2025
APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, de Havenon A, Hawkes M, Gilmore E, Schwamm L, Sheth K, Gill T, Falcone G. APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban. JAMA Neurology 2025, 82 PMID: 40549373, PMCID: PMC12186128, DOI: 10.1001/jamaneurol.2025.0182.Peer-Reviewed Original ResearchRisk of intracranial hemorrhagePopulation-based studyYears of follow-up dataApo E4Cox proportional hazards modelsAPOE e4 alleleIntracranial hemorrhageRisk prediction scoreCerebral amyloid angiopathyClinical decision-makingProportional hazards modelAtrial fibrillationIncreased risk of ICHMultivariate Cox proportional hazards modelMain OutcomesIncident intracranial hemorrhageEuropean ancestryCohort studyInclusion criteriaHistory of ischemic strokeAmyloid angiopathyE4 variantHazards modelIncreased riskE4 allelePerioperative Stroke: Mechanisms, Risk Stratification, and Management.
Shu L, Aziz Y, de Havenon A, Messe S, Nguyen T, Sur N, Xiong L, Yaghi S. Perioperative Stroke: Mechanisms, Risk Stratification, and Management. Stroke 2025 PMID: 40444359, DOI: 10.1161/strokeaha.125.051673.Peer-Reviewed Original ResearchCerebrovascular eventsPerioperative strokeProcedure-related risk factorsHigh-risk surgical interventionsPreoperative risk stratificationPatient-specific riskPrevalence of perioperative strokePerioperative ischemic strokeChronic vascular conditionsAging surgical populationComplexity of surgeryIncreased healthcare utilizationPostoperative settingSubstantial morbiditySurgical interventionIntraoperative hypotensionRisk stratificationSurgical populationAtrial fibrillationCardiovascular comorbiditiesIntraoperative techniquesCerebral embolismVascular manipulationAdvanced ageCarotid stenosisCurrent management of hypertrophic cardiomyopathy
Sikand N, Stendahl J, Sen S, Lampert R, Day S. Current management of hypertrophic cardiomyopathy. The BMJ 2025, 389: e077274. PMID: 40425241, DOI: 10.1136/bmj-2023-077274.Peer-Reviewed Original ResearchConceptsOutflow tract gradientObstructive hypertrophic cardiomyopathyHypertrophic cardiomyopathyAtrial fibrillationLeft ventricular outflow tract gradientNon-obstructive hypertrophic cardiomyopathyManagement of hypertrophic cardiomyopathyRisk of sudden deathCardiac sarcomere genesImplantable cardioverter-defibrillator implantationSeptal reduction therapyNon-obstructive diseaseSymptomatic atrial fibrillationCardiac myosin inhibitorLeft ventricular hypertrophySurgical treatment optionsCardioverter-defibrillator implantationAdvanced heart failureStructural heart conditionsArrhythmic riskCardiac transplantationImprove patient outcomesRhythm controlMedical therapyVentricular hypertrophyContemporary Use and Clinical Significance of Initial Triple Versus Double Therapy After Percutaneous Coronary Intervention for Myocardial Infarction in Patients With Atrial Fibrillation.
