Sachin Majumdar Jr, MD
Associate Professor of Medicine (Endocrinology)Cards
About
Research
Publications
2026
Timing of Denosumab Therapy in Relation to Parathyroidectomy in the Setting of Primary Hyperparathyroidism: Case Report
MacLeod R, Ramirez A, Gulanski B, Majumdar S. Timing of Denosumab Therapy in Relation to Parathyroidectomy in the Setting of Primary Hyperparathyroidism: Case Report. Case Reports In Endocrinology 2026, 2026: 8562872. PMID: 42256324, PMCID: PMC13239141, DOI: 10.1155/crie/8562872.Peer-Reviewed Original ResearchDual-energy X-ray absorptiometryBone mineral densityDenosumab therapyPrimary hyperparathyroidismBone densityYears of denosumab therapyReduction of bone mineral densityConsistent with primary hyperparathyroidismRisk of vertebral fracturesMid-normal rangeSteroid-induced osteoporosisTime of parathyroidectomyCalcium/vitamin D supplementationHistory of lupusTreated with alendronateX-ray absorptiometryVitamin D levelsLiberation of calciumOptimal timingPostsurgical hypocalcemiaDenosumab injectionDaily prednisoneDenosumab dosesAntiresorptive therapyParathyroid surgery
2025
Iodine for the Outpatient Management of Graves’ Disease: A Case Series of 7 Patients
Magvanjav O, MacLeod R, Balasubramanian P, Mekala K, Peter P, Inzucchi S, Majumdar S. Iodine for the Outpatient Management of Graves’ Disease: A Case Series of 7 Patients. AACE Endocrinology And Diabetes 2025, 13: 83-87. PMID: 41641309, PMCID: PMC12866150, DOI: 10.1016/j.aed.2025.10.015.Peer-Reviewed Case Reports and Technical NotesGraves' diseaseRadioactive iodineOutpatient managementManagement of Graves' diseaseBridge to surgeryMean treatment durationChemotherapy-induced pancytopeniaThyroid hormone levelsDose of iodineDefinitive treatmentCase seriesSafety profileHormone elevationUncontrolled hyperthyroidismHormone levelsThionamidesTreatment durationSurgeryPatientsAlternative treatmentPropylthiouracilMonotherapyDiseaseTherapyTreatmentMON-402 Atypical Parathyroid Tumor Presenting with Normocalcemia and Cytology Features of Follicular Thyroid Neoplasm
Ntelis S, Karachaliou A, Majumdar S. MON-402 Atypical Parathyroid Tumor Presenting with Normocalcemia and Cytology Features of Follicular Thyroid Neoplasm. Journal Of The Endocrine Society 2025, 9: bvaf149.2176. PMCID: PMC12544593, DOI: 10.1210/jendso/bvaf149.2176.Peer-Reviewed Original ResearchAtypical parathyroid tumorsFine-needle aspirationFollicular thyroid neoplasmParathyroid tumorsThyroid neoplasmsHistological diagnosisMalignant potentialWHO classificationParathyroid hormoneDifferential diagnosisCytologic featuresFamily historyLoss of parafibromin expressionPreoperative fine-needle aspirationUltrasound-guided fine-needle aspirationPatient preferencesGene expression analysisCopy number alterationsDiagnosis of endocrine tumorsHistory of hypertensionPreoperative calciumLeft hemithyroidectomyParafibromin expressionNormocalcemic hyperparathyroidismPrimary hyperparathyroidismMON-778 Optimal Timing of Denosumab with Parathyroidectomy in the Setting of Primary Hyperparathyroidism
MacLeod R, Majumdar S. MON-778 Optimal Timing of Denosumab with Parathyroidectomy in the Setting of Primary Hyperparathyroidism. Journal Of The Endocrine Society 2025, 9: bvaf149.520. PMCID: PMC12544802, DOI: 10.1210/jendso/bvaf149.520.Peer-Reviewed Original ResearchFemoral neck T-scoreAnti-resorptive therapyPrimary hyperparathyroidismT-scoreDenosumab dosesVertebral fracturesVitamin D-25-OH levelLumbar spine T-scoreTotal hip T-scoreConsistent with primary hyperparathyroidismRisk of vertebral fracturesHigh dose ergocalciferolHip T-scorePost-operative PTHSpine T-scoreSteroid-sparing agentsSteroid-induced osteoporosisHistory of psoriasisVitamin D deficiencyLiberation of calciumOptimal timingIntermittent hypercalcemiaPTH elevationDenosumab therapyElevated PTH
