2025
Modelling longitudinal cognitive test data with ceiling effects and left skewness
Grigorova D, Palejev D, Gueorguieva R, Initiative F. Modelling longitudinal cognitive test data with ceiling effects and left skewness. Frontiers In Applied Mathematics And Statistics 2025, 11: 1617381. DOI: 10.3389/fams.2025.1617381.Peer-Reviewed Original ResearchMini Mental State ExaminationCognitive test dataOlder individualsMini Mental State Examination scoreSubjective memory concernsCognitive performanceMental State ExaminationAlzheimer's Disease Neuroimaging Initiative studyMild cognitive impairmentState ExaminationCeiling effectsMemory concernsSteep cognitive declineRandom interceptEffect estimatesAlzheimer's diseaseBayesian information criterionCognitive testsBaseline individualCognitive declineCognitive impairmentDiagnostic groupsInitiative studyTwo-year periodYoung individualsDynamic and Static Resting-State Functional Connectivity of Canonical Networks in Military and Civilian Populations with Posttraumatic Stress Disorder and/or Mild Traumatic Brain Injury
Dwulit A, Sun D, Haswell C, Hussain A, Dennis E, Wilde E, Newsome M, Tate D, Walker W, Abdallah C, Averill C, Blackford J, Olatunji B, King A, Liberzon I, Angstadt M, Rektor I, Říha P, Nečasová M, Fňašková M, Daniels J, Walter H, Manthey A, Sierk A, Olff M, van Zuiden M, Koch S, Veltman D, Frijiling J, Nawijn L, Jahanshad N, Thompson P, Morey R. Dynamic and Static Resting-State Functional Connectivity of Canonical Networks in Military and Civilian Populations with Posttraumatic Stress Disorder and/or Mild Traumatic Brain Injury. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 40840859, DOI: 10.1016/j.bpsc.2025.08.002.Peer-Reviewed Original ResearchMild traumatic brain injuryPosttraumatic stress disorderDynamic functional connectivityStatic resting-state functional connectivitySalience networkStatic functional connectivityTraumatic brain injuryCentral executiveStress disorderComorbid subjectsFunctional connectivityFunctional connectomeMild traumatic brain injury groupInteraction effects of diagnosisAnxiety-related effectsExternally focused statesInteraction of diagnosisCanonical resting state networksBrain injuryEffect of diagnosisInteraction effectsDefault modeControl subjectsMilitary veteransDiagnostic groupsSex-Related Measurement Bias in Autism Spectrum Disorder Symptoms in the Baby Siblings Research Consortium
Burrows C, Sung S, Zheng S, Young G, Charman T, Klaiman C, Klin A, Marrus N, Ozonoff S, Piven J, Robins D, Schmidt R, Schwichtenberg A, Webb S, Zwaigenbaum L, Carver L, Chawarska K, Curtin S, Jeste S, Iverson J, Landa R, Messinger D, Roberts J, Stone W, Tager-Flusberg H, Esler A, Miller M, Bishop S, Elison J. Sex-Related Measurement Bias in Autism Spectrum Disorder Symptoms in the Baby Siblings Research Consortium. JAMA Network Open 2025, 8: e2525887. PMID: 40779266, PMCID: PMC12334962, DOI: 10.1001/jamanetworkopen.2025.25887.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAutism Diagnostic Observation ScheduleSex differencesQuality of social overturesMeasures of ASD symptomsResponsiveness to joint attentionAutism spectrum disorder symptomsHFL groupSocial communication difficultiesPrevalence of autism spectrum disorderConfirmatory factor analysisModerate levelsSocial overturesDisorder symptomsASD symptomsAutistic traitsClinician trainingJoint attentionMeasurement invarianceAge of diagnosisSpectrum disorderDevelopmental differencesMain OutcomesObservation ScheduleDiagnostic groupsData‐Driven Approach to Dynamic Resting State Functional Connectivity in Post‐Traumatic Stress Disorder: An ENIGMA‐PGC PTSD Study
