Lei Yan, PhD
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Associate Research Scientist in Biostatistics
Biography
I am an Associate Research Scientist in Biostatistics at Yale Public Health.
My research focuses on the application of advanced causal inference methods to questions in comparative effectiveness research, utilizing large electronic health records and other observational data to enhance health decision-making. Ongoing projects include estimating the causal effects of pharmacotherapies on the short- and long-term risk of COVID-19, examining the use of antidepressants and their effects on individuals with major depression, evaluating the effectiveness of respiratory syncytial virus vaccines, assessing the efficacy and duration of dolutegravir-based regimens for individuals with HIV, and investigating gene-environment interactions in the development of childhood acute lymphoblastic leukemia. These projects are conducted collaboratively with faculty and researchers at Yale Public Health and the Clinical Epidemiology Research Center (CERC) at the VA Connecticut Healthcare System located in West Haven. My previous research focused on the financialization of commodity markets.
Appointments
Biostatistics
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Research Associate
- University of Illinois at Urbana-Champaign (2018)
- PhD
- University of Illinois at Urbana-Champaign, Applied Economics (2017)
- MA
- Renmin University of China, Economics (2011)
- BS
- Renmin University of China, Statistics (2008)
Research
Research at a Glance
Yale Co-Authors
Publications Timeline
Mihaela Aslan, PhD
Nallakkandi Rajeevan, PhD
Pradeep Mutalik, MD
Publications
Featured Publications
Effectiveness of Nirmatrelvir-Ritonavir Against the Development of Post-COVID-19 Conditions Among U.S. Veterans : A Target Trial Emulation.
Ioannou G, Berry K, Rajeevan N, Li Y, Mutalik P, Yan L, Bui D, Cunningham F, Hynes D, Rowneki M, Bohnert A, Boyko E, Iwashyna T, Maciejewski M, Osborne T, Viglianti E, Aslan M, Huang G, Bajema K. Effectiveness of Nirmatrelvir-Ritonavir Against the Development of Post-COVID-19 Conditions Among U.S. Veterans : A Target Trial Emulation. Annals Of Internal Medicine 2023, 176: 1486-1497. PMID: 37903369, PMCID: PMC10620954, DOI: 10.7326/m23-1394.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute COVID-19Veterans Health AdministrationUntreated comparatorsThromboembolic eventsCOVID-19Severe COVID-19Target trial emulationSARS-CoV-2Post COVID-19 conditionIndex dateVenous thromboembolismBaseline characteristicsCumulative incidencePulmonary embolismAcute infectionMedian ageOral antiviralsTrial emulationVHA careOutpatient treatmentInternational ClassificationHealth AdministrationU.S. veteransVeterans AffairsOrgan systemsAnti–SARS-CoV-2 Pharmacotherapies Among Nonhospitalized US Veterans, January 2022 to January 2023
Yan L, Streja E, Li Y, Rajeevan N, Rowneki M, Berry K, Hynes D, Cunningham F, Huang G, Aslan M, Ioannou G, Bajema K. Anti–SARS-CoV-2 Pharmacotherapies Among Nonhospitalized US Veterans, January 2022 to January 2023. JAMA Network Open 2023, 6: e2331249. PMID: 37651140, PMCID: PMC10472184, DOI: 10.1001/jamanetworkopen.2023.31249.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCOVID-19 pharmacotherapyVeterans Health AdministrationVeterans Integrated Service NetworkSARS-CoV-2Higher Charlson Comorbidity Index scoresCharlson Comorbidity Index scoreNon-Hispanic veteransComorbidity Index scoreProportion of patientsSymptomatic COVID-19Multivariable logistic regressionCOVID-19 vaccinationCohort studyMedicare databaseVHA careUS veteransMAIN OUTCOMEMedical conditionsHispanic veteransPharmacotherapyHealth AdministrationIndex scoreCommunity careNonhospitalized personsWhite veteransEffectiveness of COVID-19 Treatment With Nirmatrelvir–Ritonavir or Molnupiravir Among U.S. Veterans: Target Trial Emulation Studies With One-Month and Six-Month Outcomes
