2025
Immediate Lymphatic Reconstruction (ILR) for the Prevention of Lymphedema: A Meta-analysis of Prospective Clinical Trials
Brown S, Shen Y, Klimitz F, Nair M, Mattia A, Kauke-Navarro M, Noel O, Wo L, Pomahac B, Lofti P, Golshan M, Haykal S. Immediate Lymphatic Reconstruction (ILR) for the Prevention of Lymphedema: A Meta-analysis of Prospective Clinical Trials. Annals Of Surgical Oncology 2025, 1-17. PMID: 40962960, DOI: 10.1245/s10434-025-18333-2.Peer-Reviewed Original ResearchImmediate lymphatic reconstructionProspective clinical trialIncidence of lymphedemaFollow-upCumulative incidenceMeta-analysis of prospective clinical trialsClinical trialsCumulative incidence of lymphedemaLymphatic reconstructionOdds ratioMonths of follow-upRelative riskMeta-analysisRisk of lymphedemaAverage follow-upAt-risk patientsPrevention of lymphedemaLymphedema riskMethodsOutcome dataEffective prevention strategiesLymphedema developmentProspective studyProspective outcomesProspective dataPatientsClinical effectiveness of HPV vaccine by age at vaccination: a matched case-control study
Oliveira C, Shapiro E, Sheth S, Ellingson M, Johnson N, Sullivan E, Querec T, Unger E, Niccolai L. Clinical effectiveness of HPV vaccine by age at vaccination: a matched case-control study. The Lancet Regional Health - Americas 2025, 51: 101225. PMID: 41019517, PMCID: PMC12465035, DOI: 10.1016/j.lana.2025.101225.Peer-Reviewed Original ResearchHPV vaccinationCase-control studyHuman papillomavirusVaccine effectivenessClinical effectsDose of HPV vaccineHigh-grade cervical lesionsOdds ratioBenefits of HPV vaccinationEffectiveness of HPV vaccinationMultivariable conditional logistic regression modelsVaccine-eligible womenPap smear resultsHuman papillomavirus vaccineConfidence intervalsConditional logistic regression modelsCenters for Disease Control and PreventionDisease Control and PreventionCervical lesionsSmear resultsFirst doseHPV-16Pap testControl and PreventionLogistic regression modelsGoal Setting, Feedback, and Performance in Emergency Medicine Training
Coughlin R, Devlin D, Bonner S, Srica N, Jameyfield E, Goldflam K, Tsyrulnik A, Osborne K, Phadke M, Dziura J, Gore K, Wright D, Della-Giustina D, Gottlieb M, Bod J. Goal Setting, Feedback, and Performance in Emergency Medicine Training. MedEdPublish 2025, 15: 77. DOI: 10.12688/mep.21065.1.Peer-Reviewed Original ResearchGoal settingEmergency medicineFast-paced environmentOdds ratioPostgraduate yearEmergency medicine trainingConstructive feedbackEM residentsMedicine trainingEM facultyPostgraduate year levelEM programsFeedback contentTotal residentsSurvey toolResident performancePrimary outcomeVerbal feedbackExclusion criteriaResidentsGrandmother's pregnancy complications and autism spectrum disorders in grandchildren, a California multigenerational cohort study
Chow T, Meng Q, Xiao J, O’Sharkey K, Liew Z, Ritz B. Grandmother's pregnancy complications and autism spectrum disorders in grandchildren, a California multigenerational cohort study. JCPP Advances 2025 DOI: 10.1002/jcv2.70047.Peer-Reviewed Original ResearchHypertensive disordersPregnancy complicationsBirth weightPrevalence of hypertensive disordersOdds ratioPregnancy hypertensive disordersLow birth weightFollow-up timeNormal birth weightASD riskMother-child pairsCalifornia birth cohortCohort studyPregnancyComplicationsInfectionLogistic regressionBirth cohortOffspring autism spectrum disorderSpectrum disorderDisordersBiological underpinningsAutism spectrum disorderMothersOddsThe prevalence of endometriosis in adult female patients with hidradenitis suppurativa: a cross-sectional study using the All of Us Research Programme