Tomas C, Fitzgerald J, Baird C, Haswell C, Abdallah C, Angstadt M, Baker J, Berg H, Blackford J, Cisler J, Cotton A, Daniels J, Davenport N, Davidson R, deRoon‐Cassini T, Disner S, Hage W, Fani N, Frijling J, Gordon E, Grupe D, He X, Herringa R, Hofmann D, Huggins A, Hussain A, Ipser J, Jahanshad N, Jovanovic T, Kaufman M, Kim Y, King A, Koch S, Koopowitz S, Lazarov A, Lebois L, Liberzon I, Lissek S, Manthey A, May G, McLaughlin K, Nawijn L, Nelson S, Neria Y, Nitschke J, Olatunji B, Olff M, Peverill M, Quidé Y, Ravid O, Ressler K, Ross M, Salminen L, Sambrook K, Shih C, Sierk A, Sponheim S, Stein D, Stevens J, Straube T, Suarez‐Jimenez B, Thompson P, van der Wee N, van der Werff S, van Rooij S, van Zuiden M, Veltman D, Vermeiren R, Walter H, Wang X, Xie H, Zhu X, Zilcha‐Mano S, Larson C, Morey R. Data‐Driven Approach to Dynamic Resting State Functional Connectivity in Post‐Traumatic Stress Disorder: An ENIGMA‐PGC PTSD Study. Human Brain Mapping 2025, 46: e70116. PMID: 40736265, PMCID: PMC12308910, DOI: 10.1002/hbm.70116.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderFunctional magnetic resonance imagingBrain network dynamicsFunctional connectivityStress disorderTrauma typesBrain networksHeterogeneity of posttraumatic stress disorderSymptoms of posttraumatic stress disorderPost-traumatic stress disorderGroup independent component analysisNo group differencesIndependent component analysisResting-state networksStatic functional connectivityBrain network characteristicsMulti-cohort sampleData-driven analytic approachSample of traumaSymptom profilesConnectivity statesDiagnostic groupsGroup differencesStatic FCCognitive demandsTransdiagnostic Examination of Interrelationships Between Anxiety, Insistence on Sameness and Compulsions
Spackman E, Chetcuti L, Baker E, Ferguson E, Yerys B, Herrington J, Frazier T, Leekam S, Hardan A, Harrington J, Uljarević M. Transdiagnostic Examination of Interrelationships Between Anxiety, Insistence on Sameness and Compulsions. Autism Research 2025 PMID: 40878890, DOI: 10.1002/aur.70096.Peer-Reviewed Original ResearchObsessive-compulsive disorderTransdiagnostic natureScreen for Child Anxiety Related DisordersRepetitive Behavior Scale-RevisedAttention-deficit hyperactivity disorderOppositional defiant/conduct disorderAnxiety Related DisordersSample of childrenPatterns of associationTransdiagnostic sampleODD/CD groupADHD groupInternalizing disordersHyperactivity disorderBetween-group comparisonsSingular disordersScale-RevisedWithin-group comparisonsDiagnostic groupsCompulsionAnxietyAutismEffect sizeDisordersBetween-groupCerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum
Sritharan J, Zeng V, Petr J, Mutsaerts H, Hoang D, Bolo N, Ivleva E, Dai W, Gershon E, Keedy S, Parker D, Trotti R, McDowell J, Clementz B, Tamminga C, Pearlson G, Keshavan M, Lizano P. Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum. Frontiers In Psychiatry 2025, 16: 1566184. PMID: 40365009, PMCID: PMC12069394, DOI: 10.3389/fpsyt.2025.1566184.Peer-Reviewed Original ResearchPsychosis spectrum disordersFusiform gyrusSchizoaffective disorderPseudo-continuous arterial spin-labeling scansCerebral blood flowOccipital lobeOverall cognitive performanceArterial spin labeling scansGray matter cerebral blood flowPsychosis spectrumBipolar disorderCognitive measuresCognitive performancePsychosisSpectrum disorderDiagnostic groupsPerfusion differencesVisual processingCognitive impairmentVisual hallucinationsCytoarchitectonic subregionsPerfusion alterationsLabeling scansSchizophreniaHealthy controlsCultural variables influence performance on the MATRICS Consensus Cognitive Battery among people at clinical high risk for psychosis
