2025
Molecular Breast Imaging and Digital Breast Tomosynthesis for Dense Breast Screening: The Density MATTERS Trial.
Hruska C, Hunt K, Larson N, Miller P, Ellis R, Shermis R, Rauch G, Conners A, Gasal Spilde J, Semaan D, Siegal E, Zingula S, Mandava S, Martin T, Ahmed R, Whaley D, Adrada B, Gray L, Mehta R, Roll R, Redfern R, O'Connor M, Rhodes D. Molecular Breast Imaging and Digital Breast Tomosynthesis for Dense Breast Screening: The Density MATTERS Trial. Radiology 2025, 316: e243953. PMID: 40985829, DOI: 10.1148/radiol.243953.Peer-Reviewed Original ResearchConceptsMolecular breast imagingAnnual screening roundsDigital breast tomosynthesisDense breastsIncremental cancer detection rateNode-negative cancersTyrer-Cuzick riskCancer detection rateInterval cancer rateBreast tomosynthesisInvasive cancer detectionBreast imagingYear 1Year 2Invasive cancerMulticenter trialBreast screeningBreast densityCancer ratesAdvanced cancerCancerCancer detectionFunctional uptakePrevalenceBreastLocalized Gradients in an Open Field-Cycling Low-Field MRI: First Images
Samardzija A, Sun C, Ha Y, Gross R, Sun H, Parra F, Nixon T, Galiana G, Constable T. Localized Gradients in an Open Field-Cycling Low-Field MRI: First Images. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/4257.Peer-Reviewed Original ResearchSpatial encodingTurbo spin echo pulse sequenceLow-field MRISpin-echo pulse sequenceImaging FOVFIRST imagesEcho pulse sequenceLeft-rightHigher spatial resolutionPulse sequenceSpatial resolutionScan timeLocal gradientsLower scan timeBreast imagingImaging feasibilityDetection sensitivityCancer detection sensitivityMagnetization
2024
Introduction and General Consideration of Radiology-Pathology Correlation
Harigopal M, Andrejeva L, Podany P, Lewin J, Raghu M, Singh K. Introduction and General Consideration of Radiology-Pathology Correlation. 2024, 1-9. DOI: 10.1007/978-3-031-65711-5_1.Peer-Reviewed Original ResearchFull-field digital mammographyInterval cancer rateIncreased cancer detection ratesCancer detection rateScreen-film mammographyCancer ratesBreast pathologistsYears of experiencePatient careNational expertsMultidisciplinary meetingComplex exerciseCore needle biopsyDiagnosis of breast lesionsDigital mammographyMammographyField of radiologyRadiology-pathology correlationTissue samplesRadiology reportsBreastAccurate diagnosis of breast lesionsCharacterization of lesionsBreast tissue samplesBreast imagingCalcifications
Singh K, Sheiman L, Killelea B, Brownson K, Andrejeva L. Calcifications. 2024, 209-233. DOI: 10.1007/978-3-031-65711-5_8.Peer-Reviewed Original ResearchPost-biopsy mammogramGroups of calcificationsDistribution of calcificationHistological sectionsBreast tissueTarget calcificationMagnification viewsBreast imagingNeoplastic epithelial proliferationCore needle biopsyStereotactic core biopsyTissue levelsRad-path correlationH&E-stained sectionsMilk of calciumAssociation of calcificationMammographic guidanceAmount of calcificationBiopsy planningCore biopsyNeedle biopsyDiagnostic dilemmaBiopsy siteDilated ductsEpithelial proliferation
2020
Novel Approaches to Screening for Breast Cancer
Mann R, Hooley R, Barr R, Moy L. Novel Approaches to Screening for Breast Cancer. Radiology 2020, 297: 200172. PMID: 32897163, DOI: 10.1148/radiol.2020200172.Peer-Reviewed Original ResearchConceptsBreast cancer-related mortalityBreast cancer screeningCancer screeningMolecular breast imagingCancer-related mortalityScreening modalitiesBreast imagingDigital breast tomosynthesisAggressive treatmentScreening strategiesFalse-positive rateBreast cancerSpectral mammographyLiquid biopsyBreath testScreening testBreastBreast tomosynthesisScreeningMammographyNovel approachesBreast Imaging and Image-guided Intervention in Tanzania: Initial Experience
Okello R, Rooney T, Jumbe M, Sakafu L, Koch T, Laage-Gaupp F, Minja F, Chamberlin M. Breast Imaging and Image-guided Intervention in Tanzania: Initial Experience. Journal Of Breast Imaging 2020, 2: 269-274. PMID: 38424978, DOI: 10.1093/jbi/wbaa008.Peer-Reviewed Original ResearchBreast cancer incidenceMalignant breast diseaseRadiologic-pathologic correlationAcademic medical centerAsymptomatic womenBreast imagingSymptomatic womenBreast diseaseCancer incidenceMedical CenterCare ultrasoundLocal pathologistsHand-held pointInitial experienceWound assessmentBreast interventionsInterventionWomenUltrasound imagingImage-guided interventionsTechnologist trainingImagingUltrasound technologyPatientsBiopsySupplemental screening in the dense breast: does molecular breast imaging have a role?
Rhodes DJ. Supplemental screening in the dense breast: does molecular breast imaging have a role? Menopause The Journal Of The North American Menopause Society 2020, 27: 110-112. PMID: 31880677, DOI: 10.1097/gme.0000000000001471.Peer-Reviewed Original Research
2019
Molecular Breast Imaging in Patients with Suspicious Calcifications
Hunt K, Hruska C, Johnson M, Conners A, O’connor M, Rhodes D, Basappa S, Wahner-Roedler D. Molecular Breast Imaging in Patients with Suspicious Calcifications. Journal Of Breast Imaging 2019, 1: 303-309. PMID: 38424809, DOI: 10.1093/jbi/wbz054.Peer-Reviewed Original ResearchMolecular breast imagingSuspicious calcificationsNegative predictive valueTelluride gamma cameraPredictive valueMedian pathologic sizeInvasive ductal cancerOccult breast cancerInjection of TcAreas of calcificationBreast imagingNuclear medicine techniquesPrebiopsy settingGamma cameraBiopsy findingsDuctal cancerPathologic sizeIncidental lesionsDuctal carcinomaInvasive cancerAdditional biopsiesBreast cancerStereotactic biopsyBiopsyMolecular breastClassification of Background Parenchymal Uptake on Molecular Breast Imaging Using a Convolutional Neural Network
Carter RE, Attia ZI, Geske JR, Conners AL, Whaley DH, Hunt KN, O’Connor M, Rhodes DJ, Hruska CB. Classification of Background Parenchymal Uptake on Molecular Breast Imaging Using a Convolutional Neural Network. JCO Clinical Cancer Informatics 2019, 3: 1-11. PMID: 30807208, PMCID: PMC6446086, DOI: 10.1200/cci.18.00133.Peer-Reviewed Original ResearchConceptsConvolutional neural networkNeural networkDeep learning modelsImage convolutionLearning modelModel performanceBackground parenchymal uptakeTesting dataComputer algorithmAlgorithmExpert radiologistsNetworkDirect matchingDirect matchAccuracyImagesClassificationResearch purposesPerformanceBreast imagingConvolutionEncodingMatchingModelingTrainingMolecular breast imaging detected invasive lobular carcinoma in dense breasts: A case report
Samreen N, Hunt KN, Hruska CB, Rhodes DJ. Molecular breast imaging detected invasive lobular carcinoma in dense breasts: A case report. Clinical Case Reports 2019, 7: 442-444. PMID: 30899468, PMCID: PMC6406216, DOI: 10.1002/ccr3.1945.Peer-Reviewed Original Research
2018
Adherence to Guidelines for Breast Surveillance in Breast Cancer Survivors.