Hodelin C, Cohen J, Eisenstein A. The prevalence of endometriosis in adult female patients with hidradenitis suppurativa: a cross-sectional study using the All of Us Research Programme. Clinical And Experimental Dermatology 2025, llaf395. PMID: 40898779, DOI: 10.1093/ced/llaf395.Peer-Reviewed Original ResearchOdds ratioUS National InstitutesHidradenitis suppurativaCross-sectional studyUS National Institutes of HealthBody mass indexNational Institutes of HealthInstitutes of HealthNational InstituteType 2 diabetes mellitusSmoking statusPrevalence of endometriosisAdult female patientsMass indexPolycystic ovarian syndromeFemale patientsUS databaseProgram databaseOvarian syndromeAge rangeEndometriosisHidradenitisResearch programmeYearsOddsPrenatal exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) and lung function and immune-related outcomes among males in childhood and young adulthood
Hull S, Ferguson K, London S, Hougaard K, Lindh C, Petersen K, Flachs E, Wise L, Wilcox A, Liew Z, Ramlau-Hansen C, Toft G, Bonde J, Tøttenborg S. Prenatal exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) and lung function and immune-related outcomes among males in childhood and young adulthood. Environmental Research 2025, 286: 122746. PMID: 40907682, PMCID: PMC12451454, DOI: 10.1016/j.envres.2025.122746.Peer-Reviewed Original ResearchForced Vital CapacityPhthalate metabolitesImmune-related outcomesPolyfluoroalkyl substancesPrenatal exposureSingle-pollutant analysesOdds ratioPFAS mixtureHay feverPrenatal PFAS exposureYoung adulthoodLower FEV<sub>1</sub>Associated with lower oddsYears of ageImmune system developmentCurrent hay feverAssociated with lower FEV<sub>1</sub> anPregnancy plasmaImmune maturationCohort of malesLung developmentSex-specific effectsExposure to per-Young adult malesQuantile g-computation modelsRisk of Nephrolithiasis in Cirrhosis: A Comparison between MASLD Cirrhosis and Cirrhosis Due to Other Etiologies
Boateng S, Hoteit M, Ameyaw, Joshi S, Plato A, Johnkennedy R, Ko D, Patel A, Mejia F, Tai C, Njei B, Buller G. Risk of Nephrolithiasis in Cirrhosis: A Comparison between MASLD Cirrhosis and Cirrhosis Due to Other Etiologies. Southern Medical Journal 2025, 118: 606-613. DOI: 10.14423/smj.0000000000001876.Peer-Reviewed Original ResearchRisk of nephrolithiasisOdds ratioAlcohol-related causesCirrhosis etiologyLiver diseaseMultivariate logistic regression modelViral hepatitis-related cirrhosisHigh riskUS National Inpatient SampleHigher risk of nephrolithiasisAge of patientsAlcohol-related cirrhosisLogistic regression modelsHepatitis-related cirrhosisDiagnosis of nephrolithiasisDiagnosis of cirrhosisNational Inpatient SampleRetrospective cohort studyHospital characteristicsPropensity score matchingCohort studyNephrolithiasis riskInpatient SamplePrimary outcomeMatched CohortPostoperative angiotensin II receptor blocker use is associated with reduced 2-year reoperation rates in male patients undergoing arthroscopic rotator cuff repair
Fong S, Pettinelli N, Lee M, Macleod J, Gillinov S, Monahan P, Moran J, Jonnalagadda A, Mahatme R, Apostolakos J, Jimenez A. Postoperative angiotensin II receptor blocker use is associated with reduced 2-year reoperation rates in male patients undergoing arthroscopic rotator cuff repair. JSES International 2025, 9: 1517-1523. DOI: 10.1016/j.jseint.2025.05.007.Peer-Reviewed Original ResearchArthroscopic rotator cuff repairSecondary surgery rateRotator cuff repairRevision rotator cuff repairCuff repairSurgery ratesOdds ratioRate of secondary surgeryAngiotensin II receptor blocker useSecondary shoulder surgeryRotator cuff repair patientsAssociated with lower ratesAssociated with reduced ratesArthroscopic shoulder proceduresMale-specific analysisStatistically significant differenceAssess outcome differencesRepair patientsBlocker useReoperation rateReceptor blockersSecondary surgeryMale patientsARB useShoulder surgeryAssociations of Pre-diagnostic Serum Liver Enzyme Levels with Lung Cancer Risk in Predominantly Low-income African and European Americans
