Aging of the innate immune system
Shaw AC, Joshi S, Greenwood H, Panda A, Lord JM. Aging of the innate immune system. Current Opinion In Immunology 2010, 22: 507-513. PMID: 20667703, PMCID: PMC4034446, DOI: 10.1016/j.coi.2010.05.003.Peer-Reviewed Original ResearchConceptsInnate immune systemImmune systemPro-inflammatory environmentInnate immune activationToll-like receptorsMonocytes/macrophagesAge-associated defectsNKT cellsDendritic cellsImmune activationElderly individualsTissue damageNetwork of cellsCell typesSignal transduction pathwaysCellsActivationEarly interactionsTransduction pathwaysImmunosenescenceNeutrophilsInfectionMacrophagesNKReceptorsEmergence of Resistance to Azithromycin-Atovaquone in Immunocompromised Patients with Babesia microti Infection
Wormser GP, Prasad A, Neuhaus E, Joshi S, Nowakowski J, Nelson J, Mittleman A, Aguero-Rosenfeld M, Topal J, Krause PJ. Emergence of Resistance to Azithromycin-Atovaquone in Immunocompromised Patients with Babesia microti Infection. Clinical Infectious Diseases 2010, 50: 381-386. PMID: 20047477, DOI: 10.1086/649859.Peer-Reviewed Original ResearchConceptsDrug regimenB. microtiLevel of immunosuppressionBabesia microti infectionTreatment of babesiosisDrug-resistant strainsEmergence of resistanceActive babesiosisMicrobiologic relapseLaboratory abnormalitiesDrug regimensImmunocompromised patientsOptimal therapyTreatment failureDrug therapyMicroti infectionPatientsClinical case historiesDrug resistanceBabesia microtiInfectionRegimenMicrotiEventual developmentBabesiosis