2023
Triglyceride Clearance in Hypertriglyceridemic Pancreatitis: Time Course and Its Implications for Management
Majumdar S. Triglyceride Clearance in Hypertriglyceridemic Pancreatitis: Time Course and Its Implications for Management. Endocrine Practice 2023, 29: 971-979. PMID: 37714331, DOI: 10.1016/j.eprac.2023.09.002.Peer-Reviewed Original ResearchInitial TG levelsTG levelsInsulin therapyMedical record reviewDiagnosis of pancreatitisTime courseHypertriglyceridemic pancreatitisIntravenous insulinRecord reviewTime-course evaluationTriglyceride clearanceInsulin treatmentNutritional intakeSeparate patientsTG loweringDlPatientsLonger durationPancreatitisShort durationHTGTherapyCauseClearanceDaysDiabetic Ketoacidosis Associated with Sodium‐Glucose Cotransporter 2 Inhibitors: Clinical and Biochemical Characteristics of 29 Cases
Stamatiades G, D’Silva P, Elahee M, Viana G, Sideri-Gugger A, Majumdar S. Diabetic Ketoacidosis Associated with Sodium‐Glucose Cotransporter 2 Inhibitors: Clinical and Biochemical Characteristics of 29 Cases. International Journal Of Endocrinology 2023, 2023: 6615624. PMID: 37441367, PMCID: PMC10335870, DOI: 10.1155/2023/6615624.Peer-Reviewed Original ResearchCommon presenting symptomAbdominal painEuglycemic DKAPresenting symptomSodium-glucose cotransporter 2 inhibitorsType 2 diabetes mellitusAverage blood glucose concentrationCases of DKAPoor food intakePoor oral intakeCotransporter 2 inhibitorsRetrospective case seriesSGLT2 inhibitor useDiabetic Ketoacidosis AssociatedPotential risk factorsBlood glucose concentrationVariety of drugsAnion gap valuesSGLT2i useDiabetes durationDiabetes mellitusDKA casesInhibitor useOral intakeCase series
2022
Development and Resolution of Secondary Adrenal Insufficiency after an Intra‐Articular Steroid Injection
Tan J, Majumdar S. Development and Resolution of Secondary Adrenal Insufficiency after an Intra‐Articular Steroid Injection. Case Reports In Endocrinology 2022, 2022: 4798466. PMID: 36588627, PMCID: PMC9800097, DOI: 10.1155/2022/4798466.Peer-Reviewed Original ResearchSecondary adrenal insufficiencyIntra-articular steroid injectionHypothalamic-pituitary axisSteroid injectionAdrenal insufficiencyIntra-articular steroidsIatrogenic Cushing's syndromeNonspecific gastrointestinal symptomsLow morning cortisolCorticosteroid usersSystemic corticosteroidsCorticosteroid injectionGastrointestinal symptomsLocal corticosteroidsNonspecific symptomsCushing's syndromeFurther workupInitial diagnosisAdrenal axisHPA responsivenessInflammatory conditionsTendon sheathMorning cortisolLower riskClinical practiceSpontaneous Adrenal Hemorrhage with Mild Hypoadrenalism in a Patient Anticoagulated with Apixaban for Antiphospholipid Syndrome: A Case Report and Literature Review
Tan J, Shukla A, Hu J, Majumdar S. Spontaneous Adrenal Hemorrhage with Mild Hypoadrenalism in a Patient Anticoagulated with Apixaban for Antiphospholipid Syndrome: A Case Report and Literature Review. Case Reports In Endocrinology 2022, 2022: 6538800. PMID: 36504598, PMCID: PMC9729038, DOI: 10.1155/2022/6538800.Peer-Reviewed Case Reports and Technical NotesDirect oral anticoagulantsAdrenal hemorrhageAntiphospholipid syndromeSafety of DOACsBilateral adrenal hemorrhageDeep venous thrombosesPrimary adrenal insufficiencySpontaneous adrenal hemorrhageCases of patientsPubMed/MEDLINEWarrants further studyAldosterone physiologyAPLS patientsAdrenal involvementEndocrine complicationsOral anticoagulantsVenous thrombosesAdrenal insufficiencyCortisol deficiencyAdrenal functionCortisol replacementAdrenal glandCase reportLaboratory findingsZona reticularisAccuracy of Flash Glucose Monitoring in Critically Ill Patients Receiving Intravenous Insulin
Tan JW, Majumdar SK (2022) Accuracy of Flash Glucose Monitoring in Critically Ill Patients Receiving Intravenous Insulin. Int Arch Endocrinol Clin Res 8:032. doi.org/10.23937Peer-Reviewed Original Research
