2020
Myelination- and immune-mediated MR-based brain network correlates
Cerina M, Muthuraman M, Gallus M, Koirala N, Dik A, Wachsmuth L, Hundehege P, Schiffler P, Tenberge J, Fleischer V, Gonzalez-Escamilla G, Narayanan V, Krämer J, Faber C, Budde T, Groppa S, Meuth S. Myelination- and immune-mediated MR-based brain network correlates. Journal Of Neuroinflammation 2020, 17: 186. PMID: 32532336, PMCID: PMC7293122, DOI: 10.1186/s12974-020-01827-z.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCentral nervous systemCorpus callosumBrain network characteristicsCuprizone dietAnxiety-like behaviorFractional anisotropy valuesDiffusion tensor imagingBackgroundMultiple sclerosisConsistent demyelinationMyelin dynamicsKey anatomical regionsCuprizone modelMyelin lossNeuropsychiatric symptomsAutoimmune diseasesFunctional impairmentNeurodegenerative processesHistopathological basisCortical areasMRI metricsDemyelinationDisease processNervous systemFA reduction
2016
Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis
Fleischer V, Gröger A, Koirala N, Droby A, Muthuraman M, Kolber P, Reuter E, Meuth S, Zipp F, Groppa S. Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis. Multiple Sclerosis Journal 2016, 23: 432-441. PMID: 27246143, DOI: 10.1177/1352458516651503.Peer-Reviewed Original ResearchConceptsMultiple sclerosisCentral nervous systemMagnetic resonance imagingWhite matterClinical declineClinical impairmentRelapsing-remitting MS patientsEarly multiple sclerosisVoxel-based morphometryTemporo-parietal regionsNeuronal injuryConnectivity patternsMS patientsRemission phaseDisease stageDisease onsetHealthy controlsFunctional declineNervous systemGray matter networksResonance imagingProbabilistic tractographySclerosisStructural connectivityDisease