2023
PROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol
Thom E, Saade G, Askie L, Ugwu L, Mol B, Vayssiere C, Norman J, Pajkrt E, Clifton R, Biggio J, Arnaud C, Berghella V, Canino M, Carreras E, Dugoff L, Hoffman M, Pacagnella R, Reddy U, Saccone G, van 't Hooft J, Dang V, Collaboration F. PROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol. American Journal Of Perinatology 2023, 41: e2230-e2237. PMID: 37429323, PMCID: PMC10776795, DOI: 10.1055/s-0043-1771018.Peer-Reviewed Original ResearchShort cervical lengthPreterm birthIndividual patient dataShort cervixRandomized trialsPessary trialCervical lengthTwin gestationsSubsequent spontaneous preterm birthLong-term neurological disabilityOngoing randomized trialsSpontaneous preterm birthTrial study protocolWeeks of gestationProspective Meta-AnalysisSignificant health issueCervical supportNeonatal morbidityPreterm deliverySingleton gestationsSecondary outcomesFetal deathNeurological disabilityPrimary outcomeWeeks' gestationOutcomes of induction vs prelabor cesarean delivery at <33 weeks for hypertensive disorders of pregnancy
Bushman E, Grobman W, Bailit J, Reddy U, Wapner R, Varner M, Thorp J, Caritis S, Prasad M, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J, Network E. Outcomes of induction vs prelabor cesarean delivery at <33 weeks for hypertensive disorders of pregnancy. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101032. PMID: 37244639, PMCID: PMC10521213, DOI: 10.1016/j.ajogmf.2023.101032.Peer-Reviewed Original ResearchConceptsPrelabor cesarean deliveryHypertensive disordersInduction of laborCesarean deliveryLabor inductionNeonatal morbidityInduction groupMedian durationVaginal deliveryWeeks' gestationSecondary analysisAdverse composite outcomeComposite maternal morbidityOutcome of inductionPreterm hypertensive disordersHalf of patientsCesarean delivery groupLength of inductionOptimal delivery approachMaternal morbidityComposite outcomeFetal malpresentationMultiple gestationsPreterm birthSecondary outcomesHypertension in Pregnancy and Adverse Outcomes Among Low-risk Nulliparous Women Expectantly Managed at or After 39 weeks: A Secondary Analysis of a Randomized Controlled Trial
Bartal M, Premkumar A, Rice M, Reddy U, Tita A, Silver R, El-Sayed Y, Wapner R, Rouse D, Saade G, Thorp J, Constantine M, Chien E, Casey B, Srinivas S, Swamy G, Simhan H. Hypertension in Pregnancy and Adverse Outcomes Among Low-risk Nulliparous Women Expectantly Managed at or After 39 weeks: A Secondary Analysis of a Randomized Controlled Trial. Obstetric Anesthesia Digest 2023, 43: 82-82. DOI: 10.1097/01.aoa.0000927856.60760.92.Peer-Reviewed Original ResearchLow-risk patientsLow-risk nulliparous womenHypertensive disordersMaternal morbidityMaternal outcomesNulliparous womenControlled TrialsWeeks' gestationAdverse outcomesLower riskSecondary analysisPregnancyPatientsHDPOutcomesRecent studiesHypertensionMorbidityGestationMortalityPrevalenceTrialsWeeksWomen
2021
Casual Genetic Variants in Stillbirth
Stanley K, Giordano J, Thorsten V, Buchovecky C, Thomas A, Ganapathi M, Liao J, Dharmadhikari A, Revah-Politi A, Ernst M, Lippa N, Holmes H, Povysil G, Hostyk J, Parker C, Goldenberg R, Saade G, Dudley D, Pinar H, Hogue C, Reddy U, Silver R, Aggarwal V, Allen A, Wapner R, Goldstein D. Casual Genetic Variants in Stillbirth. Obstetrical & Gynecological Survey 2021, 76: 79-81. DOI: 10.1097/01.ogx.0000733520.96334.74.Peer-Reviewed Original Research
2018
Cervical funneling or intra‐amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm
Saade G, Thom E, Grobman W, Iams J, Mercer B, Reddy U, Tita A, Rouse D, Sorokin Y, Wapner R, Leveno K, Blackwell S, Esplin M, Tolosa J, Thorp J, Caritis S, Vandorsten J, Network T. Cervical funneling or intra‐amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm. Ultrasound In Obstetrics And Gynecology 2018, 52: 757-762. PMID: 29155504, PMCID: PMC5960623, DOI: 10.1002/uog.18960.Peer-Reviewed Original ResearchConceptsCervical funnelingMidtrimester cervical lengthCervical lengthPreterm birthWeeks' gestationNulliparous womenMedian cervical lengthSecondary cohort analysisNulliparous pregnant womenSecond trimester ultrasoundAsymptomatic nulliparous womenMultivariable adjustmentSingleton gestationsMulticenter trialMultivariable analysisTransvaginal ultrasoundSecond trimesterPregnant womenCohort analysisGestationWomenHigh rateWeeksUltrasoundLtNonmedically Indicated Induction in Morbidly Obese Women is Not Associated With an Increased Risk of Cesarean Delivery
Kawakita T, Iqbal S, Huang C, Reddy U. Nonmedically Indicated Induction in Morbidly Obese Women is Not Associated With an Increased Risk of Cesarean Delivery. Obstetric Anesthesia Digest 2018, 38: 125-126. DOI: 10.1097/01.aoa.0000542343.43890.b0.Peer-Reviewed Original ResearchInduction of laborMorbidly obese womenCesarean deliveryObese womenExpectant managementClass III obesityRetrospective cohort studyNormal-weight womenIndicated inductionMaternal comorbiditiesMorbid obesityNeonatal outcomesCohort studySecondary outcomesWeeks' gestationRisk factorsHigh prevalenceClass IIObesityWomenComorbiditiesInductionOutcomesDeliveryRisk
2016
Complications of Rapid Preterm Cesarean Delivery [18A]