2021
Early-Onset Vascular Dementia in a 43-Year-Old Man with Accelerated Atherosclerotic Disease, Elevated Lipoprotein (a), and a Missense DNAJC5 Variant with Potential Association to Adult-Onset Ceroid Lipofuscinosis
Faruq RN, D’Silva P, Lau FD, Zhao C, Majumdar S. Early-Onset Vascular Dementia in a 43-Year-Old Man with Accelerated Atherosclerotic Disease, Elevated Lipoprotein (a), and a Missense DNAJC5 Variant with Potential Association to Adult-Onset Ceroid Lipofuscinosis. Case Reports In Neurology 2021, 13: 565-571. PMID: 34720963, PMCID: PMC8460928, DOI: 10.1159/000518194.Peer-Reviewed Case Reports and Technical NotesEarly-onset dementiaNew infarctsElevated lipoproteinVascular dementiaRisk factorsMemory lossCeroid lipofuscinosisAccelerated atherosclerotic diseaseEarly vascular dementiaModifiable risk factorsProgressive memory lossMissense variantsDNAJC5 geneBilateral ICABilateral PCACardiac echocardiogramAccelerated atherosclerosisAntiplatelet agentsCerebrovascular infarctsAtherosclerotic diseaseCSF studiesLeft PCASevere stenosisMMA levelsInfarcts
Academic Achievements & Community Involvement
Clinical Care
Overview
Sachin Majumdar, MD, is an endocrinologist and director of the Endocrine Neoplasia Program.
Dr. Majumdar specializes in treating diseases of the thyroid, parathyroid, adrenal, and pituitary glands. He is also director of the Active Surveillance Program for Small Papillary Thyroid Cancers.
Small papillary thyroid cancers, he notes, are often slow-growing and nonaggressive cancers that can sometimes be managed non-surgically with regular screenings. “It’s very satisfying to be able to help people with these types of cancers. We can watch them or, if they are more serious and need treatment, we can have them surgically removed and people do well,” he says.
When he first meets a patient, Dr. Majumdar says he makes it a priority to walk them through their diagnosis and options, but not to overwhelm them with too much information at once.
“I let them know what the roadmap looks like and what to expect. But I remind them that we will take it one step at a time because at a first visit, nobody remembers everything. I say, ‘Here’s the first step and we’re dong this,’ and we go from there and talk,” he says.
Dr. Majumdar became interested in endocrinology by way of nutrition. “In college, I majored in nutrition, which got me interested in sugar and fat metabolism and diabetes,” he says. “When I decided on medical school, endocrinology was almost right away a great fit for me because I had a background in insulin, diabetes, and metabolism, and endocrinology provides a landscape of how hormones and nutrients are involved in regulating the way we live.”
Dr. Majumdar’s research interests include clinical aspects of thyroid cancer management and separately, hypertriglyceridemia and its relationship to nutrient take and pancreatitis. “Also, participating in medical education has always been one of the most meaningful aspects of my work,” he says.
Clinical Specialties
Fact Sheets
Endocrine Cancer
Learn More on Yale MedicineThyroid Disease
Learn More on Yale MedicineHyperglycemia: Symptoms, Causes, and Treatments
Learn More on Yale MedicineThyroid Cancer
Learn More on Yale Medicine
Yale Medicine News
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News
- March 11, 2025Source: Yale Medicine
Thyroid Cancer: Early Diagnosis Is Key to Successful Treatment
- December 04, 2024
Smilow Shares with Primary Care: Thyroid Nodules and Cancer
- April 15, 2024
Meet Yale Internal Medicine: Sachin Majumdar Jr., MD
- January 16, 2024
Department of Internal Medicine Promotions and Appointments (January 2024)
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