2025
Incidence and predictors of immune checkpoint inhibitor treatment–related cognitive impairment in a racial and ethnic diverse population
Sayer M, Agrawal P, Ng D, Kagramanov D, Trudeau J, Othy S, Acharya M, Chan A. Incidence and predictors of immune checkpoint inhibitor treatment–related cognitive impairment in a racial and ethnic diverse population. Supportive Care In Cancer 2025, 33: 523. PMID: 40451933, PMCID: PMC12127230, DOI: 10.1007/s00520-025-09560-0.Peer-Reviewed Original ResearchConceptsIntroductionImmune checkpoint inhibitorsTherapy initiationPatient-reported outcomesGeneralized Estimating EquationsSignificant cognitive impairmentICI-treated patientsAnti-cancer immunityClinically significant cognitive impairmentCognitive functionCognitive impairmentTreatment-related cognitive impairmentPhysical functionCheckpoint inhibitorsMild to severe symptomsImpaired physical functionRisk patientsImmune dysregulationConcurrent symptomsInflammatory biomarkersPatient characteristicsSymptom scoresCancer therapyCognitive function scoresT-scoreTherapyPregnancy outcomes with increasing maternal age, greater than 40 years, in donor oocyte cycles
Sabbagh R, Meyers A, Korkidakis A, Heyward Q, Penzias A, Sakkas D, Vaughan D, Toth T. Pregnancy outcomes with increasing maternal age, greater than 40 years, in donor oocyte cycles. Human Reproduction 2025, deaf044. PMID: 40112875, DOI: 10.1093/humrep/deaf044.Peer-Reviewed Original ResearchFrozen donor oocytesDonor oocytesLive birthsMaternal ageAge groupsGeneralized Estimating EquationsDonor oocyte cyclesPaternal ageReference group of patientsPreimplantation genetic testingOutcome of IVFMinority of patientsIncreasing maternal ageRetrospective cohort studyGroup of patientsStudy periodPerinatal outcomesPGT-ALB rateOocyte cyclesPregnancy outcomesIVF outcomesOocyte qualityOlder age groupsFUNDING/COMPETING INTEREST(SPeriods of susceptibility for associations between phthalate exposure and preterm birth: Results from a pooled analysis of 16 US cohorts
Friedman A, Welch B, Keil A, Bloom M, Braun J, Buckley J, Dabelea D, Factor-Litvak P, Meeker J, Michels K, Padmanabhan V, Starling A, Weinberg C, Aalborg J, Alshawabkeh A, Barrett E, Binder A, Bradman A, Bush N, Calafat A, Cantonwine D, Christenbury K, Cordero J, Engel S, Eskenazi B, Harley K, Hauser R, Herbstman J, Holland N, James-Todd T, Jukic A, Lanphear B, McElrath T, Messerlian C, Newman R, Nguyen R, O'Brien K, Rauh V, Redmon J, Rich D, Rosen E, Sathyanarayana S, Schmidt R, Sparks A, Swan S, Wang C, Watkins D, Weinberger B, Wenzel A, Wilcox A, Yolton K, Zhang Y, Zota A, Ferguson K. Periods of susceptibility for associations between phthalate exposure and preterm birth: Results from a pooled analysis of 16 US cohorts. Environment International 2025, 198: 109392. PMID: 40132438, PMCID: PMC12021553, DOI: 10.1016/j.envint.2025.109392.Peer-Reviewed Original ResearchUrinary phthalate metabolite concentrationsPreterm birthPhthalate metabolite concentrationsGeneralized Estimating EquationsPhthalate metabolitesOdds ratioMono (2-ethylhexyl) phthalateUS cohortAssociation of preterm birthPhthalate exposureAssociated with preterm birthAssociated with odds ratiosInterquartile range increaseMetabolite concentrationsIndividual-level dataLogistic regression modelsThird trimesterTrimester-specific associationsMechanism of actionPretermPeriod of susceptibilityTime of exposurePooled analysisTrimesterTrimester exposureThe Natural History of Congenital Hepatic Hemangiomas
Ostertag-Hill C, Fevurly R, Kulungowski A, Christison-Lagay E, McGuire A, Rialon K, Duggan E, Murillo R, Zurakowski D, Staffa S, Alomari A, Kozakewich H, Al-Ibraheemi A, Fishman S, Dickie B. The Natural History of Congenital Hepatic Hemangiomas. The Journal Of Pediatrics 2025, 281: 114523. PMID: 40023218, DOI: 10.1016/j.jpeds.2025.114523.Peer-Reviewed Original ResearchCongenital hepatic hemangiomasCongenital HHHepatic hemangiomaMedical therapyRetrospective review of patientsNatural historyReview of patientsKaplan-Meier curvesMonths of ageCongenital hemangiomaRetrospective reviewClinical presentationRespiratory failureClinical behaviorHeart failureHH volumeHistological findingsEarly recognitionResidual volumeGeneralized Estimating EquationsIncorrect diagnosisHemangiomaPatientsNo differenceRate of involutionRelationships between patient‐reported and clinician‐rated toxicities and daily functioning in older adults with advanced cancer undergoing systemic therapy
