2003
Histamine Antagonizes Tumor Necrosis Factor (TNF) Signaling by Stimulating TNF Receptor Shedding from the Cell Surface and Golgi Storage Pool*
Wang J, Al-Lamki RS, Zhang H, Kirkiles-Smith N, Gaeta ML, Thiru S, Pober JS, Bradley JR. Histamine Antagonizes Tumor Necrosis Factor (TNF) Signaling by Stimulating TNF Receptor Shedding from the Cell Surface and Golgi Storage Pool*. Journal Of Biological Chemistry 2003, 278: 21751-21760. PMID: 12646554, DOI: 10.1074/jbc.m212662200.Peer-Reviewed Original ResearchMeSH KeywordsADAM ProteinsADAM17 ProteinAnimalsBrefeldin ACell MembraneCell SeparationCells, CulturedDose-Response Relationship, DrugEndothelium, VascularEnzyme InhibitorsEnzyme-Linked Immunosorbent AssayFlow CytometryGolgi ApparatusHistamineHumansI-kappa B ProteinsImmunoblottingImmunohistochemistryMetalloendopeptidasesMiceMicroscopy, ConfocalMicroscopy, ElectronMicroscopy, FluorescenceMitogen-Activated Protein Kinase 3Mitogen-Activated Protein KinasesNF-KappaB Inhibitor alphaNitric Oxide SynthaseRecombinant Fusion ProteinsReverse Transcriptase Polymerase Chain ReactionSignal TransductionSkinTime FactorsTumor Necrosis Factor-alphaConceptsTumor necrosis factorEndothelial cellsNecrosis factorNovel anti-inflammatory activityPro-inflammatory functionsAnti-inflammatory activityTNF-alpha-converting enzymeEndothelial adhesion moleculesCultured human endothelial cellsTNF-alpha protease inhibitorVascular endothelial cellsCultured endothelial cellsHuman endothelial cellsHistamine injectionH1 receptorsReceptor lossCell surfaceImmunodeficient miceMitogen-activated protein kinase pathwaySurface TNFR1TNF receptorShed receptorCell surface receptorsTNF actionTransient loss
2000
The Death Domain of Tumor Necrosis Factor Receptor 1 Is Necessary but Not Sufficient for Golgi Retention of the Receptor and Mediates Receptor Desensitization
Gaeta M, Johnson D, Kluger M, Pober J. The Death Domain of Tumor Necrosis Factor Receptor 1 Is Necessary but Not Sufficient for Golgi Retention of the Receptor and Mediates Receptor Desensitization. Laboratory Investigation 2000, 80: 1185-1194. PMID: 10950109, DOI: 10.1038/labinvest.3780126.Peer-Reviewed Original ResearchConceptsDeath domainGolgi retentionPlasma membraneC-terminal death domainGolgi apparatusNF-kappaBDominant negative inhibitorWild-type receptorDisparate localizationTNF responseIntracellular domainC-terminusEndothelial cellsNegative inhibitorTNF signalsWild typeTumor necrosis factor receptor 1Chimeric receptorsFactor receptor 1Necrosis factor receptor 1Endogenous receptorsBasal expressionReceptor moleculesType receptorTNF action
1998
Treatment of traumatic brain injury with hypothermia
Biagas K, Gaeta M. Treatment of traumatic brain injury with hypothermia. Current Opinion In Pediatrics 1998, 10: 271-277. PMID: 9716889, DOI: 10.1097/00008480-199806000-00009.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain injuryAttenuation of injuryEffects of hypothermiaNew effective therapiesSystemic hypothermiaHypothermic therapyClinical trialsEffective therapySuch injuriesLaboratory evidenceHypothermiaInjuryMild formNitric oxideTherapyPutative mechanismsPatientsMolecular mechanismsSustained applicationTreatmentFree radicalsChildrenComplicationsInflammation