2024
Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function
Metz T, Allshouse A, McMillin G, Greene T, Chung J, Grobman W, Haas D, Mercer B, Parry S, Reddy U, Saade G, Simhan H, Silver R. Cannabis Exposure and Adverse Pregnancy Outcomes Related to Placental Function. Obstetrical & Gynecological Survey 2024, 79: 307-309. DOI: 10.1097/ogx.0000000000001289.Peer-Reviewed Original Research
2023
Randomized Trial of Hyperimmune Globulin for Congenital CMV Infection — 2-Year Outcomes
Hughes B, Clifton R, Rouse D, Saade G, Dinsmoor M, Reddy U, Pass R, Allard D, Mallett G, MacPherson C, Wapner R, Metz T, Goodnight W, Tita A, Costantine M, Swamy G, Heyborne K, Chien E, Chauhan S, El-Sayed Y, Casey B, Parry S, Simhan H, Napolitano P, Macones G. Randomized Trial of Hyperimmune Globulin for Congenital CMV Infection — 2-Year Outcomes. New England Journal Of Medicine 2023, 389: 1822-1824. PMID: 37937785, PMCID: PMC10683876, DOI: 10.1056/nejmc2308286.Peer-Reviewed Original Research
2021
Maternal outcomes and risk factors for COVID-19 severity among pregnant women
Vouga M, Favre G, Martinez-Perez O, Pomar L, Acebal LF, Abascal-Saiz A, Hernandez MRV, Hcini N, Lambert V, Carles G, Sichitiu J, Salomon L, Stirnemann J, Ville Y, de Tejada BM, Goncé A, Hawkins-Villarreal A, Castillo K, Solsona EG, Trigo L, Cleary B, Geary M, Bartels H, Al-Kharouf F, Malone F, Higgins M, Keating N, Knowles S, Poncelet C, Ribeiro-do-Valle CC, Surita F, Dantas-Silva A, Borrelli C, Luz AG, Fuenzalida J, Carvajal J, Canales MG, Hernandez O, Grechukhina O, Ko AI, Reddy U, Figueiredo R, Moucho M, Pinto PV, De Luca C, De Santis M, de Campos DA, Martins I, Garabedian C, Subtil D, Bohrer B, Da Rocha Oppermann ML, Wender MCO, Schuler-Faccini L, Sanseverino MTV, Giugliani C, Friedrich L, Scherer MH, Mottet N, Ducarme G, Pelerin H, Moreau C, Breton B, Quibel T, Rozenberg P, Giannoni E, Granado C, Monod C, Mueller D, Hoesli I, Bassler D, Heldstab S, Kölble NO, Sentilhes L, Charvet M, Deprest J, Richter J, Van der Veeken L, Eggel-Hort B, Plantefeve G, Derouich M, Calvache AJN, Lopez-Giron MC, Burgos-Luna JM, Escobar-Vidarte MF, Hecher K, Tallarek AC, Hadar E, Haratz KK, Amikam U, Malinger G, Maymon R, Yogev Y, Schäffer L, Toussaint A, Rossier MC, De Sa RAM, Grawe C, Aebi-Popp K, Radan AP, Raio L, Surbek D, Böckenhoff P, Strizek B, Kaufmann M, Bloch A, Boulvain M, Johann S, Heldstab SA, Bernasconi MT, Grant G, Feki A, Brochut AM, Giral M, Sedille L, Papadia A, Brugger RC, Weber B, Fischer T, Kahlert C, Saines KN, Cambou M, Kanellos P, Chen X, Yin M, Haessig A, Ackermann S, Baud D, Panchaud A. Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Scientific Reports 2021, 11: 13898. PMID: 34230507, PMCID: PMC8260739, DOI: 10.1038/s41598-021-92357-y.Peer-Reviewed Original ResearchConceptsSevere maternal outcomesPregnant womenRisk factorsMaternal outcomesPulmonary comorbiditiesHypertensive disordersNeonatal outcomesSevere complicationsHigh riskSevere acute respiratory syndrome coronavirus 2Severe coronavirus disease-19Severe COVID-19 diseaseAcute respiratory syndrome coronavirus 2Neonatal intensive care unitSARS-CoV-2 infectionRespiratory syndrome coronavirus 2Immediate neonatal outcomeIntensive care unitSyndrome coronavirus 2COVID-19 severityCase-control studyCoronavirus disease-19SARS-CoV-2COVID-19 diseaseMaternal disease
2019
Predictors of Sleep-disordered Breathing in Pregnancy
Louis J, Koch M, Reddy U, Silver R, Parker C, Facco F, Redline S, Nhan-Chang C, Chung J, Pien G, Basner R, Grobman W, Wing D, Simhan H, Haas D, Mercer B, Parry S, Mobley D, Carper B, Saade G, Schubert F, Zee P. Predictors of Sleep-disordered Breathing in Pregnancy. Obstetric Anesthesia Digest 2019, 39: 36-37. DOI: 10.1097/01.aoa.0000552909.82459.b1.Peer-Reviewed Original ResearchSleep-disordered breathingDiagnosis of SDBSevere maternal morbidityRisk of complicationsMaternal morbidityPreterm deliverySDB symptomsVenous thromboembolismMaternal deathsOvernight polysomnographyPregnant womenAdverse outcomesLarge cohortFeasible prediction modelPregnancyBreathingWomenThromboembolismPreeclampsiaMorbidityComplicationsPolysomnographyCohortSymptomsDiagnosis