Culakova E, Mohamed M, Flannery M, Jensen‐Battaglia M, Zhang Z, Ramsdale E, Tylock R, Stauffer F, Wells M, Magnuson A, Loh K, Gada U, Janelsins M, Mohile S. Relationships between patient‐reported and clinician‐rated toxicities and daily functioning in older adults with advanced cancer undergoing systemic therapy. Cancer 2025, 131: e35766. PMID: 39945245, PMCID: PMC11822747, DOI: 10.1002/cncr.35766.Peer-Reviewed Original ResearchConceptsActivities of daily livingInstrumental ADLOlder adultsPatient-reported toxicityAdvanced cancerPhysical performanceActivities of daily living impairmentPRO-CTCAEInstrumental activities of daily livingShort Physical Performance BatteryImpaired activities of daily livingFunctional declineMitigate functional declinePhysical Performance BatteryImpaired instrumental ADLSystemic therapyGeneralized Estimating EquationsClinician-ratedIADL impairmentPerformance BatteryRisk of treatment-related toxicityDaily livingMonths of treatment initiationPatient reportsTreatment-related toxicityHousehold transmission of SARS-CoV-2 in five US jurisdictions: Comparison of Delta and Omicron variants
Baker J, Nakayama J, O’Hegarty M, McGowan A, Teran R, Bart S, Sosa L, Brockmeyer J, English K, Mosack K, Bhattacharyya S, Khubbar M, Yerkes N, Campos B, Paegle A, McGee J, Herrera R, Pearlowitz M, Williams T, Kirking H, Tate J. Household transmission of SARS-CoV-2 in five US jurisdictions: Comparison of Delta and Omicron variants. PLOS ONE 2025, 20: e0313680. PMID: 39787187, PMCID: PMC11717262, DOI: 10.1371/journal.pone.0313680.Peer-Reviewed Original ResearchConceptsPublic health jurisdictionsTransmission riskGeneralized Estimating EquationsHealth jurisdictionsSARS-CoV-2 transmissionSARS-CoV-2Household contactsIndex casePrevention strategiesRisk estimatesImpact SARS-CoV-2 transmissionConfidence intervalsSymptom statusMultivariate modelUS jurisdictionsSARS-CoV-2 DeltaEstimate differencesHousehold transmission rateOmicron variantSocial factorsSource of SARS-CoV-2 transmissionCOVID-19 vaccine dosesSARS-CoV-2 variantsRiskSymptomatic index casesActivity Space Mapping and Pre-Exposure Prophylaxis Uptake Among Gay, Bisexual, and Other Sexual Minority Men in Small Cities and Towns in the United States
Takenaka B, Barbour R, Kirklewski S, Nicholson E, Tengatenga C, Hansen N, Kershaw T. Activity Space Mapping and Pre-Exposure Prophylaxis Uptake Among Gay, Bisexual, and Other Sexual Minority Men in Small Cities and Towns in the United States. AIDS And Behavior 2025, 29: 1266-1280. PMID: 39745597, DOI: 10.1007/s10461-024-04601-x.Peer-Reviewed Original ResearchPrEP uptakeGeneralized Estimating EquationsSmall citiesActive spaceSpaces of participationPre-exposure prophylaxis uptakeHealth promotion resourcesPre-exposure prophylaxisLongitudinal cohort studyState of residenceGetis-Ord Gi statisticsGeographical inequalitiesGrowing body of literatureAdministrative boundariesBody of literaturePrEP useHIV preventionLocal spaceGetis-Ord GiGayUnmet needsStructural interventionsGeographical factorsCohort studyDriving time
2024
Ectopic pregnancy is associated with increased risk of displaced implantation window: a retrospective study
Zeng H, Chang Y, Liu N, Li S. Ectopic pregnancy is associated with increased risk of displaced implantation window: a retrospective study. BMC Pregnancy And Childbirth 2024, 24: 839. PMID: 39707276, PMCID: PMC11661333, DOI: 10.1186/s12884-024-07072-z.Peer-Reviewed Original ResearchConceptsAssisted Reproductive TechnologyBody mass indexAssociated with increased riskPrimary infertilityEmbryo transferEctopic pregnancy historyEctopic pregnancyReproductive Medicine CenterRetrospective studyStatistical significanceGeneralized Estimating EquationsInfertility typeHigher Body Mass IndexReproductive technologySecondary infertilityInfertilityPregnancy historyImplantation windowImplant failureMass indexXiangya HospitalAdvanced ageIncreased riskPatientsPregnancySocio-economic factors associated with cancer stigma among apparently healthy women in two selected municipalities Nepal
