2024
Airway microbiome signature accurately discriminates Mycobacterium tuberculosis infection status
Kayongo A, Ntayi M, Olweny G, Kyalo E, Ndawula J, Ssengooba W, Kigozi E, Kalyesubula R, Munana R, Namaganda J, Caroline M, Sekibira R, Bagaya B, Kateete D, Joloba M, Jjingo D, Sande O, Mayanja-Kizza H. Airway microbiome signature accurately discriminates Mycobacterium tuberculosis infection status. IScience 2024, 27: 110142. PMID: 38904070, PMCID: PMC11187240, DOI: 10.1016/j.isci.2024.110142.Peer-Reviewed Original ResearchImmune responseQuantiferon-gold assayMicrobiome signaturesLonger treatment durationTuberculosis infection statusInfection statusDeadly infectious agentsQuantiferon GoldDrug toxicityActive TBLatent TBTreatment durationTherapeutic strategiesPredicting disease susceptibilityFollow-up phaseAirwayMicrobiome diversityInfectious agentsRural UgandaControl TBMycobacterium tuberculosisDisease susceptibilityCohortTuberculosisGeneXpert
2023
Challenges to Implementation of Community Health Worker-Led Chronic Obstructive Pulmonary Disease (COPD) Screening and Referral in Rural Uganda: A Qualitative Study using the Implementation Outcomes Framework
Ingenhoff R, Robertson N, Munana R, Bodnar B, Weswa I, Sekitoleko I, Gaal J, Kirenga B, Kalyesubula R, Knauf F, Siddharthan T. Challenges to Implementation of Community Health Worker-Led Chronic Obstructive Pulmonary Disease (COPD) Screening and Referral in Rural Uganda: A Qualitative Study using the Implementation Outcomes Framework. International Journal Of Chronic Obstructive Pulmonary Disease 2023, 18: 2769-2783. PMID: 38046984, PMCID: PMC10693197, DOI: 10.2147/copd.s420137.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseImplementation Outcomes FrameworkCOPD screeningRural UgandaBurden of COPDReferral processCommunity health worker interventionHealth worker interventionObstructive pulmonary diseaseHealthcare providers' perceptionsCause of deathHigh patient volumeCommunity-based interventionsCHW supportCOPD awarenessCOPD careMiddle-income countriesPulmonary diseaseMedication accessBody of evidenceOutcomes FrameworkQualitative studyHealth outcomesProviders' perceptionsPatient volume