Guest R, Aberizk K, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Walker E. Cultural variables influence performance on the MATRICS Consensus Cognitive Battery among people at clinical high risk for psychosis. Schizophrenia Research 2025, 280: 60-68. PMID: 40250131, PMCID: PMC12169887, DOI: 10.1016/j.schres.2025.04.019.Peer-Reviewed Original ResearchConceptsMATRICS Consensus Cognitive BatteryConsensus Cognitive BatteryClinical high riskCognitive batteryCHR-PHopkins Verbal Learning Test-RevisedNorth American Prodrome Longitudinal StudyEnglish speakersHealthy controlsLetter-Number SpanPsychosis-Risk SyndromesMultigroup structural equation modelingInfluence cognitive performanceCultural variablesNative English speakersSample of peopleLetter-NumberNeuropsychological measuresVariables influencing performanceTest-RevisedCognitive performanceStructural equation modelingAnimal namesDiagnostic groupsCanadian sampleInterpersonal difficulties and suicidal ideation in young people at clinical high-risk for psychosis and help-seeking clinical controls
Bailey A, Bauer B, Mittal V, Ellman L, Strauss G, Walker E, Powers A, Kenney J, Corlett P, Woods S, Gold J, Schiffman J, Waltz J, Silverstein S. Interpersonal difficulties and suicidal ideation in young people at clinical high-risk for psychosis and help-seeking clinical controls. Psychiatry Research 2025, 348: 116467. PMID: 40184931, PMCID: PMC12051163, DOI: 10.1016/j.psychres.2025.116467.Peer-Reviewed Original ResearchConceptsRates of suicidal ideationPresence of suicidal ideationClinical high riskSuicidal ideationInterpersonal difficultiesMental health concernsInterpersonal traumaExperiences of suicidal ideationHelp-seeking controlsDSM-5 diagnosisSame-age peersDSM-5Interpersonal mechanismsDiagnostic groupsIdeationYoung peoplePsychosisClinical controlCHRPHealth concernHigh riskAssociated with presenceDifficultiesSuicideLogistic regression modelsNeuro- and social-cognition in schizotypal personality disorder and schizophrenia: A spectrum of severity
Goldstein K, Pietrzak R, Aladin S, Ng S, Chan C, Perez-Rodriguez M, Shafritz K, Kahn R, McClure M, Szeszko P, Hazlett E. Neuro- and social-cognition in schizotypal personality disorder and schizophrenia: A spectrum of severity. Psychiatry Research 2025, 348: 116445. PMID: 40117765, PMCID: PMC12265923, DOI: 10.1016/j.psychres.2025.116445.Peer-Reviewed Original ResearchSchizotypal personality disorderSocial cognitionPersonality disorderNegative symptomsNeuro-cognitiveSchizotypal personality disorder patientsCognitive impairmentCompared social cognitionSocial cognitive impairmentsSocial cognitive treatmentGeneral cognitive impairmentSocial-emotional cognitionGlobal cognitive impairmentProfile of clinical symptomsAssociated with greater reductionsCombined patient groupGender-matched healthy controlsNine-month follow-upSchizophrenia spectrumSchizophrenia patientsSchizophreniaDiagnostic groupsChange-over-timeCognitionGreater reductionsGrowth‐Associated Protein 43 Levels in the Cerebrospinal Fluid Correspond to the Cerebral Blood Flow Alterations in Alzheimer's Dementia Continuum: An Original Study