Park D, McLean B, Akman Z, Li D, Babapour G, Nanna M. Contemporary Use and Clinical Significance of Initial Triple Versus Double Therapy After Percutaneous Coronary Intervention for Myocardial Infarction in Patients With Atrial Fibrillation. Journal Of The American Heart Association 2025, 14: e038589. PMID: 40401606, DOI: 10.1161/jaha.124.038589.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticoagulantsAspirinAtrial FibrillationClinical RelevanceDrug Therapy, CombinationDual Anti-Platelet TherapyFemaleHemorrhageHospital MortalityHumansMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsRetrospective StudiesTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionST-segment elevation myocardial infarctionDouble therapyTriple therapyClinical adverse eventsIn-Hospital MortalityAtrial fibrillationPost-PCIMyocardial infarctionIntracranial hemorrhageAdverse eventsCourse of triple therapyCoronary interventionStent thrombosisInverse probability of treatment weightingProbability of treatment weightingHigh-risk subgroupsMultivariate logistic regressionAssociated with higher oddsRandomized trial evidenceNo significant differenceVizient clinical databaseClinical significancePrescribing patternsCompare outcomesTAVR vs. SAVR for severe aortic stenosis in the low and intermediate surgical risk population: An updated meta-analysis, meta-regression, and trial sequential analysis
Krishna M, Joseph M, Ezenna C, Pereira V, Rossi R, Akman Z, Rubens M, Mahadevan V, Nanna M, Goldsweig A. TAVR vs. SAVR for severe aortic stenosis in the low and intermediate surgical risk population: An updated meta-analysis, meta-regression, and trial sequential analysis. Cardiovascular Revascularization Medicine 2025 PMID: 40425422, DOI: 10.1016/j.carrev.2025.05.021.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve replacementPatient-prosthesis mismatchIntermediate surgical riskSevere patient-prosthesis mismatchAcute kidney injuryAortic valve replacementPermanent pacemaker implantationRandomized Controlled TrialsSurgical riskParavalvular leakFollow-upValve replacementPacemaker implantationAtrial fibrillationClinical outcomes of transcatheter aortic valve replacementOutcomes of transcatheter aortic valve replacementRate of permanent pacemaker implantationSafety of transcatheter aortic valve replacementBenefits of transcatheter aortic valve replacementNew-onset atrial fibrillationRates of all-cause deathAortic valve reinterventionNew-onset AFSevere aortic stenosisCHA2DS2-VASc Score in Patients With Atrial Fibrillation and Cancer: A U.S. Nationwide Study
Al Mouslmani M, Alahmad M, Akman Z, Rossi R, Rahman M, Nanna M. CHA2DS2-VASc Score in Patients With Atrial Fibrillation and Cancer: A U.S. Nationwide Study. The American Journal Of Cardiology 2025, 249: 59-64. PMID: 40280196, DOI: 10.1016/j.amjcard.2025.04.025.Peer-Reviewed Original ResearchConceptsCHA2DS2-VASc scoreAcute cerebrovascular accidentAtrial fibrillation/flutterNationwide Readmissions DatabaseCerebrovascular accidentOdds ratioDiagnosis of atrial fibrillation/flutterAbsence of malignancyInitiation of anticoagulationCancer-related parametersAssociated with higher oddsCHA2DS2-VAScRisk stratificationAtrial fibrillationMalignancyAnticoagulation initiationCancer patientsCross-sectional analysisIndex hospitalizationReadmissions DatabasePatientsPrimary diagnosisCohortWeighted admissionsCancerSame‐Day Discharge After Catheter Ablation of Atrial Fibrillation in the United States
