Beyond T cell exhaustion: TIM-3 regulation of myeloid cells
Dixon K, Lahore G, Kuchroo V. Beyond T cell exhaustion: TIM-3 regulation of myeloid cells. Science Immunology 2024, 9: eadf2223. PMID: 38457514, DOI: 10.1126/sciimmunol.adf2223.Peer-Reviewed Original ResearchConceptsT cell exhaustionTim-3CD8<sup>+</sup> T cellsImmune responseRegulation of myeloid cell functionT cell stemnessTim-3 regulationImmune checkpoint moleculesT cell immunoglobulinCell-extrinsic mechanismsMyeloid cell functionRegulation of myeloid cellsCheckpoint moleculesTreatment of cancerCD4<sup>+</sup>T cellsMyeloid cellsCell-intrinsicCell functionAutoimmunityAutoinflammationCancerImmunoglobulin