1 Diabetes—Results from a Randomized Crossover Study. Diabetes 2025, 74 DOI: 10.2337/db25-1186-p.Peer-Reviewed Original ResearchLow-carbohydrate dietRandomized Crossover StudyCrossover studyCarbohydrate dietPotential treatment optionStandard carbohydrate dietLower glycemic variabilityRandomized Controlled TrialsDietary recallsMetabolic kitchenTreatment optionsIncreasing hypoglycemiaImprove glycemiaGlycemic variabilityControlled TrialsT1DGlycemic benefitsWeekend daysHypoglycemiaIncreasing timeYoung adultsDietYouthGlycemiaHyperglycemiaSystematic Review and Meta‐Analysis of Dual‐Layered Stents Versus Single‐Layered Stents for Carotid Artery Stenosis
Mari T, Moeed A, Siddiqui A, Abbasi A, Arif Z, Jannat A, Akman Z, Rossi R, Unnar H, Bhatti H, Batool R, Khan M, Ali M, Batool F, Minahil, Iqbal J, Mena‐Hurtado C, Nanna M. Systematic Review and Meta‐Analysis of Dual‐Layered Stents Versus Single‐Layered Stents for Carotid Artery Stenosis. Catheterization And Cardiovascular Interventions 2025 PMID: 40518749, DOI: 10.1002/ccd.31684.Peer-Reviewed Original ResearchCarotid artery stentingCarotid artery stenosisSingle-layer stentsDual-layer stentsAll-Cause MortalityPost-procedural strokeArtery stenosisRandomized Controlled TrialsStent occlusionHigher risk of peri-procedural strokePostprocedural strokeMeta-analysisRisk of peri-procedural strokeRisk ratioHigh riskCarotid artery stenting proceduresStroke riskPeri-procedural strokeRandom-effects meta-analysisPredictors of strokeTreat carotid artery stenosisLipid-rich carotid plaquesTreatment optionsArtery stentingPrimary outcomeRandomized Controlled Trial of Weight Management Versus Weight Management With Concurrent Cognitive‐Behavioral Therapy for Binge‐Eating Disorder in US Veterans With High Weight
Masheb R, Buta E, Snow J, Munro L, Lawless M, Abel E, McWain N, Marsh A, Cary A, Grilo C, Raffa S, Ruser C. Randomized Controlled Trial of Weight Management Versus Weight Management With Concurrent Cognitive‐Behavioral Therapy for Binge‐Eating Disorder in US Veterans With High Weight. International Journal Of Eating Disorders 2025 PMID: 40485646, DOI: 10.1002/eat.24476.Peer-Reviewed Original ResearchDSM-5 binge-eating disorderBinge-eating disorderDSM-5Cognitive-behavioral therapyEating-disorder treatmentRemission rateUS military veteransBinge-eating frequencyMilitary veteransCBTVeteran populationShape-relatedVeteransWeight managementPost-treatmentWeight management programUS veteransMixed-effects modelsDisordersRandomized Controlled TrialsClinical Trials Registry numberPsychopathologyBinge-eatingWeight lossClinical guidanceA systematic review of anti-suicidal effects of sedative-hypnotics and cognitive behavioral therapy for insomnia
Valentino K, Teopiz K, Wong S, Le G, Badulescu S, Johnson D, Ho R, Rhee T, Cao B, Rosenblat J, Mansur R, McIntyre R. A systematic review of anti-suicidal effects of sedative-hypnotics and cognitive behavioral therapy for insomnia. CNS Spectrums 2025, 30: e45. PMID: 40452498, DOI: 10.1017/s1092852925000318.Peer-Reviewed Original ResearchConceptsColumbia-Suicide Severity Rating ScaleOrexin receptor antagonistsScale for Suicide IdeationCognitive behavioral therapySuicidal ideationCBT-ISedative-hypnoticsBehavioral therapySuicide completersSuicide attemptsReducing depressive symptom severityEffects of sedative-hypnoticsDepressive symptom severityMeasures of suicidalitySeverity Rating ScaleRisk of suicideSleep-related interventionsAssociated with reduced SIComorbid insomniaSuicidal thoughtsSymptom severityRandomized Controlled TrialsTreating insomniaRating ScaleSleep interventionsReducing Self-Stigma Among Survivors of Childhood Maltreatment: Randomized Controlled Trial of a Brief Video Intervention
