2017
Randomized, Controlled Trial of TRC101 to Increase Serum Bicarbonate in Patients with CKD
Bushinsky DA, Hostetter T, Klaerner G, Stasiv Y, Lockey C, McNulty S, Lee A, Parsell D, Mathur V, Li E, Buysse J, Alpern R. Randomized, Controlled Trial of TRC101 to Increase Serum Bicarbonate in Patients with CKD. Clinical Journal Of The American Society Of Nephrology 2017, 13: 26-35. PMID: 29102959, PMCID: PMC5753317, DOI: 10.2215/cjn.07300717.Peer-Reviewed Original ResearchConceptsSerum bicarbonateEnd of treatmentMetabolic acidosisTreatment groupsBaseline serum bicarbonateMean baseline eGFRMEq/LSignificant adverse effectsBaseline eGFRGastrointestinal eventsAdverse eventsFirst doseControlled TrialsHeart failurePatientsCKDBaseline levelsMean increaseAbstractTextUnit studiesAcidosisAdverse effectsPlaceboTreatmentDays
1985
A model of proximal tubular bicarbonate absorption
Alpern RJ, Rector FC. A model of proximal tubular bicarbonate absorption. American Journal Of Physiology 1985, 248: f272-f281. PMID: 3970216, DOI: 10.1152/ajprenal.1985.248.2.f272.Peer-Reviewed Original ResearchAbsorptionAcidosisAlkalosisAnimalsBicarbonatesGlomerular Filtration RateKidney Tubules, ProximalModels, BiologicalNephronsRats
1984
Regulation of proximal bicarbonate reabsorption
Cogan MG, Alpern RJ. Regulation of proximal bicarbonate reabsorption. American Journal Of Physiology 1984, 247: f387-f395. PMID: 6148019, DOI: 10.1152/ajprenal.1984.247.3.f387.Peer-Reviewed Original Research