Songhori N, Goushky M, Khaleghi M, Mojerloo M, Sadeghi M, Mozafar M, Aghdam Z, Ghajar M, Kianifar Y, Karimzadeh F, Khosravi F, Mayeli M. Growth‐Associated Protein 43 Levels in the Cerebrospinal Fluid Correspond to the Cerebral Blood Flow Alterations in Alzheimer's Dementia Continuum: An Original Study. Health Science Reports 2025, 8: e70534. PMID: 40078900, PMCID: PMC11896815, DOI: 10.1002/hsr2.70534.Peer-Reviewed Original ResearchMild cognitive impairmentComposite scoreAlzheimer's Disease Neuroimaging InitiativeMini Mental State ExaminationExecutive function composite scoreMental State ExaminationCognitive impairmentIndependent t-testDiagnostic groupsDementia continuumMultiple linear regression analysisState ExaminationAlzheimer's diseaseAPOE-e4Cognitive statusLinear regression analysisCognitive composite scoreComparison of continuous variablesCognitive scoresConfounding factorsCN individualsCerebrospinal fluid biomarkersSignificant positive correlationCognitive functionMann-Whitney testTransdiagnostic study of dynamic brain activity and connectivity among people with gambling and internet gaming disorders DYNAMIC BRAIN ACTIVITY IN GD AND IGD
Zhou H, He Y, Liu L, Yin J, Xiong A, Leong K, Wu A, Potenza M. Transdiagnostic study of dynamic brain activity and connectivity among people with gambling and internet gaming disorders DYNAMIC BRAIN ACTIVITY IN GD AND IGD. International Journal Of Clinical And Health Psychology 2025, 25: 100547. PMID: 39944189, PMCID: PMC11815891, DOI: 10.1016/j.ijchp.2025.100547.Peer-Reviewed Original ResearchInternet gaming disorder groupInternet gaming disorderIGD participantsFunctional magnetic resonance imagingDynamic brain activityGambling disorderHC participantsBrain activityTransdiagnostic studiesFrontal gyrusLeft triangular inferior frontal gyrusFeatures of behavioral addictionsResting-state functional magnetic resonance imagingTriangular inferior frontal gyrusInferior frontal gyrusCombination of self-reportHealthy controlsPositive playBehavioral addictionsSelf-reported indicatorsNeural measuresGaming disorderDiagnostic groupsBrain connectivitySelf-ReportSocial functioning and frontal alpha asymmetry in schizophrenia
Farina E, Assaf M, Corbera S, Choi J, Yantz C, Chen C. Social functioning and frontal alpha asymmetry in schizophrenia. Journal Of Psychiatric Research 2025, 182: 74-82. PMID: 39799666, PMCID: PMC11830537, DOI: 10.1016/j.jpsychires.2025.01.006.Peer-Reviewed Original ResearchConceptsFrontal alpha asymmetryAutism spectrum disorderReduced social functioningSocial functioningNeurophysiological markersAlpha asymmetryPsychiatric disordersAtypical social behaviorUnique to schizophreniaSelf-report measuresHealthy controlsResting-state electroencephalogramClinical InterviewPsychiatric diagnosisSchizophreniaSpectrum disorderDiagnostic groupsReduced motivationSocial behaviorDisordersEmotional tendencyAnalysis of varianceClinical manifestationsElectroencephalogramAutism
2024
The Cerebellum Plays a Protective Role in Cognitive Aging and Disease: Insights from a Multi‐Cohort Study
