2024
“Deficiency in ELF4, X-Linked”: a Monogenic Disease Entity Resembling Behçet’s Syndrome and Inflammatory Bowel Disease
Olyha S, O’Connor S, Kribis M, Bucklin M, Uthaya Kumar D, Tyler P, Alam F, Jones K, Sheikha H, Konnikova L, Lakhani S, Montgomery R, Catanzaro J, Du H, DiGiacomo D, Rothermel H, Moran C, Fiedler K, Warner N, Hoppenreijs E, van der Made C, Hoischen A, Olbrich P, Neth O, Rodríguez-Martínez A, Lucena Soto J, van Rossum A, Dalm V, Muise A, Lucas C. “Deficiency in ELF4, X-Linked”: a Monogenic Disease Entity Resembling Behçet’s Syndrome and Inflammatory Bowel Disease. Journal Of Clinical Immunology 2024, 44: 44. PMID: 38231408, PMCID: PMC10929603, DOI: 10.1007/s10875-023-01610-8.Peer-Reviewed Original ResearchConceptsDEX patientsClass-switched memory B cellsInborn errors of immunityTreated with anti-inflammatory agentsLow natural killerX-linkedMemory B cellsErrors of immunityCohort of patientsIncreased inflammatory cytokinesLoss-of-function variantsHeterogeneous clinical phenotypesInflammatory bowel diseaseTargeted therapeutic interventionsNatural killerAnti-inflammatory agentsAphthous ulcersTherapeutic responseAutoinflammatory syndromeInflammatory markersClinical manifestationsB cellsBehcet's syndromeGastrointestinal symptomsMechanisms of disease
2020
Five Medical Education Podcasts You Need to Know.
Lomayesva NL, Martin AS, Dowley PA, Davies NW, Olyha SJ, Wijesekera TP. Five Medical Education Podcasts You Need to Know. The Yale Journal Of Biology And Medicine 2020, 93: 461-466. PMID: 32874153, PMCID: PMC7448387.Peer-Reviewed Original ResearchFlow cytometric identification of T fh 13 cells in mouse and human
Chen JS, Grassmann JDS, Gowthaman U, Olyha SJ, Simoneau T, Berin MC, Eisenbarth SC, Williams A. Flow cytometric identification of T fh 13 cells in mouse and human. Journal Of Allergy And Clinical Immunology 2020, 147: 470-483. PMID: 32709424, PMCID: PMC7854882, DOI: 10.1016/j.jaci.2020.04.063.Peer-Reviewed Original ResearchConceptsIgE antibodiesHigh affinity IgE antibodiesLife-threatening allergic reactionFollicular helper THigh-affinity IgEIgE productionHelper TAllergic reactionsMast cellsSevere reactionsMouse modelCytometric identificationCellular mechanismsBetter therapeuticsAllergyMiceAntibodiesCellsAnaphylaxisIgEPatientsHumansAeroallergensBasophils