Aging of the innate immune system
Shaw AC, Joshi S, Greenwood H, Panda A, Lord JM. Aging of the innate immune system. Current Opinion In Immunology 2010, 22: 507-513. PMID: 20667703, PMCID: PMC4034446, DOI: 10.1016/j.coi.2010.05.003.Peer-Reviewed Original ResearchConceptsInnate immune systemImmune systemPro-inflammatory environmentInnate immune activationToll-like receptorsMonocytes/macrophagesAge-associated defectsNKT cellsDendritic cellsImmune activationElderly individualsTissue damageNetwork of cellsCell typesSignal transduction pathwaysCellsActivationEarly interactionsTransduction pathwaysImmunosenescenceNeutrophilsInfectionMacrophagesNKReceptors