Uquillas F, Sefik E, Seidlitz J, Merriman J, Zhang V, Kislin M, Cohen J, Alexander‐Bloch A, Bethlehem R, Sepulcre J, Wang S, Vannini P, Gomez J, Initiative T. The Cerebellum Plays a Protective Role in Cognitive Aging and Disease: Insights from a Multi‐Cohort Study. Alzheimer's & Dementia 2024, 20: e085743. PMCID: PMC11716736, DOI: 10.1002/alz.085743.Peer-Reviewed Original ResearchMontreal Cognitive AssessmentEstimated intracranial volumeBrain reserveCognitive declineMontreal Cognitive Assessment scoreCerebellar volumePattern of cognitive declineUK BiobankAging-related cognitive declineCerebellar tissue volumesPosterior cerebellar cortexAmyloid burdenAPOE genotypeAlzheimer's diseaseCerebellar associationsMild cognitive impairmentExecutive functionCognitive agingAmyloid-beta burdenVentral attentionPosterior cerebellumCrus IAge-related changesDiagnostic groupsProcessing speedUsing mobile eye-tracking to evaluate gaze behavior during a speech in pediatric anxiety disorders
Kitt E, Abend R, Amelio P, Galbraith J, Poe A, Gee D, Pine D, Harrewijn A. Using mobile eye-tracking to evaluate gaze behavior during a speech in pediatric anxiety disorders. Journal Of Affective Disorders 2024, 369: 462-466. PMID: 39389116, DOI: 10.1016/j.jad.2024.10.024.Peer-Reviewed Original ResearchSocial anxiety symptom severityAnxiety symptom severityAnxiety-related differencesAnxiety disordersState anxietyTask conditionsPediatric anxietySocial anxietyGaze behaviorSymptom severityNon-anxious controlsPediatric anxiety disordersSocial stress taskEye trackingAnxiety-provoking contextsPassive viewing conditionsAge-related differencesNaturalistic stressorElevated anxietyStress taskMobile eye-trackerDevelopmental sampleDiagnostic groupsEye-tracking technologyLonger gazeProgressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia
Li X, Zeng J, Liu N, Yang C, Tao B, Sun H, Gong Q, Zhang W, Li C, Lui S. Progressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2024, 135: 111127. PMID: 39181307, DOI: 10.1016/j.pnpbp.2024.111127.Peer-Reviewed Original ResearchHypothalamic functional connectivityBilateral anterior cingulate cortexAnterior cingulate cortexFunctional connectivityFES patientsCingulate cortexFC decreaseRight thalamusChronically treated schizophrenia patientsHealthy controlsSeed-based functional connectivityFirst-episode patientsPathogenesis of schizophreniaNature of schizophreniaAge-related declineAntipsychotic treatmentAntipsychotic medicationRight caudateLeft putamenIllness durationAnalysis of covarianceSchizophreniaDiagnostic groupsHC groupHypothalamus dysfunction
2023
Diagnostic group differences and exploratory sex differences in intrinsic connectivity during fMRI Stroop in individuals with and without cocaine use disorder
Zakiniaeiz Y, Lacadie C, Macdonald-Gagnon G, DeVito E, Potenza M. Diagnostic group differences and exploratory sex differences in intrinsic connectivity during fMRI Stroop in individuals with and without cocaine use disorder. Drug And Alcohol Dependence 2023, 251: 110962. PMID: 37716288, PMCID: PMC10557108, DOI: 10.1016/j.drugalcdep.2023.110962.Peer-Reviewed Original ResearchConceptsCocaine use disorderCognitive controlStroop performanceIntrinsic connectivityStroop task performanceFMRI Stroop taskDiagnostic groupsUse disordersDiagnostic group differencesMain effectHealthy comparison subjectsStroop effectStroop taskBehavioral resultsTask performanceFrontal gyrusIntrinsic connectivity distributionPrefrontal cortexAuditory areasGroup differencesBrain connectivityCingulate gyrusStroopBehavioral differencesHC groupDevelopment of peak alpha frequency reflects a distinct trajectory of neural maturation in autistic children