Ruddy KJ, Sangaralingham L, Freedman RA, Mougalian S, Neuman H, Greenberg C, Jemal A, Duma N, Haddad TC, Lemaine V, Ghosh K, Hieken TJ, Hunt K, Vachon C, Gross C, Shah ND. Adherence to Guidelines for Breast Surveillance in Breast Cancer Survivors. Journal Of The National Comprehensive Cancer Network 2018, 16: 526-534. PMID: 29752327, DOI: 10.6004/jnccn.2018.7001.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsCancer survivorsBreast cancerDecreased likelihoodDefinitive breast cancer surgeryLikelihood of mammographySurvivorship care guidelinesCurative-intent treatmentProportion of patientsNonmetastatic breast cancerResidual breast tissueBreast cancer surgeryAdministrative claims dataBreast imagingBreast cancer treatmentMedicare Advantage beneficiariesBreast surveillanceInsured cohortPatient characteristicsAnnual mammographyCancer surgeryCare guidelinesBreast surgeryHealthcare useBlack race25 Examination Techniques Roles of the Physician and Patient in Evaluating Breast Disease
Mallory M, Golshan M. 25 Examination Techniques Roles of the Physician and Patient in Evaluating Breast Disease. 2018, 331-336.e2. DOI: 10.1016/b978-0-323-35955-9.00025-8.Peer-Reviewed Original Research
2017
Patient Acceptance of Half-dose Vs. Half-time Molecular Breast Imaging
Swanson TN, Tran TD, Hruska CB, Solberg CM, Rhodes DJ, Hunt KN, Conners AL, O'Connor MK. Patient Acceptance of Half-dose Vs. Half-time Molecular Breast Imaging. Journal Of Medical Imaging And Radiation Sciences 2017, 49: 39-43. PMID: 30479286, DOI: 10.1016/j.jmir.2017.08.003.Peer-Reviewed Original ResearchConceptsMolecular breast imagingExact testFisher's exact testDuration of examinationBreast imagingPatients' opinionsPatient acceptanceDose reductionExamination comfortMost womenPatient comfortFemale volunteersRadiation doseExamination typesDoseExamination preferencesImagingPatientsGroupNumber of strategiesSurvey responsesVolunteersWomen
2016
Molecular Breast Imaging and the 2016 Update to the ACR Appropriateness Criteria for Breast Cancer Screening
Covington MF, Rhodes DJ, Pizzitola VJ. Molecular Breast Imaging and the 2016 Update to the ACR Appropriateness Criteria for Breast Cancer Screening. Journal Of The American College Of Radiology 2016, 13: 1408. PMID: 27916107, DOI: 10.1016/j.jacr.2016.09.017.Peer-Reviewed Original Research
2015
Direct-Conversion Molecular Breast Imaging of Invasive Breast Cancer: Imaging Features, Extent of Invasive Disease, and Comparison Between Invasive Ductal and Lobular Histology.
Conners AL, Jones KN, Hruska CB, Geske JR, Boughey JC, Rhodes DJ. Direct-Conversion Molecular Breast Imaging of Invasive Breast Cancer: Imaging Features, Extent of Invasive Disease, and Comparison Between Invasive Ductal and Lobular Histology. American Journal Of Roentgenology 2015, 205: w374-81. PMID: 26295674, PMCID: PMC8900216, DOI: 10.2214/ajr.14.13502.Peer-Reviewed Original ResearchConceptsInvasive breast cancerMolecular breast imagingInvasive tumor fociBreast imaging examinationsTumor fociMolecular breastBreast cancerImaging featuresInvasive diseasePathology reportsImaging examinationsHistologic profileBreast imagingBreast imaging findingsChi-square testLobular histologyHistologic subtypeInvasive DuctalImaging findingsInvasive cancerBenign reasonsInvasive fociTumor appearanceBlinded reviewLesion typeEffect of Menstrual Cycle Phase on Background Parenchymal Uptake at Molecular Breast Imaging
