Low LCAT activity is linked to acute decompensated heart failure and mortality in patients with CKD
Stadler J, Bärnthaler T, Borenich A, Emrich I, Habisch H, Rani A, Holzer M, Madl T, Heine G, Marsche G. Low LCAT activity is linked to acute decompensated heart failure and mortality in patients with CKD. Journal Of Lipid Research 2024, 65: 100624. PMID: 39154733, PMCID: PMC11416249, DOI: 10.1016/j.jlr.2024.100624.Peer-Reviewed Original ResearchAcute decompensated heart failureChronic kidney diseaseLecithin-cholesterol acyltransferase activityDecompensated heart failureLecithin-cholesterol acyltransferaseLCAT activityHeart failureFollow-upNon-dialysis CKD patientsIncreased risk of cardiovascular mortalityChronic kidney disease patientsLow LCAT activityAssociated with all-cause mortalityRisk of adverse outcomesAssociated with risk of deathRisk of cardiovascular mortalityKidney function declineAll-cause mortalityHDL particle sizeAssociated with riskRisk of deathSerum LCAT activityAtherosclerotic cardiovascular eventsAssociated with decreased activityActivity of lecithin-cholesterol acyltransferase