Sandhu A, Qin L, Minges K, Zimmerman S, Borne R, Polsinelli V, Ho P, Hsu J, Al‐Khatib S, Freeman J, Bradley S, Rao S, Hernandez A, Tzou W, Varosy P, Hess P. Same‐Day Discharge After Catheter Ablation of Atrial Fibrillation in the United States. Journal Of The American Heart Association 2025, 14: e039190. PMID: 40240938, PMCID: PMC12184264, DOI: 10.1161/jaha.124.039190.Peer-Reviewed Original ResearchConceptsSame-day dischargeRate of same-day dischargeAF ablationComplication rateAtrial fibrillationPersistent AFCatheter ablation of atrial fibrillationAblation of atrial fibrillationOvernight hospitalizationLikelihood of same-day dischargeSame-day discharge ratePostprocedural complication rateSame-day discharge patientsSubstantial hospital variationCatheter ablationDays postprocedureClinical factorsBlack raceIndex procedureComorbid conditionsPatientsHospital variationSame-dayHospitalComplicationsPolygenic Risk Factor Profiling and Risk of Intracerebral Hemorrhage In Patients with Atrial Fibrillation on Apixaban (P9-13.008)
Clocchiatti-Tuozzo S, Rivier C, Huo S, Gilmore E, Shoamanesh A, Kamel H, Murthy S, Ohno-Machado L, Sheth K, Gill T, Falcone G. Polygenic Risk Factor Profiling and Risk of Intracerebral Hemorrhage In Patients with Atrial Fibrillation on Apixaban (P9-13.008). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000212525.Peer-Reviewed Original ResearchIncidence, Prevalence, and Trends in Mortality and Stroke Among Medicare Beneficiaries With Atrial Fibrillation: 2013 to 2019
Rogovoy N, Kearing S, Zhou W, Freeman J, Piccini J, Al-Khatib S, Zeitler E. Incidence, Prevalence, and Trends in Mortality and Stroke Among Medicare Beneficiaries With Atrial Fibrillation: 2013 to 2019. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011365. PMID: 40184151, PMCID: PMC12092179, DOI: 10.1161/circoutcomes.124.011365.Peer-Reviewed Original ResearchConceptsMedicare beneficiariesIncident AFFemale beneficiariesAge- and sex-adjusted mortalityIncident cohortAtrial fibrillationAF incidenceSex-adjusted mortalityAssociated with increased risk of strokeAssociated with increased riskPrevalence of AFAssociated with mortalityRisk of strokeWhite beneficiariesDemographic subgroupsMortality riskAF prevalenceRate of strokeMedicareEvaluate trendsBeneficiariesUrban dwellingRisk factorsStudy cohortAge groupsOral Anticoagulation following intracranial haemorrhage in patients with atrial fibrillation
Shoamanesh A, Klijn C, Sheth K, Veltkamp R, Sandset E, Cordonnier C, Salman R. Oral Anticoagulation following intracranial haemorrhage in patients with atrial fibrillation. European Stroke Journal 2025, 10: 35-45. PMID: 40401653, PMCID: PMC12098311, DOI: 10.1177/23969873241296803.Peer-Reviewed Original ResearchConceptsAtrial fibrillationRandomized trialsIntracranial haemorrhagePhase II Randomized TrialMajor adverse cardiovascular eventsRandomized trials of anticoagulationPrevalence of AFAdverse cardiovascular eventsHigh-risk subgroupsTrials of anticoagulationEffects of anticoagulantsOptimal timingVulnerable patient populationOral anticoagulantsRisk subgroupsStroke prevention strategiesClinical dilemmaCardiovascular eventsPooled analysisAge-related conditionsPatient populationAnticoagulationHeterogeneity of treatment effectsObservational studyPatientsIMPACT OF SODIUM GLUCOSE COTRANSPORTER-2 INHIBITORS ON POST-OPERATIVE ATRIAL FIBRILLATION IN CARDIOTHORACIC SURGERY: A MULTICENTER COHORT STUDY
Rahhal A, Ahmed A, Shehadeh M, Nofal M, Mohammad H, Aburamadan A, Ali A, Kaspo S, Aboushawish B, Mahfouz A, Alyafei S, Zarich S, Omar A. IMPACT OF SODIUM GLUCOSE COTRANSPORTER-2 INHIBITORS ON POST-OPERATIVE ATRIAL FIBRILLATION IN CARDIOTHORACIC SURGERY: A MULTICENTER COHORT STUDY. Journal Of The American College Of Cardiology 2025, 85: 64. DOI: 10.1016/s0735-1097(25)00549-2.Peer-Reviewed Original ResearchAddressing Peri-Device Leaks in Next-Generation Transcatheter Left Atrial Appendage Occluders: An Open Question