Bajema K, Berry K, Streja E, Rajeevan N, Li Y, Mutalik P, Yan L, Cunningham F, Hynes D, Rowneki M, Bohnert A, Boyko E, Iwashyna T, Maciejewski M, Osborne T, Viglianti E, Aslan M, Huang G, Ioannou G. Effectiveness of COVID-19 Treatment With Nirmatrelvir–Ritonavir or Molnupiravir Among U.S. Veterans: Target Trial Emulation Studies With One-Month and Six-Month Outcomes. Annals Of Internal Medicine 2023, 176: m22-3565. PMID: 37276589, PMCID: PMC10243488, DOI: 10.7326/m22-3565.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVeterans Health AdministrationCOVID-19 symptom onsetCOVID-19-related outcomesSevere COVID-19Six-month outcomesCOVID-19 vaccinationCOVID-19 treatmentCOVID-19SARS-CoV-2Percent of participantsUntreated control participantsCause mortalitySymptom onsetMedian ageOral antiviralsVHA careOutpatient treatmentHospitalizationHealth AdministrationDay 31U.S. veteransVariant transmissionMost veteransVeterans AffairsOne monthEarly Adoption of Anti–SARS-CoV-2 Pharmacotherapies Among US Veterans With Mild to Moderate COVID-19, January and February 2022
Bajema K, Wang X, Hynes D, Rowneki M, Hickok A, Cunningham F, Bohnert A, Boyko E, Iwashyna T, Maciejewski M, Viglianti E, Streja E, Yan L, Aslan M, Huang G, Ioannou G. Early Adoption of Anti–SARS-CoV-2 Pharmacotherapies Among US Veterans With Mild to Moderate COVID-19, January and February 2022. JAMA Network Open 2022, 5: e2241434. PMID: 36367727, PMCID: PMC9652752, DOI: 10.1001/jamanetworkopen.2022.41434.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCOVID-19 pharmacotherapySevere COVID-19SARS-CoV-2Health care systemCohort studyRisk factorsCare systemMedical conditionsCOVID-19Positive SARS-CoV-2 testVeterans Affairs Health Care SystemCOVID-19-related hospitalizationCOVID-19-related symptomsLarge integrated health care systemSARS-CoV-2 testVA health care systemIntegrated health care systemNon-Hispanic veteransModerate COVID-19Odds of receiptMultivariable logistic regressionCOVID-19 vaccinationMedical comorbiditiesMedian ageAnti-SARS
2024
Corrigendum: Pretreatment level of serum sialic acid predicts both qualitative and quantitative bone metastases of prostate cancer
Sun J, Tian T, Wang N, Jing X, Qiu L, Cui H, Liu Z, Liu J, Yan L, Li D. Corrigendum: Pretreatment level of serum sialic acid predicts both qualitative and quantitative bone metastases of prostate cancer. Frontiers In Endocrinology 2024, 15: 1466189. PMID: 39253582, PMCID: PMC11381961, DOI: 10.3389/fendo.2024.1466189.Peer-Reviewed Original ResearchAssociation of lower urinary tract symptoms and geriatric nutritional risk index in men: a cross-sectional study based on NHANES
Zheng T, Sun H, Tang Y, Zeng Y, Yan L. Association of lower urinary tract symptoms and geriatric nutritional risk index in men: a cross-sectional study based on NHANES. Frontiers In Medicine 2024, 11: 1356921. PMID: 38975054, PMCID: PMC11224433, DOI: 10.3389/fmed.2024.1356921.Peer-Reviewed Original ResearchConceptsGeriatric Nutritional Risk IndexAssociated with GNRINutritional risk indexNutritional statusLow Geriatric Nutritional Risk IndexImpact of nutritional statusDevelopment of LUTSUrinary tract symptomsTreatment of LUTSMultivariate logistic analysisUnadjusted regression modelsCross-sectional studyImproving LUTSCross-sectional analysisNocturiaLogistic analysisEligible participantsOlder menMiddle-agedRelevant questionnairesRegression modelsRisk indexNHANESSymptomsMenPlatelet rich plasma alleviates endometritis induced by lipopolysaccharide in mice via inhibiting TLR4/NF‐κB signaling pathway
