2025
Sex-Related Measurement Bias in Autism Spectrum Disorder Symptoms in the Baby Siblings Research Consortium
Burrows C, Sung S, Zheng S, Young G, Charman T, Klaiman C, Klin A, Marrus N, Ozonoff S, Piven J, Robins D, Schmidt R, Schwichtenberg A, Webb S, Zwaigenbaum L, Carver L, Chawarska K, Curtin S, Jeste S, Iverson J, Landa R, Messinger D, Roberts J, Stone W, Tager-Flusberg H, Esler A, Miller M, Bishop S, Elison J. Sex-Related Measurement Bias in Autism Spectrum Disorder Symptoms in the Baby Siblings Research Consortium. JAMA Network Open 2025, 8: e2525887. PMID: 40779266, PMCID: PMC12334962, DOI: 10.1001/jamanetworkopen.2025.25887.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAutism Diagnostic Observation ScheduleSex differencesQuality of social overturesMeasures of ASD symptomsResponsiveness to joint attentionAutism spectrum disorder symptomsHFL groupSocial communication difficultiesPrevalence of autism spectrum disorderConfirmatory factor analysisModerate levelsSocial overturesDisorder symptomsASD symptomsAutistic traitsClinician trainingJoint attentionMeasurement invarianceAge of diagnosisSpectrum disorderDevelopmental differencesMain OutcomesObservation ScheduleDiagnostic groups
2024
Similar Gap-Overlap Profiles in Children with Fragile X Syndrome and IQ-Matched Autism
Wall C, Shic F, Will E, Wang Q, Roberts J. Similar Gap-Overlap Profiles in Children with Fragile X Syndrome and IQ-Matched Autism. Journal Of Autism And Developmental Disorders 2024, 55: 891-903. PMID: 38246961, PMCID: PMC11260273, DOI: 10.1007/s10803-024-06245-1.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderAutism spectrum disorderIntellectual abilityVisual attentionFXS groupX syndromeReaction timeControl of visual attentionGap-overlap paradigmElevated ADHD symptomsAge-matched neurotypical controlsAtypical visual attentionFragile X syndromeSaccadic reaction timesSevere cognitive impairmentIQ-matchedNeurocognitive processesADHD symptomsAttention-deficit/hyperactivityASD groupASD symptomsAttentional differencesNeurotypical controlsModerate to severe cognitive impairmentSpectrum disorder
2022
Structural language impairment in Autism Spectrum Disorder versus Loss of Autism Diagnosis: Behavioral and neural characteristics
Larson C, Rivera-Figueroa K, Thomas H, Fein D, Stevens M, Eigsti I. Structural language impairment in Autism Spectrum Disorder versus Loss of Autism Diagnosis: Behavioral and neural characteristics. NeuroImage Clinical 2022, 34: 103043. PMID: 35567947, PMCID: PMC9112023, DOI: 10.1016/j.nicl.2022.103043.Peer-Reviewed Original ResearchConceptsStructural language impairmentAutism spectrum disorderLanguage impairmentSpectrum disorderAutism diagnosisLanguage-related brain regionsStructural language abilitiesStructural language difficultiesLeft hemisphere lateralizationFunctional MRI resultsFunctional neuroimaging methodsRecalling SentencesHemisphere lateralizationLanguage abilityNeural specializationADHD symptomsSocial abilitiesASD symptomsLanguage difficultiesLanguage functionNeural characteristicsNeuroimaging methodsGroup differencesBrain regionsOmnibus measure
2021
An Electrocortical Measure Associated With Metarepresentation Mediates the Relationship Between Autism Symptoms and Theory of Mind
Libsack E, Trimber E, Hauschild K, Hajcak G, McPartland J, Lerner M. An Electrocortical Measure Associated With Metarepresentation Mediates the Relationship Between Autism Symptoms and Theory of Mind. Clinical Psychological Science 2021, 10: 324-339. PMID: 38736986, PMCID: PMC11086972, DOI: 10.1177/21677026211021975.Peer-Reviewed Original ResearchLate positive complexTheory of mindMental state inferencesLate slow waveASD symptom severityAutism spectrum disorderToM reasoningToM performanceElectrocortical measuresAutism symptomsERP componentsIndividual differencesPositive complexASD symptomsLPC scoresNeural mechanismsSpectrum disorderSymptom severityMetarepresentationDifferential recruitmentMindSlow wavesIndividualsASDAdolescents
2020
Atypical Emotional Electrodermal Activity in Toddlers with Autism Spectrum Disorder
