Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsVijay Kuchroo
Research
Publications
2026
CD5L:p40, a novel heterodimeric regulator of type 2 inflammation
Wang C, Zaghouani S, Wallrapp A, Newcomer K, Greenfield E, Johnson J, Barilla R, Pawlak M, Christian E, Burkett P, Leabo M, Li P, Soto H, Chen R, Monell C, Brown M, Almo S, Singer M, Regev A, Kuchroo V. CD5L:p40, a novel heterodimeric regulator of type 2 inflammation. The Journal Of Immunology 2026, 215: vkaf348. PMID: 41847855, PMCID: PMC13017054, DOI: 10.1093/jimmun/vkaf348.Peer-Reviewed Original ResearchConceptsIL-23IL-12Airway inflammationIL-12p40Experimental model of colitisEffector Th17 cellsFunction of IL-12Type 2 inflammationIL-13 expressionExperimental modelModel of colitisCentral nervous systemTh17 cellsTh17 responsesTh2 responsesT cellsAutoimmune inflammationMyeloid cellsTh1 differentiationIL-13Inflammatory diseasesInflammatory conditionsMonoclonal antibodiesIL-12p35Nervous system
2025
Immune dysfunction in Alzheimer disease
Butovsky O, Rosenzweig N, Kleemann K, Jorfi M, Kuchroo V, Tanzi R, Weiner H. Immune dysfunction in Alzheimer disease. Nature Reviews Neuroscience 2025, 27: 196-218. PMID: 41315874, PMCID: PMC13010386, DOI: 10.1038/s41583-025-00997-0.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseGenome-wide association studiesAD risk variantsPathology of Alzheimer's diseaseAmyloid plaque accumulationFeatures of ADImmune cellsAssociation studiesTau pathologyRisk variantsEpigenetic reprogrammingPeripheral immune alterationsImmune checkpoint inhibitionImmune cell crosstalkPeripheral immune cellsChronic peripheral inflammationAdaptive immune pathwaysNext-generation therapiesImmune pathwaysGenetic riskHuman-derived dataCheckpoint inhibitionImmune exhaustionImmune alterationsImmune dysfunctionType 2 cytokines act on enteric sensory neurons to promote parasitic host defense 9411
Barilla R, Berard C, Sun L, Sandhu S, Zaghouani S, Iyer K, Altun G, Su C, Deguine J, Singh V, Hou Y, Kusumakar K, Rutlin M, Rao M, Zaghouani H, Shi H, Xavier R, Kuchroo V. Type 2 cytokines act on enteric sensory neurons to promote parasitic host defense 9411. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.2815.Peer-Reviewed Original ResearchEnteric sensory neuronsType 2 cytokinesEnteric neuronsImmune cellsIL-13Sensory neuronsIL-4Neuromedin URNA sequencing datasetsType 2 cytokines IL-4Conditional knockoutType 2 inflammationNational InstituteUp-regulatedEnteric neuronal functionCKO miceCytokine responsesNeuropeptide expressionNeuronal mediatorsNeuronal subsetsHost defenseNeuronal functionNeuronsNeuropeptideHelminth infectionsInterleukin-23 receptor signaling drives inflammatory Th17 cell state via modulation of chromatin remodeling and nuclear hormone receptor activity 3404
Yang D, Anderson A, Kuchroo V. Interleukin-23 receptor signaling drives inflammatory Th17 cell state via modulation of chromatin remodeling and nuclear hormone receptor activity 3404. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.1215.Peer-Reviewed Original ResearchIL-23Chromatin remodeling proteinsTranscriptome analysisTh17 cellsIL-23RInterleukin-23Chromatin remodelingHormone receptorsRemodeling proteinsIL-17-producingModulation of chromatin remodelingInflammatory gene signatureInterleukin-23 receptorNuclear hormone receptor activityAutoimmune tissue inflammationHormone receptor modulatorsHuman T cellsIL-23R signalingTh17 lineage commitmentAutoimmune inflammationReceptor modulatorsT cellsNuclear hormone receptorsIL-12Tissue inflammationin vivo CRISPR screen identifies novel regulators of microglia state in Alzheimer’s disease 9094
Kuchroo M, Rosenzweig N, Starr B, Valenbreder I, Carpenter M, Kleemann K, Kuchroo V, Butovsky O. in vivo CRISPR screen identifies novel regulators of microglia state in Alzheimer’s disease 9094. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.2544.Peer-Reviewed Original ResearchGenome-wide association studiesIn vivo CRISPR screeningCRISPR screensGenome-wide association study hitsAlzheimer's diseaseAD risk genesGenetic deletionDisease-associated stateAD-GWASFunction in vivoAssociation studiesAD pathogenesisRisk genesFunctional microgliaIntrinsic roleMicroglia statesGenesP2-P4Plaque loadMicroglial biologyPerturbation platformPhenotypeMicroglial developmentSynapse densityAlzheimerCircadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt
Bhattarai B, Antonova A, Fachi J, Hopkins L, McCullen M, Saini A, Oliveira S, Beatty W, Musiek E, Kuchroo V, Lazar M, Oltz E, Colonna M. Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt. Nature Immunology 2025, 26: 1527-1539. PMID: 40804530, PMCID: PMC12633719, DOI: 10.1038/s41590-025-02240-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasic-Leucine Zipper Transcription FactorsCell PlasticityCircadian RhythmCitrobacter rodentiumEnergy MetabolismEnterobacteriaceae InfectionsEpigenesis, GeneticImmunity, InnateInterferon-gammaInterleukin-22InterleukinsLymphocytesMiceMice, Inbred C57BLMice, KnockoutNuclear Receptor Subfamily 1, Group D, Member 1Nuclear Receptor Subfamily 1, Group F, Member 3ConceptsGroup 3 innate lymphoid cellsEpigenetic configurationCis-regulatory elementsCitrobacter rodentium infectionSingle-cell multiomicsRegulate clock genesCircadian proteinsGut homeostasisCircadian circuitsMetabolic circuitsIL-22 productionClock genesIL-22Rev-erbARORC geneMetabolic analysisGenesGut integrityGene editingEnergy metabolismGutNutrient absorptionLymphoid cellsInterleukin-22Intestinal inflammationThe glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity
Wang C, Wagner A, Fessler J, DeTomaso D, Zaghouani S, Zhou Y, Pierce K, Sobel R, Clish C, Yosef N, Kuchroo V. The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity. Cell Reports 2025, 44: 115799. PMID: 40482033, PMCID: PMC12443480, DOI: 10.1016/j.celrep.2025.115799.Peer-Reviewed Original ResearchConceptsNon-pathogenic phenotypesPathogenic gene expression programsNegative regulatorPathogenic stateSingle-cell RNA sequencingGene expression programsPathogenic Th17 cell differentiationGene modulesPhosphoglycerate mutaseRNA sequencingGlycolytic enzymesExpression programsGlycolytic reactionsCell differentiationMetabolic shuntMetabolic stateTh17 cell differentiationPathogensAdoptive transfer modelEnzymeTh17 cellsCellsGlucose metabolismT helper 17Effector differentiationType 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense
Barilla R, Berard C, Sun L, Sandhu S, Zaghouani S, Iyer K, Altun G, Su C, Deguine J, Singh V, Hou Y, Kusumakar K, Rutlin M, Rao M, Zaghouani H, Shi H, Xavier R, Kuchroo V. Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense. Science 2025, 389: 260-267. PMID: 40403128, PMCID: PMC12632183, DOI: 10.1126/science.adn9850.Peer-Reviewed Original ResearchConceptsNeuropeptide neuromedin UEnteric sensory neuronsType 2 cytokinesSensory neuronsInterleukin-4Type 2 cytokines interleukin-4Host defenseImpaired host defenseAnti-helminth immunityNeuroimmune cross-talkImmune cell functionEnteric nervous systemCo-administrationIL-13Neuromedin UCoexpress receptorsInflammatory cuesImmune responseNeuronal responsesNervous systemCell functionIn vivoIn vitroNeuropeptideNeuronsPsychedelic control of neuroimmune interactions governing fear
Chung E, Lee J, Polonio C, Choi J, Akl C, Kilian M, Weiß W, Gunner G, Ye M, Heo T, Drake S, Yang L, d’Eca C, Lee J, Deng L, Farrenkopf D, Schüle A, Lee H, Afolabi O, Ghaznavi S, Smirnakis S, Chiu I, Kuchroo V, Quintana F, Wheeler M. Psychedelic control of neuroimmune interactions governing fear. Nature 2025, 641: 1276-1286. PMID: 40269152, PMCID: PMC12119215, DOI: 10.1038/s41586-025-08880-9.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorNeuroimmune interactionsEpidermal growth factor receptor expressionRelevant to neuropsychiatric disordersEpidermal growth factor receptor signalingFear behaviorBrain resident cellsGrowth factor receptorNeuron-glial crosstalkAccumulation of monocytesSignal transduction cascadesAmygdala neuronsFactor receptorInflammatory diseasesNeuropsychiatric disordersNeuroimmuneClinical samplesAmygdalaChronic stressBehavioral screeningBrain meningesMonocytesAstrocytesStress-inducedPsychedelic compoundsImmune checkpoint TIM-3 regulates microglia and Alzheimer’s disease
Kimura K, Subramanian A, Yin Z, Khalilnezhad A, Wu Y, He D, Dixon K, Chitta U, Ding X, Adhikari N, Guzchenko I, Zhang X, Tang R, Pertel T, Myers S, Aastha A, Nomura M, Eskandari-Sedighi G, Singh V, Liu L, Lambden C, Kleemann K, Gupta N, Barry J, Durao A, Cheng Y, Silveira S, Zhang H, Suhail A, Delorey T, Rozenblatt-Rosen O, Freeman G, Selkoe D, Weiner H, Blurton-Jones M, Cruchaga C, Regev A, Suvà M, Butovsky O, Kuchroo V. Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease. Nature 2025, 641: 718-731. PMID: 40205047, PMCID: PMC12079183, DOI: 10.1038/s41586-025-08852-z.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-PeptidesAnimalsCognitive DysfunctionDisease Models, AnimalFemaleHepatitis A Virus Cellular Receptor 2HomeostasisHumansMaleMiceMice, TransgenicMicrogliaPhagocytosisPhosphorylationReceptor, Transforming Growth Factor-beta Type IISignal TransductionSmad2 ProteinTransforming Growth Factor betaConceptsDisease-associated microgliaFAD miceGene expressionSingle-cell RNA sequencing dataCarboxy-terminal tailAlzheimer's diseaseRNA sequencing dataSingle-nucleus RNA sequencingTGFB signalingGenetic deletionGene expression profilesGenetic risk factorsSequence dataAmyloid-bPro-inflammatory gene expressionRNA sequencingTranscriptomic changesPro-phagocyticMicroglial clustersAnti-inflammatory gene expressionMicroglia homeostasisMicroglial homeostasisSmad2 phosphorylationTim-3Resident immune cells