2017
AP2 α modulates cystic fibrosis transmembrane conductance regulator function in the human intestine
Kumari V, Desai S, Ameen NA. AP2 α modulates cystic fibrosis transmembrane conductance regulator function in the human intestine. Journal Of Cystic Fibrosis 2017, 16: 327-334. PMID: 28438500, PMCID: PMC5502754, DOI: 10.1016/j.jcf.2017.03.012.Peer-Reviewed Original Research
1999
CFTR channel insertion to the apical surface in rat duodenal villus epithelial cells is upregulated by VIP in vivo
Ameen N, Martensson B, Bourguinon L, Marino C, Isenberg J, McLaughlin G. CFTR channel insertion to the apical surface in rat duodenal villus epithelial cells is upregulated by VIP in vivo. Journal Of Cell Science 1999, 112: 887-894. PMID: 10036238, DOI: 10.1242/jcs.112.6.887.Peer-Reviewed Original ResearchConceptsCystic fibrosis transmembrane conductance regulator (CFTR) channelVillus epithelial cellsApical surfaceApical plasma membraneAnti-CFTR antibodiesQuantitative confocal microscopyNew protein synthesisApical membrane insertionIntestinal villus epithelial cellsEpithelial cellsMembrane CFTRMembrane insertionApical cytoskeletonNormal CFTRCHE cellsPlasma membraneAbsence of cycloheximideSubcellular redistributionCFTR channelsC-terminusCAMP stimulationIntracellular cAMP levelsProtein synthesisChannel insertionCFTR function