Xu S, Cai H, Wu J, Shi J, Courtney R, Yoon H, Shu X, Blot W, Zheng W, Cai Q. Associations of Pre-diagnostic Serum Liver Enzyme Levels with Lung Cancer Risk in Predominantly Low-income African and European Americans. Carcinogenesis 2025, bgaf052. PMID: 40879454, DOI: 10.1093/carcin/bgaf052.Peer-Reviewed Original ResearchLC riskOdds ratioSouthern Community Cohort StudyIncident LC casesAfrican AmericansConfidence intervalsCommunity Cohort StudyLung cancer riskSerum ALT levelsPotential effect modifiersConditional logistic regressionLiver enzyme levelsEuropean AmericansMatched ControlsALT levelsCancer riskInverse associationLow-incomeEffect modifiersStudy participantsBaseline serum alanine aminotransferaseBaseline serum alkaline phosphataseLowest tertileMedian follow-up timeCohort studyExcessive daytime sleepiness and mortality: racial/ethnic variations in a large cohort of veterans
Maghsoudi A, Azarian M, Razjouyan J, Hirshkowitz M, Kryger M, Dashti M, Ramezani A, Sharafkhaneh A. Excessive daytime sleepiness and mortality: racial/ethnic variations in a large cohort of veterans. Sleep Medicine 2025, 135: 106752. PMID: 40865361, DOI: 10.1016/j.sleep.2025.106752.Peer-Reviewed Original ResearchConceptsAll-Cause MortalityBody mass indexRace/ethnic groupsRacial/ethnic groupsCharlson Comorbidity IndexAssociated with all-cause mortalityHealth care systemAssociated with higher all-cause mortalityCohort of veteransMarkers of healthMean body mass indexExcessive daytime sleepinessVeteran recordsCare systemRacial/ethnic variationOdds ratioBlack individualsMass indexEligibility criteriaEffect sizeVeteransStudy findingsComorbidity indexOutcome differencesEthnic groupsCritical window of gestational greenspace exposure for the risk of low birth weight
Heo S, Fong K, Son J, Bell M. Critical window of gestational greenspace exposure for the risk of low birth weight. Environmental Research Letters 2025, 20: 094028. PMID: 40822040, PMCID: PMC12355035, DOI: 10.1088/1748-9326/adf86b.Peer-Reviewed Original ResearchGreenspace exposureOdds ratioLow birthweightComplex exposure-response relationshipsInterquartile range increaseRisk of low birth weightWeeks 0Significant ORsGestational weeks 0Zip code levelCase-control studyLow birth weightCritical windowExposure-response relationshipRange increaseMaternal characteristicsBirth dataLogistic regressionBirth weightLate pregnancyPregnancyUS statesBirthweightExposure levelsRiskWho Keeps Using Lysergic acid diethylamide? Correlates of Past-Year Use in People Who Initiated Use at least Five Years Ago
Barnett B, Anand A, Weleff J, King F, Dewey E. Who Keeps Using Lysergic acid diethylamide? Correlates of Past-Year Use in People Who Initiated Use at least Five Years Ago. Psychedelic Medicine 2025 DOI: 10.1177/28314425251367321.Peer-Reviewed Original ResearchLysergic acid diethylamideEstimated weighted prevalencesAcid diethylamideLSD useDrug Use and HealthSmall metropolitan areasPast-yearPast-year useLSD usersLysergic acid diethylamide usePublic health implicationsLevel of educationLifetime stimulant useMultivariate analysisOdds ratioUS adultsLow riskStimulant useDrug sellersMultivariate modelNational surveyIllegal drugsMetropolitan areaDrugHealth implicationsThe role of financial stress, food insecurity, and COVID-19-related illness concerns shaping mental health in five South Asian countries during the pandemic (2020–2022): A secondary analysis of the online COVID-19 Trends and Impact Survey (CTIS) data