Haim-Nachum S, Martin A, Fisch C, Lazarov A, Neria Y, Amsalem D. Reducing Self-Stigma Among Survivors of Childhood Maltreatment: Randomized Controlled Trial of a Brief Video Intervention. Psychological Trauma Theory Research Practice And Policy 2025, 17: s186-s195. PMID: 39786857, DOI: 10.1037/tra0001805.Peer-Reviewed Original ResearchReduce self-stigmaSelf-StigmaRandomized Controlled TrialsTreatment-seekingIntervention groupSurvivors of childhood maltreatmentVideo interventionCM survivorsSocial contact-based interventionsChildhood maltreatmentSelf-stigma scoresExperience self-stigmaContact-based interventionsHistory of CMControl group participantsVideo-based interventionFollow-up assessmentReduce stigmaExacerbate psychiatric distressPsychiatric distressGroup participantsControlled TrialsDaily activitiesSelf-BlameInterventionParent engagement with a short, animated storytelling video aimed at reducing stigma towards transgender children and adolescents: Post-trial assessment of a randomized controlled trial
Greuel M, Amsalem D, Seeff M, Gates J, Liu S, Martin A, Bärnighausen T, Adam M. Parent engagement with a short, animated storytelling video aimed at reducing stigma towards transgender children and adolescents: Post-trial assessment of a randomized controlled trial. SSM - Mental Health 2025, 7: 100410. DOI: 10.1016/j.ssmmh.2025.100410.Peer-Reviewed Original ResearchReduce stigmaSAS videosAssociated with sociodemographic factorsAdverse health outcomesUS parentsControl groupPost-trial assessmentRandomized Controlled TrialsStigma ScaleHealth outcomesSociodemographic factorsChi-square testReduce transphobiaPearson correlation testMale participantsPost-trial accessDemographic characteristicsStigmaVulnerable groupsParental engagementTest engagementParticipantsFemale subjectsInterventionCorrelation testAn Evaluation a PrEP-Focused HIV Prevention Intervention Tailored for Individuals with Opioid Use Disorder and Cognitive Dysfunction
Mistler C, Huedo-Medina T, Shrestha R, Gunstad J, Zelenev A, Copenhaver M. An Evaluation a PrEP-Focused HIV Prevention Intervention Tailored for Individuals with Opioid Use Disorder and Cognitive Dysfunction. Neuropsychiatric Disease And Treatment 2025, 21: 1235-1248. PMID: 40584207, PMCID: PMC12205702, DOI: 10.2147/ndt.s490266.Peer-Reviewed Original ResearchHIV risk behaviorsImprove HIV prevention effortsRisk behaviorsHIV prevention outcomesHIV prevention effortsPre-exposure prophylaxisExperimental group participantsCognitive dysfunctionRandomized Controlled TrialsLongitudinal regression analysisPrEP knowledgeIntervention tailoringPrEP outcomesIntervention effectsAdherence skillsPrevention outcomesOpioid use disorderGroup participantsPrevention effortsCompensatory strategiesCondom skillsMOUD patientsOutcome variablesInterventionMOUDThe landscape and effectiveness of patient retention strategies in cancer clinical trials.
