Richard Young, MD
Medical Services ProviderCards
Titles
Assoc Clin Prof Pediatrics & Neurology
About
Titles
Medical Services Provider
Assoc Clin Prof Pediatrics & NeurologyAppointments
General Pediatrics
Associate Clinical ProfessorPrimary
Other Departments & Organizations
Education & Training
- MD
- Yale University (1973)
Research
Research at a Glance
Publications Timeline
A big-picture view of Richard Young's research output by year.
4Publications
2Citations
Publications
2024
MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons
Liu Y, Flamier A, Bell G, Diao A, Whitfield T, Wang H, Wu Y, Schulte F, Friesen M, Guo R, Mitalipova M, Liu X, Vos S, Young R, Jaenisch R. MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons. Neuron 2024, 112: 1943-1958.e10. PMID: 38697112, DOI: 10.1016/j.neuron.2024.04.007.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPromoter-proximal regionRNA polymerase IIPolymerase IIHuman neuronsMethylated DNA binding protein MeCP2RNA Pol IIWild-typeLoss of gene activityAutism risk genesPol IIPositive cofactorCpG islandsTranscriptional regulationModulate transcriptionProtein MeCP2Patient mutationsNeurodevelopmental disorder Rett syndromeGene activationRisk genesProteomic analysisNeuronal genesRett syndromeGene expressionGenesRNA
2023
TIF1γ Counteracts Ferroptosis to Drive Erythroid Progenitor Differentiation
Rossmann M, Yang S, Abraham B, Wang Y, Young R, Hekimi S, Zon L. TIF1γ Counteracts Ferroptosis to Drive Erythroid Progenitor Differentiation. Blood 2023, 142: 8. DOI: 10.1182/blood-2023-184853.Peer-Reviewed Original ResearchConceptsTranscription elongationErythroid differentiationErythroid lineageNucleotide metabolismHematopoietic stem cell differentiationCell fate decisionsGenome-wide expressionChromatin immunoprecipitation analysisOnset of hematopoiesisTranscription regulatory processesErythroid progenitor differentiationStem cell differentiationElectron transport chainInhibitor of ferroptosisTranscriptional intermediary factor 1 gammaEnzyme dihydroorotate dehydrogenaseChromatin factorsSuppressor screenMutant embryosFate decisionsTranscriptome profilingZebrafish embryosProgenitor differentiationLineage differentiationBlood differentiation
1990
Conditional Mutations Occur Predominantly in Highly Conserved Residues of RNA Polymerase II Subunits
Scafe C, Martin C, Nonet M, Podos S, Okamura S, Young R. Conditional Mutations Occur Predominantly in Highly Conserved Residues of RNA Polymerase II Subunits. Molecular And Cellular Biology 1990, 10: 1270-1275. DOI: 10.1128/mcb.10.3.1270-1275.1990.Peer-Reviewed Original ResearchConceptsRNA polymerase II largest subunitRNA polymerase mutantsAmino acid residuesRPB1 geneLarge subunitInvariant residuesEucaryotic organismsPolymerase mutantsConditional mutationsYeast cellsSequence analysisAcid residuesRPB2RPB1MutationsCold sensitivityResiduesYeastMutantsCellsHomologyPlasmidGenesRNASubunit
1989
RNA Polymerase II Subunit RPB4 Is Essential for High- and Low-Temperature Yeast Cell Growth
Woychik N, Young R. RNA Polymerase II Subunit RPB4 Is Essential for High- and Low-Temperature Yeast Cell Growth. Molecular And Cellular Biology 1989, 9: 2854-2859. DOI: 10.1128/mcb.9.7.2854-2859.1989.Peer-Reviewed Original ResearchConceptsRPB4 subunitRNA polymerase II subunitEscherichia coli RNA polymeraseSequence analysis of tryptic peptidesAmino acid sequence analysis of tryptic peptidesRNA polymerase II activityAmino acid sequence analysisDeletion of RPB4Polymerase II subunitAnalysis of tryptic peptidesRNA polymerase IIAmino acidsPolymerase II activityRPB4 geneSigma subunitCrude extracts in vitroPolymerase IIRNA polymeraseSaccharomyces cerevisiaeEnzyme assemblyDNA sequencesRpb4Purified subunitsExtracts in vitroMRNA synthesis
Clinical Care
Overview
Clinical Specialties
Pediatrics; Pediatric Neurology
Board Certifications
Neurology with Special Qual in Child Neurology
- Certification Organization
- AB of Psychiatry & Neurology
- Original Certification Date
- 1983
Pediatrics
- Certification Organization
- AB of Pediatrics
- Original Certification Date
- 1979
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