Kawakita T, Desale S, Reddy U. Complications of Rapid Preterm Cesarean Delivery [18A]. Obstetrics And Gynecology 2016, 127: 16s. DOI: 10.1097/01.aog.0000483311.42509.08.Peer-Reviewed Original ResearchPreterm cesarean deliveryCesarean deliveryMaternal characteristicsMulticenter retrospective cohort studyPlacenta previa/accretaPrevious uterine scarRetrospective cohort studyRepeat cesarean deliveryMultivariable regression modelsMaternal complicationsPregnancy complicationsCohort studyMultiple gestationsOperative complicationsUterine scarWeeks' gestationPostpartum hemorrhageGeneral anesthesiaRapid groupComplicationsWomenGestationP-valueRiskRegression models
2015
Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms
Esplin MS, Manuck TA, Varner MW, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J. Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms. American Journal Of Obstetrics And Gynecology 2015, 213: 429.e1-429.e9. PMID: 26070700, PMCID: PMC4556543, DOI: 10.1016/j.ajog.2015.06.011.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthDecidual hemorrhagePlacental dysfunctionProspective case-control multicenter studyCase-control multicenter studyPremature membrane ruptureGroup of womenCommon biologic pathwaysMaternal comorbiditiesPreterm singletonsPreterm birthWeeks' gestationMulticenter studyMaternal stressSecondary analysisBiologic pathwaysFamilial factorsGenetic factorsWomenPhenotypic profileGestationInfectionMembrane ruptureCommon mechanismPhenotypeThe phenotype of spontaneous preterm birth: application of a clinical phenotyping tool
Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J, Research E. The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool. American Journal Of Obstetrics And Gynecology 2015, 212: 487.e1-487.e11. PMID: 25687564, PMCID: PMC4456184, DOI: 10.1016/j.ajog.2015.02.010.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthEarly spontaneous preterm birthInfection/inflammationDecidual hemorrhageGestational ageCervical insufficiencyPreterm birthWeeks' gestationPlacental dysfunctionWhite womenMaternal stressSingleton spontaneous preterm birthDelivery gestational ageFinal common pathwayAfrican American womenMaternal comorbiditiesPremature ruptureProspective studyPlanned analysisUterine distentionClinical dataMultiple possible causesGestationHemorrhageComprehensive classification system
2014
Maternal serum serpin B7 is associated with early spontaneous preterm birth
Parry S, Zhang H, Biggio J, Bukowski R, Varner M, Xu Y, Andrews WW, Saade GR, Esplin MS, Leite R, Ilekis J, Reddy UM, Sadovsky Y, Blair IA, Research E. Maternal serum serpin B7 is associated with early spontaneous preterm birth. American Journal Of Obstetrics And Gynecology 2014, 211: 678.e1-678.e12. PMID: 24954659, PMCID: PMC4254341, DOI: 10.1016/j.ajog.2014.06.035.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthEarly spontaneous preterm birthPreterm birthMaternal serumSerum samplesPrevious spontaneous preterm birthSubsequent preterm deliveryProtein expressionLower gestational ageGestational age windowsCase-control studyCandidate protein expressionSerum proteomic analysisIndividual serum samplesPooled serum samplesSpontaneous pretermPreterm deliveryWeeks' gestationGestational ageTerm deliveryPregnant womenSerum biomarkersSerum concentrationsFetal membranesClinical sites
2011
Stillbirth Collaborative Research Network: design, methods and recruitment experience
Parker CB, Hogue CJ, Koch MA, Willinger M, Reddy UM, Thorsten VR, Dudley DJ, Silver RM, Coustan D, Saade GR, Conway D, Varner MW, Stoll B, Pinar H, Bukowski R, Carpenter M, Goldenberg R, Network F. Stillbirth Collaborative Research Network: design, methods and recruitment experience. Paediatric And Perinatal Epidemiology 2011, 25: 425-435. PMID: 21819424, PMCID: PMC3665402, DOI: 10.1111/j.1365-3016.2011.01218.x.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkPost-mortem examinationMaternal interviewsPlacental pathological examinationMedical record abstractionCase-control studyCase-control study participantsTime of deliveryHigher consent ratesGeographical catchment areasRecruitment experienceRecruitment hospitalChart abstractionProspective enrollmentPlacental pathologyRecord abstractionWeeks' gestationPathological examinationRisk factorsConsent ratesLivebirthsStillbirthClinical sitesStudy participantsAdditional surveillance
2010
Respiratory Morbidity in Late Preterm Births
Hibbard J, Wilkins I, Sun L, Gregory K, Haberman S, Hoffman M, Kominiarek M, Reddy U, Bailit J, Branch D, Burkman R, Gonzalez Quintero V, Hatjis C, Landy H, Ramirez M, VanVeldhuisen P, Troendle J, Zhang J. Respiratory Morbidity in Late Preterm Births. JAMA 2010, 304: 419-425. PMID: 20664042, PMCID: PMC4146396, DOI: 10.1001/jama.2010.1015.Peer-Reviewed Original ResearchConceptsLate preterm birthNeonatal intensive care unitRespiratory distress syndromePreterm birthDistress syndromeRespiratory morbidityRespiratory failureTransient tachypneaVentilator supportRespiratory compromiseTerm birthsContemporary cohortMultivariate logistic regression analysisShort-term morbidityNeonatal hospital stayIntensive care unitWeeks of gestationLogistic regression analysisHospital stayRespiratory outcomesRespiratory supportTerm infantsRespiratory diagnosesWeeks' gestationTerm delivery