Reductions in World Health Organization Risk Drinking Level Are Associated With Reductions in Alcohol Use Disorder Diagnosis and Criteria: Evidence From an Alcohol Pharmacotherapy Trial
Richards D, Tuchman F, Hallgren K, Kranzler H, Aubin H, O'Malley S, Mann K, Aldridge A, Anton R, Witkiewitz K. Reductions in World Health Organization Risk Drinking Level Are Associated With Reductions in Alcohol Use Disorder Diagnosis and Criteria: Evidence From an Alcohol Pharmacotherapy Trial. Journal Of Addiction Medicine 2024, 18: 418-424. PMID: 38606854, PMCID: PMC11290995, DOI: 10.1097/adm.0000000000001303.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingAlcoholismDelayed-Action PreparationsFemaleHumansMaleMiddle AgedTreatment OutcomeWorld Health OrganizationConceptsWorld Health Organization risk drinking levelsAlcohol use disorderAlcohol use disorder diagnosisAlcohol use disorder criteriaDrinking levelsMini International Neuropsychiatric InterviewSevere alcohol use disorderCurrent alcohol use disorderGabapentin enacarbilRisk drinking levelsMultisite randomized controlled trialAlcohol intervention trialPharmacotherapy trialsAUD diagnosisAUD treatmentNeuropsychiatric InterviewBaseline to endDisorder diagnosisEnd of treatmentFollow-backUse disorderAssess DiagnosticWorld Health OrganizationAssociated with reductionsSecondary data analysisReductions in World Health Organization risk drinking level are associated with improvements in sleep problems among individuals with alcohol use disorder
Garcia C, Richards D, Tuchman F, Hallgren K, Kranzler H, Aubin H, O’Malley S, Mann K, Aldridge A, Hoffman M, Anton R, Witkiewitz K. Reductions in World Health Organization risk drinking level are associated with improvements in sleep problems among individuals with alcohol use disorder. Alcohol And Alcoholism 2024, 59: agae022. PMID: 38606931, PMCID: PMC11010310, DOI: 10.1093/alcalc/agae022.Peer-Reviewed Original ResearchConceptsAlcohol use disorderSleep problemsAssociated with improvementsUse disorderMaintenance of alcohol use disorderDrinking levelsWorld Health Organization risk drinking levelsRisk drinking levelsTimeline Follow-BackSleep problem scoreFewer sleep problemsMonths of treatmentDrinking reductionFollow-backPittsburgh Sleep Quality IndexActive medicationSleep Quality IndexProblem scoresExtended-releaseAlcohol usePlacebo groupSleep disturbanceHarm reduction approachesSleep qualityControlled trials