Roshanfar M, Jang S, Sinusas A, Wong S, Mosadegh B. Addressing Peri-Device Leaks in Next-Generation Transcatheter Left Atrial Appendage Occluders: An Open Question. Surgeries 2025, 6: 15. DOI: 10.3390/surgeries6010015.Peer-Reviewed Original ResearchPeri-device leakLeft atrial appendageFDA-approved devicesRisk of thrombo-embolic eventsNon-valvular atrial fibrillationLeft atrial appendage anatomyLong-term anticoagulationPercutaneous LAA occlusionCHA2DS2-VASc scoreThrombo-embolic eventsIncreased risk of strokeRisk of strokeCircular cross-sectionLeft atrial appendage occluderSystemic embolismAnticoagulant therapyLAA occlusionObservational registryCHA2DS2-VAScNon-pharmacological alternativeAdverse eventsAtrial fibrillationAtrial appendageClinical dataIncreased riskNatriuretic peptide testing in veterans hospitalized with heart failure: Potential differences by sex
Gandhi P, Runels T, Han L, Skanderson M, Bastian L, Brandt C, Hauser R, Feder S, Rodwin B, Farmer M, Bean-Mayberry B, Placide S, Gaffey A, Akgün K. Natriuretic peptide testing in veterans hospitalized with heart failure: Potential differences by sex. Heart & Lung 2025, 71: 25-31. PMID: 39970822, DOI: 10.1016/j.hrtlng.2025.02.001.Peer-Reviewed Original ResearchConceptsNatriuretic peptide testingHeart failure hospitalizationFacility characteristicsVeterans Affairs Healthcare SystemPeptide testingSex-based differencesFacility-related factorsSex-stratified modelsAssociated with increased likelihoodAssociated with decreased likelihoodHealthcare systemHF diagnosisEjection fractionCardiac comorbiditiesFailure hospitalizationClinical outcomesLogistic regressionAtrial fibrillationHeart failureVeteransClinical covariatesPatientsAdmissionSexAssociationA comprehensive evaluation of the left atrium using cardiovascular magnetic resonance
Pradella M, Elbaz M, Lee D, Hong K, Passman R, Kholmovski E, Peters D, Baraboo J, Herzka D, Nezafat R, Edelman R, Kim D. A comprehensive evaluation of the left atrium using cardiovascular magnetic resonance. Journal Of Cardiovascular Magnetic Resonance 2025, 27: 101852. PMID: 39920924, PMCID: PMC11889362, DOI: 10.1016/j.jocmr.2025.101852.Peer-Reviewed Original ResearchCardiovascular magnetic resonanceLeft atriumCardiac imaging modalitiesLeft atrial appendageContext of atrial fibrillationAtrial fibrillationAtrial appendageHeart failureAtrial diseaseAtrial myopathyImaging modalitiesMagnetic resonanceCardiovascular medicineClinical applicationImaging parametersAtriumMyopathyTissue characterizationMechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR
Cunningham C, Hubbard Z, Kasem R, Elawady S, Sowlat M, Matsukawa H, Maier I, Jabbour P, Kim J, Wolfe S, T A, Starke R, Psychogios M, Samaniego E, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Grandhi R, Crosa R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Altschul D, Al Kasab S, Spiotta A. Mechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR. Journal Of NeuroInterventional Surgery 2025, 17: e206-e215. PMID: 39855673, DOI: 10.1136/jnis-2024-022677.Peer-Reviewed Original ResearchAlberta Stroke Program Early CT ScoreLow Alberta Stroke Program Early CT ScorePropensity score matchingSymptomatic intracranial hemorrhageEndovascular thrombectomyAnterior circulation large vessel occlusion acute ischemic strokeElderly patientsLVO-AISAssociated with 90-day mortalityRate of atrial fibrillationScore matchingLarge vessel occlusion acute ischemic strokeFirst-pass reperfusionAcute ischemic strokeCT scoreIntracranial hemorrhagePatient selectionMRS scoreAtrial fibrillationClinical factorsFavorable outcomeRecanalization ratePrimary outcomeMechanical thrombectomyPatientsA Bayesian Interpretation of CABANA and Other Randomized Controlled Trials for Catheter Ablation in Patients With Atrial Fibrillation