Yang Y, Zimmermann L, Pramanik S, Wahl B, Mukherjee B. The role of financial stress, food insecurity, and COVID-19-related illness concerns shaping mental health in five South Asian countries during the pandemic (2020–2022): A secondary analysis of the online COVID-19 Trends and Impact Survey (CTIS) data. PLOS Global Public Health 2025, 5: e0004704. PMID: 40779535, PMCID: PMC12334018, DOI: 10.1371/journal.pgph.0004704.Peer-Reviewed Original ResearchFood insecurityOdds ratioIllness concernsMental healthSurvey-weighted logistic regression modelsImpact SurveyCalendar timeFinancial stressMental health worldwidePandemic-related worriesRandom-effects meta-analysisMental health resilienceMiddle-income countriesAssociated with depressionLevels of depressionLogistic regression modelsSocioeconomic stressorsAsian LMICsSecondary analysisHealth resiliencePost-changeLMICsCountry-specific analysisResidential statusSurvey designDevice-Detected Atrial Fibrillation in Patients With and Without Cryptogenic Ischemia: The ANTARCTICA Pooled Analysis
Yaghi S, Sposato L, Shu L, García-Rodríguez D, Urda V, Kreimer F, Gotzmann M, Greisenegger S, Nahab F, Alshaer Q, Koge J, Ikenouchi H, Kitsiou A, Tsivgoulis G, Triantafyllou S, Skrebelyte-Strøm L, Rønning O, Lambert A, Aamodt A, Bufano G, Renda G, Godia E, Pikija S, Buck B, Ondraskova E, Healey J, McIntyre W, Hill M, Saver J, Kasner S, Kamel H, Elkind M, Schwamm L, Kent D, Katsanos A, Fridman S, Investigators O. Device-Detected Atrial Fibrillation in Patients With and Without Cryptogenic Ischemia: The ANTARCTICA Pooled Analysis. Stroke 2025, 56: 2895-2903. PMID: 40765508, DOI: 10.1161/strokeaha.125.051749.Peer-Reviewed Original ResearchConceptsIndividual-participant data meta-analysisRandomized Controlled TrialsMeta-analysis of prospective studiesMultilevel logistic regression analysisMultilevel multivariable logistic regression modelNonstroke patientsInsertable cardiac monitorAF detection rateIschemic strokeMultivariate logistic regression modelHistory of strokeLogistic regression modelsLogistic regression analysisProspective studyAtrial fibrillationOdds ratioMultiple imputationPrimary outcomeStudy populationPatient characteristicsRubin's rulesRegression modelsPooled analysisTransient ischemic attackCryptogenic strokePrevalence and determinants of excessive daytime sleepiness among men who have sex with men in Nepal: A cross-sectional study
Paudel K, Gautam K, Sharma M, Wickersham J, Sujan S, Ha T, Copenhaver M, Adhikari T, Shrestha R. Prevalence and determinants of excessive daytime sleepiness among men who have sex with men in Nepal: A cross-sectional study. Medicine 2025, 104: e42341. PMID: 40760630, PMCID: PMC12323900, DOI: 10.1097/md.0000000000042341.Peer-Reviewed Original ResearchConceptsPrevalence of excessive daytime sleepinessSocial supportDepressive symptomsPatient Health QuestionnaireExcessive daytime sleepinessConfidence intervalsHealth care providersCross-sectional surveySevere depressive symptomsStrong social supportMiddle-income countriesCross-sectional studyModerate prevalenceFactors associated with excessive daytime sleepinessCare providersHealth QuestionnaireMultivariate logistic regression analysisPHQ-9Public health concernEffective careLogistic regression analysisHigher oddsStudy participantsMSMOdds ratioExamining Pathways Among Teen Dating Violence, Substance Use, and Suicidal Ideation Among Black Girls: A Cross-Sectional Study.