Hruska CB, Conners AL, Vachon CM, O'Connor MK, Shuster LT, Bartley AC, Rhodes DJ. Effect of Menstrual Cycle Phase on Background Parenchymal Uptake at Molecular Breast Imaging. Academic Radiology 2015, 22: 1147-1156. PMID: 26112057, PMCID: PMC4532620, DOI: 10.1016/j.acra.2015.04.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultBreastBreast DensityChromatography, LiquidCohort StudiesEstradiolEstroneFemaleFollicle Stimulating HormoneFollicular PhaseHumansLuteal PhaseMammographyMiddle AgedMolecular ImagingPremenopauseProgesteroneProspective StudiesRadiopharmaceuticalsSex Hormone-Binding GlobulinTandem Mass SpectrometryTechnetium Tc 99m SestamibiTestosteroneConceptsBackground parenchymal uptakeMolecular breast imagingMenstrual cycle phaseLuteal phaseMenstrual cycleNondense breastsFollicular phaseHormone levelsParenchymal uptakeDense breastsExogenous hormone useRegular menstrual cyclesLevels of TCCycle phaseNormal fibroglandular tissuePremenopausal volunteersPremenopausal womenHormone useSpearman correlation coefficientBreast imagingStudy radiologistsMammographic densityBreastFibroglandular tissueWomenFactors Influencing the Uptake of 99mTc-Sestamibi in Breast Tissue on Molecular Breast Imaging
O’Connor M, Hruska CB, Tran TD, Swanson T, Conners AL, Jones K, Rhodes DJ. Factors Influencing the Uptake of 99mTc-Sestamibi in Breast Tissue on Molecular Breast Imaging. Journal Of Nuclear Medicine Technology 2015, 43: 13-20. PMID: 25613340, DOI: 10.2967/jnmt.114.150128.Peer-Reviewed Original ResearchConceptsMolecular breast imagingBreast tissuePrandial statusOptimal patient preparationPeripheral blood flowBody surface areaCounts/Type of interventionBreast imagingPatient heightPeripheral warmingStudy groupBlood flowSestamibiBreast activityPatient preparationFed stateCount densityMetabolic statusReference groupOblique viewMediolateral oblique viewTissueInterventionBreast thickness
2013
3D Molecular Breast Imaging Using a High-Resolution Dedicated Cardiac SPECT Camera
Liu H, Chan C, Grobshtein Y, Ma T, Liu Y, Wang S, Kench P, Sinusas A, Liu C. 3D Molecular Breast Imaging Using a High-Resolution Dedicated Cardiac SPECT Camera. 2013, 1-4. DOI: 10.1109/nssmic.2013.6829097.Peer-Reviewed Original ResearchMolecular breast imagingChest wallRight breastBreast imagingLeft breastCentral breastSPECT patientsAdjacent organsSupine positionLesion sizeBreast tumorsLesionsBreastLesion diameterDiameter lesionsTumor contrastTumorsDedicated cardiac SPECT cameraDifferent lesion sizesLesion contrastImagingOrgansSPECT cameraContrast levelsCardiac SPECT systemBreast imaging of the pregnant and lactating patient: imaging modalities and pregnancy-associated breast cancer.
Vashi R, Hooley R, Butler R, Geisel J, Philpotts L. Breast imaging of the pregnant and lactating patient: imaging modalities and pregnancy-associated breast cancer. American Journal Of Roentgenology 2013, 200: 321-8. PMID: 23345353, DOI: 10.2214/ajr.12.9814.Peer-Reviewed Original ResearchBreast imaging of the pregnant and lactating patient: physiologic changes and common benign entities.
Vashi R, Hooley R, Butler R, Geisel J, Philpotts L. Breast imaging of the pregnant and lactating patient: physiologic changes and common benign entities. American Journal Of Roentgenology 2013, 200: 329-36. PMID: 23345354, DOI: 10.2214/ajr.12.9845.Peer-Reviewed Original ResearchConceptsPhysiologic changesCommon benign breast diseasesPregnancy-associated breast cancerBenign breast diseaseCommon benign entitiesBenign breast abnormalitiesBreast diseaseImaging featuresBenign entityPatient managementBreast cancerBreast abnormalitiesBreast imagingPregnancyHistologicCancerAbnormalitiesBreastDisease
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