Nogueira A, Felix N, Kalil F, Tramujas L, Godoi A, Miyawaki I, Bellavia A, Moura F, Cardoso R, d'Avila A, Fernandes G. A Bayesian Interpretation of CABANA and Other Randomized Controlled Trials for Catheter Ablation in Patients With Atrial Fibrillation. Journal Of Cardiovascular Electrophysiology 2025, 36: 617-624. PMID: 39834105, DOI: 10.1111/jce.16552.Peer-Reviewed Original ResearchConceptsBayesian analysisTreatment effect distributionAdverse cardiovascular outcomesAll-Cause MortalityCardiovascular outcomesRandomized Controlled TrialsFrequentist estimatorsCatheter ablationMedical therapyAtrial fibrillationBayesian interpretationImpact of catheter ablationControlled TrialsAnalysis of randomized controlled trialsProbability distributionAtrial fibrillation patientsReduce adverse cardiovascular outcomesImpact of ablationEffective distributionRandom-effects modelBayes' theoremTrial-level dataProbabilistic understandingSurvival outcomesFibrillation patientsState of the Art in Left Atrial Appendage Occlusion
Garg J, Kabra R, Gopinathannair R, Di Biase L, Wang D, Saw J, Hahn R, Freeman J, Ellis C, Lakkireddy D. State of the Art in Left Atrial Appendage Occlusion. JACC Clinical Electrophysiology 2025, 11: 602-641. PMID: 39797854, DOI: 10.1016/j.jacep.2024.10.024.Peer-Reviewed Original ResearchConceptsLeft atrial appendage occlusionAppendage occlusionStroke preventionLeft atrial appendage occlusion devicesNonvalvular atrial fibrillationOptimal patient selectionDevice-related thrombusLeft atrial appendagePericardial effusionPostprocedural complicationsPatient selectionAtrial fibrillationAtrial appendageArrhythmia therapyDevice leakTherapeutic targetClinical needOcclusionPreventionStrokeEffects of sex on imaging-based intravenous thrombolysis for ischaemic stroke with unknown onset time: a pooled analysis of clinical trials.
Fukuda-Doi M, Koga M, Thomalla G, Jensen M, Inoue M, Yoshimura S, Miwa K, Gerloff C, Davis S, Donnan G, Ma H, Hacke W, Ringleb P, Wu O, Schwamm L, Warach S, Toyoda K. Effects of sex on imaging-based intravenous thrombolysis for ischaemic stroke with unknown onset time: a pooled analysis of clinical trials. European Stroke Journal 2025, 23969873241309512. PMID: 39749428, PMCID: PMC11696941, DOI: 10.1177/23969873241309512.Peer-Reviewed Original ResearchFavorable outcomeIntravenous thrombolysisPooled analysis of individual patient-level dataPooled analysisClinical trialsBaseline National Institutes of Health Stroke Scale scoreSex-based differencesPooled analysis of clinical trialsIschaemic strokeNational Institutes of Health Stroke Scale scoreSevere clinical statusIndividual patient-level dataStroke Scale scorePatient-level dataAnalysis of clinical trialsOrdinal regression modelAtrial fibrillationPatient sexClinical statusMultivariable adjustmentFemale sexThrombolysis trialsOnset timePrimary outcomeFunctional outcomesPerioperative Atrial Fibrillation and Anticoagulation Management
Tao J, Oprea A. Perioperative Atrial Fibrillation and Anticoagulation Management. 2025, 148-161. DOI: 10.1093/med/9780190902001.003.0013.Peer-Reviewed Original ResearchRisk of thrombosisAbstract Atrial fibrillationOral anticoagulantsPreoperative evaluation of surgical patientsCerebral vascular accidentClasses of oral anticoagulantsPatient's risk of thrombosisRisk of surgical bleedingEvaluation of surgical patientsVitamin K antagonistsPerioperative anticoagulation managementK antagonistsSurgical bleedingPreoperative evaluationAnticoagulation managementAtrial fibrillationSurgical patientsCardiac arrhythmiasPatient riskPatientsVascular accidentAnticoagulationRisk
2024
Concomitant Procedures in Robotic Mitral Valve Surgery
Waldron C, Mori M, LaLonde M, Geirsson A. Concomitant Procedures in Robotic Mitral Valve Surgery. Seminars In Thoracic And Cardiovascular Surgery 2024 PMID: 39672523, DOI: 10.1053/j.semtcvs.2024.11.007.Peer-Reviewed Original Research
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