Paneru B, Karmacharya A, Makaju S, Kafle D, Poudel L, Mali S, Timsina P, Shrestha N, Timalsena D, Chaudhary K, Bhandari N, Rai P, Shakya S, Spiegelman D, Sheth S, Stangl A, Eastment M, Shrestha A. Socio-economic factors associated with cancer stigma among apparently healthy women in two selected municipalities Nepal. PLOS ONE 2024, 19: e0301059. PMID: 39680514, PMCID: PMC11649127, DOI: 10.1371/journal.pone.0301059.Peer-Reviewed Original ResearchConceptsCancer Stigma ScaleCancer stigmaMean stigma scoreGeneralized Estimating EquationsStigma scoresDomains of stigmaPublic health researchSocio-demographic factorsCross-sectional studyStigma ScaleMultivariate linear regressionHealthy womenLower educationHealth researchMarital statusCause of deathStigmaLow overall prevalenceEstimating EquationsFemale populationLikert scalePrimary cause of deathOverall prevalenceOlder ageScoresMaternal self‐efficacy during infancy: Investigating the roles of depression and social support among mothers in rural Pakistan
Frost A, Hagaman A, Haight S, Ikram N, Turner L, Bhalotra S, Sikander S, Maselko J. Maternal self‐efficacy during infancy: Investigating the roles of depression and social support among mothers in rural Pakistan. Infant Mental Health Journal Infancy And Early Childhood 2024, 46: 85-94. PMID: 39614836, DOI: 10.1002/imhj.22146.Peer-Reviewed Original ResearchMaternal self-efficacyAssociated with increased self-efficacySocial supportSelf-EfficacyMonths postpartumEmotional supportRural PakistanMaternal mental healthChildcare supportInterview measures of depressionEmotional social supportMother's self-efficacyGeneralized Estimating EquationsMeasures of depressionMothers of infantsMental healthInterview measuresPostpartumDepressionWeak evidenceMothersChildcare tasksChildcareParticipantsSupportPhenotypes of sleep health among adults with chronic heart failure in a randomized controlled trial of cognitive behavioral therapy for insomnia
Jeon S, Conley S, O'Connell M, Wang Z, Redeker N. Phenotypes of sleep health among adults with chronic heart failure in a randomized controlled trial of cognitive behavioral therapy for insomnia. Sleep Health 2024, 10: 705-712. PMID: 39482227, PMCID: PMC11624990, DOI: 10.1016/j.sleh.2024.09.006.Peer-Reviewed Original ResearchEmergency department visitsRandomized controlled trial of cognitive behavioral therapyCognitive behavioral therapyTrial of cognitive behavioral therapyDepartment visitsHealth phenotypesRandomized Controlled TrialsBehavioral therapyProportion of participantsGeneralized Estimating EquationsCox proportional hazards modelsProportional hazards modelCircadian quotientLinear mixed modelsLower fatigueGeneralized linear mixed modelsSecondary analysisWalking distanceSleep healthCollected hospitalFunctional performanceSleep phenotypesPoor sleepAdverse healthHeart failure outcomesA review of current practice in the design and analysis of extremely small stepped-wedge cluster randomized trials
Tong G, Nevins P, Ryan M, Davis-Plourde K, Ouyang Y, Macedo J, Meng C, Wang X, Caille A, Li F, Taljaard M. A review of current practice in the design and analysis of extremely small stepped-wedge cluster randomized trials. Clinical Trials 2024, 22: 45-56. PMID: 39377196, PMCID: PMC11810615, DOI: 10.1177/17407745241276137.Peer-Reviewed Original ResearchSmall-sample correctionsStepped-wedge cluster randomized trialCluster randomized trialSample size calculation methodGeneralized linear mixed modelsLongitudinal correlation structureSize calculation methodLinear mixed modelsPermutation testSample sizeBayesian approachRandomized trialsCorrelation structureMixed modelsBayesian analysisGeneralized Estimating EquationsPermutationMedian sample sizeIntervention conditionRandomization methodEquationsHow to achieve model-robust inference in stepped wedge trials with model-based methods?
