2024
Understanding how space travel affects the female reproductive system to the Moon and beyond
Mathyk B, Imudia A, Quaas A, Halicigil C, Karouia F, Avci P, Nelson N, Guzeloglu-Kayisli O, Denbo M, Sanders L, Scott R, Basar M, Guevara-Cerdán A, Strug M, Monseur B, Kayisli U, Szewczyk N, Mason C, Young S, Tasoglu S, Costes S, Beheshti A. Understanding how space travel affects the female reproductive system to the Moon and beyond. Npj Women's Health 2024, 2: 20. DOI: 10.1038/s44294-024-00009-z.Peer-Reviewed Original ResearchHypothalamic-pituitary-gonadalFemale reproductive systemEndometrial receptivityReproductive endocrinologyHealthy live birthPreimplantation embryo developmentHypothalamic-pituitary-gonadal (HPG) axisFemale reproductive healthReproductive systemOvarian folliculogenesisCircadian rhythm changesLive birthsEmbryo implantationFemale reproductive endocrinologyEffects of space travelPregnancySpace travelReproductive healthEmbryo developmentRhythm changesAdverse effectsEndocrinologySuccessful transitionEffects of spaceflightInterplanetary species
2014
Unfolded protein response prevents blastocyst formation during preimplantation embryo development in vitro
Basar M, Bozkurt I, Guzeloglu-Kayisli O, Sozen B, Tekmen I, Schatz F, Arici A, Lockwood CJ, Kayisli UA. Unfolded protein response prevents blastocyst formation during preimplantation embryo development in vitro. Fertility And Sterility 2014, 102: 1777-1784. PMID: 25305729, DOI: 10.1016/j.fertnstert.2014.09.004.Peer-Reviewed Original ResearchConceptsUnfolded protein responseProtein responseBlastocyst formationEmbryo developmentActivation of UPRPreimplantation embryo developmentTM treatmentBlastocyst developmentEffect of tunicamycinEndoplasmic reticulum stressEmbryonic developmentER stressCell embryosNuclear fragmentationMorphological differencesImmunoglobulin proteinBlastocyst stageReticulum stressTunicamycinDevelopment ratePregnant mare serum gonadotropinBlastocyst development rateProtein-1 mRNA expressionNongenomic mechanismsEmbryos