2018
Defining Failed Induction of Labor
Grobman W, Bailit J, Lai Y, Reddy U, Wapner R, Varner M, Thorp J, Leveno K, Caritis S, Prasad M, Tita A, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J. Defining Failed Induction of Labor. Obstetric Anesthesia Digest 2018, 38: 215. DOI: 10.1097/01.aoa.0000547313.79293.f8.Peer-Reviewed Original ResearchCervical funneling or intra‐amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm
Saade G, Thom E, Grobman W, Iams J, Mercer B, Reddy U, Tita A, Rouse D, Sorokin Y, Wapner R, Leveno K, Blackwell S, Esplin M, Tolosa J, Thorp J, Caritis S, Vandorsten J, Network T. Cervical funneling or intra‐amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm. Ultrasound In Obstetrics And Gynecology 2018, 52: 757-762. PMID: 29155504, PMCID: PMC5960623, DOI: 10.1002/uog.18960.Peer-Reviewed Original ResearchConceptsCervical funnelingMidtrimester cervical lengthCervical lengthPreterm birthWeeks' gestationNulliparous womenMedian cervical lengthSecondary cohort analysisNulliparous pregnant womenSecond trimester ultrasoundAsymptomatic nulliparous womenMultivariable adjustmentSingleton gestationsMulticenter trialMultivariable analysisTransvaginal ultrasoundSecond trimesterPregnant womenCohort analysisGestationWomenHigh rateWeeksUltrasoundLt
2017
Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women
Esplin M, Elovitz M, Iams J, Parker C, Wapner R, Grobman W, Simhan H, Wing D, Haas D, Silver R, Hoffman M, Peaceman A, Caritis S, Parry S, Wadhwa P, Foroud T, Mercer B, Hunter S, Saade G, Reddy U. Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women. Obstetric Anesthesia Digest 2017, 37: 204. DOI: 10.1097/01.aoa.0000527046.29057.df.Peer-Reviewed Original ResearchFetal fibronectin levelsCervical lengthPreterm deliveryFibronectin levelsProspective observational cohort studyTransvaginal cervical lengthObservational cohort studySpontaneous preterm birthSpontaneous preterm deliveryNulliparous pregnant womenLong-term health effectsSpontaneous premature birthHigher medical costsCohort studyFetal fibronectinNulliparous womenPreterm birthPremature birthPregnant womenCervicovaginal fluidSerial measurementsUniversal screeningMedical costsMajor causeHealth effectsOnset of human preterm and term birth is related to unique inflammatory transcriptome profiles at the maternal fetal interface
Bukowski R, Sadovsky Y, Goodarzi H, Zhang H, Biggio JR, Varner M, Parry S, Xiao F, Esplin SM, Andrews W, Saade GR, Ilekis JV, Reddy UM, Baldwin DA. Onset of human preterm and term birth is related to unique inflammatory transcriptome profiles at the maternal fetal interface. PeerJ 2017, 5: e3685. PMID: 28879060, PMCID: PMC5582610, DOI: 10.7717/peerj.3685.Peer-Reviewed Original ResearchMaternal-fetal interfacePreterm birthTerm birthsFetal interfaceDownregulation of chemokinesAbsence of laborBurden of diseasePremature deliveryCesarean deliveryOverall mortalityChemokine expressionTerm laborNeonatal mortalityPregnant womenUterine fundusTerm parturitionHuman pretermPlacental functionMaternal bloodMultiple pathwaysFetal bloodPretermExpression profilesImmune rejectionImmune system
2014
Maternal serum serpin B7 is associated with early spontaneous preterm birth
Parry S, Zhang H, Biggio J, Bukowski R, Varner M, Xu Y, Andrews WW, Saade GR, Esplin MS, Leite R, Ilekis J, Reddy UM, Sadovsky Y, Blair IA, Research E. Maternal serum serpin B7 is associated with early spontaneous preterm birth. American Journal Of Obstetrics And Gynecology 2014, 211: 678.e1-678.e12. PMID: 24954659, PMCID: PMC4254341, DOI: 10.1016/j.ajog.2014.06.035.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthEarly spontaneous preterm birthPreterm birthMaternal serumSerum samplesPrevious spontaneous preterm birthSubsequent preterm deliveryProtein expressionLower gestational ageGestational age windowsCase-control studyCandidate protein expressionSerum proteomic analysisIndividual serum samplesPooled serum samplesSpontaneous pretermPreterm deliveryWeeks' gestationGestational ageTerm deliveryPregnant womenSerum biomarkersSerum concentrationsFetal membranesClinical sites