Proteolethargy is a pathogenic mechanism in chronic disease
Dall'Agnese A, Zheng M, Moreno S, Platt J, Hoang A, Kannan D, Dall'Agnese G, Overholt K, Sagi I, Hannett N, Erb H, Corradin O, Chakraborty A, Lee T, Young R. Proteolethargy is a pathogenic mechanism in chronic disease. Cell 2024 PMID: 39610243, DOI: 10.1016/j.cell.2024.10.051.Peer-Reviewed Original ResearchPathogenic signalsExcessive reactive oxygen speciesMobility phenotypeCellular functionsAffected proteinsPathogenic mechanismsReactive oxygen speciesCysteine residuesSpectra of proteinsProtein mobilityPathogenic stimuliPathogenic featuresOxygen speciesMolecular levelCellular mechanismsDiverse chronic diseasesProteinChronic diseases