2021
Cholinergic receptor nicotinic beta 3 subunit polymorphisms and smoking in male Chinese patients with schizophrenia.
Shi J, Chen N, Wang Z, Wang F, Tan Y, Tan S, Tong J, An H, Guo X, Zuo L, Wang X, Yang F, Luo X. Cholinergic receptor nicotinic beta 3 subunit polymorphisms and smoking in male Chinese patients with schizophrenia. EC Psychology And Psychiatry 2021, 10: 11-23. PMID: 34368810, PMCID: PMC8341072.Peer-Reviewed Original ResearchMRNA expressionSmoking behaviorSingle nucleotide polymorphismsGABAergic receptor expressionMale Chinese patientsHuman brainPromoter single nucleotide polymorphismsBeta 3 subunitSignificant mRNA expressionChinese patientsReceptor expressionHealthy volunteersNicotine dependenceSmokingSchizophreniaBrainReceptor genePatientsDopaminergicRegulatory effectsSubunit polymorphismsTotal sampleCis-acting regulatory effectsNucleotide polymorphismsCommon genetic basis
2020
Replicated risk CACNA1C variants for major psychiatric disorders may serve as potential therapeutic targets for the shared depressive endophenotype.
Guo X, Fu Y, Zhang Y, Wang T, Lu L, Luo X, Wang K, Huang J, Xie T, Zheng C, Yang K, Tong J, Zuo L, Kang L, Tan Y, Jiang K, Li CR, Luo X. Replicated risk CACNA1C variants for major psychiatric disorders may serve as potential therapeutic targets for the shared depressive endophenotype. 2020, 4 PMID: 34046650, PMCID: PMC8153461.Peer-Reviewed Original ResearchMajor psychiatric disordersGenome-wide association studiesL-type voltage-gated calcium channelsMajor depressive disorderMRNA expression regulationPsychiatric disordersTherapeutic targetBipolar disorderChronic mild stress (CMS) ratsHuman hippocampusExpression regulationDepressive endophenotypeType voltage-gated calcium channelsRole of venlafaxineVoltage-gated calcium channelsPotential therapeutic targetRisk genesSignificant mRNA expressionVenlafaxine treatmentDepressive disorderStress ratsDepressive symptomsIndependent cohortCalcium channelsMRNA expression