María José Ortuño Romero, PhD
Associate Research Scientist in GeneticsCards
About
Research
Publications
2024
GLP-1 programs the neurovascular landscape
Chen B, Yu X, Horvath-Diano C, Ortuño M, Tschöp M, Jastreboff A, Schneeberger M. GLP-1 programs the neurovascular landscape. Cell Metabolism 2024, 36: 2173-2189. PMID: 39357509, DOI: 10.1016/j.cmet.2024.09.003.Peer-Reviewed Original ResearchConceptsGLP-1R agonismGLP-1RMetabolic healthChronic low-grade inflammationLow-grade inflammationGlucagon-like peptide-1 receptorPersistent health issuesCognitive well-beingNutrient-rich foodsPeptide-1 receptorMetabolic syndromeHealth issuesMetabolic defectsBrain healthMetabolic environmentObesityWell-beingWeight lossHealthMetabolic conditionsAgonismNeurological conditions
2022
Author Correction: Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction
Schneeberger M, Brice N, Pellegrino K, Parolari L, Shaked J, Page K, Marchildon F, Barrows D, Carroll T, Topilko T, Mulligan V, Newman R, Doyle K, Bürli R, Barker D, Glen A, Ortuño M, Nectow A, Renier N, Cohen P, Carlton M, Heintz N, Friedman J. Author Correction: Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction. Nature Metabolism 2022, 5: 183-183. PMID: 36572826, PMCID: PMC9886547, DOI: 10.1038/s42255-022-00727-1.Peer-Reviewed Original ResearchPharmacological targeting of glutamatergic neurons within the brainstem for weight reduction
Schneeberger M, Brice N, Pellegrino K, Parolari L, Shaked J, Page K, Marchildon F, Barrows D, Carroll T, Topilko T, Mulligan V, Newman R, Doyle K, Bürli R, Barker D, Glen A, Ortuño M, Nectow A, Renier N, Cohen P, Carlton M, Heintz N, Friedman J. Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction. Nature Metabolism 2022, 4: 1495-1513. PMID: 36411386, PMCID: PMC9684079, DOI: 10.1038/s42255-022-00677-8.Peer-Reviewed Original ResearchConceptsDorsal raphe nucleusLateral hypothalamusGlutamatergic neuronsLeptin-resistant diet-inducedFood intakeVGLUT3 neuronsHuman dorsal raphe nucleusOrexin-1 receptorSuppression of food intakeAcute activationBody weightRaphe nucleusBrain regionsPharmacological targetsCentral nervous system disordersNervous system disordersLeptin deficiencyMale miceVGLUT3Diet-inducedNeurons projectMolecular profilingSystem disordersFeeding centerBrain
2021
Melanocortin 4 receptor stimulation prevents anti-depressant-associated weight gain in mice caused by long-term fluoxetine exposure
Ortuno M, Schneeberger M, Ilanges A, Marchildon F, Pellegrino K, Friedman J, Ducy P. Melanocortin 4 receptor stimulation prevents anti-depressant-associated weight gain in mice caused by long-term fluoxetine exposure. Journal Of Clinical Investigation 2021, 131 PMID: 34673574, PMCID: PMC8670849, DOI: 10.1172/jci151976.Peer-Reviewed Original ResearchConceptsCAMP response element-binding proteinInterfere with treatment complianceSerotonin reuptake inhibitorsBrainstem serotonergic neuronsFood intakeReuptake inhibitorsResponse element-binding proteinSerotonergic neuronsFluoxetine exposureSerotonin SignalingPhosphorylation of cAMP response element-binding proteinSSRIsAnorexigenic effectReceptor 1aBody weightElement-binding proteinMelanocortin-4 receptorTreatment complianceFLXProducts of pro-opiomelanocortinPro-opiomelanocortinLonger treatment periodHypothalamic neuronsCotreated miceLong-term use
2016
Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect
Ortuño M, Robinson S, Subramanyam P, Paone R, Huang Y, Guo X, Colecraft H, Mann J, Ducy P. Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect. Nature Medicine 2016, 22: 1170-1179. PMID: 27595322, PMCID: PMC5053870, DOI: 10.1038/nm.4166.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAnimalsBone and BonesBone RemodelingBone ResorptionCalciumFluoxetineGene ExpressionImmunohistochemistryIn Vitro TechniquesMiceMice, KnockoutNFATC Transcription FactorsOptical ImagingOsteogenesisPropranololSelective Serotonin Reuptake InhibitorsSerotonin Plasma Membrane Transport ProteinsSympathetic Nervous SystemTryptophan HydroxylaseX-Ray Microtomography
2013
How understanding gut serotonin secretion could potentially lead to new treatments for osteoporosis
