2024
9365 Now You See Me: The Case Of The Ectopic Thyroid
Suarez S, Majumdar S. 9365 Now You See Me: The Case Of The Ectopic Thyroid. Journal Of The Endocrine Society 2024, 8: bvae163.2018. PMCID: PMC11454156, DOI: 10.1210/jendso/bvae163.2018.Peer-Reviewed Original ResearchEctopic thyroid tissueThyroid tissueLingual thyroidFamily history of autoimmune disordersCase of lingual thyroidHistory of autoimmune disordersSoft tissue of neckHead and neck surgeryAbsence of goiterDetectable thyroid tissueI-123 scansLingual thyroid tissueEctopic thyroid glandFree T4 levelsDifferent treatment modalitiesTissue of neckHead or neckConclusions HypothyroidismFailed descentProgressive hypothyroidismLevothyroxine doseLevothyroxine replacementThyroid bedEctopic thyroidElevated TSH6645 Paraganglioma or Benign Ectopic Thyroid Tissue?
Dower J, MacLeod R, Cardoso B, Matouk C, Mehra S, Riccio G, Williams L, Majumdar S. 6645 Paraganglioma or Benign Ectopic Thyroid Tissue? Journal Of The Endocrine Society 2024, 8: bvae163.2032. PMCID: PMC11454000, DOI: 10.1210/jendso/bvae163.2032.Peer-Reviewed Original ResearchEctopic thyroid tissueBenign thyroid tissueThyroid tissueHealthy 32-year-old womanLateral ectopic thyroid tissueLow likelihood of malignancyRight carotid spaceRight thyroid lobeInternal carotid artery branchesLikelihood of malignancyCarotid artery branchesPermanent tissue sectionsDOTATATE PET/CTCervical adenopathyJaw painNeck dissectionBiochemical workupTumor embolizationMimics malignancyNeck CTNeck MRIPlasma metanephrinesT2 lesionsChest CTThyroid FNA7045 A Rare Case of Lyme-Associated Thyroiditis in an Otherwise Healthy Patient
Windham M, Majumdar S. 7045 A Rare Case of Lyme-Associated Thyroiditis in an Otherwise Healthy Patient. Journal Of The Endocrine Society 2024, 8: bvae163.1865. PMCID: PMC11454719, DOI: 10.1210/jendso/bvae163.1865.Peer-Reviewed Original ResearchEndemic Lyme diseaseElevated high-sensitivity CRPHealthy 41-year-old manCardiac conduction defectsHigh-sensitivity CRPFollow-up visitHistory of hypertensionLyme diseasePrednisone taperUndetectable TSHBRCA2 mutationsFrequent palpitationsSensitive CRPInitial presentationLyme antibodiesMultiorgan inflammationHealthy patientsRare caseThyroid uptakeConduction defectsOverall incidenceGastroesophageal refluxNear normalizationDry coughThyroid7029 Changes In Adrenal Gland Size Seen By Linear Assessment On Routine Abdominal CT During Critical Illness
Vangipuram D, Bhagat N, Borkar R, Mazengia N, Williams S, Majumdar S. 7029 Changes In Adrenal Gland Size Seen By Linear Assessment On Routine Abdominal CT During Critical Illness. Journal Of The Endocrine Society 2024, 8: bvae163.133. PMCID: PMC11454092, DOI: 10.1210/jendso/bvae163.133.Peer-Reviewed Original ResearchIntensive care unit admissionIntensive care unitAdrenal gland volumeAdrenal gland sizeAdrenal glandAdrenocorticotropic hormoneCritical illnessGland volumeGland sizeIncreased adrenal blood flowContrast CT scanLeft adrenal glandHypothalamus-pituitary-adrenal (HPA) axisAdrenal blood flowStatistically significant decreaseAbdominal CTRetrospective studyAdult patientsCT scanSeptic shockControl patientsPituitary glandNon-contrastCare unitVolumetric evaluation
2023
FRI694 Hypercalcemia And Renal Failure As Initial Presentation Of A Rare Case Of Primary Splenic Large B Cell Lymphoma
Ding N, Majumdar S. FRI694 Hypercalcemia And Renal Failure As Initial Presentation Of A Rare Case Of Primary Splenic Large B Cell Lymphoma. Journal Of The Endocrine Society 2023, 7: bvad114.462. PMCID: PMC10555323, DOI: 10.1210/jendso/bvad114.462.Peer-Reviewed Original ResearchSplenic large B-cell lymphomaLarge B-cell lymphomaB-cell lymphomaDihydroxy vitamin DRenal failureVitamin DPg/mLCell lymphomaPg/Diffuse large B-cell lymphomaR-CHOP therapyPatient underwent splenectomyBence Jones proteinuriaBone marrow biopsyPrimary splenic lymphomaNon-Hodgkin lymphomaPrimary care doctorsAbdominal painElderly patientsInitial presentationUnderwent splenectomyCalcium 1000Further workupMRI abdomenRare etiologyTriglyceride Clearance in Hypertriglyceridemic Pancreatitis: Time Course and Its Implications for Management