Wang B, Wang X, Li F. How to achieve model-robust inference in stepped wedge trials with model-based methods? Biometrics 2024, 80: ujae123. PMID: 39499239, PMCID: PMC11536888, DOI: 10.1093/biomtc/ujae123.Peer-Reviewed Original ResearchConceptsTreatment effect estimandsWorking correlation structureSandwich variance estimatorExchangeable working correlation structureFunction of calendar timeEffect estimandsVariance estimationLink functionStepped wedge trialEstimandsTheoretical resultsCorrelation structureWedge trialsEstimating EquationsCluster randomized trialG-computationLinear mixed modelsInferencePotential outcomesMisspecificationEstimationEffective structureModel-based methodsGeneralized Estimating EquationsMixed modelsMediation analysis in longitudinal study with high-dimensional methylation mediators
Cui Y, Lin Q, Yuan X, Jiang F, Ma S, Yu Z. Mediation analysis in longitudinal study with high-dimensional methylation mediators. Briefings In Bioinformatics 2024, 25: bbae496. PMID: 39406521, PMCID: PMC11479716, DOI: 10.1093/bib/bbae496.Peer-Reviewed Original ResearchConceptsBody mass indexMediation analysisPaternal body mass indexGeneralized Estimating EquationsLinear mixed-effects modelsCohort dataMass indexMixed-effects modelsDNA methylation sitesHigh-dimensional mediation analysisLongitudinal studyBonferroni correctionAccurate parameter estimatesSobel testVariable selectionLongitudinal dataSimulation studyIndependence screeningMethylation sitesCpG sitesIndirect effectsParameter estimationLinearization methodHypothesis testingCamp-style lifestyle modification program (CAMP) for diabetes prevention among rural women with prior GDM: study protocol for a three-arm cluster hybrid type 2 randomized controlled trial
Chen Y, Zhong Q, Lv W, Long Q, Wang M, Chen J, Willey J, Whittemore R, Guo J. Camp-style lifestyle modification program (CAMP) for diabetes prevention among rural women with prior GDM: study protocol for a three-arm cluster hybrid type 2 randomized controlled trial. BMC Public Health 2024, 24: 2570. PMID: 39304869, PMCID: PMC11414119, DOI: 10.1186/s12889-024-20080-0.Peer-Reviewed Original ResearchConceptsIntensive lifestyle modificationLifestyle modification programLifestyle interventionGestational diabetes mellitusImplementation outcomesHealth consultationModification programCluster randomized clinical trialBackgroundIntensive lifestyle interventionsImprove postpartum careRandomized clinical trialsHealth promotion programsUsual care groupRisk of type 2 diabetes mellitusPrimary care settingIn-person sessionsEffective delivery modelsRisk of T2DMGestational diabetes mellitus historyGeneralized Estimating EquationsChinese Clinical Trial RegistryPostpartum careTechnology-based supportUsual careClinical Trials RegistryGroup cohesion and alliance predict cognitive-behavioral group treatment outcomes for youth with anxiety disorders
Fjermestad K, Wallin M, Naujokat F, McLeod B, Silverman W, Öst L, Lerner M, Heiervang E, Wergeland G. Group cohesion and alliance predict cognitive-behavioral group treatment outcomes for youth with anxiety disorders. Cognitive Behaviour Therapy 2024, 54: 96-114. PMID: 39105346, DOI: 10.1080/16506073.2024.2385906.Peer-Reviewed Original ResearchGroup cognitive behavioral therapyAnxiety disordersAnxiety symptomsDiagnostic recoveryParent-reported anxiety symptomsGroup cohesionCognitive behavioral therapyRandomized controlled effectiveness trialBehavioral therapyAlliance changeParent-reported outcomesEffectiveness trialClinical severityTreatment outcomesAnxietyPost-treatmentDisordersAllianceSymptomsYouthFollow-upGeneralized Estimating EquationsSeveritySessionsOutcomesSymptom Burden and Its Impact on Quality of Life in Patients With Moderate to Severe CKD: The International Chronic Kidney Disease Outcomes and Practice Patterns Study (CKDopps)