Weintraub L, Karol A, Paredes R, Argulian A, Oguntuyo K, Miller J, Fujiwara Y, Joshi H, Doroshow D, Galsky M. The landscape and effectiveness of patient retention strategies in cancer clinical trials. Journal Of Clinical Oncology 2025, 43 DOI: 10.1200/jco.2025.43.16_suppl.e23005.Peer-Reviewed Original ResearchTherapeutic cancer clinical trialsCancer clinical trialsRetention strategiesRate ratiosSupportive care trialsConfidence intervalsPatient education materialsEfficacy of current practicesBenefits of participationRandomized Controlled TrialsCare trialsClinical trialsPatient retentionReduced generalizabilityContact patientsUnivariate linear regressionInclusion criteriaPersonalized interventionsEducational materialsControlled TrialsIncreased likelihoodMulti-siteProtocol documentsSupportive careCurrent practicesUtilizing peer educators to increase genetic testing for prostate cancer among black males: results of a randomized controlled trial
Leader A, Godbolt J, Crumpler N, Gross L, Hartman R, Keith S, Giri V. Utilizing peer educators to increase genetic testing for prostate cancer among black males: results of a randomized controlled trial. Journal Of The National Medical Association 2025 PMID: 40447525, DOI: 10.1016/j.jnma.2025.05.005.Peer-Reviewed Original ResearchPeer educatorsGenetic testingBenefits of genetic testingRates of genetic testingGroup-based discussionsBlack malesIncreased genetic testingPeer-based strategiesProstate cancerRandomized Controlled TrialsDecisional conflictIntervention armEducational interventionCommunity settingsEndpoint surveyControl armEducational materialsGenetic counselingDecreased intentionIncreased intentionStudy armsInformation materialsInterventionEducationComplex decisionsImmune checkpoint inhibitor (ICI) efficacy in triple-negative breast cancer (TNBC) patients with liver metastases (LM): A meta-analysis.
Park D, Abid M, Lustberg M, Kalinski P, Gandhi S, Huang C. Immune checkpoint inhibitor (ICI) efficacy in triple-negative breast cancer (TNBC) patients with liver metastases (LM): A meta-analysis. Journal Of Clinical Oncology 2025, 43: e13131-e13131. DOI: 10.1200/jco.2025.43.16_suppl.e13131.Peer-Reviewed Original ResearchProgrammed death-ligand1Triple-negative breast cancerImmune checkpoint inhibitorsProgression free survivalLiver metastasesHazard ratioBreast cancerEfficacy of immune checkpoint inhibitorsTriple-negative breast cancer casesLog-transformed hazard ratioProgression free survival benefitImmune checkpoint inhibitor therapyAssociated with poor prognosisSite of diseaseAggressive breast cancerMeta-analysisArea of translational researchRandom-effects modelCheckpoint inhibitorsRandomized Controlled TrialsSystematic literature searchFree survivalOverall survivalDistant metastasisImmunocompromised stateThe efficacy of lithium in the treatment of suicidal ideation, behavior and suicide: An updated systematic review and meta-analysis of randomized controlled trials
Wang J, Le G, Wong S, Teopiz K, Kwan A, Rosenblat J, Rhee T, Ho R, Lo H, Goldberg J, Vinberg M, Grande I, Mansur R, Meyer J, McIntyre R. The efficacy of lithium in the treatment of suicidal ideation, behavior and suicide: An updated systematic review and meta-analysis of randomized controlled trials. Journal Of Affective Disorders 2025, 387: 119487. PMID: 40441661, DOI: 10.1016/j.jad.2025.119487.Peer-Reviewed Original ResearchConceptsSuicidal ideationBipolar disorderSuicide attemptsCompleted SuicideTreatment of suicidal ideationTreating acute maniaRate of completed suicideAnti-suicidal effectsEfficacy of lithiumAcute maniaDiagnostic heterogeneityBD-I.Randomized Controlled TrialsTreatment fidelitySuicide measuresLithium effectsSuicideIdeationLithium levelsMethodological limitationsAssociated with nonsignificant reductionsMeta-analysis of randomized controlled trialsControlled TrialsFirst-line treatmentMeta-analysisPsychosocial burden of axial spondyloarthritis and impact of different disease domains: a systematic literature review
