Vijay Kuchroo
Research
Publications
2024
BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells
Thakore P, Schnell A, Huang L, Zhao M, Hou Y, Christian E, Zaghouani S, Wang C, Singh V, Singaraju A, Krishnan R, Kozoriz D, Ma S, Sankar V, Notarbartolo S, Buenrostro J, Sallusto F, Patsopoulos N, Rozenblatt-Rosen O, Kuchroo V, Regev A. BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells. Nature Immunology 2024, 25: 1395-1410. PMID: 39009838, DOI: 10.1038/s41590-024-01901-1.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsTransposase-accessible chromatin sequencingSingle-cell RNA sequencingTh17 heterogeneitySingle-cell assaysScATAC-seqChromatin landscapeChromatin stateChromatin sequencingRegulatory networksScRNA-seqTh17 cell pathogenicityHuman geneticsIn vivoRNA sequencingChromatin configurationRegulatory pathwaysTissue homeostasisCell statesCells in vitroBach2ChromatinSequenceCellsType 1 helper T (Th1) cellsCD4+ T cell subsetsAutoimmunity and the microbiome
Cox L, Kuchroo V. Autoimmunity and the microbiome. Immunological Reviews 2024, 325: 4-8. PMID: 38980198, DOI: 10.1111/imr.13363.Peer-Reviewed Original ResearchAltmetricTIGIT predominantly regulates the immune response via regulatory T cells
Kurtulus S, Sakuishi K, Ngiow S, Joller N, Tan D, Teng M, Smyth M, Kuchroo V, Anderson A. TIGIT predominantly regulates the immune response via regulatory T cells. Journal Of Clinical Investigation 2024, 134: e183278. PMID: 38949028, PMCID: PMC11213499, DOI: 10.1172/jci183278.Peer-Reviewed Original ResearchAltmetricOncogene induced TIM-3 ligand expression dictates susceptibility to anti-TIM-3 therapy in mice
Talvard-Balland N, Braun L, Dixon K, Zwick M, Engel H, Hartmann A, Duquesne S, Penter L, Andrieux G, Rindlisbacher L, Acerbis A, Ehmann J, Köllerer C, Ansuinelli M, Rettig A, Moschallski K, Apostolova P, Brummer T, Illert A, Schramm M, Cheng Y, Köttgen A, Duyster J, Menssen H, Ritz J, Blazar B, Boerries M, Graeff A, Sariipek N, van Galen P, Buescher J, Cabezas-Wallscheid N, Pahl H, Pearce E, Soiffer R, Wu C, Vago L, Becher B, Köhler N, Wertheimer T, Kuchroo V, Zeiser R. Oncogene induced TIM-3 ligand expression dictates susceptibility to anti-TIM-3 therapy in mice. Journal Of Clinical Investigation 2024 PMID: 38916965, DOI: 10.1172/jci177460.Peer-Reviewed Original ResearchAltmetricConceptsAcute graft-versus-host diseaseAcute myeloid leukemiaPost-allo-HCTTim-3GVL effectLigand expressionGraft-versus-host diseaseAllogeneic hematopoietic cell transplantationCD8+ T cellsEnhanced GVL effectIFN-g productionLow ligand expressionTim-3 ligandAnti-PD-1TIM-3 blockadeAnti-Tim-3Hematopoietic cell transplantationSurvival of miceCells of patientsAllo-HCTLeukemia relapseCell transplantationCause of deathMyeloid leukemiaT cellsHuman regulatory memory B cells defined by expression of TIM-1 and TIGIT are dysfunctional in multiple sclerosis
Varghese J, Kaskow B, von Glehn F, Case J, Li Z, Julé A, Berdan E, Sui S, Hu Y, Krishnan R, Chitnis T, Kuchroo V, Weiner H, Baecher-Allan C. Human regulatory memory B cells defined by expression of TIM-1 and TIGIT are dysfunctional in multiple sclerosis. Frontiers In Immunology 2024, 15: 1360219. PMID: 38745667, PMCID: PMC11091236, DOI: 10.3389/fimmu.2024.1360219.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsMemory B cell subsetsMemory B cellsB cell subsetsT cell activationB cellsT cellsMultiple sclerosisIL-17ATIM-1Levels of CD4+ T cell activationAllogeneic CD4+ T cellsRelapsing-remittingAssociated with response to therapyAnti-CD20 treated patientsCD4+ T cell activationDouble positive (DPCD4+ T cellsExpression of TIM-1Genes associated with T-cell activationInduction of inflammatory markersInduce T cell proliferationHuman memory B cellsLack of cell surface markersRegulatory B cellsExpression of genes associated with T-cell activationIL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy
Krueger J, Eyerich K, Kuchroo V, Ritchlin C, Abreu M, Elloso M, Fourie A, Fakharzadeh S, Sherlock J, Yang Y, J. D, McInnes I. IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy. Frontiers In Immunology 2024, 15: 1331217. PMID: 38686385, PMCID: PMC11056518, DOI: 10.3389/fimmu.2024.1331217.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsImmune-mediated inflammatory diseasesIL-23 inhibitionIL-23Anti-IL-23 therapyOptimal identification of patientsTreat immune-mediated inflammatory diseasesIL-12 cytokine family memberInterleukin (IL)-23Identification of patientsIL-23 signalingCytokine family membersInflammatory bowel diseaseMolecular ontologiesRegulatory cytokinesIL-12Psoriatic arthritisInflammatory diseasesBowel diseaseDiseaseTherapyFamily membersBiologyCharting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling
Cadinu P, Sivanathan K, Misra A, Xu R, Mangani D, Yang E, Rone J, Tooley K, Kye Y, Bod L, Geistlinger L, Lee T, Mertens R, Ono N, Wang G, Sanmarco L, Quintana F, Anderson A, Kuchroo V, Moffitt J, Nowarski R. Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling. Cell 2024, 187: 2010-2028.e30. PMID: 38569542, PMCID: PMC11017707, DOI: 10.1016/j.cell.2024.03.013.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMultiplexed error-robust fluorescence in situ hybridizationFluorescence in situ hybridizationSpatial organizationCell-cell interactionsDiverse cell populationsHealthy gutMouse colitis modelExpression profilesBiogeographyGutNon-immune cellsGut inflammationSpatial remodelingInflammation-associated fibroblastsTissue neighborhoodsInflammation-induced remodelingCell populationsFibroblastsImmune cellsCellsColitis modelUlcerative colitisFibroblastic originStage progressionExpressionBeyond T cell exhaustion: TIM-3 regulation of myeloid cells
Dixon K, Lahore G, Kuchroo V. Beyond T cell exhaustion: TIM-3 regulation of myeloid cells. Science Immunology 2024, 9: eadf2223. PMID: 38457514, DOI: 10.1126/sciimmunol.adf2223.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsT cell exhaustionTim-3CD8<sup>+</sup> T cellsImmune responseRegulation of myeloid cell functionT cell stemnessTim-3 regulationImmune checkpoint moleculesT cell immunoglobulinCell-extrinsic mechanismsMyeloid cell functionRegulation of myeloid cellsCheckpoint moleculesTreatment of cancerCD4<sup>+</sup>T cellsMyeloid cellsCell-intrinsicCell functionAutoimmunityAutoinflammationCancerImmunoglobulinA mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes
Qi L, Iskols M, Shi D, Reddy P, Walker C, Lezgiyeva K, Voisin T, Pawlak M, Kuchroo V, Chiu I, Ginty D, Sharma N. A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes. Cell 2024, 187: 1508-1526.e16. PMID: 38442711, PMCID: PMC10947841, DOI: 10.1016/j.cell.2024.02.006.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsAuthor Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
Huang Y, Zhu C, Kondo Y, Anderson A, Gandhi A, Russell A, Dougan S, Petersen B, Melum E, Pertel T, Clayton K, Raab M, Chen Q, Beauchemin N, Yazaki P, Pyzik M, Ostrowski M, Glickman J, Rudd C, Ploegh H, Franke A, Petsko G, Kuchroo V, Blumberg R. Author Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature 2024, 626: e19-e19. PMID: 38336833, DOI: 10.1038/s41586-024-07164-y.Peer-Reviewed Original ResearchAltmetric