Ortuño M, Ducy P. How understanding gut serotonin secretion could potentially lead to new treatments for osteoporosis. Expert Review Of Endocrinology & Metabolism 2013, 8: 93-95. PMID: 30736168, DOI: 10.1586/eem.12.80.Peer-Reviewed Original Research
2012
Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions
Ortuño M, Susperregui A, Artigas N, Rosa J, Ventura F. Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions. Bone 2012, 52: 548-556. PMID: 23159876, DOI: 10.1016/j.bone.2012.11.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBinding SitesBone and BonesBone Morphogenetic Protein 2Cell LineCollagen Type ICollagen Type I, alpha 1 ChainCore Binding Factor Alpha 1 SubunitEnhancer Elements, GeneticGene Expression RegulationHumansMiceMolecular Sequence Datap38 Mitogen-Activated Protein KinasesPhosphorylationPromoter Regions, GeneticProtein BindingSp1 Transcription FactorSp7 Transcription FactorTranscription FactorsTranscriptional ActivationConceptsSp1 sitesLong isoformBinding to Sp1 sitesConsensus Sp1 sequencePromoter in vitroProximal promoter regionPromoter reporter constructsERK-MAPK signalingBone-specific genesSp1 sequencesBinding to sitesOsteoblastic cell typesProximal promoterPromoter regionTranscription factorsEndogenous genesBinding regionReporter constructsTranscriptional effectsOsteoblastic cell phenotypeBone enhancementCOL1A1 gene expressionCOL1A1 transcriptionGene expressionMAPK signalingSimplified microenvironments and reduced cell culture size influence the cell differentiation outcome in cellular microarrays
Rodríguez-Seguí S, Ortuño M, Ventura F, Martínez E, Samitier J. Simplified microenvironments and reduced cell culture size influence the cell differentiation outcome in cellular microarrays. Journal Of Materials Science: Materials In Medicine 2012, 24: 189-198. PMID: 23080375, DOI: 10.1007/s10856-012-4785-1.Peer-Reviewed Original ResearchConceptsCellular microarraysCulture sizeGrowth factor stimuliCommitment stepSignaling cuesCellular differentiationCell differentiationMicroarraySignaling effectsMultiplex evaluationOsteoblast fateCell proliferationDifferentiationCellsOsteoblast differentiationSignalMicrospotsDifferential outcomesFate
2011
Noncanonical BMP signaling regulates cyclooxygenase-2 transcription.
Susperregui A, Gamell C, Rodríguez-Carballo E, Ortuño M, Bartrons R, Rosa J, Ventura F. Noncanonical BMP signaling regulates cyclooxygenase-2 transcription. Endocrinology 2011, 25: 1006-17. PMID: 21436263, PMCID: PMC5417253, DOI: 10.1210/me.2010-0515.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 2Cell LineCore Binding Factor Alpha 1 SubunitCyclooxygenase 2Enzyme InhibitorsGene Expression RegulationImidazolesMesenchymal Stem CellsMicep38 Mitogen-Activated Protein KinasesPromoter Regions, GeneticProto-Oncogene Proteins c-junPyrazolesPyridinesPyrimidinesRegulatory Elements, TranscriptionalResponse ElementsSignal TransductionSkullTissue Culture TechniquesTranscription, GeneticConceptsBone morphogenetic proteinTranscriptional inductionBMP-2 activityBMP signalingCAMP response element siteEfficient transcriptional activationFunction of p38Smad-binding elementActivation of p38 MAPKActivation of p38Cyclooxygenase-2 transcriptionRegulatory elementsProximal promoterTranscriptional responseGenetic analysisTranscriptional activityTranscription factorsBinding elementsTranscription factor 2Factor 2Target genesKinase 1Element siteBMP-2Transcription
2010
p38 Regulates Expression of Osteoblast-specific Genes by Phosphorylation of Osterix*
Ortuño M, Ruiz-Gaspà S, Rodríguez-Carballo E, Susperregui A, Bartrons R, Rosa J, Ventura F. p38 Regulates Expression of Osteoblast-specific Genes by Phosphorylation of Osterix*. Journal Of Biological Chemistry 2010, 285: 31985-31994. PMID: 20682789, PMCID: PMC2952199, DOI: 10.1074/jbc.m110.123612.Peer-Reviewed Original ResearchConceptsSp1 sequencesConsensus Sp1 sequenceZinc finger transcription factorTranscriptional activation complexP38 MAPK in vitroTarget gene promotersProtein-protein interactionsPromoter in vitroRecruitment of coactivatorsRecruitment of p300MAPK in vitroSer-73Ser-77Alternative promotersOsteoblastic cell typesTranscription factorsGene promoterRegulatory sitesBinding regionIn vivoOsx-null micePhosphorylationCell typesP38Bone-sialoprotein promoter