Featured Publications
De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report
Gandhi S, Klein J, Robertson AJ, Peña-Hernández MA, Lin MJ, Roychoudhury P, Lu P, Fournier J, Ferguson D, Mohamed Bakhash SAK, Catherine Muenker M, Srivathsan A, Wunder EA, Kerantzas N, Wang W, Lindenbach B, Pyle A, Wilen CB, Ogbuagu O, Greninger AL, Iwasaki A, Schulz WL, Ko AI. De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report. Nature Communications 2022, 13: 1547. PMID: 35301314, PMCID: PMC8930970, DOI: 10.1038/s41467-022-29104-y.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionVirologic responsePersistent SARS-CoV-2 infectionResistance mutationsPre-treatment specimensB-cell deficiencyRemdesivir resistanceRemdesivir therapyViral sheddingCase reportAntiviral agentsPatientsCombinatorial therapyInfectionTherapyWhole-genome sequencingTreatmentImportance of monitoringDe novo emergenceFold increaseRNA-dependent RNA polymeraseNovo emergencePotential benefitsMutationsIndolent
2007
Role of APOBEC3G/F-Mediated Hypermutation in the Control of Human Immunodeficiency Virus Type 1 in Elite Suppressors
Gandhi S, Siliciano J, Bailey J, Siliciano R, Blankson J. Role of APOBEC3G/F-Mediated Hypermutation in the Control of Human Immunodeficiency Virus Type 1 in Elite Suppressors. Journal Of Virology 2007, 82: 3125-3130. PMID: 18077705, PMCID: PMC2259015, DOI: 10.1128/jvi.01533-07.Peer-Reviewed Original ResearchConceptsElite suppressorsAntiretroviral therapyHuman immunodeficiency virus type 1 (HIV-1) replicationHIV-1-infected individualsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Control of viremiaActive antiretroviral therapyType 1 replicationVirus type 1Host defense mechanismsViral loadCopies/Clinical significanceAPOBEC3 activityType 1APOBEC3 familyViremiaPatientsTherapyProviral genomeCytidine deaminasesF proteinDefense mechanismsNovel assay