Majumdar S. Triglyceride Clearance in Hypertriglyceridemic Pancreatitis: Time Course and Its Implications for Management. Endocrine Practice 2023, 29: 971-979. PMID: 37714331, DOI: 10.1016/j.eprac.2023.09.002.Peer-Reviewed Original ResearchInitial TG levelsTG levelsInsulin therapyMedical record reviewDiagnosis of pancreatitisTime courseHypertriglyceridemic pancreatitisIntravenous insulinRecord reviewTime-course evaluationTriglyceride clearanceInsulin treatmentNutritional intakeSeparate patientsTG loweringDlPatientsLonger durationPancreatitisShort durationHTGTherapyCauseClearanceDaysDiabetic Ketoacidosis Associated with Sodium‐Glucose Cotransporter 2 Inhibitors: Clinical and Biochemical Characteristics of 29 Cases
Stamatiades G, D’Silva P, Elahee M, Viana G, Sideri-Gugger A, Majumdar S. Diabetic Ketoacidosis Associated with Sodium‐Glucose Cotransporter 2 Inhibitors: Clinical and Biochemical Characteristics of 29 Cases. International Journal Of Endocrinology 2023, 2023: 6615624. PMID: 37441367, PMCID: PMC10335870, DOI: 10.1155/2023/6615624.Peer-Reviewed Original ResearchCommon presenting symptomAbdominal painEuglycemic DKAPresenting symptomSodium-glucose cotransporter 2 inhibitorsType 2 diabetes mellitusAverage blood glucose concentrationCases of DKAPoor food intakePoor oral intakeCotransporter 2 inhibitorsRetrospective case seriesSGLT2 inhibitor useDiabetic Ketoacidosis AssociatedPotential risk factorsBlood glucose concentrationVariety of drugsAnion gap valuesSGLT2i useDiabetes durationDiabetes mellitusDKA casesInhibitor useOral intakeCase series
2022
Development and Resolution of Secondary Adrenal Insufficiency after an Intra‐Articular Steroid Injection
Tan J, Majumdar S. Development and Resolution of Secondary Adrenal Insufficiency after an Intra‐Articular Steroid Injection. Case Reports In Endocrinology 2022, 2022: 4798466. PMID: 36588627, PMCID: PMC9800097, DOI: 10.1155/2022/4798466.Peer-Reviewed Original ResearchSecondary adrenal insufficiencyIntra-articular steroid injectionHypothalamic-pituitary axisSteroid injectionAdrenal insufficiencyIntra-articular steroidsIatrogenic Cushing's syndromeNonspecific gastrointestinal symptomsLow morning cortisolCorticosteroid usersSystemic corticosteroidsCorticosteroid injectionGastrointestinal symptomsLocal corticosteroidsNonspecific symptomsCushing's syndromeFurther workupInitial diagnosisAdrenal axisHPA responsivenessInflammatory conditionsTendon sheathMorning cortisolLower riskClinical practiceSpontaneous Adrenal Hemorrhage with Mild Hypoadrenalism in a Patient Anticoagulated with Apixaban for Antiphospholipid Syndrome: A Case Report and Literature Review
Tan J, Shukla A, Hu J, Majumdar S. Spontaneous Adrenal Hemorrhage with Mild Hypoadrenalism in a Patient Anticoagulated with Apixaban for Antiphospholipid Syndrome: A Case Report and Literature Review. Case Reports In Endocrinology 2022, 2022: 6538800. PMID: 36504598, PMCID: PMC9729038, DOI: 10.1155/2022/6538800.Peer-Reviewed Case Reports and Technical NotesDirect oral anticoagulantsAdrenal hemorrhageAntiphospholipid syndromeSafety of DOACsBilateral adrenal hemorrhageDeep venous thrombosesPrimary adrenal insufficiencySpontaneous adrenal hemorrhageCases of patientsPubMed/MEDLINEWarrants further studyAldosterone physiologyAPLS patientsAdrenal involvementEndocrine complicationsOral anticoagulantsVenous thrombosesAdrenal insufficiencyCortisol deficiencyAdrenal functionCortisol replacementAdrenal glandCase reportLaboratory findingsZona reticularisAccuracy of Flash Glucose Monitoring in Critically Ill Patients Receiving Intravenous Insulin