Finn C, Han G, Naples A, Wolf J, McPartland J. Development of peak alpha frequency reflects a distinct trajectory of neural maturation in autistic children. Autism Research 2023, 16: 2077-2089. PMID: 37638733, DOI: 10.1002/aur.3017.Peer-Reviewed Original ResearchConceptsPeak alpha frequencyAutism spectrum disorderCognitive abilitiesAutistic childrenNonverbal IQNeural maturationSpectrum disorderTypical age-related increaseAlpha frequencyDifferent developmental trajectoriesDistinct trajectoriesSample of childrenCurrent study clarifiesDiagnostic groupsNeurotypical childrenNeurotypical controlsBehavioral measuresDevelopmental trajectoriesDiagnostic statusAge-related increaseFunction of ageIQEffect of ageBivariate relationsPrevious findings
2022
Clinical and cortical similarities identified between bipolar disorder I and schizophrenia: A multivariate approach
Rootes-Murdy K, Edmond J, Jiang W, Rahaman M, Chen J, Perrone-Bizzozero N, Calhoun V, van Erp T, Ehrlich S, Agartz I, Jönsson E, Andreassen O, Westlye L, Wang L, Pearlson G, Glahn D, Hong E, Buchanan R, Kochunov P, Voineskos A, Malhotra A, Tamminga C, Liu J, Turner J. Clinical and cortical similarities identified between bipolar disorder I and schizophrenia: A multivariate approach. Frontiers In Human Neuroscience 2022, 16: 1001692. PMID: 36438633, PMCID: PMC9684186, DOI: 10.3389/fnhum.2022.1001692.Peer-Reviewed Original ResearchHealthy volunteersSymptom profilesGM patternsClinical symptom presentationGray matter deficitsGray matter alterationsSevere symptom profileDistinct symptom profilesUnique symptom profileStructural neuroimaging studiesCurrent diagnostic criteriaPattern of schizophreniaBipolar disorder IBrains of individualsGM alterationsPANSS scoresCingulate gyrusDiagnostic criteriaTemporal poleSymptom presentationBilateral insulaDiagnostic groupsDisorder ISchizophreniaNeuroimaging studiesProfiles of Odorant Specific Performance in Olfactory Testing
Schlosser RJ, Soler ZM, Mace J, Farrell N, Rimmer R, Alt JA, Ramakrishnan VR, Edwards TS, Smith TL. Profiles of Odorant Specific Performance in Olfactory Testing. American Journal Of Rhinology 2022, 37: 26-34. PMID: 36069003, DOI: 10.1177/19458924221124692.Peer-Reviewed Original ResearchConceptsOlfactory dysfunctionPsychophysical testingNon-CRS subjectsVariety of etiologiesHealthy control adultsSinus complaintsTrigeminal functionChronic rhinosinusitisNasal polypsSniffin' SticksOlfactory testingDiagnostic groupsControl adultsOlfactory assessmentHyposmicSimilar findingsEtiologyAdultsUnique profileCRSRhinosinusitisSpecific odorantsPathophysiologyDysfunctionCohortDistinct Symptom Network Structure and Shared Central Social Communication Symptomatology in Autism and Schizophrenia: A Bayesian Network Analysis
Han GT, Trevisan DA, Foss-Feig J, Srihari V, McPartland JC. Distinct Symptom Network Structure and Shared Central Social Communication Symptomatology in Autism and Schizophrenia: A Bayesian Network Analysis. Journal Of Autism And Developmental Disorders 2022, 53: 3636-3647. PMID: 35752729, PMCID: PMC10202012, DOI: 10.1007/s10803-022-05620-0.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum disordersSocial communication difficultiesSymptom networksCognitive-perceptual symptomsSpectrum disorderRepetitive behaviorsNeurodevelopmental conditionsCommunication difficultiesASDPotential treatment targetAutismSymptom network structureDiagnostic groupsTreatment targetsNetwork analysis approachHigh centralitySymptomatologySchizophreniaSymptomsOrganizationAdultsDisordersBayesian network analysisDifficultiesAnalysis approach
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply