2025
Articular Cartilage Injuries in Pediatric and Adolescent Patients Undergoing Medial Meniscal Ramp Lesion Repair During Primary Anterior Cruciate Ligament Reconstruction: A Multicenter Study.
Moran J, Amaral J, Tollefson L, Jones R, Dave U, Lee M, Ferrell S, LaPrade C, Katz L, Salandra J, Schenble C, Allen C, Gardner E, Jimenez A, Medvecky M, Hewett T, Verma N, Chahla J, LaPrade R, Fabricant P, McKay S. Articular Cartilage Injuries in Pediatric and Adolescent Patients Undergoing Medial Meniscal Ramp Lesion Repair During Primary Anterior Cruciate Ligament Reconstruction: A Multicenter Study. The American Journal Of Sports Medicine 2025, 3635465251366440. PMID: 40952167, DOI: 10.1177/03635465251366440.Peer-Reviewed Original ResearchMedial meniscal ramp lesionsDelayed ACL reconstructionTime of surgeryAdolescent patientsArticular cartilage injuryACL reconstructionRisk factorsMulticenter studyPrimary anterior cruciate ligament reconstructionMedial femoral condyleCartilage injuryInternational Cartilage Repair Society classificationAnterior cruciate ligament (ACL) tearsPatients aged <Meniscal ramp lesionsHigh-risk patientsRamp lesion repairAnterior cruciate ligament reconstructionPrimary ACL reconstructionRetrospective cohort studyMultivariate logistic regression modelCruciate ligament reconstructionLevel of evidenceRed-red zoneAssociated with articular cartilage damageSerum Proteomic Profile Based on the TGF‐β Pathway Stratifies Risk of Hepatocellular Carcinoma
Xiang X, Shetty K, Yu H, Mishra B, Wong L, Zhou X, Satapathy S, Crawford J, Latham P, Han S, Mathew B, Dagher N, Lau L, Cacaj F, Vegesna A, Dasarathy S, He A, Huang H, Amdur R, Mishra L. Serum Proteomic Profile Based on the TGF‐β Pathway Stratifies Risk of Hepatocellular Carcinoma. Liver International 2025, 45: e70325. PMID: 40919824, PMCID: PMC12416123, DOI: 10.1111/liv.70325.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkers, TumorCarcinoma, HepatocellularCross-Sectional StudiesFemaleHumansLiver CirrhosisLiver NeoplasmsLogistic ModelsLongitudinal StudiesMaleMiddle AgedProspective StudiesProteomicsReceptor, Transforming Growth Factor-beta Type IIRisk AssessmentRisk FactorsTransforming Growth Factor betaConceptsRisk of hepatocellular carcinomaHepatocellular carcinomaCohort ALogistic regression analysisCohort CLongitudinal follow-up analysisTGF-bHepatocellular carcinoma riskCancer-related deathsProtein signaturesSix-protein panelSerum proteomic profilesLate-stage diagnosisAFP levelsCirrhotic patientsCohort BMulticenter studyLogistic regression analyses of cross-sectional dataClinical factorsMultivariable prediction modelEarly diagnosisMatched subgroupsPatientsCirrhosisFunction biomarkersStandard complete blood count to predict long‐term outcomes in febrile infection–related epilepsy syndrome (FIRES): A multicenter study
Guillemaud M, Hanin A, Riviello J, Chavez M, Batra A, Berry M, Bisulli F, Castillo‐Pinto C, Cobos‐Hernandez C, Demeret S, Eschbach K, Farias‐Moeller R, Fields M, Gaspard N, Gerard E, Gofton T, Gopaul M, Gruen M, Jimenez A, Kazazian K, Kim M, Mansour M, Marcuse L, Marois C, Morales M, Muccioli L, Pasini E, Pham M, Rosas S, Struck A, Torcida N, Wainwright M, Yoo J, Muscal E, Navarro V, Hirsch L, Lai Y. Standard complete blood count to predict long‐term outcomes in febrile infection–related epilepsy syndrome (FIRES): A multicenter study. Epilepsia 2025 PMID: 40844418, DOI: 10.1111/epi.18605.Peer-Reviewed Original ResearchFebrile infection-related epilepsy syndromeMonocyte-to-lymphocyte ratioNeutrophil-to-lymphocyte ratioComplete blood countNew-onset refractory status epilepticusSecond-line immunotherapyUnfavorable outcomeBlood countComplete blood count levelsHigh red cell distribution widthEpilepsy syndromesTreatment phaseFirst-line immunotherapyInitiation of immunotherapyRed cell distribution widthRefractory status epilepticusComplete blood count dataCell distribution widthLong-term outcomesIntensive care unitSubtypes of leukocytesLeave-one-patient-outMulticenter studyStatus epilepticusImmunotherapyShifting respiratory pathogens: Post-COVID-19 trends in community-acquired infections in underserved communities
Rafei R, Osman M, Barake B, Mallat H, Dabboussi F, Hamze M. Shifting respiratory pathogens: Post-COVID-19 trends in community-acquired infections in underserved communities. PLOS ONE 2025, 20: e0329481. PMID: 40845032, PMCID: PMC12373226, DOI: 10.1371/journal.pone.0329481.Peer-Reviewed Original ResearchConceptsInfluenza ARespiratory infectionsLogistic regression modelsCommunity-acquired acute respiratory infectionsRespiratory pathogensCommunity-acquired infectionsParainfluenza virus infectionEpidemiology of respiratory infectionsRespiratory tract infectionsSARS-CoV-2Multivariate logistic regression modelAcute respiratory infectionsAntimicrobial stewardship strategiesLogistic regression analysisGlobal health burdenTract infectionsHuman rhinovirus/enterovirusMulticenter studyParainfluenza virusNasopharyngeal samplesCo-InfectionVirus infectionPatientsRegression modelsPediatric clinicMachine learning-based prediction of tubulointerstitial lesions in diabetic kidney disease: a multicenter validation study
Xu C, Shen Z, Zhong Y, Han S, Liao H, Duan Y, Tian X, Ren X, Lu C, Jiang H. Machine learning-based prediction of tubulointerstitial lesions in diabetic kidney disease: a multicenter validation study. Renal Failure 2025, 47: 2547266. PMID: 40841991, PMCID: PMC12372483, DOI: 10.1080/0886022x.2025.2547266.Peer-Reviewed Original ResearchConceptsDiabetic kidney diseaseDecision curve analysisTubulointerstitial lesionsKidney diseaseIdentification of high-risk patientsEarly identification of high-risk patientsManagement of diabetic kidney diseaseDeterioration of renal functionProgression of diabetic kidney diseaseHigh-risk patientsEarly identificationExternal validation cohortMulticenter validation studyBiopsy puncturesRenal functionClinical benefitMulticenter studyValidation cohortInvasive biopsyPrecision nephrologyMetabolic markersKidney functionInternal validityMultivariate analysisPathological featuresNot All Temperature Control Is Equal: High-Quality Temperature Control Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest
Beekman R, Nguyen C, Deng Y, Chakravartty A, Perman S, Wira C, Khosla A, Miller P, Sheth K, Greer D, Gilmore E. Not All Temperature Control Is Equal: High-Quality Temperature Control Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest. Annals Of Emergency Medicine 2025 PMID: 40817896, DOI: 10.1016/j.annemergmed.2025.06.622.Peer-Reviewed Original ResearchSingle-center studyInverse probability treatment weightsNeurological outcomeCardiac arrestOut-of-hospital cardiac arrestOut-of-hospital cardiac arrest patientsHospital dischargeSecondary outcomesTreatment weightingCerebral Performance Category scoreAssociated with improved outcomesNeuroprotective benefitsProspective multicenter studyFavorable neurologic outcomeSmall effect sizesSurvivors of cardiac arrestCardiac arrest patientsAdjunctive pharmacologic treatmentStandardized mean differenceAchievement of target temperatureHigh-quality groupHospital arrivalArrest patientsMulticenter studyClinical outcomesClinical Features of Chinese Patients with Thyroid Eye Disease: A Multicenter Retrospective Study
Lei C, Lyu X, Ren Y, Wei D, Zhang S, Zhang Y, Wang L, Liu L, Wen J, Liu X, Lin C, Lu W, Liu J, Li R, Zhang S, Song X, Yu Z, Bahn R, Zhou H. Clinical Features of Chinese Patients with Thyroid Eye Disease: A Multicenter Retrospective Study. Thyroid 2025 PMID: 40658134, DOI: 10.1177/10507256251359559.Peer-Reviewed Original ResearchThyroid eye diseaseSight-threatening thyroid eye diseaseTED severityRetrospective multicenter studyClinical featuresTreatment responseIntravenous glucocorticoidsMulticenter studyEye diseaseClinical features of Chinese patientsChinese cohortSevere thyroid eye diseaseFeatures of Chinese patientsClinical activity scoreMulticenter retrospective studyDegree of exophthalmosDebilitating autoimmune disorderModerate-to-severeConclusions:</i></b>Area under the receiver operating curveReceiver operating curveDiplopia scoreSight-threateningOphthalmology departmentThyroid dysfunctionPreferences, Acceptability, and Utilization of Multimodal Self-Help Interventions in Adults With Inflammatory Bowel Diseases: A Pragmatic Multicenter Study With Patients and Clinicians
Tse C, Hunt M, Lewis J, Ostrov A, Shah S, Fiske H, Burwell S, Forster E, Gaidos J, Kuehnel R, Sheng E, Lu M, Weng C, Wolk C, Soto C, Weaver S, Melmed G, Siegel C, van Deen W. Preferences, Acceptability, and Utilization of Multimodal Self-Help Interventions in Adults With Inflammatory Bowel Diseases: A Pragmatic Multicenter Study With Patients and Clinicians. Inflammatory Bowel Diseases 2025, izaf154. PMID: 40736230, DOI: 10.1093/ibd/izaf154.Peer-Reviewed Original ResearchSelf-help resourcesClinician experiencePatient preferencesLearning health systemExperiences of patientsSelf-help interventionInflammatory bowel diseaseHealth confidenceHealth systemFocus groupsLack of knowledgeChronic diseasesGastroenterology practiceE-surveyBowel diseaseCliniciansConfidenceKnowledge gapsPatientsAcceptanceProvidersMulticenter studyInterventionGastroenterologyConfident optimismMixed Autoimmune Hemolytic Anemia: A Systematic Review of Epidemiology, Clinical Characteristics, Therapies, and Outcomes
Jacobs J, Raza S, Clark L, Stephens L, Allen E, Woo J, Walden R, Villalba C, Tormey C, Stanek C, Adkins B, Bloch E, Booth G. Mixed Autoimmune Hemolytic Anemia: A Systematic Review of Epidemiology, Clinical Characteristics, Therapies, and Outcomes. American Journal Of Hematology 2025, 100: 1397-1407. PMID: 40392014, PMCID: PMC12232602, DOI: 10.1002/ajh.27721.Peer-Reviewed Original ResearchAutoimmune hemolytic anemiaDiagnostic criteriaClinical characteristicsMixed autoimmune hemolytic anemiaMultiple lines of therapyComplex hematological disorderLines of therapyNadir hemoglobin levelsReview of epidemiologyInnovative treatment modalitiesEvaluate epidemiological patternsFrequent underlying etiologyCombination therapyHematologic malignanciesImprove patient outcomesFemale predominanceHematological disordersMulticenter studyChronic hemolysisClinical featuresTreatment modalitiesHemoglobin levelsUnderlying etiologyHemolytic anemiaAutoimmune diseasesHuman Immunodeficiency Virus Infection and Long COVID: A RECOVER Program, Electronic Health Record–Based Cohort Study
Hawkins K, Dandachi D, Verzani Z, Brannock M, Lewis C, Abedian S, Jaferian S, Wuller S, Truong J, Witvliet M, Dymond G, Mehta H, Patel P, Hill E, Weiner M, Carton T, Kaushal R, Feuerriegel E, Tran H, Marks K, Oliveira C, Gardner E, Ofotokun I, Gulick R, Erlandson K. Human Immunodeficiency Virus Infection and Long COVID: A RECOVER Program, Electronic Health Record–Based Cohort Study. Clinical Infectious Diseases 2025, ciaf242. PMID: 40354184, DOI: 10.1093/cid/ciaf242.Peer-Reviewed Original ResearchDefinition of Long COVIDICD-10Baseline chronic conditionsLong COVIDElectronic health record databaseIncreased riskHealth record databaseICD-10 codesICD-10 definitionRisk of long COVIDClinical Research NetworkChronic conditionsAcute SARS-CoV-2 infectionHIV statusAnalytic sampleOdds ratioCohort definitionsCohort CollaborationComputable phenotypePhenotype definitionRecord databaseSARS-CoV-2 infectionLogistic regressionResearch NetworkMulticenter studyOpioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice
Fisher C, Janda A, Zhao X, Deng Y, Bardia A, Yanez N, Burns M, Aziz M, Treggiari M, Mathis M, Lin H, Schonberger R. Opioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice. Anesthesia & Analgesia 2025, 140: 1016-1027. PMID: 39167548, PMCID: PMC11842693, DOI: 10.1213/ane.0000000000007128.Peer-Reviewed Original ResearchCardiac surgeryOpioid doseDose variationIntraoperative opioid administrationIntraoperative opioid doseHigh-dose opioidsAdult cardiac surgerySurgical differencesOpioid-freeOpioid administrationOpioid useMultimodal analgesiaAnalgesic techniquesCardiopulmonary bypassMulticenter studyFentanyl equivalentsSufentanil infusionSurgical patientsOpioidSurgeryAnesthetic techniqueCardiac casesAttending anesthesiologistPatientsDoseSa1903: PREDICTORS AND OUTCOMES OF UPADACITINIB EXTENDED INDUCTION AND HIGHER DOSE MAINTENANCE THERAPY IN INFLAMMATORY BOWEL DISEASE: A MULTICENTER STUDY
Johnkennedy R, Azar J, Levine L, AlOmar I, AlMutairdi A, Attamimi M, Proctor D, Gaidos J, Al-Bawardy B. Sa1903: PREDICTORS AND OUTCOMES OF UPADACITINIB EXTENDED INDUCTION AND HIGHER DOSE MAINTENANCE THERAPY IN INFLAMMATORY BOWEL DISEASE: A MULTICENTER STUDY. Gastroenterology 2025, 169: s-575-s-576. DOI: 10.1016/s0016-5085(25)02265-6.Peer-Reviewed Original ResearchBridging radiotherapy before chimeric antigen receptor T cells for B-cell lymphomas: an ILROG multicenter study
Yegya-Raman N, Plastaras J, Wright C, Chelius M, Zhang S, Baron J, Hubbeling H, Sim A, Robinson T, Jain M, Imber B, Fregonese B, Yahalom J, Ladbury C, Dandapani S, Pinnix C, Gunther J, Fang P, Wu S, Dabaja B, Yang J, Chew J, Braunstein S, Sinha S, Delinger N, Sun S, Terezakis S, Sakthivel G, Constine L, Chowdhry A, Reagan P, Burke S, Tseng Y, LaRiviere M, Maity A, Schuster S, Chong E, Figura N. Bridging radiotherapy before chimeric antigen receptor T cells for B-cell lymphomas: an ILROG multicenter study. Blood Advances 2025, 9: 3293-3303. PMID: 40203192, PMCID: PMC12268022, DOI: 10.1182/bloodadvances.2025015855.Peer-Reviewed Original ResearchConceptsChimeric antigen receptor T-cell therapyImmune effector cell-associated neurotoxicity syndromeSuperior progression-free survivalProgression-free survivalB-cell lymphomaCytokine release syndromeAssociated with superior progression-free survivalOverall survivalTwo-year progression-free survivalChimeric antigen receptor T cellsLactate dehydrogenaseRelapsed/refractory B-cell lymphomaLactate dehydrogenase normalizationAmerican Society for TransplantationT-cell therapyBaseline lactate dehydrogenaseMedian Follow-UpRetrospectively reviewed patientsAdvanced-stage diseaseHigh-risk cohortAxicabtagene ciloleucelBrexucabtagene autoleucelSystemic therapyMulticenter studyT cellsCARDIOVASCULAR EVENTS IN PATIENTS WITH ACUTE MYELOID LEUKEMIA TREATED WITH VENETOCLAX: A MULTICENTER STUDY
Filimon S, Ghamari A, Vakilpour A, Patel R, Achar R, Akhter N, Shallis R, DeCara J, Anazco F, Altman J, Smith A, Matthews A, Lai C, Brunner A, Farina K, Gilman H, Neilan T, Upadhyay D, Patel A, Tremblay D, Scherrer-Crosbie M. CARDIOVASCULAR EVENTS IN PATIENTS WITH ACUTE MYELOID LEUKEMIA TREATED WITH VENETOCLAX: A MULTICENTER STUDY. Journal Of The American College Of Cardiology 2025, 85: 2865. DOI: 10.1016/s0735-1097(25)03349-2.Peer-Reviewed Original ResearchA Descriptive 5‐Year Analysis of the Demographics and Therapies for Patients With Immune Thrombotic Thrombocytopenic Purpura in the USA: A Multicenter Study of 390 Disease Episodes From 2017 to 2021
Jacobs J, Adkins B, Booth G, Stanek C, Allen E, Grossman B, Stephens L, Crowe E, Daou L, Marques M, Siniard R, Wallace L, Yamada C, Duque M, Wu Y, Aljuboori O, Harrington T, Byrnes D, Eichbaum Q, Villalba C, Juskewitch J, Klapper E, Perez‐Alvarez I, Klein M, Aldarweesh F, Alkhateb R, Parsons M, Schlueter A, Tormey C, Wheeler A, Powers A, Webb C, Yates S, Bloch E, Raval J. A Descriptive 5‐Year Analysis of the Demographics and Therapies for Patients With Immune Thrombotic Thrombocytopenic Purpura in the USA: A Multicenter Study of 390 Disease Episodes From 2017 to 2021. Journal Of Clinical Apheresis 2025, 40: e70017. PMID: 40145682, PMCID: PMC11948952, DOI: 10.1002/jca.70017.Peer-Reviewed Original ResearchConceptsImmune thrombotic thrombocytopenic purpuraTherapeutic plasma exchangeThrombotic thrombocytopenic purpuraThrombocytopenic purpuraStandardization of treatment regimensMicroangiopathic hemolytic anemiaThirty-day mortalityPlasma exchangeADAMTS13 deficiencyThirty-dayMulticenter studyTreatment regimensHemolytic anemiaMicrovascular occlusionInitial episodesReplacement fluidCaplacizumabTherapeutic agentsPatientsDisease episodesPurpuraMortalityTherapyEpisodesTreatment practicesEfficacy of anal botulinum toxin injection in children with functional constipation
Patel D, Saikumar P, Jayaraman M, Desai C, Rosen J, Rodriguez L. Efficacy of anal botulinum toxin injection in children with functional constipation. Journal Of Pediatric Gastroenterology And Nutrition 2025, 80: 956-962. PMID: 40123476, DOI: 10.1002/jpn3.70040.Peer-Reviewed Original ResearchConceptsResponse to therapyBotulinum toxin injectionFunctional constipationMedical therapyBotulinum toxinGroup 2Group 1No factorsGroup 3Side effectsRefractory to medical therapyResults of anorectal manometryDevelopmental delayDevelopment of side effectsPediatric age groupFrequency of BMPresence of developmental delayDose of botulinum toxinMedian doseMedian followAnorectal manometryMedian ageMulticenter studyBM frequencyLaxative regimensInspired Oxygen Concentration During the Re-initiation of Two-Lung Ventilation in Thoracic Surgery: A Post Hoc Analysis of Data From the Multicenter Perioperative Outcomes Group
Douville N, Mathis M, Smolkin M, Martin L, Popescu W, Blank R. Inspired Oxygen Concentration During the Re-initiation of Two-Lung Ventilation in Thoracic Surgery: A Post Hoc Analysis of Data From the Multicenter Perioperative Outcomes Group. Anesthesia & Analgesia 2025, 141: 667-670. PMID: 40063506, PMCID: PMC12286577, DOI: 10.1213/ane.0000000000007479.Peer-Reviewed Original ResearchPostoperative pulmonary complicationsSingle-lung ventilationInspired oxygen fractionPulmonary complicationsAssociated with postoperative pulmonary complicationsLung reinflationDevelopment of postoperative pulmonary complicationsMulticenter retrospective cohort studyTwo-lung ventilationRetrospective cohort studyAlveolar hyperoxiaMultivariate logistic regressionOxygen fractionPotential clinical implicationsInspired oxygen concentrationPost Hoc AnalysisThoracic surgeryMulticenter studyHyperoxic injuryRetrospective natureCohort studyMulticenter Perioperative Outcomes GroupOutcome groupComplicationsSecondary analysis of dataSociodemographic and Systems Risk Factors Associated With Nil by Mouth Noncompliance and Day-of-Procedure Cancellations: A Retrospective Multicenter Case-Control Study.
Goldstein D, Jimenez N, Faulk D, Jones J, Reece-Nguyen T, Gooden C, Markowitz D, Dalal P. Sociodemographic and Systems Risk Factors Associated With Nil by Mouth Noncompliance and Day-of-Procedure Cancellations: A Retrospective Multicenter Case-Control Study. Anesthesia & Analgesia 2025 PMID: 40036165, DOI: 10.1213/ane.0000000000007451.Peer-Reviewed Original ResearchCase-control studySystemic risk factorsRisk factorsNPO guidelinesRetrospective multicenter case-control studyMulticenter retrospective case-control studyRetrospective case-control studyMulticenter case-control studySingle-center studyDay of procedureMultivariate logistic regressionPublic health insuranceYears of ageLanguage of carePediatric patientsMulticenter studyAffected patientsNoncompliance eventsHealth insurance typeIncreased riskMultivariate analysisPrimary outcomeSecondary outcomesElective proceduresHealth insuranceThree-dimensional right ventricular ejection fraction: a strong predictor of outcomes in patients undergoing cardiac surgery, a multicenter study.
Posada-Martinez E, Ivey-Miranda J, Ortiz-Leon X, Arias-Godinez J, Fritche-Salazar J, Rodriguez-Zanella H, Esparza M, Romero-Zertuche D, Silvestre-Flores I, Morales-Portano J, Mcnamara R, Sugeng L. Three-dimensional right ventricular ejection fraction: a strong predictor of outcomes in patients undergoing cardiac surgery, a multicenter study. European Heart Journal - Cardiovascular Imaging 2025, 26: jeae333.356. DOI: 10.1093/ehjci/jeae333.356.Peer-Reviewed Original ResearchLower RV ejection fractionRV ejection fractionCardiac surgeryPredictors of outcomePrimary outcomeEjection fractionMulticenter studyMechanical ventilationRight ventricular (RV) functionCohort study of adult patientsLeft ventricular ejection fractionRV-pulmonary arterial couplingComposite of in-hospital mortalityMultivariate Cox regression modelStudy of adult patientsBackground Cardiac surgeryAortic valve repairRV function parametersVentricular ejection fractionAssociated with shorter timeEvaluation of patientsAssociated with in-hospital outcomesBaseline demographic characteristicsTomTec Imaging SystemsIn-Hospital MortalityReliability of Central Vein Sign Imaging With 3T FLAIR* in a Multicenter Study
Martin M, Cao Q, Luskin E, Renner B, Daboul L, O'Donnell C, Rodrigues P, Derbyshire J, Azevedo C, Bar‐Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Pelletier D, Prchkovska V, Ramos M, Samudralwar R, Schindler M, Sotirchos E, Sicotte N, Solomon A, Reich D, Ontaneda D, Shinohara R, Sati P. Reliability of Central Vein Sign Imaging With 3T FLAIR* in a Multicenter Study. Journal Of Neuroimaging 2025, 35: e70011. PMID: 39838609, DOI: 10.1111/jon.70011.Peer-Reviewed Original ResearchConceptsCentral vein signMulticenter studyMultiple sclerosisT2-weighted fluid-attenuated inversion recoveryClinical settingMRI vendorsFluid-attenuated inversion recoveryDiagnosis of MSPost-GdContrast-to-noise ratioGd-based contrast agentsNo significant differenceT2*-weightedImaging sitesDiagnostic imaging biomarkersImaging biomarkersInversion recoverySignificant differenceMRIFLAIRContrast agents
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