2010
Anti-inflammatory property of the cannabinoid receptor-2-selective agonist in spinal cord injury (35.11)
Adhikary S, Hongbo L, Skarica M, Tuma R, Ganea D. Anti-inflammatory property of the cannabinoid receptor-2-selective agonist in spinal cord injury (35.11). The Journal Of Immunology 2010, 184: 35.11-35.11. DOI: 10.4049/jimmunol.184.supp.35.11.Peer-Reviewed Original ResearchAcute spinal cord injurySpinal cord injuryAgonist treatmentImmune cellsCannabinoid receptor-2 selective agonistCord injurySpinal cordAnimal models of CNS disordersContusion model of spinal cord injuryInfiltration of immune cellsModels of CNS disordersT-cell-activating cytokinesTreat neuropathic painExpression of inflammatory moleculesModel of spinal cord injuryModel of acute spinal cord injuryInflammatory immune cellsToll-like receptorsO-1966Neuropathic painCannabinoid receptorsBladder functionRecovery of motorIL-23Anti-inflammatory properties
2009
Signal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune Encephalomyelitis
Skarica M, Wang T, McCadden E, Kardian D, Calabresi P, Small D, Whartenby K. Signal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune Encephalomyelitis. The Journal Of Immunology 2009, 182: 4192-4199. PMID: 19299717, PMCID: PMC3727416, DOI: 10.4049/jimmunol.0803631.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisPeripheral dendritic cellsDendritic cellsT cellsSignal transduction inhibitorsAutoimmune encephalomyelitisMultiple sclerosisIFN-gamma-secreting T cellsBone marrow chimera systemAg-specific T cellsTransduction inhibitorsT cell responsesT cell subsetsSignal transduction inhibitionCNS infiltrationCytokine polarizationIL-17IL-23Th1 responseAutoimmune responseCell subsetsCostimulatory moleculesIL-6TNF-alphaCEP-701