Opara I, Weerakoon S, Srikanth N, Brooks Stephens J, Wan X, Willie T. Examining Pathways Among Teen Dating Violence, Substance Use, and Suicidal Ideation Among Black Girls: A Cross-Sectional Study. Journal Of Interpersonal Violence 2025, 8862605251353484. PMID: 40741816, DOI: 10.1177/08862605251353484.Peer-Reviewed Original ResearchTeen dating violenceSubstance useBlack adolescent girlsOdds ratioRates of teen dating violenceOdds of substance useAdolescent girlsBlack girlsConfidence intervalsAssociated with substance usePoor mental health outcomesYouth Risk Behavior Surveillance SystemBehavior Surveillance SystemA cross-sectional studyOdds of suicidal ideationSuicidal ideationBlack female adolescentsMental health challengesMental health outcomesDating violenceRisk factorsPublic health initiativesIndirect pathwaysFemale adolescentsViolenceAnaphylaxis to Penicillin: Harvesting Insights from the Food and Drug Administration's Adverse Event Reporting System
Belmont A, Novotny S, Mukherjee E, Park D, Wong K, Martin-Pozo M, Phillips E, Stone C. Anaphylaxis to Penicillin: Harvesting Insights from the Food and Drug Administration's Adverse Event Reporting System. The Journal Of Allergy And Clinical Immunology In Practice 2025 PMID: 40752738, DOI: 10.1016/j.jaip.2025.07.039.Peer-Reviewed Original ResearchFood and Drug Administration Adverse Event Reporting SystemAnd Drug Administration Adverse Event Reporting SystemReports of anaphylaxisContemporary epidemiologyAdverse Event Reporting SystemReporting odds ratioPenicillin antibioticsCross-sectional studyEvent Reporting SystemReporting systemUnited StatesFAERS databaseHighest proportionSpecific PAOdds ratioAssociated with deathOddsPiperacillin-tazobactamMedicationAdverse eventsProportional reporting ratioAnaphylaxis reportsDisproportionality signalPharmacovigilance methodsAnaphylaxisHumoral determinants of checkpoint immunotherapy
Dai Y, Aizenbud L, Qin K, Austin M, Jaycox J, Cunningham J, Wang E, Zhang L, Fischer S, Carroll S, van Aggelen H, Kluger Y, Herold K, Furchtgott L, Kluger H, Ring A. Humoral determinants of checkpoint immunotherapy. Nature 2025, 644: 527-536. PMID: 40702172, DOI: 10.1038/s41586-025-09188-4.Peer-Reviewed Original ResearchConceptsCheckpoint immunotherapyPreclinical mouse tumor modelsImmune-related adverse eventsIFN-IAntibody-mediated humoral immunityResponse to therapyTumor surface proteinMouse tumor modelsType I interferonIndividual autoantibodiesAutoantibody signaturesAdverse eventsAutoantibody responseCellular immunityTumor modelHumoral immunityAutoantibodiesOdds ratioIL-6Healthy control participantsHealthy individualsControl individualsI interferonPatientsGrowth factorAssociation Between Angiotensin Converting Enzyme Insertion / Deletion Genotypes and Diabetic Nephropathy Defined by Urinary Albumin-to-Creatinine Ratio: A Systematic Review and Meta-Analysis
Kiconco R, Kalyesubula R, Tumusiime J, Atwine R, Bagenda C, Rugera S, Agaba B, Ondari E, Tusubira D, Lyaka M, Ocan M, Kinengyere A, Obuku E, Kiwanuka G. Association Between Angiotensin Converting Enzyme Insertion / Deletion Genotypes and Diabetic Nephropathy Defined by Urinary Albumin-to-Creatinine Ratio: A Systematic Review and Meta-Analysis. F1000Research 2025, 14: 697. DOI: 10.12688/f1000research.166660.1.Peer-Reviewed Original ResearchFogarty International CenterACE II genotypeEgger's testMeta-analysisOdds ratioPublication biasSystematic reviewACE I/D polymorphismDN riskConfidence intervalsQuality of studiesRisk of biasPooled odds ratioACE genotypeRandom-effects modelWeb of ScienceInfluence of ACE I/D polymorphismI/D polymorphismROBINS-E toolType 2 diabetes mellitusDiabetic nephropathyIndependent reviewersRayyan softwareFrequencies of ACE genotypesMeta-RegressionSex Differences in Illicitly Manufactured Fentanyl Use: Prevalence and Sociodemographic, Health, and Environmental Correlates.
Stefanovics E, Tsai J, Potenza M. Sex Differences in Illicitly Manufactured Fentanyl Use: Prevalence and Sociodemographic, Health, and Environmental Correlates. Journal Of Addiction Medicine 2025 PMID: 40662593, DOI: 10.1097/adm.0000000000001543.Peer-Reviewed Original ResearchWeighted lifetime prevalenceUS populationAssociated with middle agePopulation-based interventionsNoninstitutionalized US populationHealth concernDrug Use and HealthPhysical health concernsFederal poverty levelHigh school educational attainmentPublic health concernHealth characteristicsLower educationPhysical healthTargeted interventionsHispanic ethnicityLow-incomeSex differencesOdds ratioElevated riskIllicitly manufactured fentanyl useImproved supportEducational attainmentHigher incomeNational survey
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