A Proinflammatory Role for Interleukin-22 in the Immune Response to Hepatitis B Virus
Zhang Y, Cobleigh MA, Lian J, Huang C, Booth CJ, Bai X, Robek MD. A Proinflammatory Role for Interleukin-22 in the Immune Response to Hepatitis B Virus. Gastroenterology 2011, 141: 1897-1906. PMID: 21708106, PMCID: PMC3199295, DOI: 10.1053/j.gastro.2011.06.051.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAnimalsCase-Control StudiesDisease Models, AnimalFemaleHepatitis BHepatitis B virusHepatitis B, ChronicHumansImmunity, InnateInterferon-gammaInterleukinsLiverMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicSeverity of Illness IndexTh17 CellsVirus ReplicationConceptsHepatitis B virusHBV transgenic miceIL-22Transgenic miceHBV infectionB virusT cellsImmune responseProinflammatory genesHBV-specific cytotoxic T cellsAntigen-nonspecific inflammatory cellsIL-22-induced expressionVirus replicationAcute HBV infectionSubsequent liver damageCytotoxic T cellsCytokine-based therapiesTh17 cellsLiver inflammationProinflammatory roleInflammatory cellsLiver damagePeripheral bloodSingle doseInflammatory response