Poddubnyy D, Kiltz U, Danve A, Wright G, Haberman R, Biljan A, Clewell J, Urbanik J, Jones H, Magrey M. Psychosocial burden of axial spondyloarthritis and impact of different disease domains: a systematic literature review. Rheumatology Advances In Practice 2025, 9: rkaf063. PMID: 40584930, PMCID: PMC12202762, DOI: 10.1093/rap/rkaf063.Peer-Reviewed Original ResearchRandomized Controlled TrialsPsychosocial outcomesDisease burdenHolistic treatment of patientsDisease domainsAxial spondyloarthritisPoor psychosocial outcomesDomains of disease activityOverall disease burdenPhysical functionPsychosocial burdenPsychosocial impactSystematic literature reviewHolistic treatmentLiterature searchAxSpAPsychosocial impairmentMorning stiffnessOverall functionOutcomesBidirectional relationshipLiterature reviewBurdenTNF inhibitor treatmentOptimal treatment responseIs there harm in behavioral lifestyle weight management for binge-eating disorder in patients with obesity: Findings from a randomized controlled trial
Grilo C, Ivezaj V, Yurkow S, Lydecker J. Is there harm in behavioral lifestyle weight management for binge-eating disorder in patients with obesity: Findings from a randomized controlled trial. Journal Of Psychosomatic Research 2025, 195: 112169. PMID: 40516275, DOI: 10.1016/j.jpsychores.2025.112169.Peer-Reviewed Original ResearchEating-disorder psychopathologyBinge-eating disorderIncreased symptomsSymptoms of binge eatingRandomized Controlled TrialsBinge-eating frequencyBinge eatingPsychopathologyRandomized to placeboBinge-eatingWeight managementPlaceboHeterogeneity of outcomesDisordersParticipantsPosttreatmentSecondary analysisFrequency of casesSymptomsClinical contextIndividual levelObesityControlled TrialsSmall magnitudePatientsTAVR vs. SAVR for severe aortic stenosis in the low and intermediate surgical risk population: An updated meta-analysis, meta-regression, and trial sequential analysis
Krishna M, Joseph M, Ezenna C, Pereira V, Rossi R, Akman Z, Rubens M, Mahadevan V, Nanna M, Goldsweig A. TAVR vs. SAVR for severe aortic stenosis in the low and intermediate surgical risk population: An updated meta-analysis, meta-regression, and trial sequential analysis. Cardiovascular Revascularization Medicine 2025 PMID: 40425422, DOI: 10.1016/j.carrev.2025.05.021.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve replacementPatient-prosthesis mismatchIntermediate surgical riskSevere patient-prosthesis mismatchAcute kidney injuryAortic valve replacementPermanent pacemaker implantationRandomized Controlled TrialsSurgical riskParavalvular leakFollow-upValve replacementPacemaker implantationAtrial fibrillationClinical outcomes of transcatheter aortic valve replacementOutcomes of transcatheter aortic valve replacementRate of permanent pacemaker implantationSafety of transcatheter aortic valve replacementBenefits of transcatheter aortic valve replacementNew-onset atrial fibrillationRates of all-cause deathAortic valve reinterventionNew-onset AFSevere aortic stenosis0740 Loop Gain Predicts Residual Sleep Apnea Events Among People Using Positive Airway Pressure
Eschbach E, Kushida C, Peker Y, Xu Z, Deng A, Azarbarzin A, Wellman A, Yaggi H, Sands S, Zinchuk A. 0740 Loop Gain Predicts Residual Sleep Apnea Events Among People Using Positive Airway Pressure. Sleep 2025, 48: a321-a321. DOI: 10.1093/sleep/zsaf090.0740.Peer-Reviewed Original ResearchPositive airway pressureObstructive sleep apneaPositive airway pressure therapyBody mass indexSleep apneaBaseline AHIPAP therapyAirway pressurePharyngeal collapseIncreased riskOdds ratioPositive airway pressure devicesAssociated with increased riskCoronary artery diseaseSleep apnea eventsEpisodic airway obstructionBaseline polysomnogramRandomized Controlled TrialsBaseline polysomnographyHigh LGAdjunctive therapyAirway obstructionUpper airwayMass indexApneaBiosocial Variation in Treatment Response to GLP-1s: Implications for Clinical Care and Health Policy
Horwitz R, Otaka S, Conroy A, Cullen M, Matory A, Singer B, Sim I. Biosocial Variation in Treatment Response to GLP-1s: Implications for Clinical Care and Health Policy. The American Journal Of Medicine 2025 PMID: 40393609, DOI: 10.1016/j.amjmed.2025.05.016.Peer-Reviewed Original ResearchTreatment-resistant obesityTrajectory of obesityResponse to treatmentObesity-related disordersRandomized Controlled TrialsReal-world evidence studiesTreatment responseClinical managementEvidence studiesGLP-1sControlled TrialsPatientsObesityWeight lossBody weightPathogenesisAverage treatment responseHealth policyTreatmentPhysiological systems
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