2011
A Proinflammatory Role for Interleukin-22 in the Immune Response to Hepatitis B Virus
Zhang Y, Cobleigh MA, Lian J, Huang C, Booth CJ, Bai X, Robek MD. A Proinflammatory Role for Interleukin-22 in the Immune Response to Hepatitis B Virus. Gastroenterology 2011, 141: 1897-1906. PMID: 21708106, PMCID: PMC3199295, DOI: 10.1053/j.gastro.2011.06.051.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAnimalsCase-Control StudiesDisease Models, AnimalFemaleHepatitis BHepatitis B virusHepatitis B, ChronicHumansImmunity, InnateInterferon-gammaInterleukinsLiverMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicSeverity of Illness IndexTh17 CellsVirus ReplicationConceptsHepatitis B virusHBV transgenic miceIL-22Transgenic miceHBV infectionB virusT cellsImmune responseProinflammatory genesHBV-specific cytotoxic T cellsAntigen-nonspecific inflammatory cellsIL-22-induced expressionVirus replicationAcute HBV infectionSubsequent liver damageCytotoxic T cellsCytokine-based therapiesTh17 cellsLiver inflammationProinflammatory roleInflammatory cellsLiver damagePeripheral bloodSingle doseInflammatory response
2010
A Vesicular Stomatitis Virus-Based Hepatitis B Virus Vaccine Vector Provides Protection against Challenge in a Single Dose
Cobleigh MA, Buonocore L, Uprichard SL, Rose JK, Robek MD. A Vesicular Stomatitis Virus-Based Hepatitis B Virus Vaccine Vector Provides Protection against Challenge in a Single Dose. Journal Of Virology 2010, 84: 7513-7522. PMID: 20504927, PMCID: PMC2897621, DOI: 10.1128/jvi.00200-10.Peer-Reviewed Original ResearchConceptsHepatitis B virusT cell responsesSingle immunizationVaccine vectorVesicular stomatitis virusCD8 T cell responsesCD8 T cell activationSerious worldwide public health problemWorldwide public health problemRecombinant protein immunizationEffective prophylactic vaccineCommon infectious diseasesRecombinant vesicular stomatitis virusSimilar antibody titersPublic health problemRecombinant protein vaccineT cell activationStomatitis virusHBV vaccineLiver diseaseProphylactic vaccinesAntibody titersMultiple dosesProtein immunizationSingle dose