Vernetti A, Shic F, Boccanfuso L, Macari S, Kane‐Grade F, Milgramm A, Hilton E, Heymann P, Goodwin MS, Chawarska K. Atypical Emotional Electrodermal Activity in Toddlers with Autism Spectrum Disorder. Autism Research 2020, 13: 1476-1488. PMID: 32896980, PMCID: PMC10081486, DOI: 10.1002/aur.2374.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderPhysiological arousalTypical developmentEmotional challengesAge-matched toddlersAutism symptom severityEmotion-eliciting conditionsCore ASD symptomsSeverity of autismSkin conductance levelFear emotionCognitive processesFear conditionTD peersASD groupEmotional expressivityEmotional expressionASD symptomsPleasant eventsExternalizing problemsSpectrum disorderThreatening eventsUnderstanding of precursorsBehavioral problemsBehavioral expressionAutism Spectrum Disorder and Schizophrenia Are Better Differentiated by Positive Symptoms Than Negative Symptoms
Trevisan DA, Foss-Feig JH, Naples AJ, Srihari V, Anticevic A, McPartland JC. Autism Spectrum Disorder and Schizophrenia Are Better Differentiated by Positive Symptoms Than Negative Symptoms. Frontiers In Psychiatry 2020, 11: 548. PMID: 32595540, PMCID: PMC7301837, DOI: 10.3389/fpsyt.2020.00548.Peer-Reviewed Original ResearchAutism spectrum disorderSpectrum disorderNegative symptomsAutism Diagnostic Observation SchedulePositive symptomsGold standard diagnostic assessmentHeterogenous neurodevelopmental disorderAnalysis of covarianceDSM-5 criteriaStereotyped languageTD adultsASD symptomsTypical developmentObservation ScheduleRepetitive behaviorsCommunicative behaviorNegative Syndrome ScaleStandardized measuresSZ groupSymptom domainsGroup differencesParticipant groupsSymptom overlapSZ symptomsNeurodevelopmental disorders
2019
Anger Rumination is Associated with Restricted and Repetitive Behaviors in Children with Autism Spectrum Disorder
Ibrahim K, Kalvin C, Marsh CL, Anzano A, Gorynova L, Cimino K, Sukhodolsky DG. Anger Rumination is Associated with Restricted and Repetitive Behaviors in Children with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2019, 49: 3656-3668. PMID: 31144231, PMCID: PMC7035789, DOI: 10.1007/s10803-019-04085-y.Peer-Reviewed Original Research
2017
Brief Report: Bullying and Anxiety in High-Functioning Adolescents with ASD
van Schalkwyk G, Smith IC, Silverman WK, Volkmar FR. Brief Report: Bullying and Anxiety in High-Functioning Adolescents with ASD. Journal Of Autism And Developmental Disorders 2017, 48: 1819-1824. PMID: 29152669, DOI: 10.1007/s10803-017-3378-8.Peer-Reviewed Original ResearchCellular and Circuitry Bases of Autism: Lessons Learned from the Temporospatial Manipulation of Autism Genes in the Brain
Hulbert SW, Jiang YH. Cellular and Circuitry Bases of Autism: Lessons Learned from the Temporospatial Manipulation of Autism Genes in the Brain. Neuroscience Bulletin 2017, 33: 205-218. PMID: 28271437, PMCID: PMC5360850, DOI: 10.1007/s12264-017-0112-7.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderDifferent neurotransmitter systemsCell typesNeurotransmitter systemsInhibitory neuronsAdult miceTransgenic miceBrain regionsCre linesDevelopmental time periodCre-loxPCertain cell typesMiceCore ASD symptomsDisordersMolecular underpinningsTime periodSpectrum disorderASD symptomsGene expressionMutationsDistinct neural bases of disruptive behavior and autism symptom severity in boys with autism spectrum disorder
Yang YJ, Sukhodolsky DG, Lei J, Dayan E, Pelphrey KA, Ventola P. Distinct neural bases of disruptive behavior and autism symptom severity in boys with autism spectrum disorder. Journal Of Neurodevelopmental Disorders 2017, 9: 1. PMID: 28115995, PMCID: PMC5240249, DOI: 10.1186/s11689-017-9183-z.Peer-Reviewed Original ResearchAutism spectrum disorderAutism symptom severityMedial prefrontal cortexAnterior cingulate cortexLow disruptive behaviorCore ASD symptomsBiological motionNeural basisDMN deactivationDisruptive behaviorADHD symptomsASD symptomsSpectrum disorderAnxiety symptomsSymptom severityPosterior superior temporal sulcusBetween-group analysisDefault mode network deactivationDistinct neural basesSuperior temporal sulcusInferior frontal gyrusHigh disruptive behaviorLateral parietal cortexASD participantsNeural underpinnings
2016
Non‐ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study