Speyer E, Tu C, Zee J, Sesso R, Lopes A, Moutard E, Omorou A, Stengel B, Finkelstein F, Pecoits-Filho R, de Pinho N, Pisoni R, Investigators C, Lopes A, Pecoits-Filho R, Combe C, Jacquelinet C, Massy Z, Stengel B, de Pinho N, Duttlinger J, Fliser D, Lonnemann G, Reichel H, Wada T, Yamagata K, Pisoni R, Robinson B, da Silva V, Sesso R, Speyer E, Asahi K, Hoshino J, Narita I, Perlman R, Port F, Sukul N, Wong M, Young E, Zee J. Symptom Burden and Its Impact on Quality of Life in Patients With Moderate to Severe CKD: The International Chronic Kidney Disease Outcomes and Practice Patterns Study (CKDopps). American Journal Of Kidney Diseases 2024, 84: 696-707.e1. PMID: 39117097, DOI: 10.1053/j.ajkd.2024.06.011.Peer-Reviewed Original ResearchSymptom burdenQuality of lifeSevere CKDKDQOL-SFND-CKDMental component summary scoresKDQOL-SF questionnaireSymptom burden scoresHigh symptom burdenComponent summary scoresAdjusted prevalence ratiosBurden of symptomsOverall symptom burdenNon-dialysis chronic kidney diseaseModerate to severe CKDND-CKD patientsPrevalence of symptomsPatient-reported symptomsGeneralized Estimating EquationsChronic kidney disease outcomesPrevalence of crampsChronic kidney diseaseMCS scoresKidney disease outcomesPoorer HRQoLAsymptomatic Rectal Bacterial Pathogens Show Large Prospective Relationships With HIV Incidence in a Cohort of Young Sexual and Gender Minorities: Implications for STI Screening and HIV Prevention
Baiers R, Ryan D, Clifford A, Munson E, D’Aquila R, Newcomb M, Mustanski B. Asymptomatic Rectal Bacterial Pathogens Show Large Prospective Relationships With HIV Incidence in a Cohort of Young Sexual and Gender Minorities: Implications for STI Screening and HIV Prevention. Open Forum Infectious Diseases 2024, 11: ofae444. PMID: 39183815, PMCID: PMC11342390, DOI: 10.1093/ofid/ofae444.Peer-Reviewed Original ResearchHIV seroconversionGeneralized Estimating EquationsChlamydia trachomatisNeisseria gonorrhoeaeHIV infectionPredictors of HIV seroconversionLongitudinal cohort studyPrevent HIV InfectionGender minoritiesSTI screeningRectal NGHIV preventionBiobehavioral interventionsHIV incidenceMultivariate GEE analysisAsymptomatic screeningMethods DataStatistically significant predictorsProspective relationshipHIVChicago metropolitan areaPredictive valueEstimating EquationsGEE analysisStatistically significant pairwise differencesElectronic Patient-Reported Outcome-Driven Symptom Management by Oncology Pharmacists in a Majority-Minority Population: An Implementation Study
Chan A, Ng D, Arcos D, Heshmatipour M, Lee B, Chen A, Duong L, Van L, Nguyen T, Green V, Hoang D. Electronic Patient-Reported Outcome-Driven Symptom Management by Oncology Pharmacists in a Majority-Minority Population: An Implementation Study. JCO Oncology Practice 2024, 20: 1744-1754. PMID: 39008806, PMCID: PMC11649175, DOI: 10.1200/op.24.00050.Peer-Reviewed Original ResearchConceptsOncology pharmacistsRacial/Ethnic MinoritiesSymptom managementImplementation outcomesPatient-Reported Outcomes Measurement Information System measuresImplementation studyRE-AIM frameworkSymptom management toolSevere pain interferenceUrgent care utilizationNon-Hispanic whitesSupportive care issuesGeneralized Estimating EquationsRE-AIMHealth disparitiesMultilevel interventionsPain interferenceCare utilizationNon-HispanicCare issuesSymptom screeningHigher RatesTreatment counselingSymptom assessmentSymptom trajectoriesP101 Sustained improvement in atopic dermatitis disease control and treatment satisfaction with dupilumab in clinical practice: 4-year follow-up results from the RELIEVE-AD study
Wang Z, Yang M, Chao J, Martins B, Chuang C, Shumel B, Sierka D, Carboni M, Strober B. P101 Sustained improvement in atopic dermatitis disease control and treatment satisfaction with dupilumab in clinical practice: 4-year follow-up results from the RELIEVE-AD study. British Journal Of Dermatology 2024, 191: i63-i64. DOI: 10.1093/bjd/ljae090.128.Peer-Reviewed Original ResearchAtopic dermatitisEpisodes of itchingTreatment satisfactionMonth 1Disease controlClinical practiceProportion of patientsPatient survey studyPercentage of patientsSustained improvementFollow-up resultsPrescribed dupilumabGeneralized Estimating EquationsQuality of lifePatient support programmeSingle-armDupilumabSkin symptomsBaseline surveyPatientsSupport programmesPatient satisfactionPractice guidelinesStatistical significanceMonths
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