Tan JW, Majumdar SK (2022) Accuracy of Flash Glucose Monitoring in Critically Ill Patients Receiving Intravenous Insulin. Int Arch Endocrinol Clin Res 8:032. doi.org/10.23937Peer-Reviewed Original Research
2021
Early-Onset Vascular Dementia in a 43-Year-Old Man with Accelerated Atherosclerotic Disease, Elevated Lipoprotein (a), and a Missense DNAJC5 Variant with Potential Association to Adult-Onset Ceroid Lipofuscinosis
Faruq RN, D’Silva P, Lau FD, Zhao C, Majumdar S. Early-Onset Vascular Dementia in a 43-Year-Old Man with Accelerated Atherosclerotic Disease, Elevated Lipoprotein (a), and a Missense DNAJC5 Variant with Potential Association to Adult-Onset Ceroid Lipofuscinosis. Case Reports In Neurology 2021, 13: 565-571. PMID: 34720963, PMCID: PMC8460928, DOI: 10.1159/000518194.Peer-Reviewed Case Reports and Technical NotesEarly-onset dementiaNew infarctsElevated lipoproteinVascular dementiaRisk factorsMemory lossCeroid lipofuscinosisAccelerated atherosclerotic diseaseEarly vascular dementiaModifiable risk factorsProgressive memory lossMissense variantsDNAJC5 geneBilateral ICABilateral PCACardiac echocardiogramAccelerated atherosclerosisAntiplatelet agentsCerebrovascular infarctsAtherosclerotic diseaseCSF studiesLeft PCASevere stenosisMMA levelsInfarctsAlbumin-Corrected Calcium and the Prevalence and Categories of Hypercalcemia in Hospitalized Patients With 1-Year Follow-Up of Undiagnosed Cases
Priyadarshini Balasubramanian & Sachin K. Majumdar. Albumin-Corrected Calcium and the Prevalence and Categories of Hypercalcemia in Hospitalized Patients With 1-Year Follow-Up of Undiagnosed Cases. Endocrine Practice 2021: 27:279-285Peer-Reviewed Original ResearchImpact of COVID-19 on Diagnoses, Monitoring, and Mortality in People With Type 2 Diabetes in the UK
Majumdar S. Impact of COVID-19 on Diagnoses, Monitoring, and Mortality in People With Type 2 Diabetes in the UK. PracticeUpdate website. May 2021.Commentaries, Editorials and Letters
2020
Ventricular fibrillation in Graves disease reveals a rare SCN5A mutation with W1191X variant associated with Brugada syndrome
Stawiarski K, Clarke JD, Pollack A, Winslow R, Majumdar S. Ventricular fibrillation in Graves disease reveals a rare SCN5A mutation with W1191X variant associated with Brugada syndrome. HeartRhythm Case Reports 2020, 7: 95-99. PMID: 33665110, PMCID: PMC7897746, DOI: 10.1016/j.hrcr.2020.11.010.Peer-Reviewed Case Reports and Technical NotesA Novel Variant in the Calcium‐Sensing Receptor Associated with Familial Hypocalciuric Hypercalcemia and Low‐to‐Normal PTH
Majumdar SK, Jacob T, Bale A, Bailey A, Kwon J, Hughes T, Barbieri AL, Laskin W, Cohen P, Carling TJE. A Novel Variant in the Calcium‐Sensing Receptor Associated with Familial Hypocalciuric Hypercalcemia and Low‐to‐Normal PTH. Case Reports In Endocrinology 2020, 2020: 8752610. PMID: 33062349, PMCID: PMC7555459, DOI: 10.1155/2020/8752610.Peer-Reviewed Case Reports and Technical NotesFamilial hypocalciuric hypercalcemiaLow urinary calcium excretionUrinary calcium excretionCalcium excretionSerum calciumHypocalciuric hypercalcemiaCalcium-sensing receptor geneElevated set pointOsteitis fibrosa cysticaNovel heterozygous variantElevated calcitriolParathyroid histologyIntact PTHMild hypercalcemiaSubtotal parathyroidectomyFibrosa cysticaPrimary hyperparathyroidismMild elevationNormal PTHClinical manifestationsNovel variantsBony findingsBony lesionsCASR geneParathyroid glands
2019
Correction: Multidisciplinary strategies to treat severe hypoglycemia in hospitalized patients with diabetes mellitus reduce inpatient mortality rate: Experience from an academic community hospital
Kana Kadayakkara D, Balasubramanian P, Araque K, Davis K, Javed F, Niaki P, Majumdar S, Buller G. Correction: Multidisciplinary strategies to treat severe hypoglycemia in hospitalized patients with diabetes mellitus reduce inpatient mortality rate: Experience from an academic community hospital. PLOS ONE 2019, 14: e0222475. PMID: 31491034, PMCID: PMC6730911, DOI: 10.1371/journal.pone.0222475.Peer-Reviewed Original ResearchMultidisciplinary strategies to treat severe hypoglycemia in hospitalized patients with diabetes mellitus reduce inpatient mortality rate: Experience from an academic community hospital
Kadayakkara D, Balasubramanian P, Araque K, Davis K, Javed F, Niaki P, Majumdar S, Buller G. Multidisciplinary strategies to treat severe hypoglycemia in hospitalized patients with diabetes mellitus reduce inpatient mortality rate: Experience from an academic community hospital. PLOS ONE 2019, 14: e0220956. PMID: 31393971, PMCID: PMC6687156, DOI: 10.1371/journal.pone.0220956.Peer-Reviewed Original ResearchConceptsPatient mortality ratesSevere hypoglycemiaReadmission ratesDiabetes mellitusMortality rateNotification ratesStandardized treatmentGeneral internal medicine wardsMultidisciplinary strategyPatient's medical teamInpatient mortality rateInternal medicine wardsICD-10 codesPost-intervention studyStandardization of treatmentGlucose measurementsAcademic community hospitalSame observation periodDiabetic patientsHospitalized patientsMedicine wardsRetrospective reviewPhysician notificationPoor outcomeSecondary diagnosisA Novel Mutation in Calcium-Sensing Receptor Presenting as Familial Hypocalciuric Hypercalcemia in a Young Man
Madhavan P, Van Do TH, Bale A, Majumdar S. A Novel Mutation in Calcium-Sensing Receptor Presenting as Familial Hypocalciuric Hypercalcemia in a Young Man. AACE Clinical Case Reports 2019, 5: e226-e229. PMID: 31967040, PMCID: PMC6873832, DOI: 10.4158/accr-2018-0236.Peer-Reviewed Case Reports and Technical NotesFamilial hypocalciuric hypercalcemiaCalcium-sensing receptorHypocalciuric hypercalcemiaParathyroid growthLow urinary calcium excretionLong-term clinical followEvaluation of hypercalcemiaEvidence of adenomaElevated serum calciumUrinary calcium excretionMultiple endocrine neoplasiaAltered set pointCalcium excretionPrimary hyperparathyroidismClinical followSerum calciumClinical findingsSignificant hypercalcemiaSurgical interventionTomography scanEndocrine neoplasiaFamily historyHypercalcemiaBipolar disorderCalcium homeostasisProinsulin Expressing Neuroendocrine Tumors of the Pancreas
Celli R, Tang LH, Cai G, Freedman-Weiss M, Colunga M, Salem RR, Majumdar S, Jain D. Proinsulin Expressing Neuroendocrine Tumors of the Pancreas. Pancreas 2019, 48: 55-59. PMID: 30451800, DOI: 10.1097/mpa.0000000000001196.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPancreatic neuroendocrine tumorsNeuroendocrine tumorsAvailable clinicopathologic dataIHC-negative tumorsSurgical oncology centersNormal insulin levelsIHC-positive tumorsSerum proinsulinClinicopathologic featuresPNET patientsClinicopathologic dataHypoglycemic patientsInsulin levelsProspective studyOncology centersSerum glucoseSuch tumorsClinical significanceInsulin immunohistochemistryRare casePatientsImmunohistochemistryProinsulinomaTumorsInsulinoma
2018
Reducing severe hypoglycaemia in hospitalised patients with diabetes: Early outcomes of standardised reporting and management
Araque KA, Kadayakkara DK, Gigauri N, Sheehan D, Majumdar S, Buller G, Flannery CA. Reducing severe hypoglycaemia in hospitalised patients with diabetes: Early outcomes of standardised reporting and management. BMJ Open Quality 2018, 7: e000120. PMID: 29756070, PMCID: PMC5942454, DOI: 10.1136/bmjoq-2017-000120.Peer-Reviewed Original ResearchSystems-based interventionsGeneral medical wardsHypoglycaemic eventsMedian timeHospitalised adultsMedical wardsBasal-bolus insulin regimenRecurrent hypoglycaemic eventsSevere hypoglycaemic eventsFS testingHypoglycemia protocolInsulin regimenSevere hypoglycaemiaAdult patientsCumulative incidenceRecurrent hypoglycemiaSecondary outcomesAcute managementPrimary outcomeProlonged hospitalizationEndocrine consultationPhysician notificationEarly outcomesPoor outcomeMin postintervention