Liu X, Wang Y, Wen X, Hao C, Ma J, Yan L. Platelet rich plasma alleviates endometritis induced by lipopolysaccharide in mice via inhibiting TLR4/NF‐κB signaling pathway. American Journal Of Reproductive Immunology 2024, 91: e13833. PMID: 38467595, DOI: 10.1111/aji.13833.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPlatelet-rich plasmaPlatelet-rich plasma treatmentTLR4/NF-kB pathwayUterine tissuePlatelet-rich-plasma intrauterine infusionMouse model of endometritisRich plasmaEffect of platelet-rich plasmaInfiltration of inflammatory cellsProduction of proinflammatory cytokinesNitric oxideExpression of TNF-aHematoxylin-eosin stainingProtective effect of platelet-rich plasmaSignaling pathwayAnti-inflammatory effectsIntrauterine perfusionSuppressed LPS-induced activationTLR4/NF-kB signaling pathwayProinflammatory chemokinesReal-time PCRConcentrations of nitric oxideInflammatory cellsProinflammatory cytokinesOccurrence of infertilityPretreatment level of serum sialic acid predicts both qualitative and quantitative bone metastases of prostate cancer
Sun J, Tian T, Wang N, Jing X, Qiu L, Cui H, Liu Z, Liu J, Yan L, Li D. Pretreatment level of serum sialic acid predicts both qualitative and quantitative bone metastases of prostate cancer. Frontiers In Endocrinology 2024, 15: 1338420. PMID: 38384968, PMCID: PMC10880016, DOI: 10.3389/fendo.2024.1338420.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsHigh-volume diseasePresence of bone metastasesSerum sialic acidBone metastasesProstate-specific antigenProstate cancer patientsProstate cancerArea under the curveCut-off valueReceiver operating characteristicAssociated with high volume diseasePredictors of bone metastasisLevels of serum sialic acidClinical parameters of patientsDiagnosis of prostate cancerMetastasis of prostate cancerReceiver operating characteristic curve analysisBone metastasis of prostate cancerDiagnosed PCa patientsMultivariate logistic regression analysisSerum SA levelsMann-Whitney U testParameters of patientsLogistic regression analysisLevels of alkaline phosphatase
2023
Pregnancy outcomes of 4 endometrial preparation protocols in adenomyosis patients with thin endometrium during frozen embryo transfer: a retrospective cohort study
Yu Y, Zhang X, Xu X, Yan L, Zhang Y. Pregnancy outcomes of 4 endometrial preparation protocols in adenomyosis patients with thin endometrium during frozen embryo transfer: a retrospective cohort study. Global Reproductive Health 2023, 9: e0079. DOI: 10.1097/grh.0000000000000079.Peer-Reviewed Original ResearchConceptsEndometrial preparation protocolsFrozen embryo transferHormone replacement therapy groupReplacement therapy groupThin endometriumPregnancy outcomesInfant complicationsMiscarriage ratePregnancy rateEmbryo transferTherapy groupDifferent endometrial preparation protocolsGonadotropin-releasing hormone agonistFull-term pregnancy rateEarly miscarriage rateLate miscarriage rateNatural cycle treatmentClinical pregnancy rateRetrospective cohort studyReproductive Hospital AffiliatedEmbryologic characteristicsAdenomyosis patientsCohort studyHormone agonistLivebirth rateReproductive outcomes of single frozen-thawed embryo transfer in patients with endometriosis after preimplantation genetic testing
Qu H, Lv H, Kang Y, Yan L, Du Y. Reproductive outcomes of single frozen-thawed embryo transfer in patients with endometriosis after preimplantation genetic testing. Journal Of Assisted Reproduction And Genetics 2023, 41: 429-435. PMID: 38079077, PMCID: PMC10894775, DOI: 10.1007/s10815-023-02996-5.Peer-Reviewed Original ResearchCitationsConceptsPreimplantation genetic testingControl groupClinical pregnancyBiochemical pregnancyClinical abortionsEndometriosis groupLive birthsReproductive outcomesEmbryo transferSingle frozen-thawed embryo transferBlastocyst frozen embryo transfersMethodsThis retrospective cohort studyFrozen-thawed embryo transferGenetic testingRetrospective cohort studyPremature birth rateData of patientsFrozen embryo transferQuality of oocytesReproductive hospitalCohort studyPregnancy outcomesEndometrial receptivityPremature birthResultsA total