Charman T, Young GS, Brian J, Carter A, Carver LJ, Chawarska K, Curtin S, Dobkins K, Elsabbagh M, Georgiades S, Hertz‐Picciotto I, Hutman T, Iverson JM, Jones EJ, Landa R, Macari S, Messinger DS, Nelson CA, Ozonoff S, Saulnier C, Stone WL, Tager‐Flusberg H, Webb SJ, Yirmiya N, Zwaigenbaum L. Non‐ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study. Autism Research 2016, 10: 169-178. PMID: 27417857, PMCID: PMC5993543, DOI: 10.1002/aur.1669.Peer-Reviewed Original ResearchConceptsAutism Diagnostic Observation ScheduleAutism spectrum disorderHigh-risk siblingsLow-risk controlsBroader autism phenotypeModerate language delayAdaptive functioningASD symptomsLanguage delayVineland Adaptive Behavior ScalesLower adaptive functioningAge 3 yearsAutism Diagnostic InterviewProportion of toddlersAdaptive behavior outcomesAdaptive Behavior ScalesOngoing clinical monitoringAutism phenotypeMullen ScalesSpectrum disorderObservation ScheduleEarly learningBehavioral outcomesElevated scoresDevelopmental outcomes
2015
Early sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study
Messinger DS, Young GS, Webb SJ, Ozonoff S, Bryson SE, Carter A, Carver L, Charman T, Chawarska K, Curtin S, Dobkins K, Hertz-Picciotto I, Hutman T, Iverson JM, Landa R, Nelson CA, Stone WL, Tager-Flusberg H, Zwaigenbaum L. Early sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study. Molecular Autism 2015, 6: 32. PMID: 26045943, PMCID: PMC4455973, DOI: 10.1186/s13229-015-0027-y.Peer-Reviewed Original ResearchAutism spectrum disorderHigh-risk siblingsASD outcomeLow-risk childrenCognitive functioningASD symptomsASD recurrenceSubscale scoresSex differencesBaby Siblings Research Consortium StudyHigh-risk childrenHR-ASD groupNon-ASD groupEarly sex differencesMullen ScalesDomain scoresCognitive performanceEffect hypothesisSpectrum disorderRepetitive behaviorsLearning subscaleSA scoresASD probandsGroup differencesYounger siblings
2014
A contrast of comorbid condition and adaptive function between children with Autism Spectrum Disorder from clinical and non-clinical populations
Park J, Kim Y, Koh Y, Song J, Leventhal B. A contrast of comorbid condition and adaptive function between children with Autism Spectrum Disorder from clinical and non-clinical populations. Research In Autism Spectrum Disorders 2014, 8: 1471-1481. DOI: 10.1016/j.rasd.2014.07.014.Peer-Reviewed Original ResearchAutism spectrum disorderASD groupNon-clinical populationsAdaptive skillsSpectrum disorderAdaptive functionBASC-2 PRSCore ASD symptomsHigher adaptive skillsConduct problem scalesComorbid behavioral problemsGroup of childrenSocial skillsASD symptomsConduct problemsExternalizing problemsBehavioral problemsClinical populationsLeadership ScaleCommunity childrenProblem scaleSkillsChildrenComorbid conditionsEarly identification
2013
The role of imitation in the observed heterogeneity in EEG mu rhythm in autism and typical development
Bernier R, Aaronson B, McPartland J. The role of imitation in the observed heterogeneity in EEG mu rhythm in autism and typical development. Brain And Cognition 2013, 82: 69-75. PMID: 23511847, DOI: 10.1016/j.bandc.2013.02.008.Peer-Reviewed Original ResearchConceptsMirror neuron system functionAutism spectrum disorderEEG mu rhythmImitation abilityMNS activityMu rhythmExecution/observation matching systemGoal-directed hand actionsMirror neuron systemObservation of actionsRole of imitationImitative skillsMNS functionCore deficitAction observationTypical developmentUniversal impairmentASD symptomsASD sampleHand actionsSocial deficitsSpectrum disorderSubset of childrenNeuron systemNormative patterns
2006
Autism spectrum disorder in the second year: stability and change in syndrome expression
Chawarska K, Klin A, Paul R, Volkmar F. Autism spectrum disorder in the second year: stability and change in syndrome expression. Journal Of Child Psychology And Psychiatry 2006, 48: 128-138. PMID: 17300551, DOI: 10.1111/j.1469-7610.2006.01685.x.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSymptoms of ASDAutism Diagnostic Observation Schedule-GenericSyndrome expressionSpectrum disorderParental reportsAcquisition of languageAutism Diagnostic InterviewSymptoms of autismPervasive developmental disorderDyadic social behaviorASD symptomsPDD-NOSSocial dysfunctionSocial behaviorAutismLanguage characteristicsDevelopmental disordersDiagnostic InterviewDiagnostic classificationYoung childrenADOSStereotyped behaviorSecond yearArt diagnostic methods
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